YCR072C / RSA4

WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCR072C / RSA4

Click on Significant Values for Screen Details ID:SGTC_153|Compound:4077-0274|FD-Score:3.78|P-value:3.30E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.94|P-value:1.36E-6 ID:SGTC_564|Compound:3555-0129|FD-Score:3.86|P-value:2.09E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:3.39|P-value:2.73E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:2.72|P-value:6.17E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.48|P-value:1.73E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:-2.78|P-value:4.20E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.27|P-value:1.42E-10 ID:SGTC_876|Compound:0720-0963|FD-Score:3.37|P-value:3.01E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.34|P-value:3.45E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.94|P-value:2.31E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.64|P-value:8.58E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.24|P-value:5.83E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.55|P-value:1.05E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.61|P-value:8.59E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-2.73|P-value:5.30E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.14|P-value:4.11E-7 ID:SGTC_1896|Compound:st058441|FD-Score:-3.96|P-value:1.06E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-3.24|P-value:5.24E-5 ID:SGTC_2285|Compound:7945142|FD-Score:2.99|P-value:1.89E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.10|P-value:1.02E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.19|P-value:7.43E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.20|P-value:7.03E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.47|P-value:1.64E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:2.85|P-value:3.44E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.08|P-value:1.26E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.92|P-value:1.53E-6 ID:SGTC_3299|Compound:9121982|FD-Score:2.88|P-value:3.09E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.78|P-value:3.30E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.94|P-value:1.36E-6 ID:SGTC_564|Compound:3555-0129|FD-Score:3.86|P-value:2.09E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:3.39|P-value:2.73E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:2.72|P-value:6.17E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.48|P-value:1.73E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:-2.78|P-value:4.20E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.27|P-value:1.42E-10 ID:SGTC_876|Compound:0720-0963|FD-Score:3.37|P-value:3.01E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.34|P-value:3.45E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.94|P-value:2.31E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.64|P-value:8.58E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.24|P-value:5.83E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.55|P-value:1.05E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.61|P-value:8.59E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-2.73|P-value:5.30E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.14|P-value:4.11E-7 ID:SGTC_1896|Compound:st058441|FD-Score:-3.96|P-value:1.06E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-3.24|P-value:5.24E-5 ID:SGTC_2285|Compound:7945142|FD-Score:2.99|P-value:1.89E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.10|P-value:1.02E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.19|P-value:7.43E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.20|P-value:7.03E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.47|P-value:1.64E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:2.85|P-value:3.44E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.08|P-value:1.26E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.92|P-value:1.53E-6 ID:SGTC_3299|Compound:9121982|FD-Score:2.88|P-value:3.09E-4

Top fitness defect scores for YCR072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1733 st037357 4.14 54.9 µM 4.11E-7 60S ribosome export 4 1.75E-5 0.08
2 SGTC_198 3454-2873 3.94 16.2 µM 1.36E-6 60S ribosome export 4 4.11E-5 0.22
3 SGTC_3287 9117173 3.92 37.1 µM 1.53E-6 60S ribosome export 2 4.48E-5 0.33
4 SGTC_564 3555-0129 3.86 330.0 µM 2.09E-6 3 5.60E-5 0.05
5 SGTC_153 4077-0274 3.78 519.7 µM 3.30E-6 9 7.76E-5 0.29
6 SGTC_665 3914-0008 3.48 307.0 µM 1.73E-5 5 2.53E-4 0.05
7 SGTC_567 1080-0542 3.39 68.4 µM 2.73E-5 5 3.52E-4 0.10
8 SGTC_876 0720-0963 3.37 56.8 µM 3.01E-5 12 3.77E-4 0.20
9 SGTC_1269 0831-0796 3.34 3.0 µM 3.45E-5 60S ribosome export 12 4.16E-4 0.19
10 SGTC_1382 3002-2117 3.24 298.0 µM 5.83E-5 8 6.06E-4 0.02
11 SGTC_2608 thymoquinone 3.20 42.7 µM 7.03E-5 10 6.93E-4 0.04
12 SGTC_2605 digitonin 3.19 300.0 nM 7.43E-5 11 7.21E-4 0.01
13 SGTC_2791 5663188 3.08 71.4 µM 1.26E-4 RPP1 & pyrimidine depletion 23 0.00105 0.04
14 SGTC_2285 7945142 2.99 200.0 µM 1.89E-4 23 0.00141 0.01
15 SGTC_1284 0929-0043 2.94 16.0 µM 2.31E-4 14 0.00163 0.05
16 SGTC_3299 9121982 2.88 43.1 µM 3.09E-4 15 0.00201 0.01
17 SGTC_2614 arthonioic acid 2.85 13.4 µM 3.44E-4 11 0.00217 0.02
18 SGTC_588 3970-1144 2.72 52.9 µM 6.17E-4 5 0.00331 0.07
19 SGTC_1332 1480-0653 2.64 17.5 µM 8.58E-4 TSC3-RPN4 15 0.00420 0.07
20 SGTC_1206 3978-0017 2.53 132.0 µM 0.00128 ERG2 38 0.00563 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.72E-27 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.183 1.50E-26 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.160 9.42E-21 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.157 6.90E-20 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.144 4.93E-17 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.144 5.01E-17 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.144 5.60E-17 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.143 9.59E-17 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.142 1.59E-16 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.140 4.07E-16 YLR290C_p YLR290C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
0.131 2.66E-14 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.131 4.15E-14 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.126 2.96E-13 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.124 5.67E-13 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.120 3.20E-12 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions