YDL004W / ATP16

Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL004W / ATP16

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.79|P-value:7.88E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.41|P-value:4.64E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.79|P-value:7.70E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.22|P-value:6.40E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.56|P-value:2.80E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:9.41|P-value:6.16E-21 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.95|P-value:4.04E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.40|P-value:4.77E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.94|P-value:4.37E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.47|P-value:3.79E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.55|P-value:2.00E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.17|P-value:7.76E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.26|P-value:7.81E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:5.72|P-value:6.61E-9 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.31|P-value:6.55E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.29|P-value:1.47E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.80|P-value:7.57E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.74|P-value:1.35E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.31|P-value:8.90E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.04|P-value:2.85E-5 ID:SGTC_1553|Compound:gossypol|FD-Score:-4.25|P-value:1.73E-5 ID:SGTC_1558|Compound:st069300|FD-Score:-5.06|P-value:3.99E-7 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.38|P-value:5.21E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.55|P-value:1.97E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.88|P-value:5.43E-5 ID:SGTC_1923|Compound:st058458|FD-Score:6.86|P-value:5.09E-12 ID:SGTC_1969|Compound:st069479|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_2013|Compound:4024628|FD-Score:11.90|P-value:3.72E-32 ID:SGTC_2019|Compound:4016004|FD-Score:5.17|P-value:1.38E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.19|P-value:9.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.31|P-value:4.75E-4 ID:SGTC_2346|Compound:9031566|FD-Score:4.55|P-value:2.91E-6 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.72|P-value:1.04E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:4.24|P-value:1.19E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.33|P-value:8.20E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.32|P-value:6.25E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.38|P-value:3.69E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.48|P-value:3.57E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.75|P-value:1.30E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.64|P-value:1.41E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.36|P-value:5.48E-4 ID:SGTC_3205|Compound:9113483|FD-Score:7.78|P-value:6.45E-15 ID:SGTC_3212|Compound:9128307|FD-Score:-7.93|P-value:3.94E-15 ID:SGTC_3293|Compound:9120939|FD-Score:-3.61|P-value:2.27E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.79|P-value:7.88E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.41|P-value:4.64E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.79|P-value:7.70E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.22|P-value:6.40E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.56|P-value:2.80E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:9.41|P-value:6.16E-21 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.95|P-value:4.04E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.40|P-value:4.77E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.94|P-value:4.37E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.47|P-value:3.79E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.55|P-value:2.00E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.17|P-value:7.76E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.26|P-value:7.81E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:5.72|P-value:6.61E-9 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.31|P-value:6.55E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.29|P-value:1.47E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.80|P-value:7.57E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.74|P-value:1.35E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.31|P-value:8.90E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.04|P-value:2.85E-5 ID:SGTC_1553|Compound:gossypol|FD-Score:-4.25|P-value:1.73E-5 ID:SGTC_1558|Compound:st069300|FD-Score:-5.06|P-value:3.99E-7 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.38|P-value:5.21E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.55|P-value:1.97E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.88|P-value:5.43E-5 ID:SGTC_1923|Compound:st058458|FD-Score:6.86|P-value:5.09E-12 ID:SGTC_1969|Compound:st069479|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_2013|Compound:4024628|FD-Score:11.90|P-value:3.72E-32 ID:SGTC_2019|Compound:4016004|FD-Score:5.17|P-value:1.38E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.19|P-value:9.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.31|P-value:4.75E-4 ID:SGTC_2346|Compound:9031566|FD-Score:4.55|P-value:2.91E-6 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.72|P-value:1.04E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:4.24|P-value:1.19E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.33|P-value:8.20E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.32|P-value:6.25E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.38|P-value:3.69E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.48|P-value:3.57E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.75|P-value:1.30E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.64|P-value:1.41E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.36|P-value:5.48E-4 ID:SGTC_3205|Compound:9113483|FD-Score:7.78|P-value:6.45E-15 ID:SGTC_3212|Compound:9128307|FD-Score:-7.93|P-value:3.94E-15 ID:SGTC_3293|Compound:9120939|FD-Score:-3.61|P-value:2.27E-4

Top fitness defect scores for YDL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2013 4024628 11.90 200.0 µM 3.72E-32 1 7.86E-33 4.67
2 SGTC_236 1509-0011 9.41 5.3 µM 6.16E-21 3 2.53E-21 1.76
3 SGTC_3205 9113483 7.78 49.5 µM 6.45E-15 1 3.73E-15 2.73
4 SGTC_1923 st058458 6.86 19.1 µM 5.09E-12 2 3.44E-12 0.92
5 SGTC_971 1315-0384 5.72 26.7 µM 6.61E-9 cell wall signaling 2 5.25E-9 0.94
6 SGTC_2019 4016004 5.17 108.0 µM 1.38E-7 4 1.17E-7 0.22
7 SGTC_120 rhodamine 6G 4.56 52.3 µM 2.80E-6 mitochondrial processes 12 2.52E-6 0.05
8 SGTC_2346 9031566 4.55 143.8 µM 2.91E-6 Golgi 10 2.63E-6 0.71
9 SGTC_2763 lisinopril 4.33 49.3 µM 8.20E-6 1 7.55E-6 0.52
10 SGTC_1381 2324-0066 4.31 62.1 µM 8.90E-6 7 8.20E-6 0.05
11 SGTC_2761 levamisole 4.24 97.9 µM 1.19E-5 3 1.10E-5 0.61
12 SGTC_1469 k284-2957 4.04 126.0 µM 2.85E-5 12 2.69E-5 0.07
13 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.95 150.0 µM 4.04E-5 Golgi 2 3.83E-5 0.16
14 SGTC_655 k060-0012 3.94 42.0 µM 4.37E-5 6 4.15E-5 0.09
15 SGTC_1744 st037937 3.88 38.9 µM 5.43E-5 8 5.18E-5 0.40
16 SGTC_1278 0874-0585 3.80 172.0 µM 7.57E-5 6 7.25E-5 0.03
17 SGTC_87 0100-0052 3.79 35.5 µM 7.70E-5 19 7.38E-5 0.02
18 SGTC_59 0330-0160 3.79 1.3 µM 7.88E-5 5 7.56E-5 0.08
19 SGTC_2663 amphotericin b 3.72 100.0 µM 1.04E-4 7 1.00E-4 0.12
20 SGTC_1245 0418-0076 3.65 17.2 µM 1.34E-4 ERG2 10 1.30E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.64E-40 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.226 4.30E-40 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.221 1.76E-38 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.219 1.19E-37 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.208 5.67E-34 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.204 5.07E-33 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.204 6.26E-33 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.204 1.05E-32 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.201 4.56E-32 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.201 4.59E-32 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.196 2.19E-30 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.195 4.71E-30 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.194 8.09E-30 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.193 2.33E-29 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.191 5.59E-29 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit