YCR045C / RRT12

Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR045C / RRT12

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.54|P-value:2.52E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.59|P-value:2.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.41|P-value:6.76E-17 ID:SGTC_72|Compound:0744-0168|FD-Score:3.38|P-value:4.51E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.41|P-value:3.72E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.43|P-value:6.64E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.43|P-value:3.55E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.04|P-value:3.59E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.36|P-value:4.44E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.42|P-value:3.88E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:7.66|P-value:2.46E-14 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.26|P-value:6.44E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.20|P-value:8.53E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.63|P-value:1.58E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.87|P-value:8.59E-7 ID:SGTC_433|Compound:pimozide|FD-Score:3.67|P-value:1.54E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.39|P-value:4.42E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:4.00|P-value:4.29E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.28|P-value:5.99E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:5.24|P-value:1.31E-7 ID:SGTC_909|Compound:3448-9333|FD-Score:9.47|P-value:5.88E-21 ID:SGTC_993|Compound:3909-8757|FD-Score:6.13|P-value:8.51E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:4.28|P-value:1.32E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.32|P-value:5.11E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.57|P-value:2.16E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.27|P-value:6.60E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.35|P-value:2.42E-13 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.60|P-value:2.84E-6 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.19|P-value:1.96E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.20|P-value:1.85E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.82|P-value:1.11E-6 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.40|P-value:4.28E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.72|P-value:1.28E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.72|P-value:1.32E-4 ID:SGTC_1660|Compound:st012960|FD-Score:5.35|P-value:7.23E-8 ID:SGTC_1675|Compound:st018485|FD-Score:3.48|P-value:3.18E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.44|P-value:3.70E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.89|P-value:6.72E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.62|P-value:1.90E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.26|P-value:6.96E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.27|P-value:1.39E-5 ID:SGTC_2080|Compound:5212524|FD-Score:3.27|P-value:6.69E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.39|P-value:4.37E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.97|P-value:4.76E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.34|P-value:1.01E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.93|P-value:5.68E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.51|P-value:2.81E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.66|P-value:1.60E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.93|P-value:5.58E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.46|P-value:3.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.28|P-value:5.92E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.28|P-value:6.46E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.53|P-value:2.66E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-6.02|P-value:1.39E-9 ID:SGTC_3080|Compound:9117754|FD-Score:4.30|P-value:1.19E-5 ID:SGTC_3161|Compound:9100388|FD-Score:3.51|P-value:2.84E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.06|P-value:1.30E-9 ID:SGTC_3259|Compound:9138485|FD-Score:4.45|P-value:6.26E-6 ID:SGTC_3266|Compound:9136860|FD-Score:4.42|P-value:7.08E-6 ID:SGTC_3276|Compound:9139060|FD-Score:3.88|P-value:6.91E-5 ID:SGTC_3282|Compound:9108498|FD-Score:4.34|P-value:9.86E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.32|P-value:1.12E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.54|P-value:2.52E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.59|P-value:2.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.41|P-value:6.76E-17 ID:SGTC_72|Compound:0744-0168|FD-Score:3.38|P-value:4.51E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.41|P-value:3.72E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.43|P-value:6.64E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.43|P-value:3.55E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.04|P-value:3.59E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.36|P-value:4.44E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.42|P-value:3.88E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:7.66|P-value:2.46E-14 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.26|P-value:6.44E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.20|P-value:8.53E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.63|P-value:1.58E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.87|P-value:8.59E-7 ID:SGTC_433|Compound:pimozide|FD-Score:3.67|P-value:1.54E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.39|P-value:4.42E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:4.00|P-value:4.29E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.28|P-value:5.99E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:5.24|P-value:1.31E-7 ID:SGTC_909|Compound:3448-9333|FD-Score:9.47|P-value:5.88E-21 ID:SGTC_993|Compound:3909-8757|FD-Score:6.13|P-value:8.51E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:4.28|P-value:1.32E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.32|P-value:5.11E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.57|P-value:2.16E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.27|P-value:6.60E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.35|P-value:2.42E-13 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.60|P-value:2.84E-6 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.19|P-value:1.96E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.20|P-value:1.85E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.82|P-value:1.11E-6 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.40|P-value:4.28E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.72|P-value:1.28E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.72|P-value:1.32E-4 ID:SGTC_1660|Compound:st012960|FD-Score:5.35|P-value:7.23E-8 ID:SGTC_1675|Compound:st018485|FD-Score:3.48|P-value:3.18E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.44|P-value:3.70E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.89|P-value:6.72E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.62|P-value:1.90E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.26|P-value:6.96E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.27|P-value:1.39E-5 ID:SGTC_2080|Compound:5212524|FD-Score:3.27|P-value:6.69E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.39|P-value:4.37E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.97|P-value:4.76E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.34|P-value:1.01E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.93|P-value:5.68E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.51|P-value:2.81E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.66|P-value:1.60E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.93|P-value:5.58E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.46|P-value:3.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.28|P-value:5.92E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.28|P-value:6.46E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.53|P-value:2.66E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-6.02|P-value:1.39E-9 ID:SGTC_3080|Compound:9117754|FD-Score:4.30|P-value:1.19E-5 ID:SGTC_3161|Compound:9100388|FD-Score:3.51|P-value:2.84E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.06|P-value:1.30E-9 ID:SGTC_3259|Compound:9138485|FD-Score:4.45|P-value:6.26E-6 ID:SGTC_3266|Compound:9136860|FD-Score:4.42|P-value:7.08E-6 ID:SGTC_3276|Compound:9139060|FD-Score:3.88|P-value:6.91E-5 ID:SGTC_3282|Compound:9108498|FD-Score:4.34|P-value:9.86E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.32|P-value:1.12E-5

Top fitness defect scores for YCR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_909 3448-9333 9.47 149.0 µM 5.88E-21 1 1.37E-21
2 SGTC_58 0957-0393 8.41 9.0 µM 6.76E-17 cell wall 112 2.12E-17
3 SGTC_375 3970-0961 7.66 9.3 µM 2.46E-14 tubulin folding & SWR complex 3 9.29E-15
4 SGTC_1130 3454-2858 7.35 15.9 µM 2.42E-13 NEO1 25 9.83E-14
5 SGTC_993 3909-8757 6.13 62.7 µM 8.51E-10 5 4.48E-10
6 SGTC_3202 9113761 6.06 49.5 µM 1.30E-9 13 6.96E-10
7 SGTC_423 5-fluorouracil 5.63 457.0 µM 1.58E-8 exosome 3 9.10E-9
8 SGTC_1000 4048-0884 5.57 8.7 µM 2.16E-8 copper-dependent oxidative stress 11 1.26E-8
9 SGTC_1660 st012960 5.35 28.1 µM 7.23E-8 iron homeostasis 13 4.38E-8
10 SGTC_907 3448-6986 5.24 75.5 µM 1.31E-7 6 8.11E-8
11 SGTC_430 0958-0115 4.87 16.4 µM 8.59E-7 11 5.64E-7
12 SGTC_1338 1486-1223 4.82 76.0 µM 1.11E-6 6 7.31E-7
13 SGTC_3259 9138485 4.45 49.5 µM 6.26E-6 6 4.38E-6
14 SGTC_176 1486-1328 4.43 72.8 µM 6.64E-6 42 4.65E-6
15 SGTC_3266 9136860 4.42 49.5 µM 7.08E-6 cell wall 37 4.96E-6
16 SGTC_3282 9108498 4.34 15.5 µM 9.86E-6 23 6.99E-6
17 SGTC_2477 5967686 4.34 25.2 µM 1.01E-5 18 7.15E-6
18 SGTC_3294 9122953 4.32 26.3 µM 1.12E-5 tubulin folding & SWR complex 18 7.93E-6
19 SGTC_3080 9117754 4.30 49.5 µM 1.19E-5 12 8.48E-6
20 SGTC_995 3931-2021 4.28 34.6 µM 1.32E-5 RPP1 & pyrimidine depletion 18 9.46E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 4.56E-25 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.153 5.51E-19 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.153 6.05E-19 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.148 7.31E-18 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.145 3.05E-17 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.143 9.60E-17 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.136 2.96E-15 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.134 7.02E-15 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.125 3.08E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.116 1.37E-11 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.115 2.61E-11 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.113 4.42E-11 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.113 5.25E-11 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.111 1.00E-10 YCR024C-A PMP1 hom Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication
0.108 4.20E-10 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency