YCR095W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR095W-A / YCR095W-A

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.99|P-value:8.25E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.04|P-value:6.78E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.73|P-value:4.91E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.25|P-value:4.45E-6 ID:SGTC_707|Compound:0865-0008|FD-Score:3.25|P-value:3.53E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.08|P-value:6.02E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.60|P-value:7.74E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.32|P-value:2.38E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.31|P-value:2.73E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.17|P-value:4.67E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.07|P-value:6.87E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.32|P-value:2.43E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.13|P-value:5.48E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.52|P-value:1.06E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.44|P-value:1.62E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.04|P-value:6.83E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.64|P-value:7.11E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.15|P-value:5.01E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.16|P-value:4.40E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.82|P-value:2.99E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.39|P-value:2.04E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.78|P-value:3.90E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.70|P-value:5.61E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.39|P-value:2.29E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-4.45|P-value:1.43E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.67|P-value:6.30E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.14|P-value:5.27E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.25|P-value:3.52E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.31|P-value:3.37E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.87|P-value:2.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.99|P-value:8.15E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.86|P-value:1.89E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.16|P-value:4.38E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.85|P-value:2.93E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.92|P-value:1.89E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:6.44|P-value:7.99E-12 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.02|P-value:1.18E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.19|P-value:6.12E-6 ID:SGTC_3103|Compound:9120822|FD-Score:6.02|P-value:1.48E-10 ID:SGTC_3109|Compound:9122853|FD-Score:3.01|P-value:8.37E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.97|P-value:8.89E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.81|P-value:3.04E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-4.13|P-value:6.97E-6 ID:SGTC_3188|Compound:9110789|FD-Score:3.19|P-value:4.34E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.74|P-value:3.63E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.17|P-value:4.67E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.12|P-value:5.66E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.18|P-value:4.54E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.06|P-value:6.99E-4 ID:SGTC_3298|Compound:9116858|FD-Score:6.43|P-value:9.02E-12 ID:SGTC_3319|Compound:9138450|FD-Score:-3.19|P-value:3.93E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.33|P-value:2.99E-6 ID:SGTC_1|Compound:0258-0098|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.99|P-value:8.25E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.04|P-value:6.78E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.73|P-value:4.91E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.25|P-value:4.45E-6 ID:SGTC_707|Compound:0865-0008|FD-Score:3.25|P-value:3.53E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.08|P-value:6.02E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.60|P-value:7.74E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.32|P-value:2.38E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.31|P-value:2.73E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.17|P-value:4.67E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.07|P-value:6.87E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.32|P-value:2.43E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.13|P-value:5.48E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.52|P-value:1.06E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.44|P-value:1.62E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.04|P-value:6.83E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.64|P-value:7.11E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.15|P-value:5.01E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.16|P-value:4.40E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.82|P-value:2.99E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.39|P-value:2.04E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.78|P-value:3.90E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.70|P-value:5.61E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.39|P-value:2.29E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-4.45|P-value:1.43E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.67|P-value:6.30E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.14|P-value:5.27E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.25|P-value:3.52E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.31|P-value:3.37E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.87|P-value:2.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.99|P-value:8.15E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.86|P-value:1.89E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.16|P-value:4.38E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.85|P-value:2.93E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.92|P-value:1.89E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:6.44|P-value:7.99E-12 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.02|P-value:1.18E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.19|P-value:6.12E-6 ID:SGTC_3103|Compound:9120822|FD-Score:6.02|P-value:1.48E-10 ID:SGTC_3109|Compound:9122853|FD-Score:3.01|P-value:8.37E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.97|P-value:8.89E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.81|P-value:3.04E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-4.13|P-value:6.97E-6 ID:SGTC_3188|Compound:9110789|FD-Score:3.19|P-value:4.34E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.74|P-value:3.63E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.17|P-value:4.67E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.12|P-value:5.66E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.18|P-value:4.54E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.06|P-value:6.99E-4 ID:SGTC_3298|Compound:9116858|FD-Score:6.43|P-value:9.02E-12 ID:SGTC_3319|Compound:9138450|FD-Score:-3.19|P-value:3.93E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.33|P-value:2.99E-6

Top fitness defect scores for YCR095W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2749 bexarotene 6.44 57.4 µM 7.99E-12 2 5.88E-11
2 SGTC_3298 9116858 6.43 71.4 µM 9.02E-12 2 6.58E-11
3 SGTC_3103 9120822 6.02 49.5 µM 1.48E-10 2 8.50E-10
4 SGTC_2587 piperic acid 4.86 92.2 µM 1.89E-7 7 5.88E-7
5 SGTC_3191 9110352 4.74 49.5 µM 3.63E-7 2 1.07E-6
6 SGTC_2426 5582046 4.39 32.2 µM 2.29E-6 17 5.78E-6
7 SGTC_3326 9140064 4.33 16.4 µM 2.99E-6 15 7.37E-6
8 SGTC_2511 berberine 4.31 10.5 µM 3.37E-6 60S ribosome export 15 8.24E-6
9 SGTC_651 3253-0966 4.25 34.4 µM 4.45E-6 calcium & mitochondrial duress 25 1.06E-5
10 SGTC_3077 9117319 4.19 49.5 µM 6.12E-6 16 1.42E-5
11 SGTC_2514 salinomycin 3.87 42.7 µM 2.62E-5 50 5.40E-5
12 SGTC_2646 retinol 3.85 96.8 µM 2.93E-5 13 5.98E-5
13 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.78 200.0 µM 3.90E-5 17 7.77E-5
14 SGTC_212 3807-4682 3.73 38.8 µM 4.91E-5 tubulin folding & SWR complex 81 9.60E-5
15 SGTC_2422 chlorphenesin carbamate 3.70 384.2 µM 5.61E-5 36 1.08E-4
16 SGTC_2436 5633522 3.67 8.1 µM 6.30E-5 23 1.21E-4
17 SGTC_1907 st060210 3.64 83.7 µM 7.11E-5 34 1.35E-4
18 SGTC_1245 0418-0076 3.49 17.2 µM 1.36E-4 ERG2 47 2.45E-4
19 SGTC_1695 st026914 3.44 34.5 µM 1.62E-4 34 2.87E-4
20 SGTC_2347 9049783 3.39 174.8 µM 2.04E-4 48 3.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.98E-11 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.110 2.00E-10 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.102 3.42E-9 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.101 4.91E-9 YDL098C SNU23 het Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
0.098 1.32E-8 YGL228W SHE10 hom Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
0.086 5.57E-7 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.086 6.09E-7 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.083 1.55E-6 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.083 1.58E-6 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.082 2.25E-6 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.081 2.50E-6 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.081 2.94E-6 YBR121C GRS1 het Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
0.079 4.30E-6 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.076 9.93E-6 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.076 1.08E-5 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data