HIPHOP chemogenomics database

YCR079W / PTC6

Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase

Zygosity: Homozygous strain

fixedexpanded
Profile for YCR079W / PTC6

Click on Significant Values for Screen Details

Top fitness defect scores for YCR079W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_221	trifluoperazine	10.70	10.3 µM	2.11E-24	NEO1-PIK1	51	4.07E-27
2	SGTC_3225	9130819	6.39	49.5 µM	7.98E-10	amide catabolism	6	8.15E-11
3	SGTC_2322	7413319	6.30	38.2 µM	1.34E-9	ERAD & cell cycle	58	1.45E-10
4	SGTC_568	1193-0097	5.94	7.5 µM	1.05E-8	ERAD & cell cycle	60	1.45E-9
5	SGTC_2059	5238311	5.28	157.0 µM	3.18E-7		4	6.55E-8
6	SGTC_58	0957-0393	5.15	9.0 µM	5.76E-7	cell wall	267	1.27E-7
7	SGTC_1910	st062352	4.85	60.4 µM	2.42E-6		13	6.32E-7
8	SGTC_2162	5663267	4.83	200.0 µM	2.57E-6		4	6.74E-7
9	SGTC_545	4218-0007	4.71	221.0 µM	4.52E-6		13	1.27E-6
10	SGTC_786	4544-0069	4.70	423.0 µM	4.54E-6		15	1.27E-6
11	SGTC_985	1493-0307	4.65	8.7 µM	5.73E-6	TSC3-RPN4	15	1.65E-6
12	SGTC_319	1348-1596	4.64	45.5 µM	5.93E-6	RSC & ERG11	10	1.71E-6
13	SGTC_2006	4011487	4.60	200.0 µM	7.06E-6	endomembrane recycling	64	2.08E-6
14	SGTC_449	xestospongin c	4.54	11.2 µM	9.08E-6	NEO1-PIK1	44	2.76E-6
15	SGTC_831	k061-1017	4.43	217.0 µM	1.46E-5	translation	39	4.70E-6
16	SGTC_1803	st050068	4.40	52.4 µM	1.67E-5	NEO1-PIK1	147	5.45E-6
17	SGTC_2842	9000675	4.36	19.5 µM	1.95E-5		16	6.47E-6
18	SGTC_2131	toluylene red	4.35	5.3 µM	2.04E-5	60S ribosome export	15	6.80E-6
19	SGTC_457	grayanotoxin iii	4.21	135.0 µM	3.54E-5		54	1.26E-5
20	SGTC_1161	k007-0610	4.08	110.0 µM	6.00E-5	ERAD & cell cycle	114	2.27E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.226	6.96E-40	YOL144W	NOP8	het	Nucleolar protein required for 60S ribosomal subunit biogenesis
0.196	2.57E-30	YNL077W	APJ1	hom	Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.193	2.42E-29	YNL295W_p	YNL295W_p	hom	Putative protein of unknown function
0.192	3.69E-29	YBR245C	ISW1	hom	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.192	4.30E-29	YOR115C	TRS33	hom	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.190	1.27E-28	YGR202C	PCT1	hom	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.188	3.58E-28	YCL001W-A_p	YCL001W-A_p	hom	Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.188	5.09E-28	YGL077C	HNM1	hom	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.186	1.47E-27	YDL025C	RTK1	hom	Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.182	1.64E-26	YJL154C	VPS35	hom	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.178	1.95E-25	YNL115C_p	YNL115C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.176	9.55E-25	YBR246W	RRT2	hom	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.175	2.16E-24	YOR357C	SNX3	hom	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.171	1.88E-23	YCR049C_d	YCR049C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.168	1.08E-22	YGR166W	TRS65	hom	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response