YCR071C / IMG2

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR071C / IMG2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.98|P-value:1.03E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.65|P-value:3.30E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.14|P-value:5.47E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:3.33|P-value:9.35E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.58|P-value:4.63E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:13.90|P-value:1.86E-38 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.80|P-value:3.90E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.16|P-value:5.98E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:11.40|P-value:1.05E-26 ID:SGTC_327|Compound:1273-0057|FD-Score:3.33|P-value:9.32E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.99|P-value:1.90E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.64|P-value:3.87E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.77|P-value:5.15E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.83|P-value:3.95E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.84|P-value:1.69E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.87|P-value:2.65E-8 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.57|P-value:4.83E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.52|P-value:1.60E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.66|P-value:3.17E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.97|P-value:1.13E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.93|P-value:6.07E-17 ID:SGTC_596|Compound:1155-0152|FD-Score:3.47|P-value:6.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.43|P-value:6.82E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.19|P-value:4.65E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.47|P-value:6.00E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.22|P-value:4.21E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.60|P-value:3.95E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.36|P-value:9.60E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.32|P-value:9.85E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.37|P-value:8.27E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.67|P-value:3.09E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.40|P-value:8.37E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.00|P-value:9.67E-5 ID:SGTC_1695|Compound:st026914|FD-Score:4.00|P-value:9.78E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.70|P-value:3.13E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.29|P-value:3.15E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.50|P-value:6.08E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.65|P-value:3.64E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.48|P-value:6.52E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.42|P-value:7.07E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.92|P-value:1.29E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.64|P-value:7.58E-6 ID:SGTC_2024|Compound:5144227|FD-Score:4.09|P-value:6.95E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.18|P-value:4.84E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.68|P-value:2.96E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.34|P-value:2.58E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-3.90|P-value:1.52E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.94|P-value:1.21E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:6.54|P-value:5.63E-10 ID:SGTC_2472|Compound:5377652|FD-Score:4.38|P-value:2.25E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.54|P-value:4.76E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.47|P-value:6.58E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.35|P-value:2.82E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.39|P-value:2.45E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:7.67|P-value:4.76E-13 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.28|P-value:6.27E-12 ID:SGTC_2620|Compound:irigenin|FD-Score:5.39|P-value:2.64E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.51|P-value:1.30E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.43|P-value:2.18E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.78|P-value:4.78E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.53|P-value:5.44E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.91|P-value:1.34E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.14|P-value:6.43E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.87|P-value:1.71E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.72|P-value:2.62E-4 ID:SGTC_2927|Compound:9011802|FD-Score:7.26|P-value:7.13E-12 ID:SGTC_3202|Compound:9113761|FD-Score:-4.79|P-value:4.64E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.98|P-value:1.02E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.82|P-value:2.03E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.77|P-value:4.40E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-5.78|P-value:4.31E-8 ID:SGTC_10|Compound:0279-0212|FD-Score:3.98|P-value:1.03E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.65|P-value:3.30E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.14|P-value:5.47E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:3.33|P-value:9.35E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.58|P-value:4.63E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:13.90|P-value:1.86E-38 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.80|P-value:3.90E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.16|P-value:5.98E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:11.40|P-value:1.05E-26 ID:SGTC_327|Compound:1273-0057|FD-Score:3.33|P-value:9.32E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.99|P-value:1.90E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.64|P-value:3.87E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.77|P-value:5.15E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.83|P-value:3.95E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.84|P-value:1.69E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.87|P-value:2.65E-8 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.57|P-value:4.83E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.52|P-value:1.60E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.66|P-value:3.17E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.97|P-value:1.13E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.93|P-value:6.07E-17 ID:SGTC_596|Compound:1155-0152|FD-Score:3.47|P-value:6.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.43|P-value:6.82E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.19|P-value:4.65E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.47|P-value:6.00E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.22|P-value:4.21E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.60|P-value:3.95E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.36|P-value:9.60E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.32|P-value:9.85E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.37|P-value:8.27E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.67|P-value:3.09E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.40|P-value:8.37E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.00|P-value:9.67E-5 ID:SGTC_1695|Compound:st026914|FD-Score:4.00|P-value:9.78E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.70|P-value:3.13E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.29|P-value:3.15E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.50|P-value:6.08E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.65|P-value:3.64E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.48|P-value:6.52E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.42|P-value:7.07E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.92|P-value:1.29E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.64|P-value:7.58E-6 ID:SGTC_2024|Compound:5144227|FD-Score:4.09|P-value:6.95E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.18|P-value:4.84E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.68|P-value:2.96E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.34|P-value:2.58E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-3.90|P-value:1.52E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.94|P-value:1.21E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:6.54|P-value:5.63E-10 ID:SGTC_2472|Compound:5377652|FD-Score:4.38|P-value:2.25E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.54|P-value:4.76E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.47|P-value:6.58E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.35|P-value:2.82E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.39|P-value:2.45E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:7.67|P-value:4.76E-13 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.28|P-value:6.27E-12 ID:SGTC_2620|Compound:irigenin|FD-Score:5.39|P-value:2.64E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.51|P-value:1.30E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.43|P-value:2.18E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.78|P-value:4.78E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.53|P-value:5.44E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.91|P-value:1.34E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.14|P-value:6.43E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.87|P-value:1.71E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.72|P-value:2.62E-4 ID:SGTC_2927|Compound:9011802|FD-Score:7.26|P-value:7.13E-12 ID:SGTC_3202|Compound:9113761|FD-Score:-4.79|P-value:4.64E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.98|P-value:1.02E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.82|P-value:2.03E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.77|P-value:4.40E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-5.78|P-value:4.31E-8

Top fitness defect scores for YCR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.90 5.3 µM 1.86E-38 120 3.57E-44
2 SGTC_310 1273-0058 11.40 1.1 µM 1.05E-26 mitochondrial stress 26 1.42E-30
3 SGTC_2589 lobaric acid 7.67 100.0 µM 4.76E-13 3 8.59E-15
4 SGTC_2617 dihydrotanshinone i 7.28 20.8 µM 6.27E-12 copper-dependent oxidative stress 8 1.68E-13
5 SGTC_2927 9011802 7.26 47.9 µM 7.13E-12 1 1.95E-13
6 SGTC_173 1273-0061 6.58 2.7 µM 4.63E-10 mitochondrial stress 96 2.41E-11
7 SGTC_2454 5-benzylidenerhodanine 6.54 10.4 µM 5.63E-10 TRP & mitochondrial translation 9 3.02E-11
8 SGTC_63 0099-0242 6.14 26.7 µM 5.47E-9 mitochondrial stress 27 4.14E-10
9 SGTC_2688 kanamycin b 5.43 96.7 µM 2.18E-7 calcium & mitochondrial duress 201 2.89E-8
10 SGTC_2620 irigenin 5.39 100.0 µM 2.64E-7 11 3.61E-8
11 SGTC_275 trichlorophene 4.80 5.7 µM 3.90E-6 mitochondrial stress 183 7.98E-7
12 SGTC_3218 9131285 4.77 49.5 µM 4.40E-6 endomembrane recycling 21 9.18E-7
13 SGTC_2017 5132927 4.64 60.6 µM 7.58E-6 15 1.71E-6
14 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.51 100.0 µM 1.30E-5 16 3.20E-6
15 SGTC_2472 5377652 4.38 49.4 µM 2.25E-5 TRP & mitochondrial translation 41 5.99E-6
16 SGTC_2250 alverine citrate 4.34 130.0 µM 2.58E-5 130 6.98E-6
17 SGTC_1750 st081859 4.29 2.4 µM 3.15E-5 endomembrane recycling 163 8.79E-6
18 SGTC_883 0850-0245 4.22 24.6 µM 4.21E-5 cell wall 27 1.23E-5
19 SGTC_831 k061-1017 4.19 217.0 µM 4.65E-5 translation 53 1.38E-5
20 SGTC_2078 5212016 4.18 200.0 µM 4.84E-5 60S ribosome export 11 1.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.473 1.78E-186 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.425 2.72E-147 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.425 7.69E-147 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.420 1.36E-143 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.416 1.52E-140 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.413 2.53E-137 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.412 1.42E-137 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.401 1.20E-129 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.397 1.58E-126 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.394 8.07E-125 YNL073W MSK1 hom Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
0.393 4.34E-124 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.392 1.16E-123 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.392 1.70E-123 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.390 7.05E-122 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.390 8.47E-122 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress