HIPHOP chemogenomics database

YCR049C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YCR049C / YCR049C

Click on Significant Values for Screen Details

Top fitness defect scores for YCR049C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1161	k007-0610	7.12	110.0 µM	2.79E-11	ERAD & cell cycle	36	5.24E-13
2	SGTC_1075	aripiprazole	6.50	15.2 µM	1.10E-9		3	3.90E-11
3	SGTC_708	3448-5400	5.70	146.0 µM	8.05E-8		11	6.02E-9
4	SGTC_2759	disulfiram	5.61	3.4 µM	1.23E-7		8	9.92E-9
5	SGTC_58	0957-0393	5.57	9.0 µM	1.55E-7	cell wall	239	1.30E-8
6	SGTC_752	1896-0090	5.41	130.0 µM	3.31E-7	TSC3-RPN4	4	3.16E-8
7	SGTC_1638	st008370	5.31	60.6 µM	5.33E-7	ergosterol biosynthesis	11	5.52E-8
8	SGTC_518	1021-0119	5.13	62.6 µM	1.19E-6	ERG2	13	1.42E-7
9	SGTC_392	N-ethylmaleimide	5.10	8.3 µM	1.41E-6	RNA pol III & RNase P/MRP	3	1.73E-7
10	SGTC_103	0844-0104	4.95	51.8 µM	2.66E-6	ERAD & cell cycle	103	3.64E-7
11	SGTC_2322	7413319	4.71	38.2 µM	7.68E-6	ERAD & cell cycle	114	1.26E-6
12	SGTC_1541	2',3',6-trimethoxyflavone	4.65	64.0 µM	9.86E-6		7	1.69E-6
13	SGTC_516	3992-2719	4.45	87.3 µM	2.15E-5		11	4.22E-6
14	SGTC_1545	lovastatin	4.41	49.4 µM	2.59E-5		13	5.23E-6
15	SGTC_2688	kanamycin b	4.35	96.7 µM	3.21E-5	calcium & mitochondrial duress	317	6.72E-6
16	SGTC_1844	rapamycin	4.32	4.0 nM	3.61E-5		136	7.71E-6
17	SGTC_568	1193-0097	4.27	7.5 µM	4.47E-5	ERAD & cell cycle	130	9.92E-6
18	SGTC_553	k007-0256	4.19	45.7 µM	6.06E-5	heme biosynthesis & mitochondrial translocase	17	1.42E-5
19	SGTC_2203	7227154	4.13	166.4 µM	7.41E-5		7	1.79E-5
20	SGTC_1512	0259-0544	4.00	12.2 µM	1.23E-4		15	3.23E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.263	2.34E-54	YDL148C	NOP14	het	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.221	2.02E-38	YOL065C	INP54	hom	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.196	2.31E-30	YNL179C_d	YNL179C_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.193	1.21E-29	YMR022W	UBC7	hom	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.185	3.46E-27	YIL030C	SSM4	hom	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.182	1.77E-26	YDL025C	RTK1	hom	Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.173	5.50E-24	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.171	1.88E-23	YCR079W	PTC6	hom	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.170	4.16E-23	YFR008W	FAR7	hom	Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.168	1.12E-22	YML016C	PPZ1	hom	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.168	1.30E-22	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.164	1.36E-21	YMR116C	ASC1	hom	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.159	2.18E-20	YLR380W	CSR1	hom	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.154	2.76E-19	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.154	3.57E-19	YMR029C	FAR8	hom	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p