YCR065W / HCM1

Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR065W / HCM1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.39|P-value:5.24E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:3.52|P-value:2.50E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.27|P-value:6.19E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.23|P-value:6.97E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.00|P-value:3.86E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.43|P-value:3.55E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.48|P-value:4.76E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:5.29|P-value:8.71E-8 ID:SGTC_616|Compound:4092-0450|FD-Score:3.51|P-value:2.65E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.35|P-value:8.77E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:5.07|P-value:2.75E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.26|P-value:6.40E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.73|P-value:1.14E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.36|P-value:8.43E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.81|P-value:8.41E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.96|P-value:4.53E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.31|P-value:1.02E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.46|P-value:3.18E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.08|P-value:2.80E-5 ID:SGTC_1708|Compound:st033234|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.59|P-value:1.97E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.35|P-value:4.60E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.55|P-value:2.27E-4 ID:SGTC_1852|Compound:st056254|FD-Score:6.56|P-value:4.87E-11 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.25|P-value:1.36E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.26|P-value:6.42E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.47|P-value:3.00E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.48|P-value:2.95E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.42|P-value:3.60E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.48|P-value:4.96E-6 ID:SGTC_2108|Compound:5365811|FD-Score:4.53|P-value:3.91E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.59|P-value:2.90E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.53|P-value:2.42E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.74|P-value:1.12E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.14|P-value:9.54E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.46|P-value:3.10E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.42|P-value:3.64E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.30|P-value:1.06E-5 ID:SGTC_2570|Compound:licareol|FD-Score:4.85|P-value:8.34E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.20|P-value:7.78E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.34|P-value:5.06E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.05|P-value:3.11E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.26|P-value:6.81E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.34|P-value:9.67E-6 ID:SGTC_2867|Compound:9039098|FD-Score:3.82|P-value:7.92E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.16|P-value:8.87E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.95|P-value:5.18E-5 ID:SGTC_3157|Compound:9099274|FD-Score:-3.41|P-value:3.99E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.18|P-value:8.35E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.22|P-value:7.63E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.32|P-value:5.12E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.16|P-value:8.82E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.01|P-value:3.79E-5 ID:SGTC_3331|Compound:9141060|FD-Score:6.06|P-value:1.08E-9 ID:SGTC_3333|Compound:9141820|FD-Score:4.98|P-value:4.48E-7 ID:SGTC_3348|Compound:9149464|FD-Score:3.50|P-value:2.69E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.45|P-value:3.24E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.39|P-value:5.24E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:3.52|P-value:2.50E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.27|P-value:6.19E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.23|P-value:6.97E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.00|P-value:3.86E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.43|P-value:3.55E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.48|P-value:4.76E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:5.29|P-value:8.71E-8 ID:SGTC_616|Compound:4092-0450|FD-Score:3.51|P-value:2.65E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.35|P-value:8.77E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:5.07|P-value:2.75E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.26|P-value:6.40E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.73|P-value:1.14E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.36|P-value:8.43E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.81|P-value:8.41E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.96|P-value:4.53E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.31|P-value:1.02E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.46|P-value:3.18E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.08|P-value:2.80E-5 ID:SGTC_1708|Compound:st033234|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.59|P-value:1.97E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.35|P-value:4.60E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.55|P-value:2.27E-4 ID:SGTC_1852|Compound:st056254|FD-Score:6.56|P-value:4.87E-11 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.25|P-value:1.36E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.26|P-value:6.42E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.47|P-value:3.00E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.48|P-value:2.95E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.42|P-value:3.60E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.48|P-value:4.96E-6 ID:SGTC_2108|Compound:5365811|FD-Score:4.53|P-value:3.91E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.59|P-value:2.90E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.53|P-value:2.42E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.74|P-value:1.12E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.14|P-value:9.54E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.46|P-value:3.10E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.42|P-value:3.64E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.30|P-value:1.06E-5 ID:SGTC_2570|Compound:licareol|FD-Score:4.85|P-value:8.34E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.20|P-value:7.78E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.34|P-value:5.06E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.05|P-value:3.11E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.26|P-value:6.81E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.34|P-value:9.67E-6 ID:SGTC_2867|Compound:9039098|FD-Score:3.82|P-value:7.92E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.16|P-value:8.87E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.95|P-value:5.18E-5 ID:SGTC_3157|Compound:9099274|FD-Score:-3.41|P-value:3.99E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.18|P-value:8.35E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.22|P-value:7.63E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.32|P-value:5.12E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.16|P-value:8.82E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.01|P-value:3.79E-5 ID:SGTC_3331|Compound:9141060|FD-Score:6.06|P-value:1.08E-9 ID:SGTC_3333|Compound:9141820|FD-Score:4.98|P-value:4.48E-7 ID:SGTC_3348|Compound:9149464|FD-Score:3.50|P-value:2.69E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.45|P-value:3.24E-4

Top fitness defect scores for YCR065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1852 st056254 6.56 31.4 µM 4.87E-11 2 2.75E-11
2 SGTC_3331 9141060 6.06 2.0 µM 1.08E-9 cell wall 10 6.65E-10
3 SGTC_53 0973-0023 5.39 40.0 µM 5.24E-8 RNA processing & uracil transport 4 3.58E-8
4 SGTC_615 k087-0205 5.29 167.0 µM 8.71E-8 7 6.03E-8
5 SGTC_911 3456-4043 5.07 236.0 µM 2.75E-7 mitochondrial processes 9 1.96E-7
6 SGTC_3333 9141820 4.98 12.1 µM 4.48E-7 9 3.24E-7
7 SGTC_2570 licareol 4.85 100.0 µM 8.34E-7 13 6.13E-7
8 SGTC_2115 tiliquinol 4.59 12.8 µM 2.90E-6 4 2.20E-6
9 SGTC_2108 5365811 4.53 200.0 µM 3.91E-6 6 3.00E-6
10 SGTC_605 1315-0399 4.48 119.0 µM 4.76E-6 Golgi 13 3.66E-6
11 SGTC_2005 4024620 4.48 188.0 µM 4.96E-6 14 3.82E-6
12 SGTC_1101 ebselen 4.36 5.3 µM 8.43E-6 15 6.59E-6
13 SGTC_772 k072-0172 4.35 35.3 µM 8.77E-6 13 6.86E-6
14 SGTC_1263 0774-1208 4.31 64.8 µM 1.02E-5 32 8.04E-6
15 SGTC_2544 sphondin 4.30 68.5 µM 1.06E-5 RNA pol III & RNase P/MRP 17 8.36E-6
16 SGTC_1875 nocodazole 4.25 6.0 µM 1.36E-5 tubulin folding & SWR complex 44 1.08E-5
17 SGTC_1683 st010134 4.08 710.0 nM 2.80E-5 23 2.25E-5
18 SGTC_2723 salbutamol 4.05 83.6 µM 3.11E-5 9 2.51E-5
19 SGTC_3325 9138760 4.01 55.2 µM 3.79E-5 Golgi 24 3.08E-5
20 SGTC_268 camptothecin 4.00 39.6 µM 3.86E-5 DNA damage response 67 3.14E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.11E-10 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.100 6.26E-9 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.092 9.62E-8 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.085 7.35E-7 YER129W SAK1 hom Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
0.084 1.13E-6 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.079 4.45E-6 YHR179W OYE2 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
0.079 4.81E-6 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.078 5.70E-6 YLR457C NBP1 het Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
0.074 1.80E-5 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.23E-5 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.071 3.84E-5 YPR159W KRE6 hom Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p
0.069 6.10E-5 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.069 6.78E-5 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.069 6.84E-5 YDR359C EAF1 hom Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
0.068 7.61E-5 YPR153W YPR153W hom Putative protein of unknown function