YCR098C / GIT1

Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR098C / GIT1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:-3.95|P-value:3.83E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:4.51|P-value:3.77E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.80|P-value:4.17E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:7.58|P-value:2.38E-14 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.49|P-value:2.34E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.81|P-value:7.88E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:4.68|P-value:1.71E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.55|P-value:2.16E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.66|P-value:1.44E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.82|P-value:6.45E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:6.74|P-value:1.10E-11 ID:SGTC_839|Compound:0122-0028|FD-Score:5.15|P-value:1.61E-7 ID:SGTC_940|Compound:3232-1287|FD-Score:3.23|P-value:6.84E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.81|P-value:7.76E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.22|P-value:6.26E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.96|P-value:4.16E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:3.90|P-value:5.58E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.20|P-value:7.64E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.03|P-value:3.19E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:6.10|P-value:6.77E-10 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.42|P-value:3.46E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.46|P-value:3.02E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.78|P-value:8.92E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.56|P-value:3.05E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.76|P-value:9.76E-5 ID:SGTC_1647|Compound:st011722|FD-Score:4.66|P-value:1.89E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:6.62|P-value:2.45E-11 ID:SGTC_1696|Compound:st025591|FD-Score:3.93|P-value:4.85E-5 ID:SGTC_1773|Compound:st048542|FD-Score:4.15|P-value:1.95E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.17|P-value:1.45E-7 ID:SGTC_1795|Compound:st049545|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.69|P-value:1.59E-6 ID:SGTC_2058|Compound:5236698|FD-Score:4.72|P-value:1.38E-6 ID:SGTC_2085|Compound:5307070|FD-Score:5.15|P-value:1.58E-7 ID:SGTC_2109|Compound:5483026|FD-Score:3.12|P-value:9.89E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.97|P-value:4.20E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.05|P-value:2.91E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.18|P-value:1.68E-5 ID:SGTC_2295|Compound:7971645|FD-Score:5.05|P-value:2.66E-7 ID:SGTC_2296|Compound:7971656|FD-Score:-3.13|P-value:8.64E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.72|P-value:1.11E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.37|P-value:4.15E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.10|P-value:2.42E-5 ID:SGTC_2433|Compound:5607874|FD-Score:3.41|P-value:3.66E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.25|P-value:6.43E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.27|P-value:2.43E-13 ID:SGTC_2620|Compound:irigenin|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.34|P-value:4.07E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.35|P-value:4.48E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:4.28|P-value:1.09E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.52|P-value:2.11E-8 ID:SGTC_2789|Compound:5281112|FD-Score:5.55|P-value:1.75E-8 ID:SGTC_2818|Compound:7996756|FD-Score:3.35|P-value:4.57E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.52|P-value:3.60E-6 ID:SGTC_2908|Compound:7930301|FD-Score:4.60|P-value:2.45E-6 ID:SGTC_2947|Compound:9072639|FD-Score:4.45|P-value:5.00E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.27|P-value:1.14E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.67|P-value:1.39E-4 ID:SGTC_3116|Compound:9124943|FD-Score:5.40|P-value:4.04E-8 ID:SGTC_3204|Compound:9114183|FD-Score:-3.24|P-value:5.84E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-4.14|P-value:1.69E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.35|P-value:4.50E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.76|P-value:9.78E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.95|P-value:3.83E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:4.51|P-value:3.77E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.80|P-value:4.17E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:7.58|P-value:2.38E-14 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.49|P-value:2.34E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.81|P-value:7.88E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:4.68|P-value:1.71E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.55|P-value:2.16E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.66|P-value:1.44E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.82|P-value:6.45E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:6.74|P-value:1.10E-11 ID:SGTC_839|Compound:0122-0028|FD-Score:5.15|P-value:1.61E-7 ID:SGTC_940|Compound:3232-1287|FD-Score:3.23|P-value:6.84E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.81|P-value:7.76E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.22|P-value:6.26E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.96|P-value:4.16E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:3.90|P-value:5.58E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.20|P-value:7.64E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.03|P-value:3.19E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:6.10|P-value:6.77E-10 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.42|P-value:3.46E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.46|P-value:3.02E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.78|P-value:8.92E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.56|P-value:3.05E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.76|P-value:9.76E-5 ID:SGTC_1647|Compound:st011722|FD-Score:4.66|P-value:1.89E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:6.62|P-value:2.45E-11 ID:SGTC_1696|Compound:st025591|FD-Score:3.93|P-value:4.85E-5 ID:SGTC_1773|Compound:st048542|FD-Score:4.15|P-value:1.95E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.17|P-value:1.45E-7 ID:SGTC_1795|Compound:st049545|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.69|P-value:1.59E-6 ID:SGTC_2058|Compound:5236698|FD-Score:4.72|P-value:1.38E-6 ID:SGTC_2085|Compound:5307070|FD-Score:5.15|P-value:1.58E-7 ID:SGTC_2109|Compound:5483026|FD-Score:3.12|P-value:9.89E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.97|P-value:4.20E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.05|P-value:2.91E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.18|P-value:1.68E-5 ID:SGTC_2295|Compound:7971645|FD-Score:5.05|P-value:2.66E-7 ID:SGTC_2296|Compound:7971656|FD-Score:-3.13|P-value:8.64E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.72|P-value:1.11E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.37|P-value:4.15E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.10|P-value:2.42E-5 ID:SGTC_2433|Compound:5607874|FD-Score:3.41|P-value:3.66E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.25|P-value:6.43E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.27|P-value:2.43E-13 ID:SGTC_2620|Compound:irigenin|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.34|P-value:4.07E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.35|P-value:4.48E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:4.28|P-value:1.09E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.52|P-value:2.11E-8 ID:SGTC_2789|Compound:5281112|FD-Score:5.55|P-value:1.75E-8 ID:SGTC_2818|Compound:7996756|FD-Score:3.35|P-value:4.57E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.52|P-value:3.60E-6 ID:SGTC_2908|Compound:7930301|FD-Score:4.60|P-value:2.45E-6 ID:SGTC_2947|Compound:9072639|FD-Score:4.45|P-value:5.00E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.27|P-value:1.14E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.67|P-value:1.39E-4 ID:SGTC_3116|Compound:9124943|FD-Score:5.40|P-value:4.04E-8 ID:SGTC_3204|Compound:9114183|FD-Score:-3.24|P-value:5.84E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-4.14|P-value:1.69E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.35|P-value:4.50E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.76|P-value:9.78E-5

Top fitness defect scores for YCR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 7.58 9.0 µM 2.38E-14 cell wall 141 1.67E-14
2 SGTC_2619 obliquin 7.27 87.9 µM 2.43E-13 cell wall 53 1.74E-13
3 SGTC_789 1309-1135 6.74 70.6 µM 1.10E-11 ERG2 6 8.16E-12
4 SGTC_1680 diphenhydramine 6.62 100.0 µM 2.45E-11 NEO1 3 1.84E-11
5 SGTC_1321 1326-2144 6.10 215.0 µM 6.77E-10 1 5.25E-10
6 SGTC_56 0957-0365 5.80 83.2 µM 4.17E-9 Golgi 17 3.30E-9
7 SGTC_2789 5281112 5.55 71.4 µM 1.75E-8 9 1.41E-8
8 SGTC_2695 st077686 5.52 52.0 µM 2.11E-8 10 1.70E-8
9 SGTC_3116 9124943 5.40 49.5 µM 4.04E-8 5 3.27E-8
10 SGTC_1785 bathophenanthroline 5.17 24.0 µM 1.45E-7 heme requiring 18 1.19E-7
11 SGTC_2085 5307070 5.15 144.1 µM 1.58E-7 superoxide 9 1.30E-7
12 SGTC_839 0122-0028 5.15 230.0 µM 1.61E-7 RSC complex & mRNA processing 12 1.32E-7
13 SGTC_2295 7971645 5.05 200.0 µM 2.66E-7 10 2.19E-7
14 SGTC_1023 4482-3888 4.96 16.0 µM 4.16E-7 TSC3-RPN4 5 3.45E-7
15 SGTC_2058 5236698 4.72 133.0 µM 1.38E-6 15 1.16E-6
16 SGTC_1889 st059080 4.69 5.2 µM 1.59E-6 8 1.33E-6
17 SGTC_657 3534-0529 4.68 86.7 µM 1.71E-6 5 1.44E-6
18 SGTC_1647 st011722 4.66 22.4 µM 1.89E-6 5 1.60E-6
19 SGTC_2908 7930301 4.60 100.0 µM 2.45E-6 13 2.07E-6
20 SGTC_1517 deoxycholic acid methyl ester 4.56 49.2 µM 3.05E-6 2 2.59E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.80E-23 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.152 7.52E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.139 6.29E-16 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.135 5.12E-15 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.129 6.71E-14 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.128 1.23E-13 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.127 1.72E-13 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.127 1.95E-13 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.126 2.40E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.126 2.86E-13 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.121 1.86E-12 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.120 2.70E-12 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.117 9.02E-12 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 9.86E-12 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.116 1.35E-11 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly