HIPHOP chemogenomics database
YCR069W / CPR4 
Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YCR069W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.114 | 3.75E-11 | YOR077W | RTS2 | het | Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication |
| 0.102 | 3.06E-9 | YLR361C-A_p | YLR361C-A_p | hom | Putative protein of unknown function |
| 0.099 | 9.51E-9 | YGL118C_d | YGL118C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.096 | 2.43E-8 | YLR326W_p | YLR326W_p | hom | Putative protein of unknown function, predicted to be palmitoylated |
| 0.095 | 3.13E-8 | YPR004C | AIM45 | hom | Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response |
| 0.094 | 4.32E-8 | YEL015W | EDC3 | hom | Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress |
| 0.091 | 1.49E-7 | YIL164C | NIT1 | hom | Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene |
| 0.089 | 2.62E-7 | YJR011C_p | YJR011C_p | hom | Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS |
| 0.089 | 2.70E-7 | YDR401W_d | YDR401W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.088 | 3.57E-7 | YLL038C | ENT4 | hom | Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome |
| 0.086 | 6.26E-7 | YIL032C_d | YIL032C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.086 | 6.93E-7 | YPL196W | OXR1 | hom | Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes |
| 0.085 | 8.66E-7 | YHR149C | SKG6 | hom | Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p |
| 0.084 | 9.82E-7 | YMR168C | CEP3 | het | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
| 0.079 | 4.66E-6 | YPR035W | GLN1 | het | Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |