YCR083W / TRX3

Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR083W / TRX3

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.13|P-value:2.04E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.32|P-value:8.92E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.48|P-value:2.59E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.52|P-value:3.83E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.31|P-value:4.76E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.92|P-value:8.68E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.55|P-value:3.43E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.86|P-value:1.08E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-4.14|P-value:3.60E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.54|P-value:3.55E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.39|P-value:5.92E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.82|P-value:1.27E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.32|P-value:4.59E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.34|P-value:7.09E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.91|P-value:8.81E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.18|P-value:7.45E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.73|P-value:1.79E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-4.05|P-value:5.14E-5 ID:SGTC_2388|Compound:9080168|FD-Score:-3.45|P-value:4.80E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.31|P-value:7.77E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.20|P-value:6.85E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.62|P-value:1.55E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.33|P-value:4.42E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.82|P-value:7.26E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.22|P-value:6.55E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.76|P-value:9.12E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.51|P-value:3.98E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.19|P-value:7.29E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.13|P-value:2.04E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.32|P-value:8.92E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.48|P-value:2.59E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.52|P-value:3.83E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.31|P-value:4.76E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.92|P-value:8.68E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.55|P-value:3.43E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.86|P-value:1.08E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-4.14|P-value:3.60E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.54|P-value:3.55E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.39|P-value:5.92E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.82|P-value:1.27E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.32|P-value:4.59E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.34|P-value:7.09E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.91|P-value:8.81E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.18|P-value:7.45E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.73|P-value:1.79E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-4.05|P-value:5.14E-5 ID:SGTC_2388|Compound:9080168|FD-Score:-3.45|P-value:4.80E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.31|P-value:7.77E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.20|P-value:6.85E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.62|P-value:1.55E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.33|P-value:4.42E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.82|P-value:7.26E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.22|P-value:6.55E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.76|P-value:9.12E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.51|P-value:3.98E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.19|P-value:7.29E-4

Top fitness defect scores for YCR083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_234 nsc-17383 4.32 10.7 µM 8.92E-6 ERG2 17 7.79E-6
2 SGTC_67 0335-0847 4.13 266.0 µM 2.04E-5 ubiquinone biosynthesis & proteasome 107 1.83E-5
3 SGTC_2505 galangin 3.82 7.9 µM 7.26E-5 RPP1 & pyrimidine depletion 8 6.74E-5
4 SGTC_2730 imipramine 3.76 71.3 µM 9.12E-5 34 8.53E-5
5 SGTC_2463 5473429 3.62 200.0 µM 1.55E-4 ERG2 24 1.47E-4
6 SGTC_943 3253-1379 3.57 105.0 µM 1.90E-4 36 1.81E-4
7 SGTC_1630 st005209 3.50 31.3 µM 2.42E-4 40 2.33E-4
8 SGTC_235 0330-0087 3.48 5.0 mM 2.59E-4 TSC3-RPN4 41 2.49E-4
9 SGTC_2469 5655019 3.33 90.8 µM 4.42E-4 38 4.32E-4
10 SGTC_1610 st001799 3.32 48.1 µM 4.59E-4 30 4.48E-4
11 SGTC_436 n,n-dimethylsphingosine 3.31 3.3 µM 4.76E-4 50 4.65E-4
12 SGTC_142 0335-0849 3.27 62.7 µM 5.42E-4 ubiquinone biosynthesis & proteasome 179 5.32E-4
13 SGTC_2513 baicalein 3.22 25.6 µM 6.55E-4 calcium & mitochondrial duress 51 6.45E-4
14 SGTC_2443 5493264 3.20 126.7 µM 6.85E-4 42 6.75E-4
15 SGTC_2949 9072542 3.19 2.2 µM 7.29E-4 TSC3-RPN4 77 7.21E-4
16 SGTC_1705 st027868 3.18 56.3 µM 7.45E-4 33 7.36E-4
17 SGTC_576 1073-0113 3.06 22.7 µM 0.00113 redox potentiating 134 0.00112
18 SGTC_967 1306-0166 3.05 352.0 µM 0.00114 81 0.00114
19 SGTC_1015 4130-4525 3.04 82.0 µM 0.00120 60S ribosome export 63 0.00120
20 SGTC_1285 0929-0069 3.00 65.5 µM 0.00133 59 0.00134

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.80E-16 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.132 1.91E-14 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.106 7.16E-10 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.104 1.33E-9 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.103 2.46E-9 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.103 2.49E-9 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.102 2.95E-9 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.102 3.08E-9 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.098 1.48E-8 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.096 2.41E-8 YOR143C THI80 het Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
0.096 2.47E-8 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.08E-8 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.095 3.27E-8 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.094 5.21E-8 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.093 7.29E-8 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect