YCR051W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR051W / YCR051W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.10|P-value:3.57E-7 ID:SGTC_126|Compound:0417-1624|FD-Score:4.13|P-value:2.81E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.26|P-value:9.50E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.21|P-value:8.54E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.88|P-value:1.02E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.18|P-value:9.49E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.40|P-value:6.02E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.44|P-value:5.34E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.27|P-value:1.57E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.44|P-value:3.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.69|P-value:2.16E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.45|P-value:3.84E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.36|P-value:9.57E-8 ID:SGTC_711|Compound:k292-0785|FD-Score:3.89|P-value:7.53E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.81|P-value:1.00E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.00|P-value:4.78E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.44|P-value:6.09E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.72|P-value:1.40E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.00|P-value:4.87E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.56|P-value:6.53E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.18|P-value:9.41E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:5.65|P-value:1.96E-8 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.68|P-value:2.29E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.24|P-value:7.85E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:6.11|P-value:1.51E-9 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.26|P-value:7.26E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.82|P-value:9.81E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.35|P-value:1.12E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_1722|Compound:st034304|FD-Score:8.36|P-value:2.69E-16 ID:SGTC_1733|Compound:st037357|FD-Score:3.31|P-value:6.17E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.15|P-value:3.77E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.28|P-value:8.85E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.44|P-value:5.19E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.99|P-value:4.92E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.53|P-value:2.89E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.91|P-value:6.92E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.59|P-value:2.25E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.11|P-value:3.12E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.49|P-value:3.27E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.27|P-value:9.30E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-4.20|P-value:3.01E-5 ID:SGTC_2477|Compound:5967686|FD-Score:5.14|P-value:2.88E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.04|P-value:4.20E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:5.52E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.37|P-value:4.96E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.42|P-value:5.57E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.14|P-value:2.73E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.14|P-value:3.83E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-3.48|P-value:4.52E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.95|P-value:5.92E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.28|P-value:6.75E-4 ID:SGTC_3127|Compound:9126946|FD-Score:7.79|P-value:2.09E-14 ID:SGTC_3135|Compound:9127742|FD-Score:4.64|P-value:3.19E-6 ID:SGTC_3151|Compound:9099821|FD-Score:4.62|P-value:3.49E-6 ID:SGTC_3158|Compound:9100007|FD-Score:3.71|P-value:1.46E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.59|P-value:3.98E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.10|P-value:3.57E-7 ID:SGTC_126|Compound:0417-1624|FD-Score:4.13|P-value:2.81E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.26|P-value:9.50E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.21|P-value:8.54E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.88|P-value:1.02E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.18|P-value:9.49E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.40|P-value:6.02E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.44|P-value:5.34E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.27|P-value:1.57E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.44|P-value:3.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.69|P-value:2.16E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.45|P-value:3.84E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.36|P-value:9.57E-8 ID:SGTC_711|Compound:k292-0785|FD-Score:3.89|P-value:7.53E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.81|P-value:1.00E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.00|P-value:4.78E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.44|P-value:6.09E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.72|P-value:1.40E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.00|P-value:4.87E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.56|P-value:6.53E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.18|P-value:9.41E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:5.65|P-value:1.96E-8 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.68|P-value:2.29E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.24|P-value:7.85E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:6.11|P-value:1.51E-9 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.26|P-value:7.26E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.82|P-value:9.81E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.35|P-value:1.12E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_1722|Compound:st034304|FD-Score:8.36|P-value:2.69E-16 ID:SGTC_1733|Compound:st037357|FD-Score:3.31|P-value:6.17E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.15|P-value:3.77E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.28|P-value:8.85E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.44|P-value:5.19E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.99|P-value:4.92E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.53|P-value:2.89E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.91|P-value:6.92E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.59|P-value:2.25E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.11|P-value:3.12E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.49|P-value:3.27E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.27|P-value:9.30E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-4.20|P-value:3.01E-5 ID:SGTC_2477|Compound:5967686|FD-Score:5.14|P-value:2.88E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.04|P-value:4.20E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:5.52E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.37|P-value:4.96E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.42|P-value:5.57E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.14|P-value:2.73E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.14|P-value:3.83E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-3.48|P-value:4.52E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.95|P-value:5.92E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.28|P-value:6.75E-4 ID:SGTC_3127|Compound:9126946|FD-Score:7.79|P-value:2.09E-14 ID:SGTC_3135|Compound:9127742|FD-Score:4.64|P-value:3.19E-6 ID:SGTC_3151|Compound:9099821|FD-Score:4.62|P-value:3.49E-6 ID:SGTC_3158|Compound:9100007|FD-Score:3.71|P-value:1.46E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.59|P-value:3.98E-6

Top fitness defect scores for YCR051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1722 st034304 8.36 3.6 µM 2.69E-16 mitochondrial processes 1 3.18E-17
2 SGTC_3127 9126946 7.79 49.5 µM 2.09E-14 ERG2 2 3.33E-15
3 SGTC_1356 1502-0781 6.11 85.8 µM 1.51E-9 fatty acid desaturase (OLE1) 3 5.10E-10
4 SGTC_1268 0828-0275 5.65 2.5 µM 1.96E-8 3 7.85E-9
5 SGTC_1002 4049-0206 5.44 172.0 µM 6.09E-8 8 2.62E-8
6 SGTC_691 1548-0686 5.36 185.0 µM 9.57E-8 6 4.24E-8
7 SGTC_2477 5967686 5.14 25.2 µM 2.88E-7 13 1.37E-7
8 SGTC_58 0957-0393 5.10 9.0 µM 3.57E-7 cell wall 275 1.72E-7
9 SGTC_190 3970-0790 4.88 3.7 µM 1.02E-6 2 5.27E-7
10 SGTC_3135 9127742 4.64 49.5 µM 3.19E-6 9 1.77E-6
11 SGTC_3151 9099821 4.62 49.5 µM 3.49E-6 9 1.94E-6
12 SGTC_3317 9138495 4.59 8.8 µM 3.98E-6 24 2.24E-6
13 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.35 61.9 µM 1.12E-5 7 6.73E-6
14 SGTC_399 oxolinic acid 4.27 75.0 µM 1.57E-5 6 9.63E-6
15 SGTC_2836 9010338 4.14 19.5 µM 2.73E-5 RPP1 & pyrimidine depletion 22 1.73E-5
16 SGTC_126 0417-1624 4.13 672.5 µM 2.81E-5 DNA intercalators 25 1.79E-5
17 SGTC_2109 5483026 4.11 200.0 µM 3.12E-5 RSC complex & mRNA processing 22 2.00E-5
18 SGTC_2610 ononetin 4.04 44.2 µM 4.20E-5 42 2.73E-5
19 SGTC_980 1473-0395 4.00 201.0 µM 4.78E-5 12 3.13E-5
20 SGTC_1132 3456-3614 4.00 2.5 µM 4.87E-5 tubulin folding & SWR complex 42 3.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.91E-11 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.110 1.62E-10 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.108 3.67E-10 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.104 1.60E-9 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.102 3.65E-9 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.101 4.05E-9 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.101 4.82E-9 YBR174C_d YBR174C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
0.100 7.51E-9 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.098 1.11E-8 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.097 1.71E-8 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.097 1.88E-8 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.75E-8 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.095 3.75E-8 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.092 8.77E-8 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.090 1.61E-7 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress