HIPHOP chemogenomics database
YCR091W / KIN82 
Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YCR091W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.126 | 1.98E-13 | YMR058W | FET3 | hom | Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress |
| 0.100 | 6.10E-9 | YIL084C | SDS3 | hom | Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes |
| 0.097 | 1.57E-8 | YKL102C_d | YKL102C_d | hom | Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site |
| 0.097 | 1.93E-8 | YAR007C | RFA1 | het | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
| 0.090 | 2.07E-7 | YNL149C | PGA2 | het | Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect |
| 0.085 | 7.84E-7 | YFR031C | SMC2 | het | Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus |
| 0.083 | 1.52E-6 | YER161C | SPT2 | hom | Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins |
| 0.083 | 1.63E-6 | YLR241W_p | YLR241W_p | hom | Putative protein of unknown function, may be involved in detoxification |
| 0.082 | 1.76E-6 | YGL058W | RAD6 | hom | Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p |
| 0.080 | 3.19E-6 | YHR139C | SPS100 | hom | Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin |
| 0.080 | 3.43E-6 | YPR159W | KRE6 | hom | Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p |
| 0.080 | 3.69E-6 | YNL152W | INN1 | het | Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis |
| 0.079 | 4.66E-6 | YGR099W | TEL2 | het | Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 |
| 0.078 | 6.61E-6 | YER085C_p | YER085C_p | hom | Putative protein of unknown function |
| 0.077 | 7.29E-6 | YDR270W | CCC2 | hom | Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism |