YCR107W / AAD3

Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR107W / AAD3

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:4.15|P-value:6.54E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.65|P-value:3.82E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.88|P-value:3.03E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:3.60|P-value:4.62E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.55|P-value:5.34E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.54|P-value:5.58E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.44|P-value:7.61E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.68|P-value:3.49E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.24|P-value:4.76E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.92|P-value:1.52E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:5.19|P-value:8.60E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:3.43|P-value:7.83E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.82|P-value:2.20E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.83|P-value:2.11E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.21|P-value:5.30E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:-4.15|P-value:6.68E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.49|P-value:6.49E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-4.23|P-value:4.85E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.52|P-value:1.87E-7 ID:SGTC_1627|Compound:st003713|FD-Score:3.97|P-value:1.26E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.00|P-value:1.15E-4 ID:SGTC_1828|Compound:st055811|FD-Score:-3.72|P-value:3.05E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.96|P-value:2.03E-8 ID:SGTC_1896|Compound:st058441|FD-Score:4.82|P-value:4.50E-6 ID:SGTC_1905|Compound:st060207|FD-Score:-4.06|P-value:9.34E-5 ID:SGTC_1964|Compound:st076914|FD-Score:3.47|P-value:7.06E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-4.53|P-value:1.52E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-4.61|P-value:1.11E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.94|P-value:1.42E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.66|P-value:8.82E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.97|P-value:1.26E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.44|P-value:7.62E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.57|P-value:5.00E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.39|P-value:8.91E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.65|P-value:3.92E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.63|P-value:1.00E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.40|P-value:2.53E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.82|P-value:2.16E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.45|P-value:2.08E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.14|P-value:6.91E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.63|P-value:4.14E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.75|P-value:2.81E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.50|P-value:6.38E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.60|P-value:4.60E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.77|P-value:2.56E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.35|P-value:3.14E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.15|P-value:6.54E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.65|P-value:3.82E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.88|P-value:3.03E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:3.60|P-value:4.62E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.55|P-value:5.34E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.54|P-value:5.58E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.44|P-value:7.61E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.68|P-value:3.49E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.24|P-value:4.76E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.92|P-value:1.52E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:5.19|P-value:8.60E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:3.43|P-value:7.83E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.82|P-value:2.20E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.83|P-value:2.11E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.21|P-value:5.30E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:-4.15|P-value:6.68E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.49|P-value:6.49E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-4.23|P-value:4.85E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.52|P-value:1.87E-7 ID:SGTC_1627|Compound:st003713|FD-Score:3.97|P-value:1.26E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.00|P-value:1.15E-4 ID:SGTC_1828|Compound:st055811|FD-Score:-3.72|P-value:3.05E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.96|P-value:2.03E-8 ID:SGTC_1896|Compound:st058441|FD-Score:4.82|P-value:4.50E-6 ID:SGTC_1905|Compound:st060207|FD-Score:-4.06|P-value:9.34E-5 ID:SGTC_1964|Compound:st076914|FD-Score:3.47|P-value:7.06E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-4.53|P-value:1.52E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-4.61|P-value:1.11E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.94|P-value:1.42E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.66|P-value:8.82E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.97|P-value:1.26E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.44|P-value:7.62E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.57|P-value:5.00E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.39|P-value:8.91E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.65|P-value:3.92E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.63|P-value:1.00E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.40|P-value:2.53E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.82|P-value:2.16E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.45|P-value:2.08E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.14|P-value:6.91E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.63|P-value:4.14E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.75|P-value:2.81E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.50|P-value:6.38E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.60|P-value:4.60E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.77|P-value:2.56E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.35|P-value:3.14E-5

Top fitness defect scores for YCR107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1894 3',6'-dihydroxyflavone 5.96 78.7 µM 2.03E-8 2 1.26E-9
2 SGTC_163 1327-0036 5.88 7.5 µM 3.03E-8 51 2.02E-9
3 SGTC_1565 sinapyl alcohol 5.52 95.1 µM 1.87E-7 3 1.71E-8
4 SGTC_817 1391-0715 5.19 46.0 µM 8.60E-7 4 1.03E-7
5 SGTC_1896 st058441 4.82 89.0 µM 4.50E-6 4 7.12E-7
6 SGTC_2131 toluylene red 4.66 5.3 µM 8.82E-6 60S ribosome export 9 1.57E-6
7 SGTC_2435 5706476 4.63 10.6 µM 1.00E-5 17 1.82E-6
8 SGTC_2725 haloperidol 4.45 53.2 µM 2.08E-5 plasma membrane duress 27 4.29E-6
9 SGTC_2588 indole-3-carbinol 4.40 100.0 µM 2.53E-5 28 5.39E-6
10 SGTC_3351 9150312 4.35 21.6 µM 3.14E-5 cell wall 29 6.93E-6
11 SGTC_769 0302-0231 4.24 76.0 µM 4.76E-5 30 1.13E-5
12 SGTC_1414 3917-0015 4.21 5.4 µM 5.30E-5 7 1.28E-5
13 SGTC_77 0828-0286 4.15 12.5 µM 6.54E-5 TSC3-RPN4 31 1.64E-5
14 SGTC_2933 9026794 4.14 32.5 µM 6.91E-5 13 1.74E-5
15 SGTC_1792 st045773 4.00 43.6 µM 1.15E-4 25 3.18E-5
16 SGTC_2331 7980721 3.97 200.0 µM 1.26E-4 26 3.53E-5
17 SGTC_1627 st003713 3.97 25.6 µM 1.26E-4 calcium & mitochondrial duress 75 3.54E-5
18 SGTC_2088 5278280 3.94 127.4 µM 1.42E-4 23 4.06E-5
19 SGTC_814 3342-0569 3.92 96.0 µM 1.52E-4 20 4.39E-5
20 SGTC_1068 loratadine 3.83 26.9 µM 2.11E-4 28 6.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.04E-9 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.098 1.24E-8 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.095 3.14E-8 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.095 3.97E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.094 4.70E-8 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.091 1.50E-7 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.090 1.63E-7 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.088 3.37E-7 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.084 1.19E-6 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.081 3.04E-6 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.079 4.67E-6 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.079 5.03E-6 YLR452C SST2 hom GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
0.076 9.87E-6 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.076 1.03E-5 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.075 1.20E-5 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress