YCR086W / CSM1

Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR086W / CSM1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.99|P-value:3.38E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:7.37|P-value:2.14E-11 ID:SGTC_273|Compound:hydroxyurea|FD-Score:7.78|P-value:1.76E-12 ID:SGTC_328|Compound:k915-0120|FD-Score:4.13|P-value:9.05E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.12|P-value:9.35E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:4.64|P-value:1.35E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.12|P-value:2.28E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.98|P-value:3.53E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.57|P-value:5.68E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.50|P-value:7.06E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.56|P-value:5.80E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.73|P-value:3.39E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.98|P-value:1.50E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.62|P-value:4.82E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.02|P-value:2.90E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:-4.27|P-value:1.38E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.02|P-value:1.32E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.94|P-value:1.70E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.24|P-value:5.96E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:5.17|P-value:1.58E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.31|P-value:2.95E-11 ID:SGTC_1661|Compound:st013063|FD-Score:3.80|P-value:2.77E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.86|P-value:5.76E-6 ID:SGTC_1786|Compound:berberine|FD-Score:5.17|P-value:1.54E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.75|P-value:2.47E-5 ID:SGTC_2045|Compound:5106652|FD-Score:4.53|P-value:2.09E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.08|P-value:1.05E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.78|P-value:2.95E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.94|P-value:4.15E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.04|P-value:1.21E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.48|P-value:6.66E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.59|P-value:5.26E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.33|P-value:4.44E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.74|P-value:3.34E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.56|P-value:5.82E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.79|P-value:7.48E-6 ID:SGTC_2825|Compound:7998094|FD-Score:7.19|P-value:6.06E-11 ID:SGTC_2829|Compound:7992743|FD-Score:4.83|P-value:6.40E-6 ID:SGTC_2836|Compound:9010338|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_2838|Compound:9002687|FD-Score:4.64|P-value:1.37E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.44|P-value:8.45E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.51|P-value:3.49E-7 ID:SGTC_2949|Compound:9072542|FD-Score:4.90|P-value:4.82E-6 ID:SGTC_2952|Compound:9073731|FD-Score:4.49|P-value:2.37E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.72|P-value:3.55E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.80|P-value:6.28E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.18|P-value:1.51E-6 ID:SGTC_3155|Compound:9099265|FD-Score:4.61|P-value:1.55E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.69|P-value:3.90E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.60|P-value:4.28E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-4.28|P-value:1.34E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.99|P-value:3.38E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:7.37|P-value:2.14E-11 ID:SGTC_273|Compound:hydroxyurea|FD-Score:7.78|P-value:1.76E-12 ID:SGTC_328|Compound:k915-0120|FD-Score:4.13|P-value:9.05E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.12|P-value:9.35E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:4.64|P-value:1.35E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.12|P-value:2.28E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.98|P-value:3.53E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.57|P-value:5.68E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.50|P-value:7.06E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.56|P-value:5.80E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.73|P-value:3.39E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.98|P-value:1.50E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.62|P-value:4.82E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.02|P-value:2.90E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:-4.27|P-value:1.38E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.02|P-value:1.32E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.94|P-value:1.70E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.24|P-value:5.96E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:5.17|P-value:1.58E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.31|P-value:2.95E-11 ID:SGTC_1661|Compound:st013063|FD-Score:3.80|P-value:2.77E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.86|P-value:5.76E-6 ID:SGTC_1786|Compound:berberine|FD-Score:5.17|P-value:1.54E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.75|P-value:2.47E-5 ID:SGTC_2045|Compound:5106652|FD-Score:4.53|P-value:2.09E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.08|P-value:1.05E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.78|P-value:2.95E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.94|P-value:4.15E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.04|P-value:1.21E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.48|P-value:6.66E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.59|P-value:5.26E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.33|P-value:4.44E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.74|P-value:3.34E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.56|P-value:5.82E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.79|P-value:7.48E-6 ID:SGTC_2825|Compound:7998094|FD-Score:7.19|P-value:6.06E-11 ID:SGTC_2829|Compound:7992743|FD-Score:4.83|P-value:6.40E-6 ID:SGTC_2836|Compound:9010338|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_2838|Compound:9002687|FD-Score:4.64|P-value:1.37E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.44|P-value:8.45E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.51|P-value:3.49E-7 ID:SGTC_2949|Compound:9072542|FD-Score:4.90|P-value:4.82E-6 ID:SGTC_2952|Compound:9073731|FD-Score:4.49|P-value:2.37E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.72|P-value:3.55E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.80|P-value:6.28E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.18|P-value:1.51E-6 ID:SGTC_3155|Compound:9099265|FD-Score:4.61|P-value:1.55E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.69|P-value:3.90E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.60|P-value:4.28E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-4.28|P-value:1.34E-4

Top fitness defect scores for YCR086W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_273 hydroxyurea 7.78 18.1 mM 1.76E-12 heme biosynthesis & mitochondrial translocase 6 3.67E-15
2 SGTC_71 0417-1750 7.37 47.8 µM 2.14E-11 Golgi 10 8.70E-14
3 SGTC_1599 8-chlro-1-tetrahydronorharmanone 7.31 90.6 µM 2.95E-11 6 1.30E-13
4 SGTC_2825 7998094 7.19 58.4 µM 6.06E-11 fatty acid desaturase (OLE1) 6 3.24E-13
5 SGTC_2890 9046729 5.51 58.4 µM 3.49E-7 Golgi 8 1.78E-8
6 SGTC_3152 9099253 5.18 49.5 µM 1.51E-6 NEO1-PIK1 77 1.12E-7
7 SGTC_1786 berberine 5.17 21.6 µM 1.54E-6 60S ribosome export 14 1.15E-7
8 SGTC_1578 josamycin 5.17 24.2 µM 1.58E-6 5 1.18E-7
9 SGTC_1049 3226-0134 5.02 66.0 µM 2.90E-6 8 2.53E-7
10 SGTC_58 0957-0393 4.99 9.0 µM 3.38E-6 cell wall 284 3.07E-7
11 SGTC_2311 7694451 4.94 200.0 µM 4.15E-6 7 3.95E-7
12 SGTC_2949 9072542 4.90 2.2 µM 4.82E-6 TSC3-RPN4 16 4.77E-7
13 SGTC_1784 st039334 4.86 36.3 µM 5.76E-6 7 5.97E-7
14 SGTC_2829 7992743 4.83 58.4 µM 6.40E-6 19 6.80E-7
15 SGTC_2824 7998404 4.79 52.0 µM 7.48E-6 17 8.27E-7
16 SGTC_554 4483-2211 4.64 187.0 µM 1.35E-5 9 1.72E-6
17 SGTC_2838 9002687 4.64 71.4 µM 1.37E-5 fatty acid desaturase (OLE1) 12 1.76E-6
18 SGTC_2836 9010338 4.64 19.5 µM 1.38E-5 RPP1 & pyrimidine depletion 15 1.77E-6
19 SGTC_3155 9099265 4.61 49.5 µM 1.55E-5 14 2.05E-6
20 SGTC_2045 5106652 4.53 78.0 µM 2.09E-5 6 2.98E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 8.23E-24 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.126 2.30E-13 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.103 2.11E-9 YPR193C HPA2 hom Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.102 3.10E-9 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.097 1.58E-8 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.094 5.13E-8 YBR296C PHO89 hom Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification
0.093 5.89E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.093 5.92E-8 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.090 1.57E-7 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.088 3.06E-7 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.087 3.98E-7 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.086 6.10E-7 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.084 1.22E-6 YGR282C BGL2 hom Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
0.082 2.08E-6 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.081 2.43E-6 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication