YCR077C / PAT1

Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR077C / PAT1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.48|P-value:1.18E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.39|P-value:7.49E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.64|P-value:3.00E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.35|P-value:2.53E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:8.57|P-value:4.04E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.98|P-value:8.81E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.81|P-value:3.21E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.31|P-value:2.64E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.32|P-value:2.48E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:5.20|P-value:5.30E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.22|P-value:2.63E-9 ID:SGTC_232|Compound:clozapine|FD-Score:4.82|P-value:3.04E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.98|P-value:1.46E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.38|P-value:7.64E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.92|P-value:1.90E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:9.48|P-value:2.55E-19 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.91|P-value:2.07E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:7.68|P-value:2.70E-13 ID:SGTC_245|Compound:methotrexate|FD-Score:4.23|P-value:3.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.21|P-value:3.64E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:6.30|P-value:1.69E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.14|P-value:8.76E-15 ID:SGTC_313|Compound:3474-0040|FD-Score:5.11|P-value:7.91E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.33|P-value:8.42E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.59|P-value:3.80E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.32|P-value:9.23E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.50|P-value:4.77E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.01|P-value:7.93E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.56|P-value:4.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.08|P-value:6.07E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.20|P-value:3.69E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.47|P-value:5.73E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.39|P-value:7.47E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.63|P-value:3.08E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.87|P-value:1.44E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.22|P-value:3.77E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.39|P-value:7.33E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-8.80|P-value:5.75E-17 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.61|P-value:3.54E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.70|P-value:2.61E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.93|P-value:1.14E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.15|P-value:4.95E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:6.84|P-value:6.43E-11 ID:SGTC_888|Compound:0916-0002|FD-Score:3.42|P-value:6.76E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.34|P-value:8.55E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.28|P-value:9.93E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:7.19|P-value:7.35E-12 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.68|P-value:2.82E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.79|P-value:2.77E-8 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.68|P-value:4.76E-8 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.69|P-value:1.66E-10 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.41|P-value:6.94E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.27|P-value:3.03E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.46|P-value:5.84E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.35|P-value:8.53E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.51|P-value:5.02E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-5.72|P-value:3.61E-8 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.10|P-value:6.04E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.90|P-value:1.27E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-6.94|P-value:3.06E-11 ID:SGTC_1529|Compound:apigenin|FD-Score:8.28|P-value:3.66E-15 ID:SGTC_1640|Compound:st009078|FD-Score:3.57|P-value:4.05E-4 ID:SGTC_1669|Compound:st015249|FD-Score:4.02|P-value:8.00E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.19|P-value:3.02E-9 ID:SGTC_1754|Compound:st042065|FD-Score:4.47|P-value:1.35E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.94|P-value:1.74E-6 ID:SGTC_1781|Compound:st038725|FD-Score:13.20|P-value:8.09E-36 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.11|P-value:4.84E-9 ID:SGTC_1797|Compound:st048695|FD-Score:4.00|P-value:8.81E-5 ID:SGTC_1801|Compound:st050089|FD-Score:6.76|P-value:1.11E-10 ID:SGTC_1803|Compound:st050068|FD-Score:4.72|P-value:4.76E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.74|P-value:3.53E-8 ID:SGTC_1991|Compound:st073000|FD-Score:4.79|P-value:3.48E-6 ID:SGTC_2006|Compound:4011487|FD-Score:3.57|P-value:4.08E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.22|P-value:4.75E-7 ID:SGTC_2089|Compound:5281248|FD-Score:3.66|P-value:2.95E-4 ID:SGTC_2185|Compound:6113692|FD-Score:5.12|P-value:7.67E-7 ID:SGTC_2213|Compound:7173844|FD-Score:3.63|P-value:3.33E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.64|P-value:3.22E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.54|P-value:1.02E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.58|P-value:3.92E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:5.68|P-value:4.72E-8 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.77|P-value:1.88E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.58|P-value:3.72E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.09|P-value:5.81E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.13|P-value:7.36E-7 ID:SGTC_2699|Compound:st077704|FD-Score:7.31|P-value:3.33E-12 ID:SGTC_2730|Compound:imipramine|FD-Score:4.00|P-value:8.88E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.22|P-value:3.80E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.47|P-value:5.76E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.57|P-value:3.83E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.43|P-value:6.55E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.54|P-value:4.46E-4 ID:SGTC_2951|Compound:9072950|FD-Score:7.18|P-value:7.70E-12 ID:SGTC_2989|Compound:9073649|FD-Score:7.02|P-value:2.19E-11 ID:SGTC_2999|Compound:9069765|FD-Score:4.00|P-value:8.86E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.30|P-value:2.77E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.75|P-value:2.21E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.92|P-value:1.19E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.33|P-value:8.51E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.90|P-value:1.24E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.48|P-value:1.18E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.39|P-value:7.49E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.64|P-value:3.00E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.35|P-value:2.53E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:8.57|P-value:4.04E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.98|P-value:8.81E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.81|P-value:3.21E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.31|P-value:2.64E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.32|P-value:2.48E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:5.20|P-value:5.30E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.22|P-value:2.63E-9 ID:SGTC_232|Compound:clozapine|FD-Score:4.82|P-value:3.04E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.98|P-value:1.46E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.38|P-value:7.64E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.92|P-value:1.90E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:9.48|P-value:2.55E-19 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.91|P-value:2.07E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:7.68|P-value:2.70E-13 ID:SGTC_245|Compound:methotrexate|FD-Score:4.23|P-value:3.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.21|P-value:3.64E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:6.30|P-value:1.69E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.14|P-value:8.76E-15 ID:SGTC_313|Compound:3474-0040|FD-Score:5.11|P-value:7.91E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.33|P-value:8.42E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.59|P-value:3.80E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.32|P-value:9.23E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.50|P-value:4.77E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.01|P-value:7.93E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.56|P-value:4.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.08|P-value:6.07E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.20|P-value:3.69E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.47|P-value:5.73E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.39|P-value:7.47E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.63|P-value:3.08E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.87|P-value:1.44E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.22|P-value:3.77E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.39|P-value:7.33E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-8.80|P-value:5.75E-17 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.61|P-value:3.54E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.70|P-value:2.61E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.93|P-value:1.14E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.15|P-value:4.95E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:6.84|P-value:6.43E-11 ID:SGTC_888|Compound:0916-0002|FD-Score:3.42|P-value:6.76E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.34|P-value:8.55E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.28|P-value:9.93E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:7.19|P-value:7.35E-12 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.68|P-value:2.82E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.79|P-value:2.77E-8 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.68|P-value:4.76E-8 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.69|P-value:1.66E-10 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.41|P-value:6.94E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.27|P-value:3.03E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.46|P-value:5.84E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.35|P-value:8.53E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.51|P-value:5.02E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-5.72|P-value:3.61E-8 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.10|P-value:6.04E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.90|P-value:1.27E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-6.94|P-value:3.06E-11 ID:SGTC_1529|Compound:apigenin|FD-Score:8.28|P-value:3.66E-15 ID:SGTC_1640|Compound:st009078|FD-Score:3.57|P-value:4.05E-4 ID:SGTC_1669|Compound:st015249|FD-Score:4.02|P-value:8.00E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.19|P-value:3.02E-9 ID:SGTC_1754|Compound:st042065|FD-Score:4.47|P-value:1.35E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.94|P-value:1.74E-6 ID:SGTC_1781|Compound:st038725|FD-Score:13.20|P-value:8.09E-36 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.11|P-value:4.84E-9 ID:SGTC_1797|Compound:st048695|FD-Score:4.00|P-value:8.81E-5 ID:SGTC_1801|Compound:st050089|FD-Score:6.76|P-value:1.11E-10 ID:SGTC_1803|Compound:st050068|FD-Score:4.72|P-value:4.76E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.74|P-value:3.53E-8 ID:SGTC_1991|Compound:st073000|FD-Score:4.79|P-value:3.48E-6 ID:SGTC_2006|Compound:4011487|FD-Score:3.57|P-value:4.08E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.22|P-value:4.75E-7 ID:SGTC_2089|Compound:5281248|FD-Score:3.66|P-value:2.95E-4 ID:SGTC_2185|Compound:6113692|FD-Score:5.12|P-value:7.67E-7 ID:SGTC_2213|Compound:7173844|FD-Score:3.63|P-value:3.33E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.64|P-value:3.22E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.54|P-value:1.02E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.58|P-value:3.92E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:5.68|P-value:4.72E-8 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.77|P-value:1.88E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.58|P-value:3.72E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.09|P-value:5.81E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.13|P-value:7.36E-7 ID:SGTC_2699|Compound:st077704|FD-Score:7.31|P-value:3.33E-12 ID:SGTC_2730|Compound:imipramine|FD-Score:4.00|P-value:8.88E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.22|P-value:3.80E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.47|P-value:5.76E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.57|P-value:3.83E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.43|P-value:6.55E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.54|P-value:4.46E-4 ID:SGTC_2951|Compound:9072950|FD-Score:7.18|P-value:7.70E-12 ID:SGTC_2989|Compound:9073649|FD-Score:7.02|P-value:2.19E-11 ID:SGTC_2999|Compound:9069765|FD-Score:4.00|P-value:8.86E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.30|P-value:2.77E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.75|P-value:2.21E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.92|P-value:1.19E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.33|P-value:8.51E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.90|P-value:1.24E-4

Top fitness defect scores for YCR077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 13.20 66.3 µM 8.09E-36 NEO1 9 2.79E-40
2 SGTC_241 5hr heat shock (37°C) + cantharidin 9.48 155.4 µM 2.55E-19 cell wall signaling 13 1.24E-21
3 SGTC_146 3448-8650 8.57 53.1 µM 4.04E-16 NEO1-PIK1 23 5.10E-18
4 SGTC_1529 apigenin 8.28 74.0 µM 3.66E-15 2 6.14E-17
5 SGTC_243 5hr heat shock (37°C) + splitomicin 7.68 1.0 µM 2.70E-13 heat shock/prefoldin 8 7.90E-15
6 SGTC_2699 st077704 7.31 54.6 µM 3.33E-12 endomembrane recycling 15 1.35E-13
7 SGTC_951 1171-0579 7.19 82.7 µM 7.35E-12 cell wall 20 3.30E-13
8 SGTC_2951 9072950 7.18 58.1 µM 7.70E-12 ERG2 3 3.48E-13
9 SGTC_2989 9073649 7.02 71.4 µM 2.19E-11 5 1.13E-12
10 SGTC_826 1683-5028 6.84 118.0 µM 6.43E-11 4 3.82E-12
11 SGTC_1801 st050089 6.76 28.4 µM 1.11E-10 NEO1-PIK1 39 7.10E-12
12 SGTC_1130 3454-2858 6.69 15.9 µM 1.66E-10 NEO1 31 1.11E-11
13 SGTC_301 4119-0100 6.30 24.5 µM 1.69E-9 NEO1 35 1.53E-10
14 SGTC_221 trifluoperazine 6.22 10.3 µM 2.63E-9 NEO1-PIK1 117 2.52E-10
15 SGTC_1750 st081859 6.19 2.4 µM 3.02E-9 endomembrane recycling 103 2.95E-10
16 SGTC_1785 bathophenanthroline 6.11 24.0 µM 4.84E-9 heme requiring 8 5.02E-10
17 SGTC_1054 3429-0080 5.79 167.0 µM 2.77E-8 7 3.59E-9
18 SGTC_1873 rapamycin 5.74 2.0 nM 3.53E-8 37 4.73E-9
19 SGTC_2557 derrustone 5.68 83.8 µM 4.72E-8 8 6.56E-9
20 SGTC_1060 3448-7350 5.68 82.0 µM 4.76E-8 Golgi 16 6.62E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.404 3.01E-131 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.357 2.57E-101 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.356 1.62E-100 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.354 1.18E-99 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.344 4.54E-94 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.327 2.26E-84 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.316 2.03E-78 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.306 1.12E-73 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.298 2.39E-69 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.298 1.52E-69 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.296 9.67E-69 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.284 2.06E-63 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.282 2.89E-62 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.278 1.27E-60 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.277 7.40E-60 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit