YCR102C_p

Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR102C / YCR102C

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:3.77|P-value:7.94E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.35|P-value:3.91E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.77|P-value:7.93E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.39|P-value:3.34E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.56|P-value:1.77E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.29|P-value:4.79E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.29|P-value:4.90E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.31|P-value:4.59E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:4.22|P-value:1.16E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.39|P-value:3.33E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.20|P-value:1.24E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.13|P-value:8.67E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.39|P-value:3.35E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.50|P-value:2.23E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.33|P-value:6.82E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:3.14|P-value:8.21E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.25|P-value:5.57E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.14|P-value:1.66E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.37|P-value:3.60E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.48|P-value:2.43E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.15|P-value:7.97E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.31|P-value:1.26E-10 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.17|P-value:7.55E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.09|P-value:9.73E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.88|P-value:4.95E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.10|P-value:9.45E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.37|P-value:5.98E-6 ID:SGTC_1685|Compound:st024049|FD-Score:4.42|P-value:4.75E-6 ID:SGTC_1720|Compound:st037298|FD-Score:3.98|P-value:3.30E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.92|P-value:3.95E-7 ID:SGTC_1812|Compound:st052057|FD-Score:4.35|P-value:6.43E-6 ID:SGTC_1852|Compound:st056254|FD-Score:3.22|P-value:6.23E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.66|P-value:1.19E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.59|P-value:2.03E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-5.80|P-value:2.80E-9 ID:SGTC_2010|Compound:4012422|FD-Score:4.45|P-value:4.01E-6 ID:SGTC_2044|Compound:5102272|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.53|P-value:2.01E-4 ID:SGTC_2136|Compound:5328288|FD-Score:5.36|P-value:3.73E-8 ID:SGTC_2185|Compound:6113692|FD-Score:-3.96|P-value:3.48E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.64|P-value:1.30E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.84|P-value:5.84E-5 ID:SGTC_2268|Compound:7933382|FD-Score:4.45|P-value:4.07E-6 ID:SGTC_2269|Compound:7935389|FD-Score:3.44|P-value:2.81E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.45|P-value:2.75E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.11|P-value:9.20E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.26|P-value:5.44E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.59|P-value:1.60E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.88|P-value:4.90E-7 ID:SGTC_2412|Compound:st077135|FD-Score:5.42|P-value:2.75E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.70|P-value:1.04E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.02|P-value:2.76E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.41|P-value:3.02E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.89|P-value:4.59E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.14|P-value:1.65E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.21|P-value:8.50E-8 ID:SGTC_2813|Compound:7971799|FD-Score:3.36|P-value:3.84E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.54|P-value:1.91E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_3026|Compound:9090633|FD-Score:5.23|P-value:7.67E-8 ID:SGTC_3048|Compound:9093155|FD-Score:3.94|P-value:3.88E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.32|P-value:4.35E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.16|P-value:1.12E-7 ID:SGTC_3204|Compound:9114183|FD-Score:7.04|P-value:7.98E-13 ID:SGTC_3269|Compound:9137823|FD-Score:3.20|P-value:6.71E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.17|P-value:7.37E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:3.77|P-value:7.94E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.35|P-value:3.91E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.77|P-value:7.93E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.39|P-value:3.34E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.56|P-value:1.77E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.29|P-value:4.79E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.29|P-value:4.90E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.31|P-value:4.59E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:4.22|P-value:1.16E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.39|P-value:3.33E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.20|P-value:1.24E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.13|P-value:8.67E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.39|P-value:3.35E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.50|P-value:2.23E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.33|P-value:6.82E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:3.14|P-value:8.21E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.25|P-value:5.57E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.14|P-value:1.66E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.37|P-value:3.60E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.48|P-value:2.43E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.15|P-value:7.97E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.31|P-value:1.26E-10 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.17|P-value:7.55E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.09|P-value:9.73E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.88|P-value:4.95E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.10|P-value:9.45E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.37|P-value:5.98E-6 ID:SGTC_1685|Compound:st024049|FD-Score:4.42|P-value:4.75E-6 ID:SGTC_1720|Compound:st037298|FD-Score:3.98|P-value:3.30E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.92|P-value:3.95E-7 ID:SGTC_1812|Compound:st052057|FD-Score:4.35|P-value:6.43E-6 ID:SGTC_1852|Compound:st056254|FD-Score:3.22|P-value:6.23E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.66|P-value:1.19E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.59|P-value:2.03E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-5.80|P-value:2.80E-9 ID:SGTC_2010|Compound:4012422|FD-Score:4.45|P-value:4.01E-6 ID:SGTC_2044|Compound:5102272|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.53|P-value:2.01E-4 ID:SGTC_2136|Compound:5328288|FD-Score:5.36|P-value:3.73E-8 ID:SGTC_2185|Compound:6113692|FD-Score:-3.96|P-value:3.48E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.64|P-value:1.30E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.84|P-value:5.84E-5 ID:SGTC_2268|Compound:7933382|FD-Score:4.45|P-value:4.07E-6 ID:SGTC_2269|Compound:7935389|FD-Score:3.44|P-value:2.81E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.45|P-value:2.75E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.11|P-value:9.20E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.26|P-value:5.44E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.59|P-value:1.60E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.88|P-value:4.90E-7 ID:SGTC_2412|Compound:st077135|FD-Score:5.42|P-value:2.75E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.70|P-value:1.04E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.02|P-value:2.76E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.41|P-value:3.02E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.89|P-value:4.59E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.14|P-value:1.65E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.21|P-value:8.50E-8 ID:SGTC_2813|Compound:7971799|FD-Score:3.36|P-value:3.84E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.54|P-value:1.91E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_3026|Compound:9090633|FD-Score:5.23|P-value:7.67E-8 ID:SGTC_3048|Compound:9093155|FD-Score:3.94|P-value:3.88E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.32|P-value:4.35E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.16|P-value:1.12E-7 ID:SGTC_3204|Compound:9114183|FD-Score:7.04|P-value:7.98E-13 ID:SGTC_3269|Compound:9137823|FD-Score:3.20|P-value:6.71E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.17|P-value:7.37E-4

Top fitness defect scores for YCR102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3204 9114183 7.04 49.5 µM 7.98E-13 5 9.43E-13
2 SGTC_1425 4048-4433 6.31 7.3 µM 1.26E-10 copper-dependent oxidative stress 6 1.44E-10
3 SGTC_2412 st077135 5.42 33.4 µM 2.75E-8 5 3.02E-8
4 SGTC_2136 5328288 5.36 199.3 µM 3.73E-8 4 4.08E-8
5 SGTC_3026 9090633 5.23 49.5 µM 7.67E-8 6 8.37E-8
6 SGTC_2684 capsaicin 5.21 100.0 µM 8.50E-8 8 9.26E-8
7 SGTC_3142 9086498 5.16 49.5 µM 1.12E-7 iron homeostasis 17 1.22E-7
8 SGTC_1787 fluconazole 4.92 80.0 µM 3.95E-7 iron homeostasis 11 4.26E-7
9 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.88 200.0 µM 4.90E-7 6 5.27E-7
10 SGTC_1999 st074831 4.59 12.5 µM 2.03E-6 plasma membrane duress 19 2.17E-6
11 SGTC_2010 4012422 4.45 159.0 µM 4.01E-6 12 4.25E-6
12 SGTC_2268 7933382 4.45 153.8 µM 4.07E-6 24 4.32E-6
13 SGTC_1685 st024049 4.42 53.1 µM 4.75E-6 TSC3-RPN4 8 5.04E-6
14 SGTC_1666 st014829 4.37 29.0 µM 5.98E-6 calcium & mitochondrial duress 21 6.33E-6
15 SGTC_1812 st052057 4.35 4.3 µM 6.43E-6 calcium & mitochondrial duress 16 6.80E-6
16 SGTC_598 3937-0236 4.22 20.2 µM 1.16E-5 ERG2 16 1.22E-5
17 SGTC_607 4491-0986 4.20 66.8 µM 1.24E-5 heme requiring 23 1.31E-5
18 SGTC_2626 ethyl orsellinate 4.14 100.0 µM 1.65E-5 29 1.74E-5
19 SGTC_920 mycophenolic acid 4.14 780.4 nM 1.66E-5 23 1.75E-5
20 SGTC_2574 2',4'-dihydroxychalcone 4.02 14.6 µM 2.76E-5 20 2.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.22E-9 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.095 3.97E-8 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.094 5.45E-8 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.091 1.19E-7 YMR299C DYN3 hom Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
0.084 1.26E-6 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.078 6.43E-6 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.076 1.19E-5 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.075 1.29E-5 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.070 5.32E-5 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.069 6.00E-5 YNL116W DMA2 hom Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains
0.069 7.15E-5 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.067 1.10E-4 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.067 1.11E-4 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.066 1.21E-4 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.066 1.27E-4 YOL007C CSI2 hom Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene