YDL002C / NHP10

Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL002C / NHP10

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.51|P-value:3.71E-10 ID:SGTC_12|Compound:0849-0099|FD-Score:4.53|P-value:9.00E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.50|P-value:4.65E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:9.88|P-value:4.48E-21 ID:SGTC_86|Compound:0417-1630|FD-Score:6.58|P-value:2.48E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.01|P-value:1.06E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.37|P-value:7.13E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.41|P-value:1.50E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.72|P-value:3.96E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:6.02|P-value:6.07E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.40|P-value:6.36E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.85|P-value:1.37E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.38|P-value:6.87E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.79|P-value:1.70E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.35|P-value:7.70E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:7.15|P-value:6.79E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:9.57|P-value:7.11E-20 ID:SGTC_455|Compound:paf C-16|FD-Score:6.42|P-value:6.29E-10 ID:SGTC_552|Compound:k242-0005|FD-Score:5.57|P-value:6.81E-8 ID:SGTC_589|Compound:1227-0070|FD-Score:5.77|P-value:2.38E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.48|P-value:5.02E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.11|P-value:6.68E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:4.76|P-value:3.41E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.32|P-value:8.29E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.57|P-value:3.63E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.76|P-value:1.90E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:5.31|P-value:2.50E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.67|P-value:2.58E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.14|P-value:5.77E-7 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.10|P-value:5.26E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.90|P-value:1.77E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.83|P-value:2.49E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.31|P-value:8.69E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.64|P-value:2.90E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-4.77|P-value:3.11E-6 ID:SGTC_1695|Compound:st026914|FD-Score:4.93|P-value:1.58E-6 ID:SGTC_1704|Compound:st028805|FD-Score:4.35|P-value:1.94E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.58|P-value:3.54E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.10|P-value:5.24E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.52|P-value:4.42E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.85|P-value:2.27E-6 ID:SGTC_2396|Compound:5342950|FD-Score:4.78|P-value:3.11E-6 ID:SGTC_2399|Compound:5884133|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.13|P-value:4.66E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.81|P-value:1.54E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.80|P-value:1.60E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-3.33|P-value:8.20E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.61|P-value:2.06E-10 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.34|P-value:7.96E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.61|P-value:6.50E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.41|P-value:6.28E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.83|P-value:1.45E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.42|P-value:7.91E-16 ID:SGTC_3126|Compound:9127922|FD-Score:4.24|P-value:2.98E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.52|P-value:4.35E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.96|P-value:8.99E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.55|P-value:3.98E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.67|P-value:5.07E-6 ID:SGTC_3301|Compound:9125354|FD-Score:4.46|P-value:1.23E-5 ID:SGTC_3305|Compound:9127027|FD-Score:-5.37|P-value:1.84E-7 ID:SGTC_3343|Compound:9148379|FD-Score:-3.45|P-value:5.54E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.61|P-value:3.23E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.51|P-value:3.71E-10 ID:SGTC_12|Compound:0849-0099|FD-Score:4.53|P-value:9.00E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.50|P-value:4.65E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:9.88|P-value:4.48E-21 ID:SGTC_86|Compound:0417-1630|FD-Score:6.58|P-value:2.48E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.01|P-value:1.06E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.37|P-value:7.13E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.41|P-value:1.50E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.72|P-value:3.96E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:6.02|P-value:6.07E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.40|P-value:6.36E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.85|P-value:1.37E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.38|P-value:6.87E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.79|P-value:1.70E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.35|P-value:7.70E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:7.15|P-value:6.79E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:9.57|P-value:7.11E-20 ID:SGTC_455|Compound:paf C-16|FD-Score:6.42|P-value:6.29E-10 ID:SGTC_552|Compound:k242-0005|FD-Score:5.57|P-value:6.81E-8 ID:SGTC_589|Compound:1227-0070|FD-Score:5.77|P-value:2.38E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.48|P-value:5.02E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.11|P-value:6.68E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:4.76|P-value:3.41E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.32|P-value:8.29E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.57|P-value:3.63E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.76|P-value:1.90E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:5.31|P-value:2.50E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.67|P-value:2.58E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.14|P-value:5.77E-7 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.10|P-value:5.26E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.90|P-value:1.77E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.83|P-value:2.49E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.31|P-value:8.69E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.64|P-value:2.90E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-4.77|P-value:3.11E-6 ID:SGTC_1695|Compound:st026914|FD-Score:4.93|P-value:1.58E-6 ID:SGTC_1704|Compound:st028805|FD-Score:4.35|P-value:1.94E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.58|P-value:3.54E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.10|P-value:5.24E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.52|P-value:4.42E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.85|P-value:2.27E-6 ID:SGTC_2396|Compound:5342950|FD-Score:4.78|P-value:3.11E-6 ID:SGTC_2399|Compound:5884133|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.13|P-value:4.66E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.81|P-value:1.54E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.80|P-value:1.60E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-3.33|P-value:8.20E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.61|P-value:2.06E-10 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.34|P-value:7.96E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.61|P-value:6.50E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.41|P-value:6.28E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.83|P-value:1.45E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.42|P-value:7.91E-16 ID:SGTC_3126|Compound:9127922|FD-Score:4.24|P-value:2.98E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.52|P-value:4.35E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.96|P-value:8.99E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.55|P-value:3.98E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.67|P-value:5.07E-6 ID:SGTC_3301|Compound:9125354|FD-Score:4.46|P-value:1.23E-5 ID:SGTC_3305|Compound:9127027|FD-Score:-5.37|P-value:1.84E-7 ID:SGTC_3343|Compound:9148379|FD-Score:-3.45|P-value:5.54E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.61|P-value:3.23E-4

Top fitness defect scores for YDL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 9.88 266.0 µM 4.48E-21 ubiquinone biosynthesis & proteasome 24 2.52E-23
2 SGTC_453 enantio-paf c16 9.57 10.0 µM 7.11E-20 7 5.51E-22
3 SGTC_435 c-PAF 7.15 6.7 µM 6.79E-12 4 4.39E-13
4 SGTC_2651 1327-0036 6.61 5.0 µM 2.06E-10 55 1.97E-11
5 SGTC_86 0417-1630 6.58 471.9 µM 2.48E-10 ubiquinone biosynthesis & proteasome 80 2.42E-11
6 SGTC_7 0192-1582 6.51 4.2 µM 3.71E-10 18 3.80E-11
7 SGTC_455 paf C-16 6.42 10.0 µM 6.29E-10 6 6.84E-11
8 SGTC_188 3229-0966 6.02 278.5 µM 6.07E-9 9 8.56E-10
9 SGTC_589 1227-0070 5.77 34.1 µM 2.38E-8 13 3.92E-9
10 SGTC_552 k242-0005 5.57 476.0 µM 6.81E-8 2 1.26E-8
11 SGTC_988 1497-1057 5.31 103.0 µM 2.50E-7 2 5.37E-8
12 SGTC_1045 1348-1485 5.14 165.0 µM 5.77E-7 10 1.36E-7
13 SGTC_682 0kpi-0099 5.11 17.0 µM 6.68E-7 36 1.61E-7
14 SGTC_87 0100-0052 5.01 35.5 µM 1.06E-6 52 2.69E-7
15 SGTC_1695 st026914 4.93 34.5 µM 1.58E-6 3 4.20E-7
16 SGTC_1250 0485-0349 4.90 40.2 µM 1.77E-6 12 4.76E-7
17 SGTC_2339 9000433 4.85 200.0 µM 2.27E-6 14 6.28E-7
18 SGTC_1264 0783-0040 4.83 158.0 µM 2.49E-6 9 6.95E-7
19 SGTC_2396 5342950 4.78 42.8 µM 3.11E-6 RSC complex & mRNA processing 26 8.89E-7
20 SGTC_765 1319-0117 4.76 244.0 µM 3.41E-6 60S ribosome export 4 9.85E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.290 3.92E-66 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.258 3.32E-52 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.256 2.04E-51 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.251 2.64E-49 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.250 3.65E-49 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.237 4.54E-44 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.236 1.10E-43 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.234 6.51E-43 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.231 6.98E-42 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.229 4.08E-41 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.225 6.40E-40 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.223 3.60E-39 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.221 3.19E-38 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.219 9.45E-38 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.217 5.87E-37 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene