YCR075C / ERS1

Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR075C / ERS1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.77|P-value:3.34E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.19|P-value:4.76E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.70|P-value:4.57E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.72|P-value:3.04E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:4.88|P-value:1.26E-7 ID:SGTC_337|Compound:1315-0038|FD-Score:3.53|P-value:9.79E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.35|P-value:1.98E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.15|P-value:4.42E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.53|P-value:8.54E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:3.00|P-value:7.55E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.12|P-value:4.82E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.03|P-value:6.96E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.24|P-value:3.78E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.58|P-value:7.84E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.88|P-value:2.03E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.17|P-value:4.04E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.23|P-value:3.17E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.45|P-value:1.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.07|P-value:8.43E-6 ID:SGTC_1648|Compound:st011736|FD-Score:3.20|P-value:3.63E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.02|P-value:6.99E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.90|P-value:1.93E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.17|P-value:4.07E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.01|P-value:7.36E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.07|P-value:5.87E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.18|P-value:3.93E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.22|P-value:3.40E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.42|P-value:1.50E-6 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.61|P-value:6.81E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.58|P-value:7.61E-5 ID:SGTC_2221|Compound:6807166|FD-Score:3.19|P-value:3.79E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.00|P-value:7.76E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.02|P-value:1.09E-5 ID:SGTC_2295|Compound:7971645|FD-Score:4.94|P-value:8.81E-8 ID:SGTC_2298|Compound:7976326|FD-Score:5.15|P-value:2.70E-8 ID:SGTC_2303|Compound:7774051|FD-Score:8.00|P-value:1.46E-17 ID:SGTC_2326|Compound:6164455|FD-Score:-3.95|P-value:1.50E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.78|P-value:4.94E-10 ID:SGTC_2337|Compound:9009472|FD-Score:-4.14|P-value:6.16E-6 ID:SGTC_2362|Compound:9071156|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.08|P-value:8.21E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.01|P-value:7.30E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:2.97|P-value:8.61E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:6.99|P-value:7.60E-14 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.23|P-value:1.64E-8 ID:SGTC_2782|Compound:7736369|FD-Score:-3.47|P-value:1.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.75|P-value:3.68E-5 ID:SGTC_2960|Compound:9079389|FD-Score:4.59|P-value:6.13E-7 ID:SGTC_2962|Compound:9082311|FD-Score:-3.33|P-value:2.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.15|P-value:4.39E-4 ID:SGTC_3314|Compound:9135860|FD-Score:4.07|P-value:8.73E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.12|P-value:4.93E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.69|P-value:4.90E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.77|P-value:3.34E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.19|P-value:4.76E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.70|P-value:4.57E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.72|P-value:3.04E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:4.88|P-value:1.26E-7 ID:SGTC_337|Compound:1315-0038|FD-Score:3.53|P-value:9.79E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.35|P-value:1.98E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.15|P-value:4.42E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.53|P-value:8.54E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:3.00|P-value:7.55E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.12|P-value:4.82E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.03|P-value:6.96E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.24|P-value:3.78E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.58|P-value:7.84E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.88|P-value:2.03E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.17|P-value:4.04E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.23|P-value:3.17E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.45|P-value:1.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.07|P-value:8.43E-6 ID:SGTC_1648|Compound:st011736|FD-Score:3.20|P-value:3.63E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.02|P-value:6.99E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.90|P-value:1.93E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.17|P-value:4.07E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.01|P-value:7.36E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.07|P-value:5.87E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.18|P-value:3.93E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.22|P-value:3.40E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.42|P-value:1.50E-6 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.61|P-value:6.81E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.58|P-value:7.61E-5 ID:SGTC_2221|Compound:6807166|FD-Score:3.19|P-value:3.79E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.00|P-value:7.76E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.02|P-value:1.09E-5 ID:SGTC_2295|Compound:7971645|FD-Score:4.94|P-value:8.81E-8 ID:SGTC_2298|Compound:7976326|FD-Score:5.15|P-value:2.70E-8 ID:SGTC_2303|Compound:7774051|FD-Score:8.00|P-value:1.46E-17 ID:SGTC_2326|Compound:6164455|FD-Score:-3.95|P-value:1.50E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.78|P-value:4.94E-10 ID:SGTC_2337|Compound:9009472|FD-Score:-4.14|P-value:6.16E-6 ID:SGTC_2362|Compound:9071156|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.08|P-value:8.21E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.01|P-value:7.30E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:2.97|P-value:8.61E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:6.99|P-value:7.60E-14 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.23|P-value:1.64E-8 ID:SGTC_2782|Compound:7736369|FD-Score:-3.47|P-value:1.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.75|P-value:3.68E-5 ID:SGTC_2960|Compound:9079389|FD-Score:4.59|P-value:6.13E-7 ID:SGTC_2962|Compound:9082311|FD-Score:-3.33|P-value:2.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.15|P-value:4.39E-4 ID:SGTC_3314|Compound:9135860|FD-Score:4.07|P-value:8.73E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.12|P-value:4.93E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.69|P-value:4.90E-5

Top fitness defect scores for YCR075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2303 7774051 8.00 200.0 µM 1.46E-17 2 6.38E-16
2 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 6.99 100.0 µM 7.60E-14 60S ribosome export 2 1.38E-12
3 SGTC_2332 7982454 5.78 138.9 µM 4.94E-10 20 3.64E-9
4 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 5.23 100.0 µM 1.64E-8 10 8.47E-8
5 SGTC_2298 7976326 5.15 193.8 µM 2.70E-8 2 1.33E-7
6 SGTC_2295 7971645 4.94 200.0 µM 8.81E-8 11 3.84E-7
7 SGTC_165 k038-0023 4.88 64.4 µM 1.26E-7 ubiquinone biosynthesis & proteasome 45 5.32E-7
8 SGTC_142 0335-0849 4.72 62.7 µM 3.04E-7 ubiquinone biosynthesis & proteasome 95 1.17E-6
9 SGTC_2960 9079389 4.59 6.0 µM 6.13E-7 14 2.20E-6
10 SGTC_708 3448-5400 4.53 146.0 µM 8.54E-7 27 2.96E-6
11 SGTC_2191 5911152 4.42 200.0 µM 1.50E-6 7 4.91E-6
12 SGTC_2495 cafestol 4.08 54.5 µM 8.21E-6 Golgi 23 2.27E-5
13 SGTC_1606 st000094 4.07 49.2 µM 8.43E-6 60S ribosome export 13 2.32E-5
14 SGTC_3314 9135860 4.07 59.4 µM 8.73E-6 11 2.40E-5
15 SGTC_2239 6685329 4.02 187.6 µM 1.09E-5 27 2.93E-5
16 SGTC_1805 st050013 3.90 60.3 µM 1.93E-5 9 4.91E-5
17 SGTC_1069 diphenylcyclopropenone 3.88 8.5 µM 2.03E-5 35 5.13E-5
18 SGTC_64 000l-0018 3.77 272.1 µM 3.34E-5 ubiquinone biosynthesis & proteasome 162 8.03E-5
19 SGTC_134 0269-0018 3.70 6.9 µM 4.57E-5 146 1.06E-4
20 SGTC_3348 9149464 3.69 3.5 µM 4.90E-5 20 1.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.28E-22 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.121 1.95E-12 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.120 2.67E-12 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.112 8.46E-11 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.110 1.69E-10 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.109 2.35E-10 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.109 2.49E-10 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.108 3.76E-10 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 4.33E-10 YEL028W_d YEL028W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.106 7.61E-10 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.106 8.08E-10 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.103 2.17E-9 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.101 4.33E-9 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.096 2.16E-8 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.096 2.33E-8 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein