YCR105W / ADH7

NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR105W / ADH7

Click on Significant Values for Screen Details ID:SGTC_170|Compound:4197-0004|FD-Score:3.90|P-value:1.92E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.24|P-value:9.17E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.65|P-value:4.26E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.89|P-value:2.04E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.64|P-value:1.15E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.89|P-value:2.02E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.68|P-value:1.03E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.45|P-value:2.58E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.18|P-value:7.15E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.43|P-value:9.10E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.48|P-value:7.78E-4 ID:SGTC_1830|Compound:st055982|FD-Score:4.27|P-value:5.10E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.50|P-value:7.26E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.23|P-value:6.05E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.41|P-value:9.58E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.68|P-value:4.07E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.41|P-value:9.81E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.54|P-value:6.50E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.58|P-value:1.54E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.96|P-value:1.57E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.37|P-value:3.29E-5 ID:SGTC_3298|Compound:9116858|FD-Score:6.83|P-value:2.51E-10 ID:SGTC_170|Compound:4197-0004|FD-Score:3.90|P-value:1.92E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.24|P-value:9.17E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.65|P-value:4.26E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.89|P-value:2.04E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.64|P-value:1.15E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.89|P-value:2.02E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.68|P-value:1.03E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.45|P-value:2.58E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.18|P-value:7.15E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.43|P-value:9.10E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.48|P-value:7.78E-4 ID:SGTC_1830|Compound:st055982|FD-Score:4.27|P-value:5.10E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.50|P-value:7.26E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.23|P-value:6.05E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.41|P-value:9.58E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.68|P-value:4.07E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.41|P-value:9.81E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.54|P-value:6.50E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.58|P-value:1.54E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.96|P-value:1.57E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.37|P-value:3.29E-5 ID:SGTC_3298|Compound:9116858|FD-Score:6.83|P-value:2.51E-10

Top fitness defect scores for YCR105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3298 9116858 6.83 71.4 µM 2.51E-10 1 4.16E-12
2 SGTC_171 k064-0041 5.24 9.7 µM 9.17E-7 heme requiring 12 7.86E-8
3 SGTC_1258 0671-0043 4.68 57.1 µM 1.03E-5 10 1.42E-6
4 SGTC_2816 7982706 4.58 58.4 µM 1.54E-5 azole & statin 35 2.30E-6
5 SGTC_1352 1496-0991 4.45 99.0 µM 2.58E-5 tubulin folding & SWR complex 24 4.28E-6
6 SGTC_1830 st055982 4.27 50.3 µM 5.10E-5 9 9.64E-6
7 SGTC_1842 st055362 4.23 61.2 µM 6.05E-5 10 1.18E-5
8 SGTC_1366 1683-0113 4.18 21.9 µM 7.15E-5 7 1.44E-5
9 SGTC_2975 9084847 3.96 53.7 µM 1.57E-4 22 3.69E-5
10 SGTC_170 4197-0004 3.90 226.0 µM 1.92E-4 19 4.72E-5
11 SGTC_1175 0741-0056 3.89 27.6 µM 2.02E-4 18 4.99E-5
12 SGTC_1065 prochlorperazine maleate 3.89 2.5 µM 2.04E-4 14 5.07E-5
13 SGTC_1917 st066507 3.68 28.5 µM 4.07E-4 Golgi 49 1.15E-4
14 SGTC_2564 betulinic acid 3.54 100.0 µM 6.50E-4 43 2.02E-4
15 SGTC_1836 st055642 3.50 81.0 µM 7.26E-4 33 2.30E-4
16 SGTC_1468 k284-1086 3.48 134.0 µM 7.78E-4 DNA intercalators 60 2.50E-4
17 SGTC_1395 3486-0190 3.43 4.3 µM 9.10E-4 28 3.01E-4
18 SGTC_1852 st056254 3.41 31.4 µM 9.58E-4 23 3.20E-4
19 SGTC_2405 ticlatone 3.41 3.5 µM 9.81E-4 92 3.29E-4
20 SGTC_726 3448-4391 3.37 34.2 µM 0.00110 34 3.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.04E-23 YOR284W HUA2 hom Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.153 5.56E-19 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.152 9.81E-19 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.150 2.12E-18 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.147 1.19E-17 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.140 3.91E-16 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.140 4.67E-16 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.137 1.78E-15 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.132 1.44E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.132 1.52E-14 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.131 2.74E-14 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.126 2.12E-13 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.125 3.37E-13 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.125 4.35E-13 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.117 9.26E-12 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene