YDL008W / APC11

Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL008W / APC11

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-6.26|P-value:1.89E-12 ID:SGTC_126|Compound:0417-1624|FD-Score:-2.83|P-value:8.69E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.07|P-value:3.32E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.99|P-value:4.32E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:3.64|P-value:2.55E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.66|P-value:1.03E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.58|P-value:3.31E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.08|P-value:2.99E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.30|P-value:1.26E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.76|P-value:1.41E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.93|P-value:6.54E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.09|P-value:3.08E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.16|P-value:2.15E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.52|P-value:4.38E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.26|P-value:1.15E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.90|P-value:6.17E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.47|P-value:6.05E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.34|P-value:1.07E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.03|P-value:3.71E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.04|P-value:3.75E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.37|P-value:9.48E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.33|P-value:1.13E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.68|P-value:2.27E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.40|P-value:7.55E-5 ID:SGTC_2326|Compound:6164455|FD-Score:2.79|P-value:9.28E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.39|P-value:7.84E-5 ID:SGTC_2438|Compound:5259590|FD-Score:2.91|P-value:5.92E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.27|P-value:1.34E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.05|P-value:3.37E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.12|P-value:2.52E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-2.87|P-value:7.53E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.22|P-value:1.45E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-3.04|P-value:3.75E-4 ID:SGTC_2922|Compound:7999257|FD-Score:5.55|P-value:3.27E-10 ID:SGTC_3089|Compound:9117425|FD-Score:2.86|P-value:6.99E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:2.46E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-6.26|P-value:1.89E-12 ID:SGTC_126|Compound:0417-1624|FD-Score:-2.83|P-value:8.69E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.07|P-value:3.32E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.99|P-value:4.32E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:3.64|P-value:2.55E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.66|P-value:1.03E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.58|P-value:3.31E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.08|P-value:2.99E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.30|P-value:1.26E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.76|P-value:1.41E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.93|P-value:6.54E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.09|P-value:3.08E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.16|P-value:2.15E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.52|P-value:4.38E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.26|P-value:1.15E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.90|P-value:6.17E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.47|P-value:6.05E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.34|P-value:1.07E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.03|P-value:3.71E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.04|P-value:3.75E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.37|P-value:9.48E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.33|P-value:1.13E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.68|P-value:2.27E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.40|P-value:7.55E-5 ID:SGTC_2326|Compound:6164455|FD-Score:2.79|P-value:9.28E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.39|P-value:7.84E-5 ID:SGTC_2438|Compound:5259590|FD-Score:2.91|P-value:5.92E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.27|P-value:1.34E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.05|P-value:3.37E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.12|P-value:2.52E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-2.87|P-value:7.53E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.22|P-value:1.45E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-3.04|P-value:3.75E-4 ID:SGTC_2922|Compound:7999257|FD-Score:5.55|P-value:3.27E-10 ID:SGTC_3089|Compound:9117425|FD-Score:2.86|P-value:6.99E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:2.46E-4

Top fitness defect scores for YDL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2922 7999257 5.55 32.5 µM 3.27E-10 1 1.44E-8 0.69
2 SGTC_353 1988-1175 4.66 58.3 µM 1.03E-7 unfolded protein response 3 1.55E-6 0.01
3 SGTC_341 1486-1430 3.99 230.0 µM 4.32E-6 22 3.26E-5 0.00
4 SGTC_783 0848-0141 3.76 92.7 µM 1.41E-5 RSC & ERG11 17 8.57E-5 0.14
5 SGTC_349 k015-0014 3.64 24.0 µM 2.55E-5 9 1.39E-4 0.13
6 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.58 8.0 µM 3.31E-5 16 1.72E-4 0.08
7 SGTC_1058 3448-5425 3.52 97.3 µM 4.38E-5 13 2.16E-4 0.04
8 SGTC_2188 6126565 3.40 140.7 µM 7.55E-5 mitochondrial processes 10 3.37E-4 0.06
9 SGTC_2437 5741531 3.39 144.2 µM 7.84E-5 11 3.48E-4 0.00
10 SGTC_2442 5158906 3.27 48.5 µM 1.34E-4 4 5.39E-4 0.03
11 SGTC_1013 4112-3890 3.16 241.0 µM 2.15E-4 TSC3-RPN4 13 7.94E-4 0.06
12 SGTC_3192 9110362 3.13 49.5 µM 2.46E-4 mitochondrial processes 15 8.86E-4 0.07
13 SGTC_2514 salinomycin 3.12 42.7 µM 2.52E-4 8 9.04E-4 0.07
14 SGTC_692 k241-0027 3.08 77.8 µM 2.99E-4 12 0.00104 1.06E-4
15 SGTC_2449 5812982 3.05 45.8 µM 3.37E-4 12 0.00115 0.03
16 SGTC_1686 st019653 3.03 115.5 µM 3.71E-4 mitochondrial processes 10 0.00124 0.01
17 SGTC_1753 st043925 2.94 64.0 µM 5.14E-4 14 0.00162 0.13
18 SGTC_2438 5259590 2.91 200.0 µM 5.92E-4 12 0.00182 0.01
19 SGTC_1170 0310-0127 2.90 64.8 µM 6.17E-4 29 0.00188 0.06
20 SGTC_3089 9117425 2.86 49.5 µM 6.99E-4 11 0.00209 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 5.65E-29 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.174 2.88E-24 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.163 2.36E-21 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.161 7.48E-21 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.136 2.53E-15 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.127 1.91E-13 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.125 4.25E-13 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.124 5.26E-13 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.123 7.06E-13 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.123 7.72E-13 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.123 9.71E-13 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 9.96E-13 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.120 2.57E-12 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.120 2.81E-12 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.119 4.09E-12 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B