YCR068W / ATG15

Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR068W / ATG15

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.59|P-value:4.83E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.23|P-value:6.44E-9 ID:SGTC_57|Compound:miconazole|FD-Score:-5.44|P-value:3.02E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:9.87|P-value:9.13E-20 ID:SGTC_138|Compound:0850-0259|FD-Score:3.93|P-value:1.66E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.57|P-value:5.15E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.81|P-value:2.56E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.88|P-value:1.99E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.42|P-value:9.10E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.65|P-value:4.03E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.14|P-value:8.05E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.80|P-value:2.63E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.76|P-value:6.94E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.44|P-value:8.56E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.76|P-value:3.00E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.58|P-value:5.47E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.43|P-value:2.69E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.38|P-value:3.25E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.29|P-value:4.55E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.66|P-value:4.23E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.56|P-value:5.92E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.18|P-value:6.90E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.14|P-value:7.90E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.54|P-value:6.15E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.65|P-value:1.07E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.32|P-value:4.08E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.53|P-value:1.79E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.56|P-value:5.41E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.29|P-value:4.48E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.19|P-value:1.07E-6 ID:SGTC_1845|Compound:st056753|FD-Score:4.26|P-value:4.98E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.53|P-value:6.42E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.51|P-value:6.92E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.18|P-value:6.76E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.28|P-value:4.74E-5 ID:SGTC_2084|Compound:5306078|FD-Score:4.21|P-value:6.22E-5 ID:SGTC_2181|Compound:6316240|FD-Score:-3.36|P-value:9.93E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.62|P-value:4.78E-4 ID:SGTC_2325|Compound:6158266|FD-Score:5.77|P-value:6.95E-8 ID:SGTC_2411|Compound:st077133|FD-Score:4.68|P-value:9.56E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.22|P-value:5.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.91|P-value:3.68E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.94|P-value:1.65E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.92|P-value:3.59E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.58|P-value:1.46E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.62|P-value:4.76E-4 ID:SGTC_2968|Compound:9090663|FD-Score:6.40|P-value:2.47E-9 ID:SGTC_3155|Compound:9099265|FD-Score:4.41|P-value:2.91E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.60|P-value:5.13E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.19|P-value:6.62E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.47|P-value:7.68E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.51|P-value:6.83E-4 ID:SGTC_3325|Compound:9138760|FD-Score:5.96|P-value:2.60E-8 ID:SGTC_3332|Compound:9141069|FD-Score:4.93|P-value:3.38E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.59|P-value:4.83E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.23|P-value:6.44E-9 ID:SGTC_57|Compound:miconazole|FD-Score:-5.44|P-value:3.02E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:9.87|P-value:9.13E-20 ID:SGTC_138|Compound:0850-0259|FD-Score:3.93|P-value:1.66E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.57|P-value:5.15E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.81|P-value:2.56E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.88|P-value:1.99E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.42|P-value:9.10E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.65|P-value:4.03E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.14|P-value:8.05E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.80|P-value:2.63E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.76|P-value:6.94E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.44|P-value:8.56E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.76|P-value:3.00E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.58|P-value:5.47E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.43|P-value:2.69E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.38|P-value:3.25E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.29|P-value:4.55E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.66|P-value:4.23E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.56|P-value:5.92E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.18|P-value:6.90E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.14|P-value:7.90E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.54|P-value:6.15E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.65|P-value:1.07E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.32|P-value:4.08E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.53|P-value:1.79E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.56|P-value:5.41E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.29|P-value:4.48E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.19|P-value:1.07E-6 ID:SGTC_1845|Compound:st056753|FD-Score:4.26|P-value:4.98E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.53|P-value:6.42E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.51|P-value:6.92E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.18|P-value:6.76E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.28|P-value:4.74E-5 ID:SGTC_2084|Compound:5306078|FD-Score:4.21|P-value:6.22E-5 ID:SGTC_2181|Compound:6316240|FD-Score:-3.36|P-value:9.93E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.62|P-value:4.78E-4 ID:SGTC_2325|Compound:6158266|FD-Score:5.77|P-value:6.95E-8 ID:SGTC_2411|Compound:st077133|FD-Score:4.68|P-value:9.56E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.22|P-value:5.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.91|P-value:3.68E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.94|P-value:1.65E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.92|P-value:3.59E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.58|P-value:1.46E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.62|P-value:4.76E-4 ID:SGTC_2968|Compound:9090663|FD-Score:6.40|P-value:2.47E-9 ID:SGTC_3155|Compound:9099265|FD-Score:4.41|P-value:2.91E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.60|P-value:5.13E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.19|P-value:6.62E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.47|P-value:7.68E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.51|P-value:6.83E-4 ID:SGTC_3325|Compound:9138760|FD-Score:5.96|P-value:2.60E-8 ID:SGTC_3332|Compound:9141069|FD-Score:4.93|P-value:3.38E-6

Top fitness defect scores for YCR068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.87 9.0 µM 9.13E-20 cell wall 79 2.83E-23
2 SGTC_2968 9090663 6.40 33.4 µM 2.47E-9 5 7.62E-11
3 SGTC_43 0570-0105 6.23 72.5 µM 6.44E-9 ERG2 34 2.39E-10
4 SGTC_3325 9138760 5.96 55.2 µM 2.60E-8 Golgi 7 1.26E-9
5 SGTC_2325 6158266 5.77 200.0 µM 6.95E-8 5 4.05E-9
6 SGTC_1750 st081859 5.19 2.4 µM 1.07E-6 endomembrane recycling 131 1.05E-7
7 SGTC_3332 9141069 4.93 11.2 µM 3.38E-6 4 4.10E-7
8 SGTC_2910 7948405 4.92 26.0 µM 3.59E-6 plasma membrane duress 15 4.41E-7
9 SGTC_2896 9052656 4.91 71.4 µM 3.68E-6 endomembrane recycling 64 4.54E-7
10 SGTC_834 0312-0008 4.76 75.7 µM 6.94E-6 NEO1 21 9.64E-7
11 SGTC_2411 st077133 4.68 39.9 µM 9.56E-6 RNA pol III & RNase P/MRP 16 1.41E-6
12 SGTC_1467 k284-1082 4.65 293.0 µM 1.07E-5 7 1.62E-6
13 SGTC_2912 7964298 4.58 10.9 µM 1.46E-5 cell wall 78 2.34E-6
14 SGTC_1629 st005085 4.53 44.9 µM 1.79E-5 RPP1 & pyrimidine depletion 17 2.97E-6
15 SGTC_958 1222-0007 4.43 33.0 µM 2.69E-5 18 4.81E-6
16 SGTC_3155 9099265 4.41 49.5 µM 2.91E-5 17 5.28E-6
17 SGTC_1069 diphenylcyclopropenone 4.38 8.5 µM 3.25E-5 27 6.04E-6
18 SGTC_1565 sinapyl alcohol 4.32 95.1 µM 4.08E-5 21 7.91E-6
19 SGTC_1676 st018489 4.29 23.4 µM 4.48E-5 60S ribosome export 25 8.82E-6
20 SGTC_1203 3992-3522 4.29 103.0 µM 4.55E-5 22 9.01E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 4.76E-32 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.194 1.25E-29 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.171 1.51E-23 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.170 2.96E-23 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.168 1.58E-22 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.165 6.37E-22 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.164 1.02E-21 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.164 1.15E-21 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.161 6.42E-21 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.160 1.08E-20 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.160 1.09E-20 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.157 5.93E-20 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.157 7.55E-20 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.156 1.17E-19 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.154 3.19E-19 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth