YCR076C / FUB1

Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR076C / FUB1

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-3.66|P-value:2.14E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.26|P-value:8.21E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.26|P-value:4.80E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:4.42|P-value:2.58E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.55|P-value:6.10E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.58|P-value:5.40E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.20|P-value:6.05E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.56|P-value:5.90E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.47|P-value:7.71E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.71|P-value:3.52E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:7.68|P-value:5.89E-13 ID:SGTC_746|Compound:1095-0025|FD-Score:3.99|P-value:1.33E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.71|P-value:3.57E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.55|P-value:3.12E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.96|P-value:7.18E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.71|P-value:1.76E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.11|P-value:8.45E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.54|P-value:6.34E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.95|P-value:2.72E-6 ID:SGTC_1522|Compound:st012842|FD-Score:4.58|P-value:1.33E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:8.97|P-value:4.35E-17 ID:SGTC_1581|Compound:himbacine|FD-Score:4.75|P-value:6.41E-6 ID:SGTC_1648|Compound:st011736|FD-Score:6.06|P-value:1.14E-8 ID:SGTC_1716|Compound:st033144|FD-Score:-5.10|P-value:5.39E-7 ID:SGTC_1784|Compound:st039334|FD-Score:-4.37|P-value:1.38E-5 ID:SGTC_1896|Compound:st058441|FD-Score:-5.52|P-value:6.92E-8 ID:SGTC_2000|Compound:st075254|FD-Score:3.47|P-value:7.80E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.04|P-value:1.10E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.82|P-value:2.38E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.62|P-value:2.45E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.70|P-value:3.69E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.13|P-value:3.68E-5 ID:SGTC_2811|Compound:7967822|FD-Score:4.26|P-value:4.74E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-3.23|P-value:9.19E-4 ID:SGTC_2914|Compound:7968218|FD-Score:6.11|P-value:8.51E-9 ID:SGTC_3116|Compound:9124943|FD-Score:3.72|P-value:3.46E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.59|P-value:5.30E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.47|P-value:7.92E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.69|P-value:3.76E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.66|P-value:2.14E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.26|P-value:8.21E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.26|P-value:4.80E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:4.42|P-value:2.58E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.55|P-value:6.10E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.58|P-value:5.40E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.20|P-value:6.05E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.56|P-value:5.90E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.47|P-value:7.71E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.71|P-value:3.52E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:7.68|P-value:5.89E-13 ID:SGTC_746|Compound:1095-0025|FD-Score:3.99|P-value:1.33E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.71|P-value:3.57E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.55|P-value:3.12E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.96|P-value:7.18E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.71|P-value:1.76E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.11|P-value:8.45E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.54|P-value:6.34E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.95|P-value:2.72E-6 ID:SGTC_1522|Compound:st012842|FD-Score:4.58|P-value:1.33E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:8.97|P-value:4.35E-17 ID:SGTC_1581|Compound:himbacine|FD-Score:4.75|P-value:6.41E-6 ID:SGTC_1648|Compound:st011736|FD-Score:6.06|P-value:1.14E-8 ID:SGTC_1716|Compound:st033144|FD-Score:-5.10|P-value:5.39E-7 ID:SGTC_1784|Compound:st039334|FD-Score:-4.37|P-value:1.38E-5 ID:SGTC_1896|Compound:st058441|FD-Score:-5.52|P-value:6.92E-8 ID:SGTC_2000|Compound:st075254|FD-Score:3.47|P-value:7.80E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.04|P-value:1.10E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.82|P-value:2.38E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.62|P-value:2.45E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.70|P-value:3.69E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.13|P-value:3.68E-5 ID:SGTC_2811|Compound:7967822|FD-Score:4.26|P-value:4.74E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-3.23|P-value:9.19E-4 ID:SGTC_2914|Compound:7968218|FD-Score:6.11|P-value:8.51E-9 ID:SGTC_3116|Compound:9124943|FD-Score:3.72|P-value:3.46E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.59|P-value:5.30E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.47|P-value:7.92E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.69|P-value:3.76E-4

Top fitness defect scores for YCR076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 8.97 66.5 µM 4.35E-17 1 1.45E-19
2 SGTC_742 0kpi-0133 7.68 140.0 µM 5.89E-13 ERG2 2 8.05E-15
3 SGTC_2914 7968218 6.11 45.3 µM 8.51E-9 3 4.90E-10
4 SGTC_1648 st011736 6.06 69.8 µM 1.14E-8 PDR1 1 6.85E-10
5 SGTC_1372 2752-0194 4.95 270.0 µM 2.72E-6 9 3.77E-7
6 SGTC_1581 himbacine 4.75 57.9 µM 6.41E-6 Golgi 34 1.01E-6
7 SGTC_1522 st012842 4.58 45.6 µM 1.33E-5 RNA pol III & RNase P/MRP 14 2.36E-6
8 SGTC_182 3448-4371 4.42 550.5 µM 2.58E-5 17 5.05E-6
9 SGTC_2811 7967822 4.26 32.5 µM 4.74E-5 16 1.02E-5
10 SGTC_180 1486-1293 4.26 102.8 µM 4.80E-5 36 1.03E-5
11 SGTC_396 dithiazanine 4.20 1.2 µM 6.05E-5 5 1.35E-5
12 SGTC_1243 0416-0003 4.11 5.7 µM 8.45E-5 PDR1 25 1.99E-5
13 SGTC_2061 5245884 4.04 81.0 µM 1.10E-4 tubulin folding & SWR complex 21 2.70E-5
14 SGTC_2593 nobiletin 4.03 86.2 µM 1.12E-4 23 2.74E-5
15 SGTC_397 arbidol 4.03 50.0 µM 1.12E-4 cell wall 18 2.75E-5
16 SGTC_746 1095-0025 3.99 46.6 µM 1.33E-4 RSC & ERG11 12 3.37E-5
17 SGTC_1123 mangostin 3.93 811.3 nM 1.61E-4 mitochondrial response to ROS 41 4.18E-5
18 SGTC_2408 sulbentine 3.82 18.4 µM 2.38E-4 54 6.56E-5
19 SGTC_3116 9124943 3.72 49.5 µM 3.46E-4 22 1.01E-4
20 SGTC_695 3505-6186 3.71 243.0 µM 3.52E-4 29 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.91E-8 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.084 1.03E-6 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.080 3.66E-6 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.078 6.08E-6 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.074 1.86E-5 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.070 5.28E-5 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.070 5.36E-5 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.069 6.15E-5 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.068 8.15E-5 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.067 9.39E-5 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.067 1.06E-4 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.065 1.75E-4 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.064 2.02E-4 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.063 2.35E-4 YOL047C_p YOL047C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.063 2.84E-4 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation