YCR090C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR090C / YCR090C

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.20|P-value:1.62E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.17|P-value:1.86E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.74|P-value:1.42E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.18|P-value:1.73E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.33|P-value:9.44E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.56|P-value:3.29E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.68|P-value:4.34E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.68|P-value:1.88E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.51|P-value:4.10E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:2.83|P-value:7.11E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.29|P-value:8.55E-7 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.86|P-value:6.40E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.32|P-value:2.05E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.78|P-value:1.20E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.01|P-value:3.53E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.49|P-value:2.72E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.79|P-value:4.93E-8 ID:SGTC_880|Compound:0833-0487|FD-Score:2.89|P-value:5.60E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.08|P-value:2.67E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.53|P-value:3.75E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.12|P-value:2.16E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.56|P-value:3.29E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:2.75|P-value:9.42E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.52|P-value:2.35E-7 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.20|P-value:1.61E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:2.79|P-value:8.24E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.25|P-value:2.74E-9 ID:SGTC_1264|Compound:0783-0040|FD-Score:6.10|P-value:6.67E-12 ID:SGTC_1329|Compound:1447-1697|FD-Score:2.95|P-value:4.52E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.56|P-value:3.36E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.00|P-value:3.62E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.90|P-value:6.44E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.03|P-value:3.42E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.93|P-value:2.09E-8 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:2.96|P-value:4.39E-4 ID:SGTC_1713|Compound:st033146|FD-Score:2.84|P-value:6.97E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.91|P-value:6.57E-8 ID:SGTC_1724|Compound:st037281|FD-Score:-3.50|P-value:9.65E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.49|P-value:4.62E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.28|P-value:1.14E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.58|P-value:3.10E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.65|P-value:2.14E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.56|P-value:7.39E-5 ID:SGTC_2080|Compound:5212524|FD-Score:5.15|P-value:5.25E-9 ID:SGTC_2306|Compound:7482397|FD-Score:-3.03|P-value:6.47E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-5.02|P-value:3.42E-8 ID:SGTC_2317|Compound:5986382|FD-Score:-3.23|P-value:2.97E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.41|P-value:6.52E-5 ID:SGTC_2333|Compound:9017922|FD-Score:5.42|P-value:8.66E-10 ID:SGTC_2441|Compound:5730946|FD-Score:4.08|P-value:2.61E-6 ID:SGTC_2444|Compound:5485484|FD-Score:5.00|P-value:1.30E-8 ID:SGTC_2451|Compound:5856223|FD-Score:-3.24|P-value:2.79E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.88|P-value:3.34E-11 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.81|P-value:4.37E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.93|P-value:2.10E-8 ID:SGTC_2624|Compound:nerol|FD-Score:5.26|P-value:2.43E-9 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-6.21|P-value:1.12E-11 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.24|P-value:1.35E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.74|P-value:9.80E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.08|P-value:2.63E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.32|P-value:2.07E-4 ID:SGTC_2994|Compound:9053520|FD-Score:2.85|P-value:6.60E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.00|P-value:3.84E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.24|P-value:1.14E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.34|P-value:9.11E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:3.20|P-value:1.62E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.17|P-value:1.86E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.74|P-value:1.42E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.18|P-value:1.73E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.33|P-value:9.44E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.56|P-value:3.29E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.68|P-value:4.34E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.68|P-value:1.88E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.51|P-value:4.10E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:2.83|P-value:7.11E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.29|P-value:8.55E-7 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.86|P-value:6.40E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.32|P-value:2.05E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.78|P-value:1.20E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.01|P-value:3.53E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.49|P-value:2.72E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.79|P-value:4.93E-8 ID:SGTC_880|Compound:0833-0487|FD-Score:2.89|P-value:5.60E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.08|P-value:2.67E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.53|P-value:3.75E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.12|P-value:2.16E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.56|P-value:3.29E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:2.75|P-value:9.42E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.52|P-value:2.35E-7 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.20|P-value:1.61E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:2.79|P-value:8.24E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.25|P-value:2.74E-9 ID:SGTC_1264|Compound:0783-0040|FD-Score:6.10|P-value:6.67E-12 ID:SGTC_1329|Compound:1447-1697|FD-Score:2.95|P-value:4.52E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.56|P-value:3.36E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.00|P-value:3.62E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.90|P-value:6.44E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.03|P-value:3.42E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.93|P-value:2.09E-8 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:2.96|P-value:4.39E-4 ID:SGTC_1713|Compound:st033146|FD-Score:2.84|P-value:6.97E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.91|P-value:6.57E-8 ID:SGTC_1724|Compound:st037281|FD-Score:-3.50|P-value:9.65E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.49|P-value:4.62E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.28|P-value:1.14E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.58|P-value:3.10E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.65|P-value:2.14E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.56|P-value:7.39E-5 ID:SGTC_2080|Compound:5212524|FD-Score:5.15|P-value:5.25E-9 ID:SGTC_2306|Compound:7482397|FD-Score:-3.03|P-value:6.47E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-5.02|P-value:3.42E-8 ID:SGTC_2317|Compound:5986382|FD-Score:-3.23|P-value:2.97E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.41|P-value:6.52E-5 ID:SGTC_2333|Compound:9017922|FD-Score:5.42|P-value:8.66E-10 ID:SGTC_2441|Compound:5730946|FD-Score:4.08|P-value:2.61E-6 ID:SGTC_2444|Compound:5485484|FD-Score:5.00|P-value:1.30E-8 ID:SGTC_2451|Compound:5856223|FD-Score:-3.24|P-value:2.79E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.88|P-value:3.34E-11 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.81|P-value:4.37E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.93|P-value:2.10E-8 ID:SGTC_2624|Compound:nerol|FD-Score:5.26|P-value:2.43E-9 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-6.21|P-value:1.12E-11 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.24|P-value:1.35E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.74|P-value:9.80E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.08|P-value:2.63E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.32|P-value:2.07E-4 ID:SGTC_2994|Compound:9053520|FD-Score:2.85|P-value:6.60E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.00|P-value:3.84E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.24|P-value:1.14E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.34|P-value:9.11E-5

Top fitness defect scores for YCR090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1264 0783-0040 6.10 158.0 µM 6.67E-12 2 5.32E-10
2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.88 63.6 µM 3.34E-11 15 2.02E-9
3 SGTC_2333 9017922 5.42 200.0 µM 8.66E-10 9 2.99E-8
4 SGTC_2624 nerol 5.26 100.0 µM 2.43E-9 3 7.03E-8
5 SGTC_1261 0712-0010 5.25 12.7 µM 2.74E-9 RNA processing & uracil transport 8 7.77E-8
6 SGTC_2080 5212524 5.15 12.4 µM 5.25E-9 copper-dependent oxidative stress 6 1.33E-7
7 SGTC_2444 5485484 5.00 36.4 µM 1.30E-8 14 2.81E-7
8 SGTC_1449 4112-4002 4.93 201.0 µM 2.09E-8 RPP1 & pyrimidine depletion 11 4.17E-7
9 SGTC_2619 obliquin 4.93 87.9 µM 2.10E-8 cell wall 100 4.18E-7
10 SGTC_2531 methyl deoxycholate 4.81 70.1 µM 4.37E-8 12 7.68E-7
11 SGTC_832 4083-0019 4.79 164.0 µM 4.93E-8 translation 47 8.48E-7
12 SGTC_1126 isoteolin 4.52 1.0 µM 2.35E-7 16 3.09E-6
13 SGTC_831 k061-1017 4.49 217.0 µM 2.72E-7 translation 36 3.49E-6
14 SGTC_687 k029-0044 4.29 34.9 µM 8.55E-7 PDR1 14 8.98E-6
15 SGTC_3205 9113483 4.24 49.5 µM 1.14E-6 20 1.14E-5
16 SGTC_976 1348-1067 4.12 47.6 µM 2.16E-6 60S ribosome export 24 1.93E-5
17 SGTC_2441 5730946 4.08 39.1 µM 2.61E-6 12 2.26E-5
18 SGTC_1448 4255-0083 4.03 152.0 µM 3.42E-6 ERG2 19 2.83E-5
19 SGTC_2996 9066192 4.00 71.4 µM 3.84E-6 29 3.11E-5
20 SGTC_1404 3909-7820 3.90 48.3 µM 6.44E-6 60S ribosome export 10 4.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.79E-11 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.093 6.44E-8 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.085 7.83E-7 YLR275W SMD2 het Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
0.084 1.25E-6 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.082 1.94E-6 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
0.081 2.37E-6 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.081 2.47E-6 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.079 4.63E-6 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.075 1.45E-5 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.074 1.88E-5 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.073 2.25E-5 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.073 2.27E-5 YDR506C GMC1 hom Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein
0.071 3.68E-5 YKL044W_p YKL044W_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.071 3.68E-5 YMR225C MRPL44 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.071 3.81E-5 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p