YCR079W / PTC6

Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR079W / PTC6

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.26|P-value:9.91E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.15|P-value:5.76E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:3.59|P-value:3.57E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.70|P-value:2.11E-24 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.56|P-value:3.96E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.64|P-value:5.93E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.54|P-value:9.08E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.86|P-value:1.27E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.21|P-value:3.54E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.33|P-value:8.43E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.54|P-value:4.20E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.71|P-value:4.52E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.94|P-value:1.05E-8 ID:SGTC_644|Compound:1498-1197|FD-Score:3.58|P-value:3.74E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.33|P-value:8.42E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.70|P-value:4.54E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.43|P-value:1.46E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.46|P-value:5.61E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:4.03|P-value:7.22E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.93|P-value:1.05E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.65|P-value:5.73E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.08|P-value:6.00E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.62|P-value:3.27E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.73|P-value:2.21E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.69|P-value:2.52E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.28|P-value:9.99E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.98|P-value:8.80E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.76|P-value:1.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.40|P-value:1.67E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.92|P-value:1.08E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.85|P-value:2.42E-6 ID:SGTC_1990|Compound:st072050|FD-Score:3.43|P-value:6.04E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.60|P-value:7.06E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.36|P-value:7.65E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.47|P-value:5.01E-4 ID:SGTC_2059|Compound:5238311|FD-Score:5.28|P-value:3.18E-7 ID:SGTC_2082|Compound:5219693|FD-Score:3.39|P-value:7.06E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.35|P-value:2.04E-5 ID:SGTC_2162|Compound:5663267|FD-Score:4.83|P-value:2.57E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.89|P-value:1.21E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.30|P-value:1.34E-9 ID:SGTC_2340|Compound:7987427|FD-Score:-5.40|P-value:1.53E-7 ID:SGTC_2345|Compound:9052315|FD-Score:-4.24|P-value:2.96E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.71|P-value:2.20E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-3.42|P-value:5.92E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.66|P-value:2.84E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.38|P-value:7.27E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.58|P-value:3.71E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.70|P-value:2.46E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.52|P-value:4.51E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.90|P-value:1.73E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.36|P-value:1.95E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.81|P-value:1.67E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.96|P-value:9.51E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.33|P-value:8.60E-4 ID:SGTC_3225|Compound:9130819|FD-Score:6.39|P-value:7.98E-10 ID:SGTC_3255|Compound:9139072|FD-Score:3.38|P-value:7.22E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.95|P-value:9.70E-5 ID:SGTC_3265|Compound:9137266|FD-Score:-4.44|P-value:1.30E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-3.26|P-value:9.91E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.15|P-value:5.76E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:3.59|P-value:3.57E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.70|P-value:2.11E-24 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.56|P-value:3.96E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.64|P-value:5.93E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.54|P-value:9.08E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.86|P-value:1.27E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.21|P-value:3.54E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.33|P-value:8.43E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.54|P-value:4.20E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.71|P-value:4.52E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.94|P-value:1.05E-8 ID:SGTC_644|Compound:1498-1197|FD-Score:3.58|P-value:3.74E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.33|P-value:8.42E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.70|P-value:4.54E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.43|P-value:1.46E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.46|P-value:5.61E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:4.03|P-value:7.22E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.93|P-value:1.05E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.65|P-value:5.73E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.08|P-value:6.00E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.62|P-value:3.27E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.73|P-value:2.21E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.69|P-value:2.52E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.28|P-value:9.99E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.98|P-value:8.80E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.76|P-value:1.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.40|P-value:1.67E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.92|P-value:1.08E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.85|P-value:2.42E-6 ID:SGTC_1990|Compound:st072050|FD-Score:3.43|P-value:6.04E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.60|P-value:7.06E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.36|P-value:7.65E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.47|P-value:5.01E-4 ID:SGTC_2059|Compound:5238311|FD-Score:5.28|P-value:3.18E-7 ID:SGTC_2082|Compound:5219693|FD-Score:3.39|P-value:7.06E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.35|P-value:2.04E-5 ID:SGTC_2162|Compound:5663267|FD-Score:4.83|P-value:2.57E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.89|P-value:1.21E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.30|P-value:1.34E-9 ID:SGTC_2340|Compound:7987427|FD-Score:-5.40|P-value:1.53E-7 ID:SGTC_2345|Compound:9052315|FD-Score:-4.24|P-value:2.96E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.71|P-value:2.20E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-3.42|P-value:5.92E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.66|P-value:2.84E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.38|P-value:7.27E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.58|P-value:3.71E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.70|P-value:2.46E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.52|P-value:4.51E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.90|P-value:1.73E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.36|P-value:1.95E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.81|P-value:1.67E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.96|P-value:9.51E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.33|P-value:8.60E-4 ID:SGTC_3225|Compound:9130819|FD-Score:6.39|P-value:7.98E-10 ID:SGTC_3255|Compound:9139072|FD-Score:3.38|P-value:7.22E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.95|P-value:9.70E-5 ID:SGTC_3265|Compound:9137266|FD-Score:-4.44|P-value:1.30E-5

Top fitness defect scores for YCR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 10.70 10.3 µM 2.11E-24 NEO1-PIK1 51 4.07E-27
2 SGTC_3225 9130819 6.39 49.5 µM 7.98E-10 amide catabolism 6 8.15E-11
3 SGTC_2322 7413319 6.30 38.2 µM 1.34E-9 ERAD & cell cycle 58 1.45E-10
4 SGTC_568 1193-0097 5.94 7.5 µM 1.05E-8 ERAD & cell cycle 60 1.45E-9
5 SGTC_2059 5238311 5.28 157.0 µM 3.18E-7 4 6.55E-8
6 SGTC_58 0957-0393 5.15 9.0 µM 5.76E-7 cell wall 267 1.27E-7
7 SGTC_1910 st062352 4.85 60.4 µM 2.42E-6 13 6.32E-7
8 SGTC_2162 5663267 4.83 200.0 µM 2.57E-6 4 6.74E-7
9 SGTC_545 4218-0007 4.71 221.0 µM 4.52E-6 13 1.27E-6
10 SGTC_786 4544-0069 4.70 423.0 µM 4.54E-6 15 1.27E-6
11 SGTC_985 1493-0307 4.65 8.7 µM 5.73E-6 TSC3-RPN4 15 1.65E-6
12 SGTC_319 1348-1596 4.64 45.5 µM 5.93E-6 RSC & ERG11 10 1.71E-6
13 SGTC_2006 4011487 4.60 200.0 µM 7.06E-6 endomembrane recycling 64 2.08E-6
14 SGTC_449 xestospongin c 4.54 11.2 µM 9.08E-6 NEO1-PIK1 44 2.76E-6
15 SGTC_831 k061-1017 4.43 217.0 µM 1.46E-5 translation 39 4.70E-6
16 SGTC_1803 st050068 4.40 52.4 µM 1.67E-5 NEO1-PIK1 147 5.45E-6
17 SGTC_2842 9000675 4.36 19.5 µM 1.95E-5 16 6.47E-6
18 SGTC_2131 toluylene red 4.35 5.3 µM 2.04E-5 60S ribosome export 15 6.80E-6
19 SGTC_457 grayanotoxin iii 4.21 135.0 µM 3.54E-5 54 1.26E-5
20 SGTC_1161 k007-0610 4.08 110.0 µM 6.00E-5 ERAD & cell cycle 114 2.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 6.96E-40 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.196 2.57E-30 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.193 2.42E-29 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.192 3.69E-29 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.192 4.30E-29 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.190 1.27E-28 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.188 3.58E-28 YCL001W-A_p YCL001W-A_p hom Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.188 5.09E-28 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.186 1.47E-27 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.182 1.64E-26 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.178 1.95E-25 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.176 9.55E-25 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.175 2.16E-24 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.171 1.88E-23 YCR049C_d YCR049C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.168 1.08E-22 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response