YCR087C-A_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR087C-A / YCR087C-A

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.61|P-value:2.73E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.77|P-value:1.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.15|P-value:2.77E-15 ID:SGTC_115|Compound:0527-0192|FD-Score:3.42|P-value:5.43E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.90|P-value:1.93E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.64|P-value:2.47E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:7.50|P-value:3.28E-13 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.34|P-value:6.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.78|P-value:1.49E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.57|P-value:3.16E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.40|P-value:5.76E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.00|P-value:5.87E-5 ID:SGTC_469|Compound:w7|FD-Score:3.38|P-value:6.23E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.61|P-value:2.73E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:6.49|P-value:2.47E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:3.46|P-value:4.65E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.27|P-value:2.21E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.77|P-value:1.52E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.50|P-value:4.12E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.47|P-value:4.58E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.39|P-value:6.02E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.55|P-value:6.71E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:4.55|P-value:6.59E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:3.71|P-value:1.90E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.24|P-value:9.62E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.58|P-value:2.79E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.71|P-value:7.60E-14 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.60|P-value:2.90E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.78|P-value:2.31E-6 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.41|P-value:5.48E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.32|P-value:7.41E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.57|P-value:3.22E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.97|P-value:7.33E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.53|P-value:7.09E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.36|P-value:6.59E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.51|P-value:3.93E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.87|P-value:9.29E-9 ID:SGTC_1827|Compound:berberine|FD-Score:3.25|P-value:9.52E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.39|P-value:1.34E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.40|P-value:7.65E-24 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.12|P-value:4.03E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.77|P-value:1.54E-4 ID:SGTC_2360|Compound:9040895|FD-Score:5.01|P-value:8.11E-7 ID:SGTC_2365|Compound:9042475|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.34|P-value:6.97E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.40|P-value:5.80E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.42|P-value:5.38E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.48|P-value:8.97E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.37|P-value:6.27E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2473|Compound:5854593|FD-Score:4.10|P-value:4.39E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.33|P-value:7.21E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.65|P-value:4.30E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.93|P-value:7.84E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.73|P-value:2.98E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.43|P-value:5.23E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.47|P-value:9.50E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.81|P-value:1.85E-6 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.40|P-value:1.27E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.99|P-value:6.73E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.89|P-value:9.01E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.70|P-value:2.00E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_2853|Compound:9015042|FD-Score:3.88|P-value:1.01E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.28|P-value:7.79E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.25|P-value:2.42E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_2966|Compound:9084041|FD-Score:4.58|P-value:5.86E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.92|P-value:8.94E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-4.00|P-value:5.92E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.57|P-value:3.24E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.86|P-value:1.02E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.61|P-value:2.73E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.77|P-value:1.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.15|P-value:2.77E-15 ID:SGTC_115|Compound:0527-0192|FD-Score:3.42|P-value:5.43E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.90|P-value:1.93E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.64|P-value:2.47E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:7.50|P-value:3.28E-13 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.34|P-value:6.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.78|P-value:1.49E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.57|P-value:3.16E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.40|P-value:5.76E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.00|P-value:5.87E-5 ID:SGTC_469|Compound:w7|FD-Score:3.38|P-value:6.23E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.61|P-value:2.73E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:6.49|P-value:2.47E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:3.46|P-value:4.65E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.27|P-value:2.21E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.77|P-value:1.52E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.50|P-value:4.12E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.47|P-value:4.58E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.39|P-value:6.02E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.55|P-value:6.71E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:4.55|P-value:6.59E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:3.71|P-value:1.90E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.24|P-value:9.62E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.58|P-value:2.79E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.71|P-value:7.60E-14 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.60|P-value:2.90E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.78|P-value:2.31E-6 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.41|P-value:5.48E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.32|P-value:7.41E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.57|P-value:3.22E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.97|P-value:7.33E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.53|P-value:7.09E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.36|P-value:6.59E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.51|P-value:3.93E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.87|P-value:9.29E-9 ID:SGTC_1827|Compound:berberine|FD-Score:3.25|P-value:9.52E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.39|P-value:1.34E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.40|P-value:7.65E-24 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.12|P-value:4.03E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.77|P-value:1.54E-4 ID:SGTC_2360|Compound:9040895|FD-Score:5.01|P-value:8.11E-7 ID:SGTC_2365|Compound:9042475|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.34|P-value:6.97E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.40|P-value:5.80E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.42|P-value:5.38E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.48|P-value:8.97E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.37|P-value:6.27E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2473|Compound:5854593|FD-Score:4.10|P-value:4.39E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.33|P-value:7.21E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.65|P-value:4.30E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.93|P-value:7.84E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.73|P-value:2.98E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.43|P-value:5.23E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.47|P-value:9.50E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.81|P-value:1.85E-6 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.40|P-value:1.27E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.99|P-value:6.73E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.89|P-value:9.01E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.70|P-value:2.00E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_2853|Compound:9015042|FD-Score:3.88|P-value:1.01E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.28|P-value:7.79E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.25|P-value:2.42E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_2966|Compound:9084041|FD-Score:4.58|P-value:5.86E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.92|P-value:8.94E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-4.00|P-value:5.92E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.57|P-value:3.24E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.86|P-value:1.02E-4

Top fitness defect scores for YCR087C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1877 wortmannin 10.40 25.0 µM 7.65E-24 11 9.13E-26
2 SGTC_58 0957-0393 8.15 9.0 µM 2.77E-15 cell wall 116 1.78E-16
3 SGTC_1161 k007-0610 7.71 110.0 µM 7.60E-14 ERAD & cell cycle 26 6.50E-15
4 SGTC_175 3793-3120 7.50 23.7 µM 3.28E-13 2 3.18E-14
5 SGTC_138 0850-0259 6.90 40.9 µM 1.93E-11 cell wall 77 2.65E-12
6 SGTC_530 4358-1714 6.49 28.0 µM 2.47E-10 5 4.21E-11
7 SGTC_1826 st055655 5.87 41.6 µM 9.29E-9 ERG2 15 2.16E-9
8 SGTC_2360 9040895 5.01 200.0 µM 8.11E-7 RPP1 & pyrimidine depletion 9 2.75E-7
9 SGTC_1308 1187-1617 4.78 41.4 µM 2.31E-6 fatty acid desaturase (OLE1) 23 8.58E-7
10 SGTC_2589 lobaric acid 4.73 100.0 µM 2.98E-6 15 1.13E-6
11 SGTC_2556 citropten 4.65 84.6 µM 4.30E-6 16 1.68E-6
12 SGTC_2966 9084041 4.58 48.0 µM 5.86E-6 19 2.35E-6
13 SGTC_974 1326-0144 4.55 138.0 µM 6.59E-6 ERG2 26 2.67E-6
14 SGTC_795 0685-0265 4.55 78.0 µM 6.71E-6 excess fatty acid 13 2.72E-6
15 SGTC_1565 sinapyl alcohol 4.53 95.1 µM 7.09E-6 15 2.89E-6
16 SGTC_2432 5630864 4.48 12.2 µM 8.97E-6 14 3.73E-6
17 SGTC_2615 purpurogallin-4-carboxylic acid 4.47 100.0 µM 9.50E-6 redox potentiating 51 3.97E-6
18 SGTC_2727 riluzole 4.40 51.8 µM 1.27E-5 mitochondrial processes 9 5.46E-6
19 SGTC_1838 st055369 4.39 84.5 µM 1.34E-5 11 5.78E-6
20 SGTC_629 3448-6466 4.27 76.7 µM 2.21E-5 13 9.88E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.11E-35 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.192 4.08E-29 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.180 6.16E-26 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.180 9.31E-26 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.177 4.72E-25 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.174 3.50E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.159 2.00E-20 YBR296C PHO89 hom Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification
0.153 4.20E-19 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.151 1.40E-18 YBR295W PCA1 hom Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function
0.146 1.73E-17 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.145 2.83E-17 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.145 3.37E-17 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.139 7.77E-16 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.138 8.32E-16 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.138 9.23E-16 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene