YCR052W / RSC6

Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCR052W / RSC6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.08|P-value:5.77E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.42|P-value:2.13E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.40|P-value:2.79E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.87|P-value:9.03E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.07|P-value:5.90E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:6.56|P-value:1.46E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.86|P-value:9.31E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.20|P-value:5.09E-25 ID:SGTC_288|Compound:1315-0019|FD-Score:5.68|P-value:1.42E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-6.80|P-value:1.19E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:5.89|P-value:8.55E-5 ID:SGTC_462|Compound:ag-879|FD-Score:5.68|P-value:1.41E-4 ID:SGTC_493|Compound:zm226600|FD-Score:10.50|P-value:1.63E-11 ID:SGTC_497|Compound:capsazepine|FD-Score:4.95|P-value:7.59E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-6.67|P-value:1.69E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:7.05|P-value:3.56E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:5.95|P-value:7.22E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:6.14|P-value:4.43E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:9.78|P-value:2.70E-10 ID:SGTC_708|Compound:3448-5400|FD-Score:6.00|P-value:6.46E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:7.05|P-value:3.51E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.90|P-value:5.59E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:7.60|P-value:6.59E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:6.23|P-value:3.55E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:5.29|P-value:3.58E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:6.16|P-value:4.27E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.89|P-value:8.77E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.46|P-value:1.88E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.04|P-value:6.23E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.28|P-value:3.69E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.79|P-value:1.09E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.84|P-value:9.73E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.22|P-value:3.62E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:-5.00|P-value:9.90E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.60|P-value:6.59E-7 ID:SGTC_1478|Compound:0453-0656|FD-Score:5.75|P-value:1.20E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.90|P-value:8.55E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.86|P-value:9.33E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-7.41|P-value:2.03E-6 ID:SGTC_1695|Compound:st026914|FD-Score:4.88|P-value:8.87E-4 ID:SGTC_1731|Compound:st035964|FD-Score:5.42|P-value:2.66E-4 ID:SGTC_1771|Compound:st048882|FD-Score:6.33|P-value:2.71E-5 ID:SGTC_1783|Compound:st039459|FD-Score:5.32|P-value:3.34E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.98|P-value:6.81E-5 ID:SGTC_1991|Compound:st073000|FD-Score:7.58|P-value:7.10E-7 ID:SGTC_1992|Compound:st073643|FD-Score:7.50|P-value:9.06E-7 ID:SGTC_2001|Compound:4023502|FD-Score:13.70|P-value:2.25E-18 ID:SGTC_2002|Compound:4023503|FD-Score:16.50|P-value:6.27E-26 ID:SGTC_2006|Compound:4011487|FD-Score:14.70|P-value:8.58E-21 ID:SGTC_2011|Compound:4012611|FD-Score:8.69|P-value:1.68E-8 ID:SGTC_2037|Compound:5169046|FD-Score:5.62|P-value:1.64E-4 ID:SGTC_2225|Compound:6654152|FD-Score:9.22|P-value:2.39E-9 ID:SGTC_2248|Compound:tofa|FD-Score:6.38|P-value:2.34E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.21|P-value:6.29E-4 ID:SGTC_2256|Compound:7954252|FD-Score:7.66|P-value:5.47E-7 ID:SGTC_2257|Compound:7960413|FD-Score:6.06|P-value:5.52E-5 ID:SGTC_2336|Compound:9001819|FD-Score:5.88|P-value:8.62E-5 ID:SGTC_2378|Compound:9074213|FD-Score:5.43|P-value:2.59E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.88|P-value:8.92E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-10.90|P-value:5.60E-12 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.88|P-value:1.34E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:13.30|P-value:1.55E-17 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:7.08|P-value:3.23E-6 ID:SGTC_2838|Compound:9002687|FD-Score:7.19|P-value:2.37E-6 ID:SGTC_2917|Compound:7979103|FD-Score:4.84|P-value:9.72E-4 ID:SGTC_2928|Compound:9011484|FD-Score:6.22|P-value:3.65E-5 ID:SGTC_2941|Compound:9056145|FD-Score:6.37|P-value:2.45E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.84|P-value:9.62E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.32|P-value:3.37E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.45|P-value:1.93E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-6.99|P-value:6.97E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-7.73|P-value:7.51E-7 ID:SGTC_3318|Compound:9139014|FD-Score:5.06|P-value:6.04E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.08|P-value:5.77E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.42|P-value:2.13E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.40|P-value:2.79E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.87|P-value:9.03E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.07|P-value:5.90E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:6.56|P-value:1.46E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.86|P-value:9.31E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.20|P-value:5.09E-25 ID:SGTC_288|Compound:1315-0019|FD-Score:5.68|P-value:1.42E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-6.80|P-value:1.19E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:5.89|P-value:8.55E-5 ID:SGTC_462|Compound:ag-879|FD-Score:5.68|P-value:1.41E-4 ID:SGTC_493|Compound:zm226600|FD-Score:10.50|P-value:1.63E-11 ID:SGTC_497|Compound:capsazepine|FD-Score:4.95|P-value:7.59E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-6.67|P-value:1.69E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:7.05|P-value:3.56E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:5.95|P-value:7.22E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:6.14|P-value:4.43E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:9.78|P-value:2.70E-10 ID:SGTC_708|Compound:3448-5400|FD-Score:6.00|P-value:6.46E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:7.05|P-value:3.51E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.90|P-value:5.59E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:7.60|P-value:6.59E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:6.23|P-value:3.55E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:5.29|P-value:3.58E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:6.16|P-value:4.27E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.89|P-value:8.77E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.46|P-value:1.88E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.04|P-value:6.23E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.28|P-value:3.69E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.79|P-value:1.09E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.84|P-value:9.73E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.22|P-value:3.62E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:-5.00|P-value:9.90E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.60|P-value:6.59E-7 ID:SGTC_1478|Compound:0453-0656|FD-Score:5.75|P-value:1.20E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.90|P-value:8.55E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.86|P-value:9.33E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-7.41|P-value:2.03E-6 ID:SGTC_1695|Compound:st026914|FD-Score:4.88|P-value:8.87E-4 ID:SGTC_1731|Compound:st035964|FD-Score:5.42|P-value:2.66E-4 ID:SGTC_1771|Compound:st048882|FD-Score:6.33|P-value:2.71E-5 ID:SGTC_1783|Compound:st039459|FD-Score:5.32|P-value:3.34E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.98|P-value:6.81E-5 ID:SGTC_1991|Compound:st073000|FD-Score:7.58|P-value:7.10E-7 ID:SGTC_1992|Compound:st073643|FD-Score:7.50|P-value:9.06E-7 ID:SGTC_2001|Compound:4023502|FD-Score:13.70|P-value:2.25E-18 ID:SGTC_2002|Compound:4023503|FD-Score:16.50|P-value:6.27E-26 ID:SGTC_2006|Compound:4011487|FD-Score:14.70|P-value:8.58E-21 ID:SGTC_2011|Compound:4012611|FD-Score:8.69|P-value:1.68E-8 ID:SGTC_2037|Compound:5169046|FD-Score:5.62|P-value:1.64E-4 ID:SGTC_2225|Compound:6654152|FD-Score:9.22|P-value:2.39E-9 ID:SGTC_2248|Compound:tofa|FD-Score:6.38|P-value:2.34E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.21|P-value:6.29E-4 ID:SGTC_2256|Compound:7954252|FD-Score:7.66|P-value:5.47E-7 ID:SGTC_2257|Compound:7960413|FD-Score:6.06|P-value:5.52E-5 ID:SGTC_2336|Compound:9001819|FD-Score:5.88|P-value:8.62E-5 ID:SGTC_2378|Compound:9074213|FD-Score:5.43|P-value:2.59E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.88|P-value:8.92E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-10.90|P-value:5.60E-12 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.88|P-value:1.34E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:13.30|P-value:1.55E-17 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:7.08|P-value:3.23E-6 ID:SGTC_2838|Compound:9002687|FD-Score:7.19|P-value:2.37E-6 ID:SGTC_2917|Compound:7979103|FD-Score:4.84|P-value:9.72E-4 ID:SGTC_2928|Compound:9011484|FD-Score:6.22|P-value:3.65E-5 ID:SGTC_2941|Compound:9056145|FD-Score:6.37|P-value:2.45E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.84|P-value:9.62E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.32|P-value:3.37E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.45|P-value:1.93E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-6.99|P-value:6.97E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-7.73|P-value:7.51E-7 ID:SGTC_3318|Compound:9139014|FD-Score:5.06|P-value:6.04E-4

Top fitness defect scores for YCR052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2002 4023503 16.50 131.0 µM 6.27E-26 mitochondrial processes 1 8.89E-62 8.37
2 SGTC_221 trifluoperazine 16.20 10.3 µM 5.09E-25 NEO1-PIK1 4 1.67E-59 3.11
3 SGTC_2006 4011487 14.70 200.0 µM 8.58E-21 endomembrane recycling 3 5.92E-49 4.22
4 SGTC_2001 4023502 13.70 57.7 µM 2.25E-18 mitochondrial processes 1 6.30E-43 7.97
5 SGTC_2617 dihydrotanshinone i 13.30 20.8 µM 1.55E-17 copper-dependent oxidative stress 2 7.74E-41 3.95
6 SGTC_493 zm226600 10.50 134.0 µM 1.63E-11 mitochondrial processes 1 6.84E-26 6.33
7 SGTC_643 k048-0106 9.78 28.4 µM 2.70E-10 RSC & ERG11 5 7.00E-23 2.70
8 SGTC_2225 6654152 9.22 15.4 µM 2.39E-9 10 1.51E-20 0.30
9 SGTC_2011 4012611 8.69 177.0 µM 1.68E-8 mitochondrial processes 1 1.83E-18 2.77
10 SGTC_2256 7954252 7.66 200.0 µM 5.47E-7 mitochondrial processes 2 9.35E-15 1.53
11 SGTC_745 0469-0705 7.60 296.0 µM 6.59E-7 mitochondrial processes 6 1.47E-14 2.36
12 SGTC_1371 2421-0008 7.60 32.7 µM 6.59E-7 mitochondrial processes 3 1.47E-14 0.53
13 SGTC_1991 st073000 7.58 8.9 µM 7.10E-7 NEO1 3 1.77E-14 0.27
14 SGTC_1992 st073643 7.50 23.3 µM 9.06E-7 mitochondrial processes 1 3.21E-14 2.40
15 SGTC_2838 9002687 7.19 71.4 µM 2.37E-6 fatty acid desaturase (OLE1) 4 3.35E-13 1.05
16 SGTC_2626 ethyl orsellinate 7.08 100.0 µM 3.23E-6 1 7.08E-13 1.25
17 SGTC_710 3448-4187 7.05 58.0 µM 3.51E-6 fatty acid desaturase (OLE1) 1 8.65E-13 0.94
18 SGTC_520 3584-0023 7.05 682.0 µM 3.56E-6 3 8.97E-13 0.65
19 SGTC_742 0kpi-0133 6.90 140.0 µM 5.59E-6 ERG2 1 2.69E-12 1.16
20 SGTC_172 1112-0046 6.56 2.6 µM 1.46E-5 NEO1 2 2.78E-11 1.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.330 8.70E-86 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.305 4.06E-73 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.261 2.15E-53 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.250 9.53E-49 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.245 5.22E-47 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.230 2.57E-41 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.212 3.09E-35 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.209 2.35E-34 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.193 1.59E-29 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.190 1.27E-28 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.178 4.04E-25 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.173 7.14E-24 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.164 1.18E-21 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.164 1.09E-21 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.163 1.82E-21 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases