YCR050C_p

Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR050C / YCR050C

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:5.90|P-value:1.55E-9 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.79|P-value:5.91E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:4.76|P-value:7.54E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:7.44|P-value:4.90E-14 ID:SGTC_145|Compound:3737-0113|FD-Score:3.21|P-value:5.07E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.09|P-value:7.74E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.31|P-value:3.58E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.89|P-value:4.02E-7 ID:SGTC_372|Compound:0155-0182|FD-Score:3.20|P-value:5.41E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.07|P-value:1.85E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.01|P-value:2.39E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.13|P-value:1.14E-7 ID:SGTC_698|Compound:k064-0052|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.34|P-value:5.67E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:3.96|P-value:2.93E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.59|P-value:1.30E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.29|P-value:3.90E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.07|P-value:1.82E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.43|P-value:2.31E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.84|P-value:4.81E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.92|P-value:3.43E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.36|P-value:3.01E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.14|P-value:6.56E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:5.61|P-value:8.29E-9 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.35|P-value:5.35E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.96|P-value:2.86E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.02|P-value:9.98E-13 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.01|P-value:2.14E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.71|P-value:3.17E-6 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.07|P-value:8.32E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.40|P-value:2.65E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.62|P-value:1.48E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.22|P-value:5.03E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.71|P-value:8.14E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.04|P-value:9.31E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.47|P-value:2.01E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.32|P-value:6.04E-6 ID:SGTC_1881|Compound:5652484|FD-Score:-4.01|P-value:6.57E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.89|P-value:3.91E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.46|P-value:2.06E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.88|P-value:4.11E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.82|P-value:5.24E-5 ID:SGTC_2286|Compound:7945697|FD-Score:4.04|P-value:2.08E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.10|P-value:7.42E-4 ID:SGTC_2322|Compound:7413319|FD-Score:8.93|P-value:2.59E-19 ID:SGTC_2475|Compound:5812728|FD-Score:3.13|P-value:6.79E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.78|P-value:1.61E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.14|P-value:6.58E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.12|P-value:7.11E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.53|P-value:4.01E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.45|P-value:5.23E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.37|P-value:2.95E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.29|P-value:3.87E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.94|P-value:3.18E-5 ID:SGTC_3023|Compound:9089636|FD-Score:7.79|P-value:3.48E-15 ID:SGTC_3026|Compound:9090633|FD-Score:-5.20|P-value:2.87E-7 ID:SGTC_3034|Compound:9090421|FD-Score:-3.56|P-value:3.63E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.73|P-value:7.44E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-3.54|P-value:3.90E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.11|P-value:4.43E-5 ID:SGTC_3051|Compound:9093778|FD-Score:3.20|P-value:5.31E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.45|P-value:2.17E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.37|P-value:7.08E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.37|P-value:7.09E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.34|P-value:7.78E-4 ID:SGTC_3268|Compound:9137683|FD-Score:4.15|P-value:1.32E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:5.90|P-value:1.55E-9 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.79|P-value:5.91E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:4.76|P-value:7.54E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:7.44|P-value:4.90E-14 ID:SGTC_145|Compound:3737-0113|FD-Score:3.21|P-value:5.07E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.09|P-value:7.74E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.31|P-value:3.58E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.89|P-value:4.02E-7 ID:SGTC_372|Compound:0155-0182|FD-Score:3.20|P-value:5.41E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.07|P-value:1.85E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.01|P-value:2.39E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.13|P-value:1.14E-7 ID:SGTC_698|Compound:k064-0052|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.34|P-value:5.67E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:3.96|P-value:2.93E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.59|P-value:1.30E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.29|P-value:3.90E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.07|P-value:1.82E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.43|P-value:2.31E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.84|P-value:4.81E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.92|P-value:3.43E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.36|P-value:3.01E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.14|P-value:6.56E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:5.61|P-value:8.29E-9 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.35|P-value:5.35E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.96|P-value:2.86E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.02|P-value:9.98E-13 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.01|P-value:2.14E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.71|P-value:3.17E-6 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.07|P-value:8.32E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.40|P-value:2.65E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.62|P-value:1.48E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.22|P-value:5.03E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.71|P-value:8.14E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.04|P-value:9.31E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.47|P-value:2.01E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.32|P-value:6.04E-6 ID:SGTC_1881|Compound:5652484|FD-Score:-4.01|P-value:6.57E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.89|P-value:3.91E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.46|P-value:2.06E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.88|P-value:4.11E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.82|P-value:5.24E-5 ID:SGTC_2286|Compound:7945697|FD-Score:4.04|P-value:2.08E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.10|P-value:7.42E-4 ID:SGTC_2322|Compound:7413319|FD-Score:8.93|P-value:2.59E-19 ID:SGTC_2475|Compound:5812728|FD-Score:3.13|P-value:6.79E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.78|P-value:1.61E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.14|P-value:6.58E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.12|P-value:7.11E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.53|P-value:4.01E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.45|P-value:5.23E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.37|P-value:2.95E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.29|P-value:3.87E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.94|P-value:3.18E-5 ID:SGTC_3023|Compound:9089636|FD-Score:7.79|P-value:3.48E-15 ID:SGTC_3026|Compound:9090633|FD-Score:-5.20|P-value:2.87E-7 ID:SGTC_3034|Compound:9090421|FD-Score:-3.56|P-value:3.63E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.73|P-value:7.44E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-3.54|P-value:3.90E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.11|P-value:4.43E-5 ID:SGTC_3051|Compound:9093778|FD-Score:3.20|P-value:5.31E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.45|P-value:2.17E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.37|P-value:7.08E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.37|P-value:7.09E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.34|P-value:7.78E-4 ID:SGTC_3268|Compound:9137683|FD-Score:4.15|P-value:1.32E-5

Top fitness defect scores for YCR050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2322 7413319 8.93 38.2 µM 2.59E-19 ERAD & cell cycle 27 2.20E-19
2 SGTC_3023 9089636 7.79 49.5 µM 3.48E-15 1 3.47E-15
3 SGTC_103 0844-0104 7.44 51.8 µM 4.90E-14 ERAD & cell cycle 54 5.11E-14
4 SGTC_1247 0448-0043 7.02 5.8 µM 9.98E-13 ERG2 6 1.09E-12
5 SGTC_37 0566-0070 5.90 1.6 µM 1.55E-9 5 1.85E-9
6 SGTC_1166 k206-0078 5.61 225.0 µM 8.29E-9 5 1.01E-8
7 SGTC_568 1193-0097 5.13 7.5 µM 1.14E-7 ERAD & cell cycle 82 1.43E-7
8 SGTC_1248 0469-0687 5.01 58.6 µM 2.14E-7 10 2.69E-7
9 SGTC_364 0083-0097 4.89 67.7 µM 4.02E-7 12 5.07E-7
10 SGTC_88 0180-0332 4.76 8.7 µM 7.54E-7 9 9.56E-7
11 SGTC_1352 1496-0991 4.62 99.0 µM 1.48E-6 tubulin folding & SWR complex 17 1.88E-6
12 SGTC_1175 0741-0056 4.35 27.6 µM 5.35E-6 9 6.85E-6
13 SGTC_717 1532-0246 4.34 73.2 µM 5.67E-6 Golgi 24 7.26E-6
14 SGTC_1879 gemcitabine 4.32 100.0 µM 6.04E-6 9 7.74E-6
15 SGTC_3268 9137683 4.15 49.5 µM 1.32E-5 8 1.70E-5
16 SGTC_805 3852-0218 4.07 479.0 µM 1.82E-5 ERAD & cell cycle 68 2.35E-5
17 SGTC_419 nsc-638432 4.07 893.0 µM 1.85E-5 DNA damage response 11 2.39E-5
18 SGTC_2286 7945697 4.04 125.0 µM 2.08E-5 53 2.68E-5
19 SGTC_436 n,n-dimethylsphingosine 4.01 3.3 µM 2.39E-5 26 3.08E-5
20 SGTC_1206 3978-0017 3.96 132.0 µM 2.86E-5 ERG2 35 3.69E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 4.97E-25 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.156 1.18E-19 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.155 1.63E-19 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.143 1.01E-16 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.142 1.08E-16 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.140 3.31E-16 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.135 5.08E-15 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.132 1.92E-14 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.129 5.70E-14 YMR170C ALD2 hom Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.129 6.62E-14 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.127 1.51E-13 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.127 1.75E-13 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.121 2.33E-12 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.112 9.07E-11 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.110 1.61E-10 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress