HIPHOP chemogenomics database
YCR067C / SED4 
Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YCR067C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.106 | 9.15E-10 | YGR250C | YGR250C | hom | Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress |
| 0.100 | 7.51E-9 | YLL033W | IRC19 | hom | Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.096 | 2.59E-8 | YOL102C | TPT1 | het | tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide |
| 0.092 | 8.33E-8 | YML100W-A_p | YML100W-A_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.091 | 1.33E-7 | YLL026W | HSP104 | hom | Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress |
| 0.091 | 1.44E-7 | YGR141W | VPS62 | hom | Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins |
| 0.091 | 1.47E-7 | YKL191W | DPH2 | hom | Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p |
| 0.087 | 4.62E-7 | YJL019W | MPS3 | het | Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p |
| 0.085 | 9.61E-7 | YNR070W_p | PDR18_p | hom | Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.083 | 1.41E-6 | YOR021C | SFM1 | hom | SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism |
| 0.083 | 1.71E-6 | YNL235C_d | YNL235C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex |
| 0.082 | 1.93E-6 | YCL064C | CHA1 | hom | Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine |
| 0.079 | 4.39E-6 | YOL032W | OPI10 | hom | Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress |
| 0.078 | 5.61E-6 | YKL040C | NFU1 | hom | Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria |
| 0.078 | 6.88E-6 | YKR041W | YKR041W | hom | Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking |