YCR073W-A / SOL2

Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR073W-A / SOL2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.33|P-value:7.25E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.21|P-value:3.08E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:3.24|P-value:9.59E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.24|P-value:2.44E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:5.18|P-value:3.57E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.35|P-value:6.68E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.28|P-value:8.46E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.40|P-value:5.59E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.73|P-value:1.81E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.46|P-value:4.71E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.00|P-value:6.37E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:5.88|P-value:9.12E-9 ID:SGTC_893|Compound:0958-0369|FD-Score:3.62|P-value:2.68E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.95|P-value:7.79E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:4.91|P-value:1.33E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:3.48|P-value:4.38E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.76|P-value:1.59E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.33|P-value:7.05E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:5.64|P-value:3.39E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.38|P-value:5.87E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.43|P-value:1.11E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.77|P-value:1.53E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.66|P-value:2.27E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.79|P-value:1.43E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.21|P-value:3.11E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.27|P-value:8.79E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.25|P-value:2.37E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.32|P-value:7.57E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.54|P-value:3.50E-4 ID:SGTC_1663|Compound:st014140|FD-Score:5.09|P-value:5.66E-7 ID:SGTC_1722|Compound:st034304|FD-Score:6.32|P-value:7.15E-10 ID:SGTC_1829|Compound:berberine|FD-Score:3.29|P-value:8.20E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.25|P-value:9.42E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.78|P-value:1.51E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.93|P-value:8.48E-5 ID:SGTC_2231|Compound:micatex|FD-Score:3.94|P-value:8.05E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.38|P-value:6.12E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.91|P-value:9.13E-5 ID:SGTC_2462|Compound:5162487|FD-Score:3.73|P-value:1.77E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:5.56|P-value:5.01E-8 ID:SGTC_2738|Compound:aclarubicin|FD-Score:-3.42|P-value:5.19E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:4.82|P-value:2.03E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.13|P-value:3.93E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.64|P-value:2.47E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.03|P-value:5.44E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.75|P-value:2.73E-6 ID:SGTC_2967|Compound:9089538|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.07|P-value:3.03E-9 ID:SGTC_2992|Compound:9074591|FD-Score:5.16|P-value:4.00E-7 ID:SGTC_2999|Compound:9069765|FD-Score:4.58|P-value:5.96E-6 ID:SGTC_3002|Compound:9075603|FD-Score:7.76|P-value:5.38E-14 ID:SGTC_3003|Compound:9075612|FD-Score:-4.47|P-value:8.90E-6 ID:SGTC_3014|Compound:9081533|FD-Score:-3.61|P-value:2.66E-4 ID:SGTC_3016|Compound:9080866|FD-Score:6.39|P-value:4.79E-10 ID:SGTC_3024|Compound:9090631|FD-Score:3.46|P-value:4.75E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.68|P-value:2.09E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.50|P-value:8.12E-6 ID:SGTC_3091|Compound:9116372|FD-Score:4.09|P-value:4.52E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.20|P-value:2.92E-5 ID:SGTC_3195|Compound:9113082|FD-Score:-4.15|P-value:3.38E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.57|P-value:3.02E-4 ID:SGTC_3216|Compound:9129716|FD-Score:7.13|P-value:4.30E-12 ID:SGTC_3226|Compound:9131256|FD-Score:-3.34|P-value:6.81E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.88|P-value:1.02E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.32|P-value:7.43E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.09|P-value:5.63E-7 ID:SGTC_3354|Compound:9151612|FD-Score:-4.35|P-value:1.51E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.33|P-value:7.25E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.21|P-value:3.08E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:3.24|P-value:9.59E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.24|P-value:2.44E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:5.18|P-value:3.57E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.35|P-value:6.68E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.28|P-value:8.46E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.40|P-value:5.59E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.73|P-value:1.81E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.46|P-value:4.71E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.00|P-value:6.37E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:5.88|P-value:9.12E-9 ID:SGTC_893|Compound:0958-0369|FD-Score:3.62|P-value:2.68E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.95|P-value:7.79E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:4.91|P-value:1.33E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:3.48|P-value:4.38E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.76|P-value:1.59E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.33|P-value:7.05E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:5.64|P-value:3.39E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.38|P-value:5.87E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.43|P-value:1.11E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.77|P-value:1.53E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.66|P-value:2.27E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.79|P-value:1.43E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.21|P-value:3.11E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.27|P-value:8.79E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.25|P-value:2.37E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.32|P-value:7.57E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.54|P-value:3.50E-4 ID:SGTC_1663|Compound:st014140|FD-Score:5.09|P-value:5.66E-7 ID:SGTC_1722|Compound:st034304|FD-Score:6.32|P-value:7.15E-10 ID:SGTC_1829|Compound:berberine|FD-Score:3.29|P-value:8.20E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.25|P-value:9.42E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.78|P-value:1.51E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.93|P-value:8.48E-5 ID:SGTC_2231|Compound:micatex|FD-Score:3.94|P-value:8.05E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.38|P-value:6.12E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.91|P-value:9.13E-5 ID:SGTC_2462|Compound:5162487|FD-Score:3.73|P-value:1.77E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:5.56|P-value:5.01E-8 ID:SGTC_2738|Compound:aclarubicin|FD-Score:-3.42|P-value:5.19E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:4.82|P-value:2.03E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.13|P-value:3.93E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.64|P-value:2.47E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.03|P-value:5.44E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.75|P-value:2.73E-6 ID:SGTC_2967|Compound:9089538|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.07|P-value:3.03E-9 ID:SGTC_2992|Compound:9074591|FD-Score:5.16|P-value:4.00E-7 ID:SGTC_2999|Compound:9069765|FD-Score:4.58|P-value:5.96E-6 ID:SGTC_3002|Compound:9075603|FD-Score:7.76|P-value:5.38E-14 ID:SGTC_3003|Compound:9075612|FD-Score:-4.47|P-value:8.90E-6 ID:SGTC_3014|Compound:9081533|FD-Score:-3.61|P-value:2.66E-4 ID:SGTC_3016|Compound:9080866|FD-Score:6.39|P-value:4.79E-10 ID:SGTC_3024|Compound:9090631|FD-Score:3.46|P-value:4.75E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.68|P-value:2.09E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.50|P-value:8.12E-6 ID:SGTC_3091|Compound:9116372|FD-Score:4.09|P-value:4.52E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.20|P-value:2.92E-5 ID:SGTC_3195|Compound:9113082|FD-Score:-4.15|P-value:3.38E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.57|P-value:3.02E-4 ID:SGTC_3216|Compound:9129716|FD-Score:7.13|P-value:4.30E-12 ID:SGTC_3226|Compound:9131256|FD-Score:-3.34|P-value:6.81E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.88|P-value:1.02E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.32|P-value:7.43E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.09|P-value:5.63E-7 ID:SGTC_3354|Compound:9151612|FD-Score:-4.35|P-value:1.51E-5

Top fitness defect scores for YCR073W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3002 9075603 7.76 71.4 µM 5.38E-14 2 4.21E-15
2 SGTC_3216 9129716 7.13 49.5 µM 4.30E-12 RPP1 & pyrimidine depletion 2 4.95E-13
3 SGTC_3016 9080866 6.39 49.5 µM 4.79E-10 2 8.36E-11
4 SGTC_1722 st034304 6.32 3.6 µM 7.15E-10 mitochondrial processes 5 1.29E-10
5 SGTC_2974 9094440 6.07 9.7 µM 3.03E-9 ergosterol biosynthesis 13 6.20E-10
6 SGTC_799 1310-0557 5.88 151.0 µM 9.12E-9 superoxide 7 2.06E-9
7 SGTC_1116 jasmonic acid 5.64 1.6 µM 3.39E-8 3 8.58E-9
8 SGTC_2726 cimetidine 5.56 79.3 µM 5.01E-8 1 1.32E-8
9 SGTC_100 0086-0128 5.21 49.6 µM 3.08E-7 copper-dependent oxidative stress 20 9.47E-8
10 SGTC_1360 1598-0022 5.21 39.8 µM 3.11E-7 ERG2 13 9.57E-8
11 SGTC_235 0330-0087 5.18 5.0 mM 3.57E-7 TSC3-RPN4 6 1.11E-7
12 SGTC_2992 9074591 5.16 71.4 µM 4.00E-7 7 1.26E-7
13 SGTC_3340 9146634 5.09 11.1 µM 5.63E-7 5 1.82E-7
14 SGTC_1663 st014140 5.09 55.4 µM 5.66E-7 60S ribosome export 8 1.83E-7
15 SGTC_991 3996-0057 4.91 64.7 µM 1.33E-6 7 4.63E-7
16 SGTC_2745 rifampicin 4.82 24.3 µM 2.03E-6 1 7.34E-7
17 SGTC_2887 9044784 4.75 58.4 µM 2.73E-6 fatty acid desaturase (OLE1) 15 1.01E-6
18 SGTC_2999 9069765 4.58 71.4 µM 5.96E-6 amide catabolism 12 2.37E-6
19 SGTC_3033 9090887 4.50 49.5 µM 8.12E-6 fatty acid desaturase (OLE1) 13 3.32E-6
20 SGTC_1157 4092-0394 4.43 27.6 µM 1.11E-5 21 4.67E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.04E-9 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.099 7.72E-9 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.086 5.21E-7 YNL068C FKH2 hom Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication
0.086 6.05E-7 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.080 3.85E-6 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.078 5.83E-6 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.078 5.77E-6 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.077 7.44E-6 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.077 7.71E-6 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.077 9.02E-6 YPL046C ELC1 hom Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
0.076 9.46E-6 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.075 1.43E-5 YLR434C_d YLR434C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
0.075 1.45E-5 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.074 1.74E-5 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.074 1.76E-5 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism