YCR049C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR049C / YCR049C

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.75|P-value:2.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.57|P-value:1.55E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:4.95|P-value:2.66E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.51|P-value:6.44E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.65|P-value:3.56E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:5.10|P-value:1.41E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.53|P-value:1.32E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.94|P-value:1.50E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.45|P-value:2.15E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:5.13|P-value:1.19E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:4.19|P-value:6.06E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.27|P-value:4.47E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.58|P-value:5.07E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.70|P-value:8.05E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:3.57|P-value:5.28E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:5.41|P-value:3.31E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.43|P-value:8.34E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:6.50|P-value:1.10E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.12|P-value:2.79E-11 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.00|P-value:1.23E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.65|P-value:9.86E-6 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.41|P-value:2.59E-5 ID:SGTC_1638|Compound:st008370|FD-Score:5.31|P-value:5.33E-7 ID:SGTC_1721|Compound:st082152|FD-Score:3.59|P-value:5.01E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.71|P-value:3.31E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.58|P-value:5.13E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.32|P-value:3.61E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-4.00|P-value:1.04E-4 ID:SGTC_1989|Compound:st071868|FD-Score:-3.53|P-value:5.17E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.13|P-value:7.41E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.71|P-value:7.68E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.42|P-value:8.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.35|P-value:3.21E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.61|P-value:1.23E-7 ID:SGTC_2932|Compound:9016711|FD-Score:3.68|P-value:3.69E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.06|P-value:8.30E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.51|P-value:6.52E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.75|P-value:2.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.57|P-value:1.55E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:4.95|P-value:2.66E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.51|P-value:6.44E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.65|P-value:3.56E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:5.10|P-value:1.41E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.53|P-value:1.32E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.94|P-value:1.50E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.45|P-value:2.15E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:5.13|P-value:1.19E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:4.19|P-value:6.06E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.27|P-value:4.47E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.58|P-value:5.07E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.70|P-value:8.05E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:3.57|P-value:5.28E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:5.41|P-value:3.31E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.43|P-value:8.34E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:6.50|P-value:1.10E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.12|P-value:2.79E-11 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.00|P-value:1.23E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.65|P-value:9.86E-6 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.41|P-value:2.59E-5 ID:SGTC_1638|Compound:st008370|FD-Score:5.31|P-value:5.33E-7 ID:SGTC_1721|Compound:st082152|FD-Score:3.59|P-value:5.01E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.71|P-value:3.31E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.58|P-value:5.13E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.32|P-value:3.61E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-4.00|P-value:1.04E-4 ID:SGTC_1989|Compound:st071868|FD-Score:-3.53|P-value:5.17E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.13|P-value:7.41E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.71|P-value:7.68E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.42|P-value:8.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.35|P-value:3.21E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.61|P-value:1.23E-7 ID:SGTC_2932|Compound:9016711|FD-Score:3.68|P-value:3.69E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.06|P-value:8.30E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.51|P-value:6.52E-4

Top fitness defect scores for YCR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1161 k007-0610 7.12 110.0 µM 2.79E-11 ERAD & cell cycle 36 5.24E-13
2 SGTC_1075 aripiprazole 6.50 15.2 µM 1.10E-9 3 3.90E-11
3 SGTC_708 3448-5400 5.70 146.0 µM 8.05E-8 11 6.02E-9
4 SGTC_2759 disulfiram 5.61 3.4 µM 1.23E-7 8 9.92E-9
5 SGTC_58 0957-0393 5.57 9.0 µM 1.55E-7 cell wall 239 1.30E-8
6 SGTC_752 1896-0090 5.41 130.0 µM 3.31E-7 TSC3-RPN4 4 3.16E-8
7 SGTC_1638 st008370 5.31 60.6 µM 5.33E-7 ergosterol biosynthesis 11 5.52E-8
8 SGTC_518 1021-0119 5.13 62.6 µM 1.19E-6 ERG2 13 1.42E-7
9 SGTC_392 N-ethylmaleimide 5.10 8.3 µM 1.41E-6 RNA pol III & RNase P/MRP 3 1.73E-7
10 SGTC_103 0844-0104 4.95 51.8 µM 2.66E-6 ERAD & cell cycle 103 3.64E-7
11 SGTC_2322 7413319 4.71 38.2 µM 7.68E-6 ERAD & cell cycle 114 1.26E-6
12 SGTC_1541 2',3',6-trimethoxyflavone 4.65 64.0 µM 9.86E-6 7 1.69E-6
13 SGTC_516 3992-2719 4.45 87.3 µM 2.15E-5 11 4.22E-6
14 SGTC_1545 lovastatin 4.41 49.4 µM 2.59E-5 13 5.23E-6
15 SGTC_2688 kanamycin b 4.35 96.7 µM 3.21E-5 calcium & mitochondrial duress 317 6.72E-6
16 SGTC_1844 rapamycin 4.32 4.0 nM 3.61E-5 136 7.71E-6
17 SGTC_568 1193-0097 4.27 7.5 µM 4.47E-5 ERAD & cell cycle 130 9.92E-6
18 SGTC_553 k007-0256 4.19 45.7 µM 6.06E-5 heme biosynthesis & mitochondrial translocase 17 1.42E-5
19 SGTC_2203 7227154 4.13 166.4 µM 7.41E-5 7 1.79E-5
20 SGTC_1512 0259-0544 4.00 12.2 µM 1.23E-4 15 3.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.263 2.34E-54 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.221 2.02E-38 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.196 2.31E-30 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.193 1.21E-29 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.185 3.46E-27 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.182 1.77E-26 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.173 5.50E-24 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.171 1.88E-23 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.170 4.16E-23 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.168 1.12E-22 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.168 1.30E-22 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.164 1.36E-21 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.159 2.18E-20 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.154 2.76E-19 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.154 3.57E-19 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p