YCR069W / CPR4

Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR069W / CPR4

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.61|P-value:1.20E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.80|P-value:5.64E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:4.55|P-value:1.94E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.05|P-value:1.88E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.45|P-value:2.23E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.12|P-value:7.35E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.70|P-value:8.38E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-4.55|P-value:3.07E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.78|P-value:6.03E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:-4.15|P-value:1.89E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.74|P-value:7.11E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.86|P-value:6.45E-5 ID:SGTC_1518|Compound:st038567|FD-Score:3.42|P-value:2.50E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.71|P-value:3.66E-9 ID:SGTC_1685|Compound:st024049|FD-Score:3.50|P-value:1.83E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-4.12|P-value:2.15E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.35|P-value:4.67E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.20|P-value:7.87E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.08|P-value:8.44E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.39|P-value:2.70E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.73|P-value:7.42E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.67|P-value:9.33E-5 ID:SGTC_2273|Compound:7815444|FD-Score:5.00|P-value:1.99E-7 ID:SGTC_2275|Compound:7947463|FD-Score:3.13|P-value:7.03E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-7.61|P-value:1.53E-14 ID:SGTC_2300|Compound:7976697|FD-Score:-3.49|P-value:2.72E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.02|P-value:1.81E-7 ID:SGTC_2402|Compound:5553605|FD-Score:3.61|P-value:1.17E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.46|P-value:3.07E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.69|P-value:1.29E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.74|P-value:6.95E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.53|P-value:1.61E-4 ID:SGTC_3276|Compound:9139060|FD-Score:-4.33|P-value:8.45E-6 ID:SGTC_39|Compound:0986-0283|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.61|P-value:1.20E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.80|P-value:5.64E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:4.55|P-value:1.94E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.05|P-value:1.88E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.45|P-value:2.23E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.12|P-value:7.35E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.70|P-value:8.38E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-4.55|P-value:3.07E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.78|P-value:6.03E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:-4.15|P-value:1.89E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.74|P-value:7.11E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.86|P-value:6.45E-5 ID:SGTC_1518|Compound:st038567|FD-Score:3.42|P-value:2.50E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.71|P-value:3.66E-9 ID:SGTC_1685|Compound:st024049|FD-Score:3.50|P-value:1.83E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-4.12|P-value:2.15E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.35|P-value:4.67E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.20|P-value:7.87E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.08|P-value:8.44E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.39|P-value:2.70E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.73|P-value:7.42E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.67|P-value:9.33E-5 ID:SGTC_2273|Compound:7815444|FD-Score:5.00|P-value:1.99E-7 ID:SGTC_2275|Compound:7947463|FD-Score:3.13|P-value:7.03E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-7.61|P-value:1.53E-14 ID:SGTC_2300|Compound:7976697|FD-Score:-3.49|P-value:2.72E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.02|P-value:1.81E-7 ID:SGTC_2402|Compound:5553605|FD-Score:3.61|P-value:1.17E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.46|P-value:3.07E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.69|P-value:1.29E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.74|P-value:6.95E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.53|P-value:1.61E-4 ID:SGTC_3276|Compound:9139060|FD-Score:-4.33|P-value:8.45E-6

Top fitness defect scores for YCR069W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1529 apigenin 5.71 74.0 µM 3.66E-9 8 5.72E-9
2 SGTC_2398 5228213 5.02 48.8 µM 1.81E-7 iron homeostasis 15 2.65E-7
3 SGTC_2273 7815444 5.00 169.1 µM 1.99E-7 6 2.90E-7
4 SGTC_145 3737-0113 4.80 38.4 µM 5.64E-7 DNA intercalators 50 8.07E-7
5 SGTC_1276 0871-0068 4.78 94.2 µM 6.03E-7 8 8.63E-7
6 SGTC_151 3013-0144 4.55 2.3 µM 1.94E-6 iron homeostasis 11 2.72E-6
7 SGTC_366 0181-0206 4.05 4.3 µM 1.88E-5 Golgi 37 2.52E-5
8 SGTC_2476 5806916 3.74 10.5 µM 6.95E-5 20 9.08E-5
9 SGTC_1377 2944-0135 3.74 198.0 µM 7.11E-5 calcium & mitochondrial duress 44 9.29E-5
10 SGTC_2108 5365811 3.73 200.0 µM 7.42E-5 19 9.70E-5
11 SGTC_1228 0124-0032 3.70 52.5 µM 8.38E-5 23 1.09E-4
12 SGTC_2263 7948595 3.67 193.3 µM 9.33E-5 12 1.21E-4
13 SGTC_2402 5553605 3.61 200.0 µM 1.17E-4 42 1.51E-4
14 SGTC_64 000l-0018 3.61 272.1 µM 1.20E-4 ubiquinone biosynthesis & proteasome 172 1.55E-4
15 SGTC_342 k048-0088 3.60 23.3 µM 1.23E-4 RSC & ERG11 29 1.59E-4
16 SGTC_39 0986-0283 3.54 58.4 µM 1.53E-4 calcium & mitochondrial duress 50 1.97E-4
17 SGTC_3272 9137413 3.53 49.5 µM 1.61E-4 23 2.07E-4
18 SGTC_1685 st024049 3.50 53.1 µM 1.83E-4 TSC3-RPN4 24 2.35E-4
19 SGTC_393 acivicin 3.45 6.2 µM 2.23E-4 28 2.85E-4
20 SGTC_1518 st038567 3.42 90.8 µM 2.50E-4 27 3.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.75E-11 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.102 3.06E-9 YLR361C-A_p YLR361C-A_p hom Putative protein of unknown function
0.099 9.51E-9 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.43E-8 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.095 3.13E-8 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
0.094 4.32E-8 YEL015W EDC3 hom Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
0.091 1.49E-7 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.089 2.62E-7 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.089 2.70E-7 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.57E-7 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.086 6.26E-7 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.93E-7 YPL196W OXR1 hom Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes
0.085 8.66E-7 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.084 9.82E-7 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.079 4.66E-6 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress