YCR073C / SSK22

MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR073C / SSK22

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.37|P-value:3.22E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.35|P-value:2.56E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.06|P-value:7.32E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.74|P-value:5.34E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.09|P-value:6.62E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.16|P-value:6.89E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.80|P-value:4.14E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.21|P-value:5.83E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.13|P-value:7.65E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.50|P-value:1.91E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.41|P-value:2.03E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.00|P-value:9.10E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.27|P-value:4.68E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.29|P-value:4.36E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.26|P-value:4.77E-4 ID:SGTC_1670|Compound:st016595|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.06|P-value:9.67E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.63|P-value:1.16E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.71|P-value:8.40E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-4.06|P-value:1.86E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.94|P-value:2.17E-5 ID:SGTC_2062|Compound:5245942|FD-Score:-4.37|P-value:4.52E-6 ID:SGTC_2324|Compound:6149169|FD-Score:4.18|P-value:7.36E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.53|P-value:1.75E-4 ID:SGTC_2780|Compound:5215298|FD-Score:6.24|P-value:5.81E-11 ID:SGTC_2917|Compound:7979103|FD-Score:-3.09|P-value:8.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.66|P-value:1.04E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.28|P-value:4.48E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.36|P-value:3.17E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.69|P-value:9.24E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.37|P-value:3.22E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.35|P-value:2.56E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.06|P-value:7.32E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.74|P-value:5.34E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.09|P-value:6.62E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.16|P-value:6.89E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.80|P-value:4.14E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.21|P-value:5.83E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.13|P-value:7.65E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.50|P-value:1.91E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.41|P-value:2.03E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.00|P-value:9.10E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.27|P-value:4.68E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.29|P-value:4.36E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.26|P-value:4.77E-4 ID:SGTC_1670|Compound:st016595|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.06|P-value:9.67E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.63|P-value:1.16E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.71|P-value:8.40E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-4.06|P-value:1.86E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.94|P-value:2.17E-5 ID:SGTC_2062|Compound:5245942|FD-Score:-4.37|P-value:4.52E-6 ID:SGTC_2324|Compound:6149169|FD-Score:4.18|P-value:7.36E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.53|P-value:1.75E-4 ID:SGTC_2780|Compound:5215298|FD-Score:6.24|P-value:5.81E-11 ID:SGTC_2917|Compound:7979103|FD-Score:-3.09|P-value:8.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.66|P-value:1.04E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.28|P-value:4.48E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.36|P-value:3.17E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.69|P-value:9.24E-5

Top fitness defect scores for YCR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2780 5215298 6.24 71.4 µM 5.81E-11 7 2.18E-10
2 SGTC_2999 9069765 4.36 71.4 µM 3.17E-6 amide catabolism 15 6.52E-6
3 SGTC_2324 6149169 4.18 200.0 µM 7.36E-6 17 1.44E-5
4 SGTC_1941 st076221 3.94 61.8 µM 2.17E-5 sphingolipid biosynthesis & PDR1 81 4.01E-5
5 SGTC_955 1216-0110 3.80 33.0 µM 4.14E-5 sphingolipid biosynthesis & PDR1 75 7.37E-5
6 SGTC_142 0335-0849 3.74 62.7 µM 5.34E-5 ubiquinone biosynthesis & proteasome 138 9.37E-5
7 SGTC_1380 2291-0730 3.51 164.0 µM 1.34E-4 38 2.23E-4
8 SGTC_1230 0170-0365 3.41 3.8 µM 2.03E-4 endomembrane recycling 98 3.30E-4
9 SGTC_3002 9075603 3.38 71.4 µM 2.23E-4 44 3.60E-4
10 SGTC_137 0438-0332 3.35 85.4 µM 2.56E-4 ubiquinone biosynthesis & proteasome 157 4.11E-4
11 SGTC_2929 9013348 3.29 24.6 µM 3.11E-4 50 4.94E-4
12 SGTC_376 3970-0862 3.13 59.1 µM 5.73E-4 52 8.78E-4
13 SGTC_367 0335-0881 3.09 7.1 µM 6.62E-4 ubiquinone biosynthesis & proteasome 130 0.00101
14 SGTC_139 0099-0334 3.06 718.6 µM 7.32E-4 79 0.00111
15 SGTC_1381 2324-0066 3.00 62.1 µM 9.10E-4 76 0.00136
16 SGTC_2823 7987624 2.86 58.4 µM 0.00144 103 0.00210
17 SGTC_837 0091-0265 2.86 12.5 µM 0.00148 ubiquinone biosynthesis & proteasome 70 0.00215
18 SGTC_2504 purpurogallin 2.78 52.3 µM 0.00191 RPP1 & pyrimidine depletion 75 0.00273
19 SGTC_2921 7974240 2.77 10.7 µM 0.00198 118 0.00283
20 SGTC_763 3453-1109 2.76 128.0 µM 0.00200 74 0.00285

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 4.81E-20 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 8.08E-18 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.143 1.01E-16 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.124 5.59E-13 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.123 9.43E-13 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.120 3.55E-12 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.119 4.43E-12 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 4.86E-12 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.117 1.03E-11 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.117 1.19E-11 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.115 2.73E-11 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.113 4.48E-11 YCR089W FIG2 hom Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
0.111 1.28E-10 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.109 2.34E-10 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.108 3.44E-10 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER