YCR100C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR100C / YCR100C

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-3.49|P-value:4.44E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:-3.46|P-value:4.93E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.80|P-value:3.64E-6 ID:SGTC_107|Compound:0358-0022|FD-Score:3.94|P-value:1.18E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.48|P-value:1.45E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.59|P-value:4.13E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.37|P-value:8.60E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.30|P-value:8.33E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.56|P-value:4.58E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:4.99|P-value:1.55E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:3.59|P-value:4.15E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.65|P-value:3.30E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.87|P-value:1.56E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.35|P-value:8.94E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.86|P-value:2.75E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.34|P-value:7.44E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.45|P-value:1.76E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.35|P-value:8.94E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.59|P-value:4.12E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.40|P-value:1.45E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.19|P-value:4.56E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.46|P-value:6.34E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.48|P-value:6.02E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.42|P-value:7.35E-4 ID:SGTC_1627|Compound:st003713|FD-Score:10.40|P-value:6.94E-23 ID:SGTC_1633|Compound:st005664|FD-Score:3.73|P-value:2.58E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.54|P-value:4.86E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.30|P-value:3.65E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.05|P-value:7.88E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.49|P-value:5.85E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.41|P-value:7.56E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.41|P-value:7.60E-4 ID:SGTC_1937|Compound:st074714|FD-Score:6.57|P-value:3.86E-10 ID:SGTC_2144|Compound:5628481|FD-Score:3.98|P-value:1.01E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.37|P-value:8.64E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.88|P-value:1.48E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.63|P-value:2.74E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.48|P-value:4.71E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.33|P-value:9.61E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.35|P-value:9.09E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.58|P-value:4.19E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.67|P-value:3.12E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.49|P-value:4.44E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:-3.46|P-value:4.93E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.80|P-value:3.64E-6 ID:SGTC_107|Compound:0358-0022|FD-Score:3.94|P-value:1.18E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.48|P-value:1.45E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.59|P-value:4.13E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.37|P-value:8.60E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.30|P-value:8.33E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.56|P-value:4.58E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:4.99|P-value:1.55E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:3.59|P-value:4.15E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.65|P-value:3.30E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.87|P-value:1.56E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.35|P-value:8.94E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.86|P-value:2.75E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.34|P-value:7.44E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.45|P-value:1.76E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.35|P-value:8.94E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.59|P-value:4.12E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.40|P-value:1.45E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.19|P-value:4.56E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.46|P-value:6.34E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.48|P-value:6.02E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.42|P-value:7.35E-4 ID:SGTC_1627|Compound:st003713|FD-Score:10.40|P-value:6.94E-23 ID:SGTC_1633|Compound:st005664|FD-Score:3.73|P-value:2.58E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.54|P-value:4.86E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.30|P-value:3.65E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.05|P-value:7.88E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.49|P-value:5.85E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.41|P-value:7.56E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.41|P-value:7.60E-4 ID:SGTC_1937|Compound:st074714|FD-Score:6.57|P-value:3.86E-10 ID:SGTC_2144|Compound:5628481|FD-Score:3.98|P-value:1.01E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.37|P-value:8.64E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.88|P-value:1.48E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.63|P-value:2.74E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.48|P-value:4.71E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.33|P-value:9.61E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.35|P-value:9.09E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.58|P-value:4.19E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.67|P-value:3.12E-4

Top fitness defect scores for YCR100C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1627 st003713 10.40 25.6 µM 6.94E-23 calcium & mitochondrial duress 6 9.71E-26
2 SGTC_1937 st074714 6.57 47.2 µM 3.86E-10 12 2.52E-11
3 SGTC_1178 0988-0033 5.45 191.0 µM 1.76E-7 9 2.56E-8
4 SGTC_1775 st081588 5.30 35.2 µM 3.65E-7 60S ribosome export 10 5.85E-8
5 SGTC_765 1319-0117 4.99 244.0 µM 1.55E-6 60S ribosome export 3 3.01E-7
6 SGTC_958 1222-0007 4.86 33.0 µM 2.75E-6 14 5.74E-7
7 SGTC_100 0086-0128 4.80 49.6 µM 3.64E-6 copper-dependent oxidative stress 26 7.88E-7
8 SGTC_136 0097-0015 4.48 404.5 µM 1.45E-5 60S ribosome export 8 3.76E-6
9 SGTC_1334 1486-0610 4.19 236.0 µM 4.56E-5 60S ribosome export 11 1.37E-5
10 SGTC_1785 bathophenanthroline 4.05 24.0 µM 7.88E-5 heme requiring 44 2.55E-5
11 SGTC_2144 5628481 3.98 200.0 µM 1.01E-4 ERG2 22 3.38E-5
12 SGTC_107 0358-0022 3.94 2.7 µM 1.18E-4 SWF1 & branched chain AA biosynthesis 28 4.02E-5
13 SGTC_2689 tacrolimus 3.88 100.0 µM 1.48E-4 49 5.20E-5
14 SGTC_810 3825-7150 3.87 143.0 µM 1.56E-4 60S ribosome export 11 5.53E-5
15 SGTC_1633 st005664 3.73 67.9 µM 2.58E-4 37 9.75E-5
16 SGTC_3340 9146634 3.67 11.1 µM 3.12E-4 19 1.21E-4
17 SGTC_793 0488-0545 3.65 106.0 µM 3.30E-4 20 1.29E-4
18 SGTC_1255 0566-0045 3.59 221.0 µM 4.12E-4 excess fatty acid 41 1.65E-4
19 SGTC_191 3914-0123 3.59 66.5 µM 4.13E-4 60S ribosome export 2 1.66E-4
20 SGTC_785 1270-0111 3.59 65.3 µM 4.15E-4 41 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.08E-10 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.108 3.65E-10 YOR201C MRM1 hom Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
0.091 1.12E-7 YPL097W MSY1 hom Mitochondrial tyrosyl-tRNA synthetase
0.088 3.40E-7 YBR300C_d YBR300C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
0.088 3.65E-7 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.081 2.38E-6 YDL104C QRI7 hom Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
0.081 2.82E-6 YCL010C SGF29 hom Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation
0.080 3.17E-6 YMR177W MMT1 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
0.079 5.05E-6 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.079 5.28E-6 YLR139C SLS1 hom Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.074 1.61E-5 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.074 1.88E-5 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.073 2.45E-5 YLR422W_p YLR422W_p hom Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
0.072 3.02E-5 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.072 3.10E-5 YCL047C POF1 hom ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p