YCR059C / YIH1

Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR059C / YIH1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.40|P-value:5.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.28|P-value:2.10E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.93|P-value:1.24E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.33|P-value:6.76E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.60|P-value:4.29E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.95|P-value:7.57E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:4.30|P-value:1.93E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.43|P-value:4.85E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.60|P-value:2.70E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.63|P-value:2.45E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.08|P-value:4.54E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.45|P-value:4.54E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.89|P-value:9.40E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.61|P-value:2.66E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.41|P-value:5.14E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.90|P-value:9.01E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:5.65|P-value:3.54E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:-4.10|P-value:6.93E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.94|P-value:8.01E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:3.32|P-value:6.94E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:4.17|P-value:3.21E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.47|P-value:4.29E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.20|P-value:2.90E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:4.06|P-value:4.87E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.32|P-value:1.75E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.26|P-value:2.20E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.48|P-value:4.12E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.84|P-value:1.14E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.28|P-value:7.97E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.28|P-value:8.00E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.23|P-value:9.26E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.24|P-value:9.00E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.03|P-value:1.38E-6 ID:SGTC_1711|Compound:st032263|FD-Score:5.85|P-value:1.17E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.50|P-value:3.79E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.64|P-value:2.37E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.48|P-value:4.11E-4 ID:SGTC_1910|Compound:st062352|FD-Score:5.36|P-value:1.55E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.82|P-value:1.24E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.55|P-value:3.20E-4 ID:SGTC_2412|Compound:st077135|FD-Score:5.14|P-value:4.61E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.03|P-value:5.67E-5 ID:SGTC_2467|Compound:5474540|FD-Score:4.13|P-value:3.81E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:5.51|P-value:7.30E-8 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.35|P-value:7.11E-10 ID:SGTC_2896|Compound:9052656|FD-Score:3.56|P-value:3.12E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.45|P-value:4.50E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.84|P-value:1.82E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.86|P-value:1.70E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.25|P-value:8.73E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-4.38|P-value:2.36E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.40|P-value:5.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.28|P-value:2.10E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.93|P-value:1.24E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.33|P-value:6.76E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.60|P-value:4.29E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.95|P-value:7.57E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:4.30|P-value:1.93E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.43|P-value:4.85E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.60|P-value:2.70E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.63|P-value:2.45E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.08|P-value:4.54E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.45|P-value:4.54E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.89|P-value:9.40E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.61|P-value:2.66E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.41|P-value:5.14E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.90|P-value:9.01E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:5.65|P-value:3.54E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:-4.10|P-value:6.93E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.94|P-value:8.01E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:3.32|P-value:6.94E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:4.17|P-value:3.21E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.47|P-value:4.29E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.20|P-value:2.90E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:4.06|P-value:4.87E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.32|P-value:1.75E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.26|P-value:2.20E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.48|P-value:4.12E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.84|P-value:1.14E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.28|P-value:7.97E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.28|P-value:8.00E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.23|P-value:9.26E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.24|P-value:9.00E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.03|P-value:1.38E-6 ID:SGTC_1711|Compound:st032263|FD-Score:5.85|P-value:1.17E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.50|P-value:3.79E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.64|P-value:2.37E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.48|P-value:4.11E-4 ID:SGTC_1910|Compound:st062352|FD-Score:5.36|P-value:1.55E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.82|P-value:1.24E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.55|P-value:3.20E-4 ID:SGTC_2412|Compound:st077135|FD-Score:5.14|P-value:4.61E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.03|P-value:5.67E-5 ID:SGTC_2467|Compound:5474540|FD-Score:4.13|P-value:3.81E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:5.51|P-value:7.30E-8 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.35|P-value:7.11E-10 ID:SGTC_2896|Compound:9052656|FD-Score:3.56|P-value:3.12E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.45|P-value:4.50E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.84|P-value:1.82E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.86|P-value:1.70E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.25|P-value:8.73E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-4.38|P-value:2.36E-5

Top fitness defect scores for YCR059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2666 tannic acid 6.35 100.0 µM 7.11E-10 iron homeostasis 9 1.08E-10
2 SGTC_1711 st032263 5.85 62.8 µM 1.17E-8 5 2.41E-9
3 SGTC_693 4161-2696 5.65 114.0 µM 3.54E-8 1 8.21E-9
4 SGTC_2664 lyso-paf C-16 5.51 73.5 µM 7.30E-8 2 1.83E-8
5 SGTC_1910 st062352 5.36 60.4 µM 1.55E-7 8 4.20E-8
6 SGTC_2412 st077135 5.14 33.4 µM 4.61E-7 6 1.40E-7
7 SGTC_114 0364-0001 4.93 490.3 µM 1.24E-6 17 4.18E-7
8 SGTC_1037 k284-1091 4.32 78.7 µM 1.75E-5 9 7.78E-6
9 SGTC_192 3455-0609 4.30 60.9 µM 1.93E-5 8 8.68E-6
10 SGTC_58 0957-0393 4.28 9.0 µM 2.10E-5 cell wall 345 9.52E-6
11 SGTC_1046 2001-0062 4.26 216.0 µM 2.20E-5 11 1.00E-5
12 SGTC_922 1866-0035 4.20 480.0 µM 2.90E-5 excess fatty acid 44 1.36E-5
13 SGTC_857 0438-0306 4.17 1.4 µM 3.21E-5 copper-dependent oxidative stress 11 1.52E-5
14 SGTC_2467 5474540 4.13 200.0 µM 3.81E-5 14 1.84E-5
15 SGTC_288 1315-0019 4.08 35.1 µM 4.54E-5 RSC & ERG11 20 2.23E-5
16 SGTC_937 3122-0005 4.06 46.7 µM 4.87E-5 23 2.41E-5
17 SGTC_2417 cerulenin 4.03 830.0 nM 5.67E-5 31 2.84E-5
18 SGTC_138 0850-0259 3.95 40.9 µM 7.57E-5 cell wall 200 3.91E-5
19 SGTC_702 1488-0190 3.94 94.0 µM 8.01E-5 amide catabolism 15 4.16E-5
20 SGTC_540 1187-0821 3.90 17.3 µM 9.01E-5 17 4.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.68E-15 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.130 4.89E-14 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.128 9.93E-14 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.119 5.96E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.117 9.30E-12 YCL001W-A_p YCL001W-A_p hom Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.108 3.24E-10 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.108 3.36E-10 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.106 7.65E-10 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.104 1.51E-9 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.102 2.94E-9 YAL021C CCR4 hom Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
0.097 1.66E-8 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.097 2.17E-8 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.096 2.23E-8 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.096 2.59E-8 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.096 2.99E-8 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p