YCR106W / RDS1

Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR106W / RDS1

Click on Significant Values for Screen Details ID:SGTC_268|Compound:camptothecin|FD-Score:4.20|P-value:4.60E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:3.40|P-value:1.64E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:2.97|P-value:8.60E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.39|P-value:6.69E-9 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.43|P-value:1.44E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.11|P-value:7.08E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:4.75|P-value:2.77E-7 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.49|P-value:1.35E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:7.29|P-value:8.01E-15 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.29|P-value:2.95E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.87|P-value:2.25E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.14|P-value:4.54E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.52|P-value:9.57E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:3.94|P-value:1.64E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:2.23E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.40|P-value:1.67E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.09|P-value:5.47E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.19|P-value:3.81E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.96|P-value:8.63E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.03|P-value:6.82E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.50|P-value:1.08E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.16|P-value:4.25E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.89|P-value:1.30E-7 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.01|P-value:7.31E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.18|P-value:2.43E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.88|P-value:2.87E-13 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.43|P-value:1.44E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.96|P-value:8.56E-8 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.21|P-value:3.50E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.94|P-value:9.51E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.01|P-value:7.20E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:2.94|P-value:9.37E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.93|P-value:9.75E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.25|P-value:2.98E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:2.99|P-value:7.87E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.28|P-value:2.61E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.14|P-value:4.49E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.60|P-value:1.77E-9 ID:SGTC_1618|Compound:st003135|FD-Score:5.01|P-value:6.48E-8 ID:SGTC_1632|Compound:st005650|FD-Score:3.30|P-value:2.44E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.68|P-value:5.08E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.40|P-value:1.92E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.22|P-value:4.28E-6 ID:SGTC_1738|Compound:st035555|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-4.14|P-value:7.58E-6 ID:SGTC_1799|Compound:st045822|FD-Score:3.06|P-value:6.17E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.57|P-value:8.14E-5 ID:SGTC_1893|Compound:st059353|FD-Score:2.93|P-value:9.87E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-4.33|P-value:3.01E-6 ID:SGTC_1910|Compound:st062352|FD-Score:4.01|P-value:1.17E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.14|P-value:4.46E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.67|P-value:5.45E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.50|P-value:1.11E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.83|P-value:2.23E-7 ID:SGTC_2375|Compound:9072683|FD-Score:3.09|P-value:5.46E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.21|P-value:4.46E-6 ID:SGTC_2389|Compound:9091542|FD-Score:3.63|P-value:6.25E-5 ID:SGTC_2413|Compound:inermin|FD-Score:6.39|P-value:8.44E-12 ID:SGTC_2438|Compound:5259590|FD-Score:5.65|P-value:1.32E-9 ID:SGTC_2444|Compound:5485484|FD-Score:4.06|P-value:9.38E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.97|P-value:1.41E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.13|P-value:4.76E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.83|P-value:2.69E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.69|P-value:4.88E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.62|P-value:5.61E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.08|P-value:5.60E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.07|P-value:5.92E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.10|P-value:5.18E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.32|P-value:2.31E-4 ID:SGTC_2954|Compound:9074818|FD-Score:2.99|P-value:7.98E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.02|P-value:6.95E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.02|P-value:7.08E-4 ID:SGTC_2995|Compound:9067767|FD-Score:4.91|P-value:1.13E-7 ID:SGTC_3223|Compound:9129970|FD-Score:3.77|P-value:3.42E-5 ID:SGTC_3234|Compound:9132280|FD-Score:-3.15|P-value:5.16E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.04|P-value:1.03E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.63|P-value:6.44E-5 ID:SGTC_3291|Compound:9121177|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.16|P-value:5.67E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:4.20|P-value:4.60E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:3.40|P-value:1.64E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:2.97|P-value:8.60E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.39|P-value:6.69E-9 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.43|P-value:1.44E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.11|P-value:7.08E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:4.75|P-value:2.77E-7 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.49|P-value:1.35E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:7.29|P-value:8.01E-15 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.29|P-value:2.95E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.87|P-value:2.25E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.14|P-value:4.54E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.52|P-value:9.57E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:3.94|P-value:1.64E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:2.23E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.40|P-value:1.67E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.09|P-value:5.47E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.19|P-value:3.81E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.96|P-value:8.63E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.03|P-value:6.82E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.50|P-value:1.08E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.16|P-value:4.25E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.89|P-value:1.30E-7 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.01|P-value:7.31E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.18|P-value:2.43E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.88|P-value:2.87E-13 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.43|P-value:1.44E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.96|P-value:8.56E-8 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.21|P-value:3.50E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.94|P-value:9.51E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.01|P-value:7.20E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:2.94|P-value:9.37E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.93|P-value:9.75E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.25|P-value:2.98E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:2.99|P-value:7.87E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.28|P-value:2.61E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.14|P-value:4.49E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.60|P-value:1.77E-9 ID:SGTC_1618|Compound:st003135|FD-Score:5.01|P-value:6.48E-8 ID:SGTC_1632|Compound:st005650|FD-Score:3.30|P-value:2.44E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.68|P-value:5.08E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.40|P-value:1.92E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.22|P-value:4.28E-6 ID:SGTC_1738|Compound:st035555|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-4.14|P-value:7.58E-6 ID:SGTC_1799|Compound:st045822|FD-Score:3.06|P-value:6.17E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.57|P-value:8.14E-5 ID:SGTC_1893|Compound:st059353|FD-Score:2.93|P-value:9.87E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-4.33|P-value:3.01E-6 ID:SGTC_1910|Compound:st062352|FD-Score:4.01|P-value:1.17E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.14|P-value:4.46E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.67|P-value:5.45E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.50|P-value:1.11E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.83|P-value:2.23E-7 ID:SGTC_2375|Compound:9072683|FD-Score:3.09|P-value:5.46E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.21|P-value:4.46E-6 ID:SGTC_2389|Compound:9091542|FD-Score:3.63|P-value:6.25E-5 ID:SGTC_2413|Compound:inermin|FD-Score:6.39|P-value:8.44E-12 ID:SGTC_2438|Compound:5259590|FD-Score:5.65|P-value:1.32E-9 ID:SGTC_2444|Compound:5485484|FD-Score:4.06|P-value:9.38E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.97|P-value:1.41E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.13|P-value:4.76E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.83|P-value:2.69E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.69|P-value:4.88E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.62|P-value:5.61E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.08|P-value:5.60E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.07|P-value:5.92E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.10|P-value:5.18E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.32|P-value:2.31E-4 ID:SGTC_2954|Compound:9074818|FD-Score:2.99|P-value:7.98E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.02|P-value:6.95E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.02|P-value:7.08E-4 ID:SGTC_2995|Compound:9067767|FD-Score:4.91|P-value:1.13E-7 ID:SGTC_3223|Compound:9129970|FD-Score:3.77|P-value:3.42E-5 ID:SGTC_3234|Compound:9132280|FD-Score:-3.15|P-value:5.16E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.04|P-value:1.03E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.63|P-value:6.44E-5 ID:SGTC_3291|Compound:9121177|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.16|P-value:5.67E-6

Top fitness defect scores for YCR106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_633 0437-0093 7.29 97.7 µM 8.01E-15 DNA intercalators 2 1.50E-13
2 SGTC_2413 inermin 6.39 26.1 µM 8.44E-12 15 8.26E-11
3 SGTC_2438 5259590 5.65 200.0 µM 1.32E-9 6 8.02E-9
4 SGTC_1604 st002052 5.60 72.4 µM 1.77E-9 TSC3-RPN4 7 1.05E-8
5 SGTC_403 arphamenine a 5.39 50.0 µM 6.69E-9 60S ribosome export 5 3.50E-8
6 SGTC_1103 duloxetine 5.18 36.1 µM 2.43E-8 6 1.13E-7
7 SGTC_1618 st003135 5.01 44.5 µM 6.48E-8 6 2.75E-7
8 SGTC_1123 mangostin 4.96 811.3 nM 8.56E-8 mitochondrial response to ROS 17 3.53E-7
9 SGTC_2995 9067767 4.91 71.4 µM 1.13E-7 11 4.53E-7
10 SGTC_1081 sertraline 4.89 6.0 µM 1.30E-7 60S ribosome export 18 5.16E-7
11 SGTC_619 1652-1634 4.75 108.0 µM 2.77E-7 PDR1 9 1.02E-6
12 SGTC_2770 toltrazuril 4.62 17.5 µM 5.61E-7 11 1.94E-6
13 SGTC_740 k014-0057 4.52 261.0 µM 9.57E-7 14 3.15E-6
14 SGTC_1676 st018489 4.22 23.4 µM 4.28E-6 60S ribosome export 26 1.23E-5
15 SGTC_2378 9074213 4.21 121.4 µM 4.46E-6 RSC complex & mRNA processing 12 1.27E-5
16 SGTC_268 camptothecin 4.20 39.6 µM 4.60E-6 DNA damage response 59 1.31E-5
17 SGTC_3329 9141233 4.16 27.6 µM 5.67E-6 12 1.58E-5
18 SGTC_594 1487-1584 4.11 10.8 µM 7.08E-6 20 1.94E-5
19 SGTC_2444 5485484 4.06 36.4 µM 9.38E-6 33 2.50E-5
20 SGTC_3235 9132602 4.04 49.5 µM 1.03E-5 23 2.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.58E-17 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.119 4.15E-12 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.117 8.63E-12 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.099 9.52E-9 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.098 1.16E-8 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.097 1.71E-8 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.097 1.91E-8 YPL264C_p YPL264C_p hom Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
0.096 2.73E-8 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.094 4.86E-8 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.091 1.24E-7 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.090 1.87E-7 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.090 1.92E-7 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.089 2.13E-7 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.089 2.16E-7 YBR058C UBP14 hom Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
0.089 2.59E-7 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin