YCR091W / KIN82

Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR091W / KIN82

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.27|P-value:3.37E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.25|P-value:3.69E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.43|P-value:2.36E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.54|P-value:1.38E-6 ID:SGTC_549|Compound:1661-1316|FD-Score:4.15|P-value:8.73E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:6.93|P-value:5.36E-13 ID:SGTC_768|Compound:0384-0033|FD-Score:3.26|P-value:3.57E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.83|P-value:3.60E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.37|P-value:2.32E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.79|P-value:7.55E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.87|P-value:3.00E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.09|P-value:6.46E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.53|P-value:1.46E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.26|P-value:5.32E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.70|P-value:6.34E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.25|P-value:3.69E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.65|P-value:7.71E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.85|P-value:3.28E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.73|P-value:5.55E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.32|P-value:2.84E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:5.87|P-value:7.57E-10 ID:SGTC_1607|Compound:st000305|FD-Score:3.31|P-value:2.95E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.10|P-value:1.13E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.15|P-value:8.43E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.14|P-value:5.43E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.63|P-value:1.39E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.72|P-value:9.96E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.36|P-value:2.40E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.45|P-value:9.43E-9 ID:SGTC_2073|Compound:5212005|FD-Score:-3.75|P-value:8.85E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.15|P-value:8.89E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.19|P-value:4.60E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.98|P-value:2.72E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.56|P-value:1.10E-4 ID:SGTC_2591|Compound:skatole|FD-Score:6.01|P-value:3.04E-10 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.99|P-value:9.31E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.90|P-value:2.68E-5 ID:SGTC_2601|Compound:securinine|FD-Score:2.98|P-value:9.48E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.65|P-value:7.83E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.41|P-value:3.32E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.63|P-value:8.49E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.20|P-value:6.94E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.35|P-value:2.49E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.93|P-value:2.33E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-4.40|P-value:5.09E-6 ID:SGTC_3086|Compound:9117350|FD-Score:-3.51|P-value:2.24E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.68|P-value:6.58E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.27|P-value:3.37E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.25|P-value:3.69E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.43|P-value:2.36E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.54|P-value:1.38E-6 ID:SGTC_549|Compound:1661-1316|FD-Score:4.15|P-value:8.73E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:6.93|P-value:5.36E-13 ID:SGTC_768|Compound:0384-0033|FD-Score:3.26|P-value:3.57E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.83|P-value:3.60E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.37|P-value:2.32E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.79|P-value:7.55E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.87|P-value:3.00E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.09|P-value:6.46E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.53|P-value:1.46E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.26|P-value:5.32E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.70|P-value:6.34E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.25|P-value:3.69E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.65|P-value:7.71E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.85|P-value:3.28E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.73|P-value:5.55E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.32|P-value:2.84E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:5.87|P-value:7.57E-10 ID:SGTC_1607|Compound:st000305|FD-Score:3.31|P-value:2.95E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.10|P-value:1.13E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.15|P-value:8.43E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.14|P-value:5.43E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.63|P-value:1.39E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.72|P-value:9.96E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.36|P-value:2.40E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.45|P-value:9.43E-9 ID:SGTC_2073|Compound:5212005|FD-Score:-3.75|P-value:8.85E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.15|P-value:8.89E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.19|P-value:4.60E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.98|P-value:2.72E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.56|P-value:1.10E-4 ID:SGTC_2591|Compound:skatole|FD-Score:6.01|P-value:3.04E-10 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.99|P-value:9.31E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.90|P-value:2.68E-5 ID:SGTC_2601|Compound:securinine|FD-Score:2.98|P-value:9.48E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.65|P-value:7.83E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.41|P-value:3.32E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.63|P-value:8.49E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.20|P-value:6.94E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.35|P-value:2.49E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.93|P-value:2.33E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-4.40|P-value:5.09E-6 ID:SGTC_3086|Compound:9117350|FD-Score:-3.51|P-value:2.24E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.68|P-value:6.58E-7

Top fitness defect scores for YCR091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_755 1995-0008 6.93 37.3 µM 5.36E-13 2 2.16E-12
2 SGTC_2591 skatole 6.01 100.0 µM 3.04E-10 5 9.22E-10
3 SGTC_1433 4060-0023 5.87 7.6 µM 7.57E-10 tubulin folding & SWR complex 9 2.21E-9
4 SGTC_2068 5226020 5.45 147.0 µM 9.43E-9 8 2.45E-8
5 SGTC_3325 9138760 4.68 55.2 µM 6.58E-7 Golgi 15 1.40E-6
6 SGTC_361 000s-0510 4.54 1.4 µM 1.38E-6 21 2.84E-6
7 SGTC_1150 3909-7983 4.53 10.9 µM 1.46E-6 13 3.01E-6
8 SGTC_317 4495-0002 4.43 170.0 µM 2.36E-6 6 4.73E-6
9 SGTC_1235 benzylparaben 4.26 21.5 µM 5.32E-6 9 1.03E-5
10 SGTC_549 1661-1316 4.15 519.0 µM 8.73E-6 14 1.65E-5
11 SGTC_2291 7917025 4.15 104.3 µM 8.89E-6 iron homeostasis 43 1.68E-5
12 SGTC_1674 st016616 4.10 23.6 µM 1.13E-5 23 2.10E-5
13 SGTC_2945 9067681 3.93 61.8 µM 2.33E-5 12 4.20E-5
14 SGTC_2596 sinensetin 3.90 100.0 µM 2.68E-5 34 4.78E-5
15 SGTC_966 1300-0360 3.87 30.2 µM 3.00E-5 heme requiring 27 5.33E-5
16 SGTC_1406 3909-7906 3.85 11.9 µM 3.28E-5 60S ribosome export 11 5.80E-5
17 SGTC_788 1182-0090 3.83 188.0 µM 3.60E-5 endomembrane recycling 80 6.35E-5
18 SGTC_1431 4049-0260 3.73 9.1 µM 5.55E-5 8 9.57E-5
19 SGTC_1238 0333-0287 3.70 48.8 µM 6.34E-5 Golgi 33 1.09E-4
20 SGTC_1357 1503-1303 3.65 39.5 µM 7.71E-5 44 1.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 1.98E-13 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.100 6.10E-9 YIL084C SDS3 hom Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
0.097 1.57E-8 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.097 1.93E-8 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.090 2.07E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.085 7.84E-7 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.083 1.52E-6 YER161C SPT2 hom Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
0.083 1.63E-6 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.082 1.76E-6 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.080 3.19E-6 YHR139C SPS100 hom Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
0.080 3.43E-6 YPR159W KRE6 hom Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p
0.080 3.69E-6 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.079 4.66E-6 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.078 6.61E-6 YER085C_p YER085C_p hom Putative protein of unknown function
0.077 7.29E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism