YCR089W / FIG2

Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR089W / FIG2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.45|P-value:4.22E-7 ID:SGTC_286|Compound:k060-0067|FD-Score:-2.84|P-value:8.11E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-2.91|P-value:6.13E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.35|P-value:9.86E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.02|P-value:3.93E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-2.84|P-value:7.89E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.06|P-value:3.66E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.26|P-value:1.55E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-2.87|P-value:7.13E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.53|P-value:2.46E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.63|P-value:2.70E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:7.06|P-value:2.89E-15 ID:SGTC_1581|Compound:himbacine|FD-Score:-5.65|P-value:1.77E-10 ID:SGTC_1583|Compound:clindamycin|FD-Score:-6.09|P-value:6.79E-12 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:5.40|P-value:1.17E-9 ID:SGTC_1588|Compound:farnesol|FD-Score:3.22|P-value:1.83E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.48|P-value:3.61E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-6.77|P-value:2.98E-14 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.21|P-value:1.62E-6 ID:SGTC_1910|Compound:st062352|FD-Score:-3.47|P-value:5.70E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.34|P-value:1.05E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.00|P-value:4.26E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.02|P-value:4.34E-6 ID:SGTC_2126|Compound:5251174|FD-Score:2.96|P-value:5.42E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.09|P-value:3.03E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.38|P-value:8.64E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.00|P-value:4.21E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.95|P-value:5.73E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.95|P-value:5.17E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.95|P-value:5.67E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.90|P-value:2.96E-8 ID:SGTC_2783|Compound:7738165|FD-Score:-5.91|P-value:2.76E-11 ID:SGTC_2784|Compound:7567673|FD-Score:-4.54|P-value:2.30E-7 ID:SGTC_2788|Compound:5282734|FD-Score:3.66|P-value:2.65E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.68|P-value:2.42E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.05|P-value:3.46E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.63|P-value:2.75E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.56|P-value:3.86E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.24|P-value:1.75E-4 ID:SGTC_3127|Compound:9126946|FD-Score:2.81|P-value:9.39E-4 ID:SGTC_3162|Compound:9099653|FD-Score:5.25|P-value:3.20E-9 ID:SGTC_3192|Compound:9110362|FD-Score:-3.16|P-value:2.27E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.14|P-value:2.66E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.45|P-value:4.22E-7 ID:SGTC_286|Compound:k060-0067|FD-Score:-2.84|P-value:8.11E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-2.91|P-value:6.13E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.35|P-value:9.86E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.02|P-value:3.93E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-2.84|P-value:7.89E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.06|P-value:3.66E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.26|P-value:1.55E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-2.87|P-value:7.13E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.53|P-value:2.46E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.63|P-value:2.70E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:7.06|P-value:2.89E-15 ID:SGTC_1581|Compound:himbacine|FD-Score:-5.65|P-value:1.77E-10 ID:SGTC_1583|Compound:clindamycin|FD-Score:-6.09|P-value:6.79E-12 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:5.40|P-value:1.17E-9 ID:SGTC_1588|Compound:farnesol|FD-Score:3.22|P-value:1.83E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.48|P-value:3.61E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-6.77|P-value:2.98E-14 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.21|P-value:1.62E-6 ID:SGTC_1910|Compound:st062352|FD-Score:-3.47|P-value:5.70E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.34|P-value:1.05E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.00|P-value:4.26E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.02|P-value:4.34E-6 ID:SGTC_2126|Compound:5251174|FD-Score:2.96|P-value:5.42E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.09|P-value:3.03E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.38|P-value:8.64E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.00|P-value:4.21E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.95|P-value:5.73E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.95|P-value:5.17E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.95|P-value:5.67E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.90|P-value:2.96E-8 ID:SGTC_2783|Compound:7738165|FD-Score:-5.91|P-value:2.76E-11 ID:SGTC_2784|Compound:7567673|FD-Score:-4.54|P-value:2.30E-7 ID:SGTC_2788|Compound:5282734|FD-Score:3.66|P-value:2.65E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.68|P-value:2.42E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.05|P-value:3.46E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.63|P-value:2.75E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.56|P-value:3.86E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.24|P-value:1.75E-4 ID:SGTC_3127|Compound:9126946|FD-Score:2.81|P-value:9.39E-4 ID:SGTC_3162|Compound:9099653|FD-Score:5.25|P-value:3.20E-9 ID:SGTC_3192|Compound:9110362|FD-Score:-3.16|P-value:2.27E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.14|P-value:2.66E-4

Top fitness defect scores for YCR089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 7.06 66.5 µM 2.89E-15 2 8.55E-13
2 SGTC_1587 estradiol valerate 5.40 56.1 µM 1.17E-9 3 3.34E-8
3 SGTC_3162 9099653 5.25 49.5 µM 3.20E-9 1 7.64E-8
4 SGTC_2780 5215298 4.90 71.4 µM 2.96E-8 16 4.75E-7
5 SGTC_1590 st077108 4.48 57.8 µM 3.61E-7 4 3.71E-6
6 SGTC_67 0335-0847 4.45 266.0 µM 4.22E-7 ubiquinone biosynthesis & proteasome 97 4.22E-6
7 SGTC_1596 piperlongumine 4.21 63.0 µM 1.62E-6 11 1.27E-5
8 SGTC_2002 4023503 4.02 131.0 µM 4.34E-6 mitochondrial processes 27 2.87E-5
9 SGTC_2794 7785382 3.68 27.3 µM 2.42E-5 49 1.18E-4
10 SGTC_2788 5282734 3.66 71.4 µM 2.65E-5 61 1.27E-4
11 SGTC_2564 betulinic acid 3.35 100.0 µM 1.09E-4 58 4.10E-4
12 SGTC_2447 5741742 3.31 33.8 µM 1.26E-4 53 4.62E-4
13 SGTC_1322 1348-1070 3.26 12.0 µM 1.55E-4 21 5.49E-4
14 SGTC_3100 9120536 3.24 49.5 µM 1.75E-4 31 6.08E-4
15 SGTC_1588 farnesol 3.22 29.9 µM 1.83E-4 32 6.31E-4
16 SGTC_3203 9113543 3.14 49.5 µM 2.66E-4 73 8.57E-4
17 SGTC_1009 4106-0057 3.06 9.9 µM 3.66E-4 40 0.00112
18 SGTC_2126 5251174 2.96 33.9 µM 5.42E-4 100 0.00155
19 SGTC_2633 5,7-dihydroxyisoflavone 2.95 100.0 µM 5.67E-4 74 0.00160
20 SGTC_3127 9126946 2.81 49.5 µM 9.39E-4 ERG2 62 0.00244

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 4.56E-38 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.190 1.79E-28 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.189 3.42E-28 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.180 7.83E-26 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.174 3.79E-24 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.161 6.17E-21 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.154 3.22E-19 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.150 2.06E-18 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.149 3.33E-18 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.147 1.42E-17 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.146 1.68E-17 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.145 3.02E-17 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.142 1.13E-16 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.141 2.14E-16 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.140 3.45E-16 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation