YCR082W / AHC2

Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR082W / AHC2

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.19|P-value:1.16E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.41|P-value:4.13E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.96|P-value:3.21E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.93|P-value:1.67E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.12|P-value:8.69E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.56|P-value:7.64E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.71|P-value:8.87E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.14|P-value:8.15E-5 ID:SGTC_229|Compound:benomyl|FD-Score:4.08|P-value:9.95E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:5.24|P-value:9.39E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.38|P-value:9.94E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.37|P-value:5.13E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.58|P-value:7.21E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.66|P-value:4.16E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.15|P-value:7.77E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:6.19|P-value:9.42E-9 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.90|P-value:1.84E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.95|P-value:1.42E-10 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.84|P-value:2.27E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.40|P-value:9.35E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-4.02|P-value:1.67E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.87|P-value:2.08E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.83|P-value:2.41E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.69|P-value:3.82E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:5.13|P-value:1.50E-6 ID:SGTC_1675|Compound:st018485|FD-Score:5.83|P-value:5.69E-8 ID:SGTC_1732|Compound:st034308|FD-Score:3.45|P-value:8.17E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.55|P-value:6.01E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.79|P-value:2.70E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.42|P-value:4.04E-7 ID:SGTC_1804|Compound:st050076|FD-Score:-3.76|P-value:4.03E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.39|P-value:9.72E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.54|P-value:1.75E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-3.58|P-value:7.18E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.21|P-value:6.16E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.84|P-value:3.09E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.12|P-value:1.62E-6 ID:SGTC_2452|Compound:5863136|FD-Score:7.19|P-value:3.31E-11 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.58|P-value:5.47E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.80|P-value:3.56E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.07|P-value:1.01E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.69|P-value:3.75E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.87|P-value:2.10E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.72|P-value:4.56E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.86|P-value:2.12E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.19|P-value:1.16E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.41|P-value:4.13E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.96|P-value:3.21E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.93|P-value:1.67E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.12|P-value:8.69E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.56|P-value:7.64E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.71|P-value:8.87E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.14|P-value:8.15E-5 ID:SGTC_229|Compound:benomyl|FD-Score:4.08|P-value:9.95E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:5.24|P-value:9.39E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.38|P-value:9.94E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.37|P-value:5.13E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.58|P-value:7.21E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.66|P-value:4.16E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.15|P-value:7.77E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:6.19|P-value:9.42E-9 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.90|P-value:1.84E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.95|P-value:1.42E-10 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.84|P-value:2.27E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.40|P-value:9.35E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-4.02|P-value:1.67E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.87|P-value:2.08E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.83|P-value:2.41E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.69|P-value:3.82E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:5.13|P-value:1.50E-6 ID:SGTC_1675|Compound:st018485|FD-Score:5.83|P-value:5.69E-8 ID:SGTC_1732|Compound:st034308|FD-Score:3.45|P-value:8.17E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.55|P-value:6.01E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.79|P-value:2.70E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.42|P-value:4.04E-7 ID:SGTC_1804|Compound:st050076|FD-Score:-3.76|P-value:4.03E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.39|P-value:9.72E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.54|P-value:1.75E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-3.58|P-value:7.18E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.21|P-value:6.16E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.84|P-value:3.09E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.12|P-value:1.62E-6 ID:SGTC_2452|Compound:5863136|FD-Score:7.19|P-value:3.31E-11 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.58|P-value:5.47E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.80|P-value:3.56E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.07|P-value:1.01E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.69|P-value:3.75E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.87|P-value:2.10E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.72|P-value:4.56E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.86|P-value:2.12E-4

Top fitness defect scores for YCR082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2452 5863136 7.19 48.4 µM 3.31E-11 2 3.15E-13
2 SGTC_1157 4092-0394 6.95 27.6 µM 1.42E-10 1 1.84E-12
3 SGTC_887 0885-0007 6.19 9.6 µM 9.42E-9 endomembrane recycling 11 3.03E-10
4 SGTC_1675 st018485 5.83 24.5 µM 5.69E-8 60S ribosome export 8 2.69E-9
5 SGTC_1803 st050068 5.42 52.4 µM 4.04E-7 NEO1-PIK1 99 2.90E-8
6 SGTC_527 4476-4215 5.37 268.0 µM 5.13E-7 PDR1 14 3.87E-8
7 SGTC_235 0330-0087 5.24 5.0 mM 9.39E-7 TSC3-RPN4 5 8.06E-8
8 SGTC_35 0133-0054 5.19 64.1 µM 1.16E-6 8 1.04E-7
9 SGTC_1497 4476-2978 5.13 41.3 µM 1.50E-6 2 1.42E-7
10 SGTC_2400 5203494 5.12 178.7 µM 1.62E-6 RSC complex & mRNA processing 10 1.56E-7
11 SGTC_115 0527-0192 4.96 112.0 µM 3.21E-6 34 3.57E-7
12 SGTC_184 1494-0393 4.71 24.7 µM 8.87E-6 39 1.22E-6
13 SGTC_2082 5219693 4.54 150.0 µM 1.75E-5 RNA processing & uracil transport 15 2.76E-6
14 SGTC_2286 7945697 4.21 125.0 µM 6.16E-5 46 1.27E-5
15 SGTC_793 0488-0545 4.15 106.0 µM 7.77E-5 11 1.68E-5
16 SGTC_217 ketoconazole 4.14 989.0 nM 8.15E-5 ergosterol depletion effects on membrane 18 1.77E-5
17 SGTC_126 0417-1624 4.12 672.5 µM 8.69E-5 DNA intercalators 26 1.92E-5
18 SGTC_229 benomyl 4.08 22.9 µM 9.95E-5 tubulin folding & SWR complex 28 2.25E-5
19 SGTC_3027 9089541 4.07 49.5 µM 1.01E-4 fatty acid desaturase (OLE1) 21 2.30E-5
20 SGTC_166 k072-0058 4.07 166.4 µM 1.03E-4 DNA intercalators 30 2.34E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.09E-10 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.108 3.11E-10 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.100 7.13E-9 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.099 9.20E-9 YHL009C YAP3 hom Basic leucine zipper (bZIP) transcription factor
0.096 2.28E-8 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.093 6.05E-8 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.091 1.41E-7 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.090 1.62E-7 YBL008W HIR1 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
0.090 2.01E-7 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.087 4.11E-7 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.087 4.62E-7 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.084 1.04E-6 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.083 1.44E-6 YBL083C_d YBL083C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
0.082 2.02E-6 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.082 2.21E-6 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation