YCR101C_p

Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR101C / YCR101C

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.45|P-value:2.99E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.84|P-value:6.52E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.32|P-value:4.65E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.39|P-value:3.63E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.08|P-value:2.44E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.50|P-value:2.46E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.77|P-value:8.46E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:4.32|P-value:8.36E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:3.88|P-value:5.66E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.69|P-value:1.18E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:6.18|P-value:3.67E-10 ID:SGTC_850|Compound:0388-0143|FD-Score:5.70|P-value:6.73E-9 ID:SGTC_942|Compound:3253-1115|FD-Score:7.41|P-value:7.75E-14 ID:SGTC_989|Compound:1501-0895|FD-Score:3.87|P-value:5.89E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.88|P-value:5.61E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.96|P-value:4.02E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.13|P-value:1.89E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.57|P-value:2.66E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.28|P-value:5.43E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.40|P-value:3.48E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.28|P-value:5.50E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-4.06|P-value:2.58E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.49|P-value:3.93E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.92|P-value:4.65E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.44|P-value:3.02E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.13|P-value:9.05E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.04|P-value:2.81E-5 ID:SGTC_2268|Compound:7933382|FD-Score:6.30|P-value:1.73E-10 ID:SGTC_2279|Compound:7948423|FD-Score:5.55|P-value:1.60E-8 ID:SGTC_2307|Compound:7538926|FD-Score:-3.74|P-value:9.72E-5 ID:SGTC_2315|Compound:7733312|FD-Score:12.00|P-value:5.20E-33 ID:SGTC_2322|Compound:7413319|FD-Score:4.76|P-value:1.08E-6 ID:SGTC_2366|Compound:9070441|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.24|P-value:6.29E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-7.26|P-value:2.38E-13 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.99|P-value:3.46E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.61|P-value:1.62E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.33|P-value:4.51E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.29|P-value:5.33E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.36|P-value:4.14E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.34|P-value:4.32E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.49|P-value:2.58E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.04|P-value:2.90E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.14|P-value:1.85E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.20|P-value:7.09E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.39|P-value:6.22E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-4.66|P-value:1.70E-6 ID:SGTC_3312|Compound:9133330|FD-Score:3.56|P-value:1.98E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.26|P-value:5.74E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.45|P-value:2.99E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.84|P-value:6.52E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.32|P-value:4.65E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.39|P-value:3.63E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.08|P-value:2.44E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.50|P-value:2.46E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.77|P-value:8.46E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:4.32|P-value:8.36E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:3.88|P-value:5.66E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.69|P-value:1.18E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:6.18|P-value:3.67E-10 ID:SGTC_850|Compound:0388-0143|FD-Score:5.70|P-value:6.73E-9 ID:SGTC_942|Compound:3253-1115|FD-Score:7.41|P-value:7.75E-14 ID:SGTC_989|Compound:1501-0895|FD-Score:3.87|P-value:5.89E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.88|P-value:5.61E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.96|P-value:4.02E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.13|P-value:1.89E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.57|P-value:2.66E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.28|P-value:5.43E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.40|P-value:3.48E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.28|P-value:5.50E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-4.06|P-value:2.58E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.49|P-value:3.93E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.92|P-value:4.65E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.44|P-value:3.02E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.13|P-value:9.05E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.04|P-value:2.81E-5 ID:SGTC_2268|Compound:7933382|FD-Score:6.30|P-value:1.73E-10 ID:SGTC_2279|Compound:7948423|FD-Score:5.55|P-value:1.60E-8 ID:SGTC_2307|Compound:7538926|FD-Score:-3.74|P-value:9.72E-5 ID:SGTC_2315|Compound:7733312|FD-Score:12.00|P-value:5.20E-33 ID:SGTC_2322|Compound:7413319|FD-Score:4.76|P-value:1.08E-6 ID:SGTC_2366|Compound:9070441|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.24|P-value:6.29E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-7.26|P-value:2.38E-13 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.99|P-value:3.46E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.61|P-value:1.62E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.33|P-value:4.51E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.29|P-value:5.33E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.36|P-value:4.14E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.34|P-value:4.32E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.49|P-value:2.58E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.04|P-value:2.90E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.14|P-value:1.85E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.20|P-value:7.09E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.39|P-value:6.22E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-4.66|P-value:1.70E-6 ID:SGTC_3312|Compound:9133330|FD-Score:3.56|P-value:1.98E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.26|P-value:5.74E-4

Top fitness defect scores for YCR101C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2315 7733312 12.00 200.0 µM 5.20E-33 1 3.06E-33
2 SGTC_942 3253-1115 7.41 227.0 µM 7.75E-14 3 6.29E-14
3 SGTC_2268 7933382 6.30 153.8 µM 1.73E-10 7 1.49E-10
4 SGTC_814 3342-0569 6.18 96.0 µM 3.67E-10 3 3.17E-10
5 SGTC_850 0388-0143 5.70 75.9 µM 6.73E-9 1 5.93E-9
6 SGTC_2279 7948423 5.55 32.9 µM 1.60E-8 3 1.42E-8
7 SGTC_2322 7413319 4.76 38.2 µM 1.08E-6 ERAD & cell cycle 110 9.89E-7
8 SGTC_1240 0356-0016 4.57 42.1 µM 2.66E-6 mitochondrial response to ROS 24 2.45E-6
9 SGTC_1819 st053448 4.49 58.6 µM 3.93E-6 amide catabolism 10 3.63E-6
10 SGTC_3013 9080133 4.39 71.4 µM 6.22E-6 13 5.76E-6
11 SGTC_623 k072-0108 4.32 16.9 µM 8.36E-6 heme biosynthesis & mitochondrial translocase 8 7.76E-6
12 SGTC_3000 9075062 4.14 71.4 µM 1.85E-5 13 1.73E-5
13 SGTC_571 k831-0106 4.08 44.2 µM 2.44E-5 11 2.29E-5
14 SGTC_2208 7283366 4.04 200.0 µM 2.81E-5 9 2.63E-5
15 SGTC_2939 9044578 4.04 71.4 µM 2.90E-5 35 2.72E-5
16 SGTC_1194 1488-0194 3.96 225.0 µM 4.02E-5 30 3.77E-5
17 SGTC_1928 4'-methoxychalcone 3.92 40.3 µM 4.65E-5 12 4.37E-5
18 SGTC_1035 k081-0041 3.88 55.2 µM 5.61E-5 Golgi 22 5.27E-5
19 SGTC_695 3505-6186 3.88 243.0 µM 5.66E-5 25 5.33E-5
20 SGTC_989 1501-0895 3.87 10.3 µM 5.89E-5 10 5.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.07E-9 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.100 5.88E-9 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.094 4.54E-8 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.084 9.63E-7 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.083 1.33E-6 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.080 3.87E-6 YJL066C MPM1 hom Mitochondrial intermembrane space protein of unknown function
0.080 3.96E-6 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.078 5.47E-6 YKL027W YKL027W hom Protein of unknown function, localized to the mitochondrial outer membrane
0.078 6.52E-6 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.075 1.31E-5 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.075 1.31E-5 YKR013W PRY2 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
0.075 1.42E-5 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.074 1.76E-5 YGL171W ROK1 het RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
0.073 2.08E-5 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.070 5.06E-5 YNL196C_p SLZ1_p hom Sporulation-specific protein with a leucine zipper motif