HIPHOP chemogenomics database

YCR099C_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YCR099C / YCR099C

Click on Significant Values for Screen Details

Top fitness defect scores for YCR099C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1939	st074455	6.74	53.6 µM	1.72E-12		5	7.89E-12
2	SGTC_1942	st076330	5.97	65.2 µM	3.96E-10		4	1.20E-9
3	SGTC_2562	3',7'-dimethoxyflavone	5.74	64.9 µM	1.73E-9		6	4.73E-9
4	SGTC_139	0099-0334	5.32	718.6 µM	2.27E-8		9	5.14E-8
5	SGTC_2165	5727197	4.96	32.1 µM	1.77E-7		19	3.46E-7
6	SGTC_759	3486-0358	4.84	89.3 µM	3.44E-7		12	6.40E-7
7	SGTC_1701	st028638	4.74	40.4 µM	5.83E-7		5	1.05E-6
8	SGTC_2948	9070189	4.56	9.4 µM	1.53E-6	plasma membrane duress	37	2.57E-6
9	SGTC_366	0181-0206	4.39	4.3 µM	3.64E-6	Golgi	28	5.77E-6
10	SGTC_2532	xanthone	4.39	78.9 µM	3.64E-6		20	5.77E-6
11	SGTC_1275	0867-0008	4.36	21.1 µM	4.05E-6		9	6.36E-6
12	SGTC_403	arphamenine a	4.35	50.0 µM	4.42E-6	60S ribosome export	11	6.91E-6
13	SGTC_2550	chrysin dimethyl ether	4.20	71.9 µM	9.13E-6		8	1.36E-5
14	SGTC_612	0302-0167	4.04	22.4 µM	1.86E-5	copper-dependent oxidative stress	33	2.65E-5
15	SGTC_293	4049-0273	3.80	38.5 µM	5.41E-5		16	7.18E-5
16	SGTC_3098	9119039	3.78	49.5 µM	5.88E-5	Golgi	38	7.76E-5
17	SGTC_2350	9023895	3.78	38.9 µM	6.00E-5	ergosterol biosynthesis	35	7.91E-5
18	SGTC_761	k216-0224	3.78	480.0 µM	6.05E-5		23	7.97E-5
19	SGTC_2019	4016004	3.74	108.0 µM	7.00E-5		36	9.14E-5
20	SGTC_737	1950-0117	3.68	57.9 µM	9.18E-5		32	1.18E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.088	2.93E-7	YLR072W_p	YLR072W_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.084	9.96E-7	YLR262C-A	TMA7	hom	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.080	3.50E-6	YNR001C	CIT1	hom	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.080	3.51E-6	YPR115W	RGC1	hom	Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.079	5.29E-6	YCL033C	MXR2	hom	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.078	5.88E-6	YER049W	TPA1	hom	Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.078	6.03E-6	YDL201W	TRM8	hom	Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.076	1.13E-5	YGL084C	GUP1	hom	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
0.075	1.29E-5	YMR011W	HXT2	hom	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.073	2.20E-5	YNL159C	ASI2	hom	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
0.073	2.62E-5	YPL200W	CSM4	hom	Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
0.071	3.73E-5	YNR066C_p	YNR066C_p	hom	Putative membrane-localized protein of unknown function
0.069	6.63E-5	YMR128W	ECM16	het	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.067	9.28E-5	YML026C	RPS18B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.067	9.83E-5	YMR130W_p	YMR130W_p	hom	Putative protein of unknown function; YMR130W is not an essential gene