YCR094W / CDC50

Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR094W / CDC50

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.80|P-value:4.38E-5 ID:SGTC_57|Compound:miconazole|FD-Score:4.38|P-value:1.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.04|P-value:3.90E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.90|P-value:3.16E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:9.65|P-value:1.38E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:4.58|P-value:9.22E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:9.67|P-value:1.21E-15 ID:SGTC_124|Compound:0136-0217|FD-Score:5.15|P-value:1.27E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-5.57|P-value:2.23E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:22.40|P-value:1.40E-75 ID:SGTC_138|Compound:0850-0259|FD-Score:5.19|P-value:1.10E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:10.50|P-value:3.39E-18 ID:SGTC_142|Compound:0335-0849|FD-Score:12.10|P-value:1.56E-23 ID:SGTC_146|Compound:3448-8650|FD-Score:7.51|P-value:4.10E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:9.84|P-value:3.89E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:5.56|P-value:2.76E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:5.08|P-value:1.64E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:12.40|P-value:2.27E-24 ID:SGTC_178|Compound:4092-0806|FD-Score:5.28|P-value:7.84E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:13.40|P-value:2.41E-28 ID:SGTC_201|Compound:4262-0159|FD-Score:7.65|P-value:1.90E-10 ID:SGTC_207|Compound:4185-0010|FD-Score:6.74|P-value:1.74E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:4.15|P-value:3.56E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:8.63|P-value:8.22E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.47|P-value:4.80E-10 ID:SGTC_232|Compound:clozapine|FD-Score:5.03|P-value:2.01E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:7.81|P-value:8.19E-11 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.90|P-value:7.18E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:9.25|P-value:1.82E-14 ID:SGTC_294|Compound:k038-0071|FD-Score:4.72|P-value:5.72E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.65|P-value:7.35E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:8.80|P-value:2.91E-13 ID:SGTC_313|Compound:3474-0040|FD-Score:6.14|P-value:2.61E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:5.84|P-value:9.00E-7 ID:SGTC_332|Compound:4112-0506|FD-Score:5.81|P-value:1.01E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:7.16|P-value:2.31E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:6.02|P-value:4.34E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:7.80|P-value:8.48E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:5.09|P-value:1.59E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:6.64|P-value:2.83E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:6.57|P-value:3.95E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:5.74|P-value:1.34E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.03|P-value:4.48E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:6.46|P-value:6.35E-8 ID:SGTC_439|Compound:amiodarone|FD-Score:16.50|P-value:3.56E-42 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.96|P-value:2.50E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.96|P-value:2.15E-5 ID:SGTC_459|Compound:nigericin|FD-Score:4.70|P-value:6.08E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.05|P-value:4.68E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.82|P-value:9.94E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:3.84|P-value:8.75E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.88|P-value:3.41E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:5.96|P-value:5.56E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:25.70|P-value:7.34E-99 ID:SGTC_642|Compound:0335-0876|FD-Score:4.98|P-value:2.32E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.97|P-value:5.96E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.22|P-value:2.89E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.10|P-value:3.11E-9 ID:SGTC_688|Compound:0527-0193|FD-Score:4.68|P-value:6.64E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.79|P-value:4.59E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:9.41|P-value:6.78E-15 ID:SGTC_768|Compound:0384-0033|FD-Score:9.12|P-value:4.10E-14 ID:SGTC_778|Compound:3456-2434|FD-Score:11.60|P-value:7.73E-22 ID:SGTC_788|Compound:1182-0090|FD-Score:15.30|P-value:3.32E-36 ID:SGTC_794|Compound:k038-0031|FD-Score:5.17|P-value:1.19E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:4.21|P-value:2.94E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.65|P-value:1.94E-6 ID:SGTC_834|Compound:0312-0008|FD-Score:6.22|P-value:1.80E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.53|P-value:1.09E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.22|P-value:1.00E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:5.74|P-value:1.34E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:15.30|P-value:2.91E-36 ID:SGTC_888|Compound:0916-0002|FD-Score:11.20|P-value:2.22E-20 ID:SGTC_902|Compound:1120-0002|FD-Score:5.11|P-value:1.48E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:6.13|P-value:2.73E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.96|P-value:5.46E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.01|P-value:8.43E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.73|P-value:1.85E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.36|P-value:5.81E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.05|P-value:4.76E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.59|P-value:9.03E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.08|P-value:4.35E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:21.40|P-value:3.02E-69 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.47|P-value:4.89E-10 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.84|P-value:3.91E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.10|P-value:4.12E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.79|P-value:1.37E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:12.10|P-value:1.33E-23 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.81|P-value:8.26E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.37|P-value:8.07E-10 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.95|P-value:6.41E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:7.22|P-value:1.73E-9 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.66|P-value:7.02E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:5.22|P-value:1.00E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.73|P-value:5.52E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.79|P-value:9.86E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.79|P-value:9.99E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.40|P-value:5.19E-6 ID:SGTC_1660|Compound:st012960|FD-Score:6.44|P-value:6.91E-8 ID:SGTC_1672|Compound:st016598|FD-Score:12.20|P-value:1.08E-23 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.07|P-value:4.45E-4 ID:SGTC_1715|Compound:st032160|FD-Score:10.20|P-value:4.12E-17 ID:SGTC_1750|Compound:st081859|FD-Score:6.92|P-value:7.53E-9 ID:SGTC_1754|Compound:st042065|FD-Score:4.01|P-value:5.29E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.20|P-value:3.03E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.72|P-value:1.45E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:8.00|P-value:2.87E-11 ID:SGTC_1797|Compound:st048695|FD-Score:11.80|P-value:1.57E-22 ID:SGTC_1803|Compound:st050068|FD-Score:4.89|P-value:3.20E-5 ID:SGTC_1826|Compound:st055655|FD-Score:5.77|P-value:1.20E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.35|P-value:1.68E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.82|P-value:7.92E-11 ID:SGTC_1873|Compound:rapamycin|FD-Score:12.80|P-value:6.41E-26 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.38|P-value:1.73E-4 ID:SGTC_1884|Compound:5633444|FD-Score:18.00|P-value:1.84E-49 ID:SGTC_1991|Compound:st073000|FD-Score:6.45|P-value:6.51E-8 ID:SGTC_1999|Compound:st074831|FD-Score:6.67|P-value:2.46E-8 ID:SGTC_2006|Compound:4011487|FD-Score:10.90|P-value:2.85E-19 ID:SGTC_2028|Compound:5153890|FD-Score:8.90|P-value:1.58E-13 ID:SGTC_2036|Compound:5160441|FD-Score:8.50|P-value:1.71E-12 ID:SGTC_2038|Compound:4100038|FD-Score:8.48|P-value:1.93E-12 ID:SGTC_2050|Compound:5263056|FD-Score:5.57|P-value:2.69E-6 ID:SGTC_2054|Compound:5233173|FD-Score:4.36|P-value:1.86E-4 ID:SGTC_2090|Compound:5301565|FD-Score:8.31|P-value:5.10E-12 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.51|P-value:5.08E-8 ID:SGTC_2166|Compound:5933061|FD-Score:5.86|P-value:8.23E-7 ID:SGTC_2210|Compound:7115885|FD-Score:8.54|P-value:1.37E-12 ID:SGTC_2242|Compound:6630449|FD-Score:6.81|P-value:1.24E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.01|P-value:2.75E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.21|P-value:8.92E-12 ID:SGTC_2257|Compound:7960413|FD-Score:6.26|P-value:1.55E-7 ID:SGTC_2336|Compound:9001819|FD-Score:6.26|P-value:1.54E-7 ID:SGTC_2357|Compound:9067248|FD-Score:-3.96|P-value:5.36E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.77|P-value:4.97E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.49|P-value:4.54E-10 ID:SGTC_2431|Compound:5490079|FD-Score:4.64|P-value:7.42E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.89|P-value:3.19E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.94|P-value:6.45E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:9.27|P-value:1.66E-14 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.84|P-value:3.90E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.64|P-value:1.99E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.00|P-value:1.07E-19 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:2.66E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.05|P-value:4.77E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:15.80|P-value:1.67E-38 ID:SGTC_2694|Compound:st077685|FD-Score:7.76|P-value:1.06E-10 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.89|P-value:7.44E-4 ID:SGTC_2699|Compound:st077704|FD-Score:10.00|P-value:1.06E-16 ID:SGTC_2721|Compound:ifenprodil|FD-Score:7.88|P-value:5.65E-11 ID:SGTC_2725|Compound:haloperidol|FD-Score:8.36|P-value:3.87E-12 ID:SGTC_2733|Compound:amorolfine|FD-Score:5.32|P-value:6.82E-6 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.99|P-value:5.66E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.34|P-value:1.96E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.52|P-value:4.81E-8 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.17|P-value:1.21E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.56|P-value:2.74E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.90|P-value:3.14E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:6.56|P-value:4.04E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.05|P-value:2.28E-11 ID:SGTC_2790|Compound:5423970|FD-Score:12.60|P-value:2.73E-25 ID:SGTC_2816|Compound:7982706|FD-Score:4.00|P-value:5.53E-4 ID:SGTC_2838|Compound:9002687|FD-Score:6.97|P-value:5.85E-9 ID:SGTC_2865|Compound:9030313|FD-Score:4.81|P-value:4.27E-5 ID:SGTC_2873|Compound:9040596|FD-Score:7.79|P-value:8.97E-11 ID:SGTC_2880|Compound:9042983|FD-Score:10.40|P-value:6.19E-18 ID:SGTC_2887|Compound:9044784|FD-Score:13.30|P-value:7.72E-28 ID:SGTC_2893|Compound:9048488|FD-Score:6.80|P-value:1.36E-8 ID:SGTC_2896|Compound:9052656|FD-Score:4.57|P-value:9.52E-5 ID:SGTC_2904|Compound:7225135|FD-Score:-5.17|P-value:1.04E-5 ID:SGTC_2910|Compound:7948405|FD-Score:22.50|P-value:3.71E-76 ID:SGTC_2913|Compound:7966556|FD-Score:-4.79|P-value:3.93E-5 ID:SGTC_2925|Compound:9010536|FD-Score:7.41|P-value:6.75E-10 ID:SGTC_2938|Compound:9059746|FD-Score:14.50|P-value:6.68E-33 ID:SGTC_2948|Compound:9070189|FD-Score:8.86|P-value:2.02E-13 ID:SGTC_2965|Compound:9082772|FD-Score:12.50|P-value:8.88E-25 ID:SGTC_2974|Compound:9094440|FD-Score:5.04|P-value:1.95E-5 ID:SGTC_2993|Compound:9054257|FD-Score:8.28|P-value:6.33E-12 ID:SGTC_3018|Compound:9082602|FD-Score:11.90|P-value:1.18E-22 ID:SGTC_3044|Compound:9093193|FD-Score:-6.79|P-value:1.13E-8 ID:SGTC_3054|Compound:9094397|FD-Score:6.18|P-value:2.21E-7 ID:SGTC_3062|Compound:9077494|FD-Score:11.10|P-value:5.08E-20 ID:SGTC_3071|Compound:9117417|FD-Score:8.48|P-value:1.96E-12 ID:SGTC_3081|Compound:9117243|FD-Score:9.47|P-value:4.58E-15 ID:SGTC_3102|Compound:9121669|FD-Score:4.08|P-value:4.34E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.61|P-value:8.24E-5 ID:SGTC_3126|Compound:9127922|FD-Score:8.38|P-value:3.52E-12 ID:SGTC_3145|Compound:9085516|FD-Score:5.37|P-value:5.71E-6 ID:SGTC_3152|Compound:9099253|FD-Score:6.32|P-value:1.20E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-5.93|P-value:5.18E-7 ID:SGTC_3218|Compound:9131285|FD-Score:10.80|P-value:3.91E-19 ID:SGTC_3308|Compound:9128332|FD-Score:10.00|P-value:1.07E-16 ID:SGTC_3320|Compound:9137005|FD-Score:5.06|P-value:1.76E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.22|P-value:2.86E-4 ID:SGTC_3348|Compound:9149464|FD-Score:6.54|P-value:4.46E-8 ID:SGTC_3353|Compound:9151644|FD-Score:5.05|P-value:1.84E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.80|P-value:4.38E-5 ID:SGTC_57|Compound:miconazole|FD-Score:4.38|P-value:1.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.04|P-value:3.90E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.90|P-value:3.16E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:9.65|P-value:1.38E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:4.58|P-value:9.22E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:9.67|P-value:1.21E-15 ID:SGTC_124|Compound:0136-0217|FD-Score:5.15|P-value:1.27E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-5.57|P-value:2.23E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:22.40|P-value:1.40E-75 ID:SGTC_138|Compound:0850-0259|FD-Score:5.19|P-value:1.10E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:10.50|P-value:3.39E-18 ID:SGTC_142|Compound:0335-0849|FD-Score:12.10|P-value:1.56E-23 ID:SGTC_146|Compound:3448-8650|FD-Score:7.51|P-value:4.10E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:9.84|P-value:3.89E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:5.56|P-value:2.76E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:5.08|P-value:1.64E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:12.40|P-value:2.27E-24 ID:SGTC_178|Compound:4092-0806|FD-Score:5.28|P-value:7.84E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:13.40|P-value:2.41E-28 ID:SGTC_201|Compound:4262-0159|FD-Score:7.65|P-value:1.90E-10 ID:SGTC_207|Compound:4185-0010|FD-Score:6.74|P-value:1.74E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:4.15|P-value:3.56E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:8.63|P-value:8.22E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.47|P-value:4.80E-10 ID:SGTC_232|Compound:clozapine|FD-Score:5.03|P-value:2.01E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:7.81|P-value:8.19E-11 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.90|P-value:7.18E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:9.25|P-value:1.82E-14 ID:SGTC_294|Compound:k038-0071|FD-Score:4.72|P-value:5.72E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.65|P-value:7.35E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:8.80|P-value:2.91E-13 ID:SGTC_313|Compound:3474-0040|FD-Score:6.14|P-value:2.61E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:5.84|P-value:9.00E-7 ID:SGTC_332|Compound:4112-0506|FD-Score:5.81|P-value:1.01E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:7.16|P-value:2.31E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:6.02|P-value:4.34E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:7.80|P-value:8.48E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:5.09|P-value:1.59E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:6.64|P-value:2.83E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:6.57|P-value:3.95E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:5.74|P-value:1.34E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.03|P-value:4.48E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:6.46|P-value:6.35E-8 ID:SGTC_439|Compound:amiodarone|FD-Score:16.50|P-value:3.56E-42 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.96|P-value:2.50E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.96|P-value:2.15E-5 ID:SGTC_459|Compound:nigericin|FD-Score:4.70|P-value:6.08E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.05|P-value:4.68E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.82|P-value:9.94E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:3.84|P-value:8.75E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.88|P-value:3.41E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:5.96|P-value:5.56E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:25.70|P-value:7.34E-99 ID:SGTC_642|Compound:0335-0876|FD-Score:4.98|P-value:2.32E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.97|P-value:5.96E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.22|P-value:2.89E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.10|P-value:3.11E-9 ID:SGTC_688|Compound:0527-0193|FD-Score:4.68|P-value:6.64E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.79|P-value:4.59E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:9.41|P-value:6.78E-15 ID:SGTC_768|Compound:0384-0033|FD-Score:9.12|P-value:4.10E-14 ID:SGTC_778|Compound:3456-2434|FD-Score:11.60|P-value:7.73E-22 ID:SGTC_788|Compound:1182-0090|FD-Score:15.30|P-value:3.32E-36 ID:SGTC_794|Compound:k038-0031|FD-Score:5.17|P-value:1.19E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:4.21|P-value:2.94E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.65|P-value:1.94E-6 ID:SGTC_834|Compound:0312-0008|FD-Score:6.22|P-value:1.80E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.53|P-value:1.09E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.22|P-value:1.00E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:5.74|P-value:1.34E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:15.30|P-value:2.91E-36 ID:SGTC_888|Compound:0916-0002|FD-Score:11.20|P-value:2.22E-20 ID:SGTC_902|Compound:1120-0002|FD-Score:5.11|P-value:1.48E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:6.13|P-value:2.73E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.96|P-value:5.46E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.01|P-value:8.43E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.73|P-value:1.85E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.36|P-value:5.81E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.05|P-value:4.76E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.59|P-value:9.03E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.08|P-value:4.35E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:21.40|P-value:3.02E-69 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.47|P-value:4.89E-10 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.84|P-value:3.91E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.10|P-value:4.12E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.79|P-value:1.37E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:12.10|P-value:1.33E-23 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.81|P-value:8.26E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.37|P-value:8.07E-10 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.95|P-value:6.41E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:7.22|P-value:1.73E-9 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.66|P-value:7.02E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:5.22|P-value:1.00E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.73|P-value:5.52E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.79|P-value:9.86E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.79|P-value:9.99E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.40|P-value:5.19E-6 ID:SGTC_1660|Compound:st012960|FD-Score:6.44|P-value:6.91E-8 ID:SGTC_1672|Compound:st016598|FD-Score:12.20|P-value:1.08E-23 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.07|P-value:4.45E-4 ID:SGTC_1715|Compound:st032160|FD-Score:10.20|P-value:4.12E-17 ID:SGTC_1750|Compound:st081859|FD-Score:6.92|P-value:7.53E-9 ID:SGTC_1754|Compound:st042065|FD-Score:4.01|P-value:5.29E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.20|P-value:3.03E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.72|P-value:1.45E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:8.00|P-value:2.87E-11 ID:SGTC_1797|Compound:st048695|FD-Score:11.80|P-value:1.57E-22 ID:SGTC_1803|Compound:st050068|FD-Score:4.89|P-value:3.20E-5 ID:SGTC_1826|Compound:st055655|FD-Score:5.77|P-value:1.20E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.35|P-value:1.68E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.82|P-value:7.92E-11 ID:SGTC_1873|Compound:rapamycin|FD-Score:12.80|P-value:6.41E-26 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.38|P-value:1.73E-4 ID:SGTC_1884|Compound:5633444|FD-Score:18.00|P-value:1.84E-49 ID:SGTC_1991|Compound:st073000|FD-Score:6.45|P-value:6.51E-8 ID:SGTC_1999|Compound:st074831|FD-Score:6.67|P-value:2.46E-8 ID:SGTC_2006|Compound:4011487|FD-Score:10.90|P-value:2.85E-19 ID:SGTC_2028|Compound:5153890|FD-Score:8.90|P-value:1.58E-13 ID:SGTC_2036|Compound:5160441|FD-Score:8.50|P-value:1.71E-12 ID:SGTC_2038|Compound:4100038|FD-Score:8.48|P-value:1.93E-12 ID:SGTC_2050|Compound:5263056|FD-Score:5.57|P-value:2.69E-6 ID:SGTC_2054|Compound:5233173|FD-Score:4.36|P-value:1.86E-4 ID:SGTC_2090|Compound:5301565|FD-Score:8.31|P-value:5.10E-12 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.51|P-value:5.08E-8 ID:SGTC_2166|Compound:5933061|FD-Score:5.86|P-value:8.23E-7 ID:SGTC_2210|Compound:7115885|FD-Score:8.54|P-value:1.37E-12 ID:SGTC_2242|Compound:6630449|FD-Score:6.81|P-value:1.24E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.01|P-value:2.75E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.21|P-value:8.92E-12 ID:SGTC_2257|Compound:7960413|FD-Score:6.26|P-value:1.55E-7 ID:SGTC_2336|Compound:9001819|FD-Score:6.26|P-value:1.54E-7 ID:SGTC_2357|Compound:9067248|FD-Score:-3.96|P-value:5.36E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.77|P-value:4.97E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.49|P-value:4.54E-10 ID:SGTC_2431|Compound:5490079|FD-Score:4.64|P-value:7.42E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.89|P-value:3.19E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.94|P-value:6.45E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:9.27|P-value:1.66E-14 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.84|P-value:3.90E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.64|P-value:1.99E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.00|P-value:1.07E-19 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:2.66E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.05|P-value:4.77E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:15.80|P-value:1.67E-38 ID:SGTC_2694|Compound:st077685|FD-Score:7.76|P-value:1.06E-10 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.89|P-value:7.44E-4 ID:SGTC_2699|Compound:st077704|FD-Score:10.00|P-value:1.06E-16 ID:SGTC_2721|Compound:ifenprodil|FD-Score:7.88|P-value:5.65E-11 ID:SGTC_2725|Compound:haloperidol|FD-Score:8.36|P-value:3.87E-12 ID:SGTC_2733|Compound:amorolfine|FD-Score:5.32|P-value:6.82E-6 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.99|P-value:5.66E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.34|P-value:1.96E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.52|P-value:4.81E-8 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.17|P-value:1.21E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.56|P-value:2.74E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.90|P-value:3.14E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:6.56|P-value:4.04E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.05|P-value:2.28E-11 ID:SGTC_2790|Compound:5423970|FD-Score:12.60|P-value:2.73E-25 ID:SGTC_2816|Compound:7982706|FD-Score:4.00|P-value:5.53E-4 ID:SGTC_2838|Compound:9002687|FD-Score:6.97|P-value:5.85E-9 ID:SGTC_2865|Compound:9030313|FD-Score:4.81|P-value:4.27E-5 ID:SGTC_2873|Compound:9040596|FD-Score:7.79|P-value:8.97E-11 ID:SGTC_2880|Compound:9042983|FD-Score:10.40|P-value:6.19E-18 ID:SGTC_2887|Compound:9044784|FD-Score:13.30|P-value:7.72E-28 ID:SGTC_2893|Compound:9048488|FD-Score:6.80|P-value:1.36E-8 ID:SGTC_2896|Compound:9052656|FD-Score:4.57|P-value:9.52E-5 ID:SGTC_2904|Compound:7225135|FD-Score:-5.17|P-value:1.04E-5 ID:SGTC_2910|Compound:7948405|FD-Score:22.50|P-value:3.71E-76 ID:SGTC_2913|Compound:7966556|FD-Score:-4.79|P-value:3.93E-5 ID:SGTC_2925|Compound:9010536|FD-Score:7.41|P-value:6.75E-10 ID:SGTC_2938|Compound:9059746|FD-Score:14.50|P-value:6.68E-33 ID:SGTC_2948|Compound:9070189|FD-Score:8.86|P-value:2.02E-13 ID:SGTC_2965|Compound:9082772|FD-Score:12.50|P-value:8.88E-25 ID:SGTC_2974|Compound:9094440|FD-Score:5.04|P-value:1.95E-5 ID:SGTC_2993|Compound:9054257|FD-Score:8.28|P-value:6.33E-12 ID:SGTC_3018|Compound:9082602|FD-Score:11.90|P-value:1.18E-22 ID:SGTC_3044|Compound:9093193|FD-Score:-6.79|P-value:1.13E-8 ID:SGTC_3054|Compound:9094397|FD-Score:6.18|P-value:2.21E-7 ID:SGTC_3062|Compound:9077494|FD-Score:11.10|P-value:5.08E-20 ID:SGTC_3071|Compound:9117417|FD-Score:8.48|P-value:1.96E-12 ID:SGTC_3081|Compound:9117243|FD-Score:9.47|P-value:4.58E-15 ID:SGTC_3102|Compound:9121669|FD-Score:4.08|P-value:4.34E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.61|P-value:8.24E-5 ID:SGTC_3126|Compound:9127922|FD-Score:8.38|P-value:3.52E-12 ID:SGTC_3145|Compound:9085516|FD-Score:5.37|P-value:5.71E-6 ID:SGTC_3152|Compound:9099253|FD-Score:6.32|P-value:1.20E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-5.93|P-value:5.18E-7 ID:SGTC_3218|Compound:9131285|FD-Score:10.80|P-value:3.91E-19 ID:SGTC_3308|Compound:9128332|FD-Score:10.00|P-value:1.07E-16 ID:SGTC_3320|Compound:9137005|FD-Score:5.06|P-value:1.76E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.22|P-value:2.86E-4 ID:SGTC_3348|Compound:9149464|FD-Score:6.54|P-value:4.46E-8 ID:SGTC_3353|Compound:9151644|FD-Score:5.05|P-value:1.84E-5

Top fitness defect scores for YCR094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_637 1181-0519 25.70 7.3 µM 7.34E-99 fatty acid desaturase (OLE1) 2 5.75E-146
2 SGTC_2910 7948405 22.50 26.0 µM 3.71E-76 plasma membrane duress 1 3.03E-112
3 SGTC_137 0438-0332 22.40 85.4 µM 1.40E-75 ubiquinone biosynthesis & proteasome 3 2.17E-111
4 SGTC_1130 3454-2858 21.40 15.9 µM 3.02E-69 NEO1 4 5.56E-102
5 SGTC_1884 5633444 18.00 25.0 µM 1.84E-49 redox potentiating 3 1.34E-72
6 SGTC_439 amiodarone 16.50 34.4 µM 3.56E-42 NEO1-PIK1 3 8.77E-62
7 SGTC_2619 obliquin 15.80 87.9 µM 1.67E-38 cell wall 8 2.47E-56
8 SGTC_887 0885-0007 15.30 9.6 µM 2.91E-36 endomembrane recycling 3 5.25E-53
9 SGTC_788 1182-0090 15.30 188.0 µM 3.32E-36 endomembrane recycling 6 6.37E-53
10 SGTC_2938 9059746 14.50 27.3 µM 6.68E-33 fatty acid desaturase (OLE1) 2 5.10E-48
11 SGTC_181 1447-1644 13.40 8.1 µM 2.41E-28 endomembrane recycling 4 2.95E-41
12 SGTC_2887 9044784 13.30 58.4 µM 7.72E-28 fatty acid desaturase (OLE1) 3 1.66E-40
13 SGTC_1873 rapamycin 12.80 2.0 nM 6.41E-26 3 1.17E-37
14 SGTC_2790 5423970 12.60 71.4 µM 2.73E-25 endomembrane recycling 4 1.01E-36
15 SGTC_2965 9082772 12.50 38.6 µM 8.88E-25 mitochondrial response to ROS 1 5.77E-36
16 SGTC_172 1112-0046 12.40 2.6 µM 2.27E-24 NEO1 3 2.32E-35
17 SGTC_1672 st016598 12.20 6.5 µM 1.08E-23 endomembrane recycling 4 2.35E-34
18 SGTC_1353 1498-1206 12.10 8.1 µM 1.33E-23 mitochondrial response to ROS 1 3.19E-34
19 SGTC_142 0335-0849 12.10 62.7 µM 1.56E-23 ubiquinone biosynthesis & proteasome 22 4.06E-34
20 SGTC_3018 9082602 11.90 49.5 µM 1.18E-22 8 8.11E-33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.715 0 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.509 1.58E-220 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.492 1.53E-203 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.446 1.41E-163 YAL026C DRS2 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
0.415 1.38E-139 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.396 3.81E-126 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.382 5.68E-117 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.371 6.40E-110 YJR060W CBF1 hom Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress
0.346 4.97E-95 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.340 1.29E-91 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.328 1.43E-84 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.322 7.38E-82 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.316 3.30E-78 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.303 3.38E-72 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.298 1.19E-69 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene