YCR099C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR099C / YCR099C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.33|P-value:3.62E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.32|P-value:2.27E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:3.27|P-value:4.58E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.27|P-value:4.56E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.80|P-value:5.41E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.56|P-value:1.51E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.39|P-value:3.64E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.35|P-value:4.42E-6 ID:SGTC_458|Compound:nppb|FD-Score:-2.98|P-value:5.72E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.17|P-value:6.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.04|P-value:1.86E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:3.43|P-value:2.47E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.68|P-value:9.18E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:4.84|P-value:3.44E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:3.78|P-value:6.05E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.38|P-value:3.06E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.98|P-value:8.32E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.93|P-value:1.06E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:-2.90|P-value:7.53E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-2.94|P-value:6.51E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.32|P-value:3.83E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.17|P-value:6.69E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.44|P-value:2.41E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.36|P-value:4.05E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.37|P-value:3.15E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.66|P-value:9.74E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.66|P-value:9.68E-5 ID:SGTC_1701|Compound:st028638|FD-Score:4.74|P-value:5.83E-7 ID:SGTC_1765|Compound:st044815|FD-Score:3.54|P-value:1.60E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.42|P-value:9.92E-5 ID:SGTC_1939|Compound:st074455|FD-Score:6.74|P-value:1.72E-12 ID:SGTC_1942|Compound:st076330|FD-Score:5.97|P-value:3.96E-10 ID:SGTC_1953|Compound:st076800|FD-Score:-5.16|P-value:1.50E-8 ID:SGTC_1982|Compound:st072467|FD-Score:3.56|P-value:1.48E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.74|P-value:7.00E-5 ID:SGTC_2165|Compound:5727197|FD-Score:4.96|P-value:1.77E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.78|P-value:6.00E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:4.39|P-value:3.64E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.58|P-value:5.20E-5 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.20|P-value:9.13E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.74|P-value:1.73E-9 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.30|P-value:4.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.09|P-value:3.78E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.29|P-value:4.24E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.12|P-value:8.14E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.59|P-value:1.32E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.56|P-value:1.53E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.49|P-value:1.96E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.78|P-value:5.88E-5 ID:SGTC_3246|Compound:9135460|FD-Score:3.32|P-value:3.76E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.33|P-value:3.62E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.32|P-value:2.27E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:3.27|P-value:4.58E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.27|P-value:4.56E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.80|P-value:5.41E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.56|P-value:1.51E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.39|P-value:3.64E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.35|P-value:4.42E-6 ID:SGTC_458|Compound:nppb|FD-Score:-2.98|P-value:5.72E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.17|P-value:6.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.04|P-value:1.86E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:3.43|P-value:2.47E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.68|P-value:9.18E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:4.84|P-value:3.44E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:3.78|P-value:6.05E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.38|P-value:3.06E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.98|P-value:8.32E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.93|P-value:1.06E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:-2.90|P-value:7.53E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-2.94|P-value:6.51E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.32|P-value:3.83E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.17|P-value:6.69E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.44|P-value:2.41E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.36|P-value:4.05E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.37|P-value:3.15E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.66|P-value:9.74E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.66|P-value:9.68E-5 ID:SGTC_1701|Compound:st028638|FD-Score:4.74|P-value:5.83E-7 ID:SGTC_1765|Compound:st044815|FD-Score:3.54|P-value:1.60E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.42|P-value:9.92E-5 ID:SGTC_1939|Compound:st074455|FD-Score:6.74|P-value:1.72E-12 ID:SGTC_1942|Compound:st076330|FD-Score:5.97|P-value:3.96E-10 ID:SGTC_1953|Compound:st076800|FD-Score:-5.16|P-value:1.50E-8 ID:SGTC_1982|Compound:st072467|FD-Score:3.56|P-value:1.48E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.74|P-value:7.00E-5 ID:SGTC_2165|Compound:5727197|FD-Score:4.96|P-value:1.77E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.78|P-value:6.00E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:4.39|P-value:3.64E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.58|P-value:5.20E-5 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.20|P-value:9.13E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.74|P-value:1.73E-9 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.30|P-value:4.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.09|P-value:3.78E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.29|P-value:4.24E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.12|P-value:8.14E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.59|P-value:1.32E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.56|P-value:1.53E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.49|P-value:1.96E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.78|P-value:5.88E-5 ID:SGTC_3246|Compound:9135460|FD-Score:3.32|P-value:3.76E-4

Top fitness defect scores for YCR099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1939 st074455 6.74 53.6 µM 1.72E-12 5 7.89E-12
2 SGTC_1942 st076330 5.97 65.2 µM 3.96E-10 4 1.20E-9
3 SGTC_2562 3',7'-dimethoxyflavone 5.74 64.9 µM 1.73E-9 6 4.73E-9
4 SGTC_139 0099-0334 5.32 718.6 µM 2.27E-8 9 5.14E-8
5 SGTC_2165 5727197 4.96 32.1 µM 1.77E-7 19 3.46E-7
6 SGTC_759 3486-0358 4.84 89.3 µM 3.44E-7 12 6.40E-7
7 SGTC_1701 st028638 4.74 40.4 µM 5.83E-7 5 1.05E-6
8 SGTC_2948 9070189 4.56 9.4 µM 1.53E-6 plasma membrane duress 37 2.57E-6
9 SGTC_366 0181-0206 4.39 4.3 µM 3.64E-6 Golgi 28 5.77E-6
10 SGTC_2532 xanthone 4.39 78.9 µM 3.64E-6 20 5.77E-6
11 SGTC_1275 0867-0008 4.36 21.1 µM 4.05E-6 9 6.36E-6
12 SGTC_403 arphamenine a 4.35 50.0 µM 4.42E-6 60S ribosome export 11 6.91E-6
13 SGTC_2550 chrysin dimethyl ether 4.20 71.9 µM 9.13E-6 8 1.36E-5
14 SGTC_612 0302-0167 4.04 22.4 µM 1.86E-5 copper-dependent oxidative stress 33 2.65E-5
15 SGTC_293 4049-0273 3.80 38.5 µM 5.41E-5 16 7.18E-5
16 SGTC_3098 9119039 3.78 49.5 µM 5.88E-5 Golgi 38 7.76E-5
17 SGTC_2350 9023895 3.78 38.9 µM 6.00E-5 ergosterol biosynthesis 35 7.91E-5
18 SGTC_761 k216-0224 3.78 480.0 µM 6.05E-5 23 7.97E-5
19 SGTC_2019 4016004 3.74 108.0 µM 7.00E-5 36 9.14E-5
20 SGTC_737 1950-0117 3.68 57.9 µM 9.18E-5 32 1.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 2.93E-7 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.084 9.96E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.080 3.50E-6 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.080 3.51E-6 YPR115W RGC1 hom Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.079 5.29E-6 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.078 5.88E-6 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.078 6.03E-6 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.076 1.13E-5 YGL084C GUP1 hom Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
0.075 1.29E-5 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.073 2.20E-5 YNL159C ASI2 hom Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
0.073 2.62E-5 YPL200W CSM4 hom Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
0.071 3.73E-5 YNR066C_p YNR066C_p hom Putative membrane-localized protein of unknown function
0.069 6.63E-5 YMR128W ECM16 het Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.067 9.28E-5 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.067 9.83E-5 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene