YCR093W / CDC39

Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCR093W / CDC39

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.14|P-value:1.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.41|P-value:1.19E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:6.12|P-value:4.97E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.68|P-value:2.28E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:6.82|P-value:1.43E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:6.86|P-value:1.16E-9 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.31|P-value:1.91E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:28.70|P-value:1.97E-138 ID:SGTC_320|Compound:4092-0846|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.12|P-value:1.69E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-4.25|P-value:1.07E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.93|P-value:3.16E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.80|P-value:4.72E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.90|P-value:1.42E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:-6.43|P-value:1.09E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:-4.19|P-value:1.33E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-9.81|P-value:6.82E-18 ID:SGTC_384|Compound:k007-0144|FD-Score:3.93|P-value:3.15E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.57|P-value:9.36E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.06|P-value:6.50E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.42|P-value:6.05E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.93|P-value:3.16E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.16|P-value:4.20E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:4.19|P-value:1.30E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.87|P-value:1.10E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.26|P-value:1.06E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.13|P-value:4.02E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:7.25|P-value:1.38E-10 ID:SGTC_768|Compound:0384-0033|FD-Score:5.57|P-value:6.28E-7 ID:SGTC_834|Compound:0312-0008|FD-Score:3.80|P-value:4.63E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.56|P-value:3.61E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.83|P-value:4.29E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.91|P-value:3.28E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.19|P-value:1.34E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-5.69|P-value:3.61E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.38|P-value:1.39E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:9.88|P-value:3.96E-18 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.25|P-value:1.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:22.10|P-value:7.10E-83 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.33|P-value:8.24E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.92|P-value:3.25E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-8.39|P-value:1.41E-13 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.31|P-value:2.02E-8 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.99|P-value:2.59E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:25.30|P-value:3.24E-108 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.62|P-value:4.88E-7 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.59|P-value:8.78E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.08|P-value:4.80E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.64|P-value:4.54E-7 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.59|P-value:3.19E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.91|P-value:9.74E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.80|P-value:1.45E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.24|P-value:2.58E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.56|P-value:9.81E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.60|P-value:8.68E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.38|P-value:6.87E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.76|P-value:5.30E-4 ID:SGTC_1728|Compound:st035614|FD-Score:6.02|P-value:7.89E-8 ID:SGTC_1730|Compound:st033808|FD-Score:-3.96|P-value:2.88E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.87|P-value:1.11E-5 ID:SGTC_1743|Compound:st037606|FD-Score:4.34|P-value:7.86E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.76|P-value:5.34E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-3.85|P-value:4.00E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.01|P-value:2.43E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.85|P-value:1.78E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.52|P-value:4.15E-5 ID:SGTC_1974|Compound:st069448|FD-Score:4.63|P-value:2.76E-5 ID:SGTC_2004|Compound:4023728|FD-Score:-3.66|P-value:7.22E-4 ID:SGTC_2021|Compound:4019055|FD-Score:10.80|P-value:2.72E-21 ID:SGTC_2036|Compound:5160441|FD-Score:4.90|P-value:9.83E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.87|P-value:3.78E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.46|P-value:5.17E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-4.21|P-value:1.24E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.55|P-value:3.80E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-6.68|P-value:3.04E-9 ID:SGTC_2133|Compound:5320837|FD-Score:6.55|P-value:5.86E-9 ID:SGTC_2159|Compound:5658611|FD-Score:4.20|P-value:1.27E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.17|P-value:1.41E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.57|P-value:5.28E-9 ID:SGTC_2281|Compound:7943571|FD-Score:3.59|P-value:8.77E-4 ID:SGTC_2322|Compound:7413319|FD-Score:11.20|P-value:1.02E-22 ID:SGTC_2336|Compound:9001819|FD-Score:-4.62|P-value:2.92E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.59|P-value:8.90E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.70|P-value:6.34E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.99|P-value:2.61E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.04|P-value:2.21E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.65|P-value:7.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.54|P-value:3.85E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.69|P-value:3.70E-7 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.40|P-value:6.45E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.92|P-value:9.25E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.29|P-value:9.31E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.66|P-value:7.16E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.98|P-value:2.62E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.85|P-value:1.20E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.63|P-value:7.86E-4 ID:SGTC_2867|Compound:9039098|FD-Score:7.28|P-value:1.18E-10 ID:SGTC_2896|Compound:9052656|FD-Score:7.12|P-value:2.89E-10 ID:SGTC_2925|Compound:9010536|FD-Score:-5.24|P-value:2.59E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.79|P-value:1.51E-5 ID:SGTC_2991|Compound:9074669|FD-Score:7.87|P-value:3.67E-12 ID:SGTC_3068|Compound:9116768|FD-Score:4.90|P-value:9.99E-6 ID:SGTC_3070|Compound:9117005|FD-Score:5.27|P-value:2.25E-6 ID:SGTC_3125|Compound:9127534|FD-Score:3.97|P-value:2.70E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.82|P-value:4.43E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.69|P-value:6.54E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.97|P-value:2.73E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-5.19|P-value:3.14E-6 ID:SGTC_3284|Compound:9108171|FD-Score:4.81|P-value:1.42E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-3.55|P-value:9.91E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.14|P-value:1.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.41|P-value:1.19E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:6.12|P-value:4.97E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.68|P-value:2.28E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:6.82|P-value:1.43E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:6.86|P-value:1.16E-9 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.31|P-value:1.91E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:28.70|P-value:1.97E-138 ID:SGTC_320|Compound:4092-0846|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.12|P-value:1.69E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-4.25|P-value:1.07E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.93|P-value:3.16E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.80|P-value:4.72E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.90|P-value:1.42E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:-6.43|P-value:1.09E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:-4.19|P-value:1.33E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-9.81|P-value:6.82E-18 ID:SGTC_384|Compound:k007-0144|FD-Score:3.93|P-value:3.15E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.57|P-value:9.36E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.06|P-value:6.50E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.42|P-value:6.05E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.93|P-value:3.16E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.16|P-value:4.20E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:4.19|P-value:1.30E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.87|P-value:1.10E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.26|P-value:1.06E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.13|P-value:4.02E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:7.25|P-value:1.38E-10 ID:SGTC_768|Compound:0384-0033|FD-Score:5.57|P-value:6.28E-7 ID:SGTC_834|Compound:0312-0008|FD-Score:3.80|P-value:4.63E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.56|P-value:3.61E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.83|P-value:4.29E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.91|P-value:3.28E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.19|P-value:1.34E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-5.69|P-value:3.61E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.38|P-value:1.39E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:9.88|P-value:3.96E-18 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.25|P-value:1.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:22.10|P-value:7.10E-83 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.33|P-value:8.24E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.92|P-value:3.25E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-8.39|P-value:1.41E-13 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.31|P-value:2.02E-8 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.99|P-value:2.59E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:25.30|P-value:3.24E-108 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.62|P-value:4.88E-7 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.59|P-value:8.78E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.08|P-value:4.80E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.64|P-value:4.54E-7 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.59|P-value:3.19E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.91|P-value:9.74E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.80|P-value:1.45E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.24|P-value:2.58E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.56|P-value:9.81E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.60|P-value:8.68E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.38|P-value:6.87E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.76|P-value:5.30E-4 ID:SGTC_1728|Compound:st035614|FD-Score:6.02|P-value:7.89E-8 ID:SGTC_1730|Compound:st033808|FD-Score:-3.96|P-value:2.88E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.87|P-value:1.11E-5 ID:SGTC_1743|Compound:st037606|FD-Score:4.34|P-value:7.86E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.76|P-value:5.34E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-3.85|P-value:4.00E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.01|P-value:2.43E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.85|P-value:1.78E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.52|P-value:4.15E-5 ID:SGTC_1974|Compound:st069448|FD-Score:4.63|P-value:2.76E-5 ID:SGTC_2004|Compound:4023728|FD-Score:-3.66|P-value:7.22E-4 ID:SGTC_2021|Compound:4019055|FD-Score:10.80|P-value:2.72E-21 ID:SGTC_2036|Compound:5160441|FD-Score:4.90|P-value:9.83E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.87|P-value:3.78E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.46|P-value:5.17E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-4.21|P-value:1.24E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.55|P-value:3.80E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-6.68|P-value:3.04E-9 ID:SGTC_2133|Compound:5320837|FD-Score:6.55|P-value:5.86E-9 ID:SGTC_2159|Compound:5658611|FD-Score:4.20|P-value:1.27E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.17|P-value:1.41E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.57|P-value:5.28E-9 ID:SGTC_2281|Compound:7943571|FD-Score:3.59|P-value:8.77E-4 ID:SGTC_2322|Compound:7413319|FD-Score:11.20|P-value:1.02E-22 ID:SGTC_2336|Compound:9001819|FD-Score:-4.62|P-value:2.92E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.59|P-value:8.90E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.70|P-value:6.34E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.99|P-value:2.61E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.04|P-value:2.21E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.65|P-value:7.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.54|P-value:3.85E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.69|P-value:3.70E-7 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.40|P-value:6.45E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.92|P-value:9.25E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.29|P-value:9.31E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.66|P-value:7.16E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.98|P-value:2.62E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.85|P-value:1.20E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.63|P-value:7.86E-4 ID:SGTC_2867|Compound:9039098|FD-Score:7.28|P-value:1.18E-10 ID:SGTC_2896|Compound:9052656|FD-Score:7.12|P-value:2.89E-10 ID:SGTC_2925|Compound:9010536|FD-Score:-5.24|P-value:2.59E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.79|P-value:1.51E-5 ID:SGTC_2991|Compound:9074669|FD-Score:7.87|P-value:3.67E-12 ID:SGTC_3068|Compound:9116768|FD-Score:4.90|P-value:9.99E-6 ID:SGTC_3070|Compound:9117005|FD-Score:5.27|P-value:2.25E-6 ID:SGTC_3125|Compound:9127534|FD-Score:3.97|P-value:2.70E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.82|P-value:4.43E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.69|P-value:6.54E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.97|P-value:2.73E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-5.19|P-value:3.14E-6 ID:SGTC_3284|Compound:9108171|FD-Score:4.81|P-value:1.42E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-3.55|P-value:9.91E-4

Top fitness defect scores for YCR093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_227 fluconazole 28.70 33.5 µM 1.97E-138 azole & statin 4 6.48E-182 10.50
2 SGTC_1230 0170-0365 25.30 3.8 µM 3.24E-108 endomembrane recycling 3 4.62E-142 7.46
3 SGTC_1083 didemethylchlorpromazine sulfoxide 22.10 707.4 nM 7.10E-83 redox potentiating 3 1.21E-108 7.75
4 SGTC_2322 7413319 11.20 38.2 µM 1.02E-22 ERAD & cell cycle 3 2.34E-29 1.81
5 SGTC_2021 4019055 10.80 173.0 µM 2.72E-21 endomembrane recycling 7 1.76E-27 0.51
6 SGTC_1026 k007-1105 9.88 30.6 µM 3.96E-18 ERAD & cell cycle 6 2.55E-23 1.24
7 SGTC_2991 9074669 7.87 71.4 µM 3.67E-12 azole & statin 4 1.78E-15 1.89
8 SGTC_2867 9039098 7.28 71.4 µM 1.18E-10 iron homeostasis 1 1.70E-13 0.88
9 SGTC_733 4069-0007 7.25 56.1 µM 1.38E-10 ERAD & cell cycle 7 2.09E-13 0.89
10 SGTC_2896 9052656 7.12 71.4 µM 2.89E-10 endomembrane recycling 7 5.49E-13 0.89
11 SGTC_197 4544-0043 6.86 41.6 µM 1.16E-9 endomembrane recycling 8 3.40E-12 0.17
12 SGTC_178 4092-0806 6.82 87.5 µM 1.43E-9 ergosterol depletion effects on membrane 7 4.49E-12 0.38
13 SGTC_2249 haloperidol 6.57 116.4 µM 5.28E-9 ergosterol depletion effects on membrane 14 2.48E-11 0.01
14 SGTC_2133 5320837 6.55 200.0 µM 5.86E-9 ERG2 1 2.84E-11 1.30
15 SGTC_103 0844-0104 6.41 51.8 µM 1.19E-8 ERAD & cell cycle 21 7.15E-11 0.26
16 SGTC_1161 k007-0610 6.31 110.0 µM 2.02E-8 ERAD & cell cycle 16 1.43E-10 0.15
17 SGTC_146 3448-8650 6.12 53.1 µM 4.97E-8 NEO1-PIK1 5 4.68E-10 0.74
18 SGTC_1728 st035614 6.02 33.8 µM 7.89E-8 1 8.57E-10 1.40
19 SGTC_360 0957-0399 5.90 1.0 µM 1.42E-7 cell wall 3 1.85E-9 0.96
20 SGTC_2679 rapamycin 5.69 1.0 nM 3.70E-7 29 6.48E-9 0.38

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.313 5.57E-77 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.288 8.36E-65 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.279 4.50E-61 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.279 4.95E-61 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.270 3.89E-57 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.264 1.50E-54 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.258 8.42E-52 YDR526C_d YDR526C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.235 2.53E-43 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.225 1.27E-39 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.215 2.56E-36 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.213 1.25E-35 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.207 1.27E-33 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.203 2.50E-32 YDR081C PDC2 het Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
0.202 3.44E-32 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.202 4.60E-32 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex