YCR087W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR087W / YCR087W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:9.81|P-value:3.87E-22 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.36|P-value:3.59E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.53|P-value:3.19E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.13|P-value:3.12E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.79|P-value:1.22E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.62|P-value:2.31E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.01|P-value:5.04E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.87|P-value:9.02E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:5.30|P-value:1.23E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:3.28|P-value:7.83E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.58|P-value:2.71E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.14|P-value:3.04E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.95|P-value:6.39E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.50|P-value:4.36E-8 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.69|P-value:1.54E-8 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.11|P-value:3.38E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.13|P-value:8.14E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.43|P-value:8.54E-6 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:8.64|P-value:1.47E-17 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.51|P-value:6.03E-6 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.40|P-value:5.17E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.43|P-value:4.64E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.73|P-value:2.19E-6 ID:SGTC_1975|Compound:st070967|FD-Score:4.03|P-value:4.75E-5 ID:SGTC_2024|Compound:5144227|FD-Score:4.49|P-value:6.43E-6 ID:SGTC_2066|Compound:5222451|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.53|P-value:3.25E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.74|P-value:2.09E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-4.23|P-value:1.12E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.52|P-value:3.29E-4 ID:SGTC_2294|Compound:7971431|FD-Score:5.17|P-value:2.47E-7 ID:SGTC_2301|Compound:7769476|FD-Score:-5.36|P-value:4.31E-8 ID:SGTC_2439|Compound:5492030|FD-Score:4.10|P-value:3.60E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.04|P-value:4.57E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.66|P-value:1.56E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.18|P-value:2.54E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.88|P-value:8.69E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.04|P-value:4.44E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.33|P-value:7.42E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.96|P-value:6.23E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.18|P-value:6.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.61|P-value:1.42E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.18|P-value:8.59E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.69|P-value:1.48E-8 ID:SGTC_2806|Compound:7952793|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.08|P-value:3.89E-5 ID:SGTC_2824|Compound:7998404|FD-Score:4.20|P-value:2.30E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.47|P-value:2.41E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.00|P-value:5.24E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.29|P-value:7.60E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.75|P-value:8.52E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.30|P-value:7.25E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.79|P-value:1.23E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.71|P-value:1.67E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.23|P-value:9.10E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.90|P-value:7.83E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.49|P-value:6.51E-6 ID:SGTC_3352|Compound:9151559|FD-Score:4.81|P-value:1.48E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:9.81|P-value:3.87E-22 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.36|P-value:3.59E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.53|P-value:3.19E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.13|P-value:3.12E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.79|P-value:1.22E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.62|P-value:2.31E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.01|P-value:5.04E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.87|P-value:9.02E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:5.30|P-value:1.23E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:3.28|P-value:7.83E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.58|P-value:2.71E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.14|P-value:3.04E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.95|P-value:6.39E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.50|P-value:4.36E-8 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.69|P-value:1.54E-8 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.11|P-value:3.38E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.13|P-value:8.14E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.43|P-value:8.54E-6 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:8.64|P-value:1.47E-17 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.51|P-value:6.03E-6 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.40|P-value:5.17E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.43|P-value:4.64E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.73|P-value:2.19E-6 ID:SGTC_1975|Compound:st070967|FD-Score:4.03|P-value:4.75E-5 ID:SGTC_2024|Compound:5144227|FD-Score:4.49|P-value:6.43E-6 ID:SGTC_2066|Compound:5222451|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.53|P-value:3.25E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.74|P-value:2.09E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-4.23|P-value:1.12E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.52|P-value:3.29E-4 ID:SGTC_2294|Compound:7971431|FD-Score:5.17|P-value:2.47E-7 ID:SGTC_2301|Compound:7769476|FD-Score:-5.36|P-value:4.31E-8 ID:SGTC_2439|Compound:5492030|FD-Score:4.10|P-value:3.60E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.04|P-value:4.57E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.66|P-value:1.56E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.18|P-value:2.54E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.88|P-value:8.69E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.04|P-value:4.44E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.33|P-value:7.42E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.96|P-value:6.23E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.18|P-value:6.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.61|P-value:1.42E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.18|P-value:8.59E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.69|P-value:1.48E-8 ID:SGTC_2806|Compound:7952793|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.08|P-value:3.89E-5 ID:SGTC_2824|Compound:7998404|FD-Score:4.20|P-value:2.30E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.47|P-value:2.41E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.00|P-value:5.24E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.29|P-value:7.60E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.75|P-value:8.52E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.30|P-value:7.25E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.79|P-value:1.23E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.71|P-value:1.67E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.23|P-value:9.10E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.90|P-value:7.83E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.49|P-value:6.51E-6 ID:SGTC_3352|Compound:9151559|FD-Score:4.81|P-value:1.48E-6

Top fitness defect scores for YCR087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.81 9.0 µM 3.87E-22 cell wall 81 5.05E-23
2 SGTC_1242 0402-0103 8.64 60.1 µM 1.47E-17 2 2.82E-18
3 SGTC_2756 carbadox 6.18 75.1 µM 8.59E-10 15 3.24E-10
4 SGTC_2759 disulfiram 5.69 3.4 µM 1.48E-8 7 6.24E-9
5 SGTC_1048 3161-0300 5.69 24.5 µM 1.54E-8 4 6.50E-9
6 SGTC_1037 k284-1091 5.50 78.7 µM 4.36E-8 2 1.93E-8
7 SGTC_573 3702-0553 5.30 84.7 µM 1.23E-7 2 5.67E-8
8 SGTC_2294 7971431 5.17 200.0 µM 2.47E-7 5 1.17E-7
9 SGTC_3352 9151559 4.81 45.6 µM 1.48E-6 4 7.55E-7
10 SGTC_2152 5568786 4.74 200.0 µM 2.09E-6 4 1.08E-6
11 SGTC_1762 st045503 4.73 25.5 µM 2.19E-6 14 1.14E-6
12 SGTC_1337 1486-1011 4.51 40.3 µM 6.03E-6 10 3.27E-6
13 SGTC_2024 5144227 4.49 134.0 µM 6.43E-6 25 3.49E-6
14 SGTC_3336 9143619 4.49 71.4 µM 6.51E-6 9 3.54E-6
15 SGTC_1134 3477-0009 4.43 42.5 µM 8.54E-6 33 4.69E-6
16 SGTC_2824 7998404 4.20 52.0 µM 2.30E-5 31 1.32E-5
17 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.18 13.2 µM 2.54E-5 24 1.47E-5
18 SGTC_1002 4049-0206 4.14 172.0 µM 3.04E-5 24 1.77E-5
19 SGTC_88 0180-0332 4.13 8.7 µM 3.12E-5 20 1.82E-5
20 SGTC_1053 3366-3204 4.11 134.0 µM 3.38E-5 cell wall 32 1.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 6.94E-30 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.173 4.77E-24 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.173 5.08E-24 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.173 6.17E-24 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.169 6.05E-23 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.163 2.10E-21 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.163 2.65E-21 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.162 4.29E-21 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.162 4.47E-21 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.157 4.53E-20 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.156 1.12E-19 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.151 1.17E-18 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.148 6.96E-18 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.148 7.80E-18 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.144 4.36E-17 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C