YCR095C_p / OCA4

Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR095C / OCA4

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.33|P-value:1.19E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:8.51|P-value:7.53E-17 ID:SGTC_18|Compound:0111-0177|FD-Score:4.90|P-value:8.90E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:6.18|P-value:9.09E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:7.86|P-value:1.16E-14 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.74|P-value:1.77E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.49|P-value:4.66E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.57|P-value:3.25E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.70|P-value:1.02E-25 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.38|P-value:6.28E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.68|P-value:1.60E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.51|P-value:3.04E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.66|P-value:2.35E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.82|P-value:9.55E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.35|P-value:5.34E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.85|P-value:1.14E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:4.07|P-value:3.52E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.33|P-value:5.63E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.38|P-value:9.88E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:8.26|P-value:5.31E-16 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.39|P-value:4.61E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.51|P-value:5.59E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.99|P-value:5.94E-7 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.44|P-value:3.81E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.87|P-value:8.00E-5 ID:SGTC_1621|Compound:st003705|FD-Score:-3.31|P-value:7.89E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.31|P-value:7.93E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.38|P-value:4.81E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.79|P-value:1.44E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.27|P-value:1.55E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.36|P-value:1.05E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.76|P-value:1.74E-6 ID:SGTC_1801|Compound:st050089|FD-Score:4.18|P-value:2.30E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.18|P-value:9.54E-10 ID:SGTC_1818|Compound:st052136|FD-Score:3.39|P-value:4.53E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.24|P-value:1.77E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.31|P-value:6.03E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.85|P-value:8.38E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.29|P-value:6.54E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.18|P-value:9.16E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.49|P-value:5.92E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.65|P-value:4.27E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.78|P-value:1.59E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.39|P-value:6.10E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.04|P-value:4.02E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.24|P-value:7.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.38|P-value:6.27E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.32|P-value:7.77E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.56|P-value:2.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.28|P-value:1.40E-7 ID:SGTC_2699|Compound:st077704|FD-Score:3.28|P-value:6.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.13|P-value:2.79E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.47|P-value:3.45E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.20|P-value:8.84E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.47|P-value:6.51E-6 ID:SGTC_3048|Compound:9093155|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_3100|Compound:9120536|FD-Score:4.03|P-value:4.23E-5 ID:SGTC_3102|Compound:9121669|FD-Score:-3.27|P-value:9.17E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.72|P-value:1.41E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.47|P-value:3.44E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.33|P-value:1.19E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:8.51|P-value:7.53E-17 ID:SGTC_18|Compound:0111-0177|FD-Score:4.90|P-value:8.90E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:6.18|P-value:9.09E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:7.86|P-value:1.16E-14 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.74|P-value:1.77E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.49|P-value:4.66E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.57|P-value:3.25E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.70|P-value:1.02E-25 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.38|P-value:6.28E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.68|P-value:1.60E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.51|P-value:3.04E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.66|P-value:2.35E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.82|P-value:9.55E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.35|P-value:5.34E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.85|P-value:1.14E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:4.07|P-value:3.52E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.33|P-value:5.63E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.38|P-value:9.88E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:8.26|P-value:5.31E-16 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.39|P-value:4.61E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.51|P-value:5.59E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.99|P-value:5.94E-7 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.44|P-value:3.81E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.87|P-value:8.00E-5 ID:SGTC_1621|Compound:st003705|FD-Score:-3.31|P-value:7.89E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.31|P-value:7.93E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.38|P-value:4.81E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.79|P-value:1.44E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.27|P-value:1.55E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.36|P-value:1.05E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.76|P-value:1.74E-6 ID:SGTC_1801|Compound:st050089|FD-Score:4.18|P-value:2.30E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.18|P-value:9.54E-10 ID:SGTC_1818|Compound:st052136|FD-Score:3.39|P-value:4.53E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.24|P-value:1.77E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.31|P-value:6.03E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.85|P-value:8.38E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.29|P-value:6.54E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.18|P-value:9.16E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.49|P-value:5.92E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.65|P-value:4.27E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.78|P-value:1.59E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.39|P-value:6.10E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.04|P-value:4.02E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.24|P-value:7.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.38|P-value:6.27E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.32|P-value:7.77E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.56|P-value:2.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.28|P-value:1.40E-7 ID:SGTC_2699|Compound:st077704|FD-Score:3.28|P-value:6.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.13|P-value:2.79E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.47|P-value:3.45E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.20|P-value:8.84E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.47|P-value:6.51E-6 ID:SGTC_3048|Compound:9093155|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_3100|Compound:9120536|FD-Score:4.03|P-value:4.23E-5 ID:SGTC_3102|Compound:9121669|FD-Score:-3.27|P-value:9.17E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.72|P-value:1.41E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.47|P-value:3.44E-4

Top fitness defect scores for YCR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 10.70 10.3 µM 1.02E-25 NEO1-PIK1 50 3.14E-27
2 SGTC_8 0354-0001 8.51 70.0 µM 7.53E-17 7 9.04E-18
3 SGTC_1226 3909-7979 8.26 35.4 µM 5.31E-16 8 7.23E-17
4 SGTC_87 0100-0052 7.86 35.5 µM 1.16E-14 14 1.93E-15
5 SGTC_59 0330-0160 6.18 1.3 µM 9.09E-10 34 3.12E-10
6 SGTC_1803 st050068 6.18 52.4 µM 9.54E-10 NEO1-PIK1 77 3.29E-10
7 SGTC_146 3448-8650 5.49 53.1 µM 4.66E-8 NEO1-PIK1 61 2.05E-8
8 SGTC_2688 kanamycin b 5.28 96.7 µM 1.40E-7 calcium & mitochondrial duress 222 6.61E-8
9 SGTC_1497 4476-2978 4.99 41.3 µM 5.94E-7 3 3.06E-7
10 SGTC_18 0111-0177 4.90 500.0 nM 8.90E-7 40 4.69E-7
11 SGTC_637 1181-0519 4.85 7.3 µM 1.14E-6 fatty acid desaturase (OLE1) 69 6.08E-7
12 SGTC_2541 muurolladie-3-one 4.78 83.1 µM 1.59E-6 excess fatty acid 11 8.69E-7
13 SGTC_1754 st042065 4.76 16.1 µM 1.74E-6 NEO1-PIK1 138 9.56E-7
14 SGTC_1464 k208-0027 4.51 110.0 µM 5.59E-6 16 3.29E-6
15 SGTC_2249 haloperidol 4.49 116.4 µM 5.92E-6 ergosterol depletion effects on membrane 81 3.50E-6
16 SGTC_3017 9080681 4.47 49.5 µM 6.51E-6 10 3.87E-6
17 SGTC_1225 1216-0074 4.38 20.6 µM 9.88E-6 18 6.02E-6
18 SGTC_1712 st032288 4.36 53.4 µM 1.05E-5 calcium & mitochondrial duress 158 6.42E-6
19 SGTC_7 0192-1582 4.33 4.2 µM 1.19E-5 47 7.31E-6
20 SGTC_1644 st010134 4.27 20.9 µM 1.55E-5 mitochondrial processes 10 9.70E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.379 4.81E-115 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.369 1.50E-108 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.291 1.04E-66 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.280 1.71E-61 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.273 1.42E-58 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.269 7.15E-57 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.257 1.04E-51 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.254 2.12E-50 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.251 2.49E-49 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.251 4.72E-49 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.245 5.27E-47 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.244 8.44E-47 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.243 2.53E-46 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.232 2.93E-42 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.232 3.61E-42 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic