YCR085W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR085W / YCR085W

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:-3.56|P-value:2.05E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:4.74|P-value:9.78E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:13.00|P-value:3.44E-39 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.43|P-value:5.57E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.40|P-value:3.76E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.29|P-value:4.63E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:4.46|P-value:3.67E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.27|P-value:5.99E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:3.76|P-value:7.89E-5 ID:SGTC_489|Compound:paxilline|FD-Score:4.64|P-value:1.63E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:4.49|P-value:3.31E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.82|P-value:6.24E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.71|P-value:1.11E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:4.53|P-value:2.76E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:4.82|P-value:6.44E-7 ID:SGTC_937|Compound:3122-0005|FD-Score:3.14|P-value:7.79E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.48|P-value:2.34E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.22|P-value:3.09E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.94|P-value:4.63E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.68|P-value:1.28E-6 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.61|P-value:1.82E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.29|P-value:4.66E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.15|P-value:7.65E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:-4.53|P-value:3.41E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.35|P-value:3.76E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.54|P-value:2.55E-6 ID:SGTC_1754|Compound:st042065|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.08|P-value:2.04E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.39|P-value:5.07E-6 ID:SGTC_1804|Compound:st050076|FD-Score:4.25|P-value:9.73E-6 ID:SGTC_1851|Compound:st056236|FD-Score:4.25|P-value:9.67E-6 ID:SGTC_1860|Compound:st056228|FD-Score:-3.76|P-value:9.49E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.29|P-value:4.69E-4 ID:SGTC_2069|Compound:5228469|FD-Score:5.74|P-value:4.22E-9 ID:SGTC_2096|Compound:5468907|FD-Score:3.93|P-value:3.88E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.04|P-value:2.50E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.85|P-value:5.55E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.69|P-value:1.25E-6 ID:SGTC_2241|Compound:6772625|FD-Score:3.81|P-value:6.34E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.22|P-value:7.23E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.19|P-value:6.52E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.11|P-value:1.80E-5 ID:SGTC_2330|Compound:7979373|FD-Score:4.26|P-value:9.50E-6 ID:SGTC_2337|Compound:9009472|FD-Score:-4.37|P-value:7.28E-6 ID:SGTC_2339|Compound:9000433|FD-Score:3.74|P-value:8.50E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.74|P-value:8.54E-5 ID:SGTC_2439|Compound:5492030|FD-Score:3.80|P-value:6.71E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.95|P-value:3.64E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.54|P-value:2.26E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.38|P-value:5.36E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.68|P-value:1.29E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.73|P-value:4.96E-15 ID:SGTC_2744|Compound:captopril|FD-Score:3.80|P-value:6.75E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.10|P-value:1.91E-5 ID:SGTC_2943|Compound:9068529|FD-Score:3.46|P-value:2.48E-4 ID:SGTC_2986|Compound:9022445|FD-Score:4.45|P-value:3.99E-6 ID:SGTC_3029|Compound:9088683|FD-Score:3.30|P-value:4.47E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.27|P-value:5.94E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.08|P-value:9.79E-4 ID:SGTC_3339|Compound:9145883|FD-Score:4.26|P-value:9.52E-6 ID:SGTC_3345|Compound:9148410|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.56|P-value:2.05E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:4.74|P-value:9.78E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:13.00|P-value:3.44E-39 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.43|P-value:5.57E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.40|P-value:3.76E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.29|P-value:4.63E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:4.46|P-value:3.67E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.27|P-value:5.99E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:3.76|P-value:7.89E-5 ID:SGTC_489|Compound:paxilline|FD-Score:4.64|P-value:1.63E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:4.49|P-value:3.31E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.82|P-value:6.24E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.71|P-value:1.11E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:4.53|P-value:2.76E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:4.82|P-value:6.44E-7 ID:SGTC_937|Compound:3122-0005|FD-Score:3.14|P-value:7.79E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.48|P-value:2.34E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.22|P-value:3.09E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.94|P-value:4.63E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.68|P-value:1.28E-6 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.61|P-value:1.82E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.29|P-value:4.66E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.15|P-value:7.65E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:-4.53|P-value:3.41E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.35|P-value:3.76E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.54|P-value:2.55E-6 ID:SGTC_1754|Compound:st042065|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.08|P-value:2.04E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.39|P-value:5.07E-6 ID:SGTC_1804|Compound:st050076|FD-Score:4.25|P-value:9.73E-6 ID:SGTC_1851|Compound:st056236|FD-Score:4.25|P-value:9.67E-6 ID:SGTC_1860|Compound:st056228|FD-Score:-3.76|P-value:9.49E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.29|P-value:4.69E-4 ID:SGTC_2069|Compound:5228469|FD-Score:5.74|P-value:4.22E-9 ID:SGTC_2096|Compound:5468907|FD-Score:3.93|P-value:3.88E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.04|P-value:2.50E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.85|P-value:5.55E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.69|P-value:1.25E-6 ID:SGTC_2241|Compound:6772625|FD-Score:3.81|P-value:6.34E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.22|P-value:7.23E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.19|P-value:6.52E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.11|P-value:1.80E-5 ID:SGTC_2330|Compound:7979373|FD-Score:4.26|P-value:9.50E-6 ID:SGTC_2337|Compound:9009472|FD-Score:-4.37|P-value:7.28E-6 ID:SGTC_2339|Compound:9000433|FD-Score:3.74|P-value:8.50E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.74|P-value:8.54E-5 ID:SGTC_2439|Compound:5492030|FD-Score:3.80|P-value:6.71E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.95|P-value:3.64E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.54|P-value:2.26E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.38|P-value:5.36E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.68|P-value:1.29E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.73|P-value:4.96E-15 ID:SGTC_2744|Compound:captopril|FD-Score:3.80|P-value:6.75E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.10|P-value:1.91E-5 ID:SGTC_2943|Compound:9068529|FD-Score:3.46|P-value:2.48E-4 ID:SGTC_2986|Compound:9022445|FD-Score:4.45|P-value:3.99E-6 ID:SGTC_3029|Compound:9088683|FD-Score:3.30|P-value:4.47E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.27|P-value:5.94E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.08|P-value:9.79E-4 ID:SGTC_3339|Compound:9145883|FD-Score:4.26|P-value:9.52E-6 ID:SGTC_3345|Compound:9148410|FD-Score:3.66|P-value:1.15E-4

Top fitness defect scores for YCR085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 13.00 9.0 µM 3.44E-39 cell wall 39 3.73E-39
2 SGTC_2688 kanamycin b 7.73 96.7 µM 4.96E-15 calcium & mitochondrial duress 78 5.54E-15
3 SGTC_2069 5228469 5.74 200.0 µM 4.22E-9 2 4.67E-9
4 SGTC_930 2810-3379 4.82 265.0 µM 6.44E-7 3 7.07E-7
5 SGTC_55 0767-0285 4.74 6.6 µM 9.78E-7 31 1.07E-6
6 SGTC_840 0245-0196 4.71 390.0 µM 1.11E-6 5 1.22E-6
7 SGTC_2194 5927483 4.69 104.5 µM 1.25E-6 11 1.37E-6
8 SGTC_1129 3453-1384 4.68 223.0 µM 1.28E-6 22 1.40E-6
9 SGTC_2687 chenodiol 4.68 100.0 µM 1.29E-6 11 1.41E-6
10 SGTC_489 paxilline 4.64 115.0 µM 1.63E-6 PDR1 6 1.78E-6
11 SGTC_1194 1488-0194 4.61 225.0 µM 1.82E-6 19 2.00E-6
12 SGTC_1715 st032160 4.54 10.2 µM 2.55E-6 30 2.79E-6
13 SGTC_851 0394-0702 4.53 453.0 µM 2.76E-6 mitochondrial processes 3 3.02E-6
14 SGTC_567 1080-0542 4.49 68.4 µM 3.31E-6 7 3.62E-6
15 SGTC_348 k064-0012 4.46 10.7 µM 3.67E-6 60S ribosome export 9 4.02E-6
16 SGTC_2986 9022445 4.45 71.4 µM 3.99E-6 9 4.36E-6
17 SGTC_1760 st045453 4.39 10.4 µM 5.07E-6 NEO1-PIK1 128 5.54E-6
18 SGTC_2627 acetyl isogambogic acid 4.38 100.0 µM 5.36E-6 TSC3-RPN4 33 5.86E-6
19 SGTC_2330 7979373 4.26 200.0 µM 9.50E-6 60S ribosome export 26 1.04E-5
20 SGTC_3339 9145883 4.26 14.9 µM 9.52E-6 9 1.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.273 1.31E-58 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.261 2.55E-53 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.234 6.90E-43 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.221 2.77E-38 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.212 2.48E-35 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.206 1.41E-33 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.205 3.29E-33 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.203 1.29E-32 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.200 1.54E-31 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.198 4.08E-31 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.196 2.54E-30 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.194 7.92E-30 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.193 2.21E-29 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.189 1.83E-28 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.186 1.34E-27 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids