YDL009C_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL009C / YDL009C

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:-3.24|P-value:5.20E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.24|P-value:8.56E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.74|P-value:7.85E-7 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.72|P-value:8.05E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.17|P-value:6.65E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.14|P-value:1.38E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.74|P-value:7.49E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.55|P-value:1.59E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.49|P-value:1.99E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.73|P-value:8.38E-7 ID:SGTC_347|Compound:4534-1311|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.61|P-value:1.49E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.80|P-value:5.95E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:5.35|P-value:2.95E-8 ID:SGTC_462|Compound:ag-879|FD-Score:3.43|P-value:2.57E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:4.04|P-value:2.12E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.07|P-value:9.41E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.75|P-value:7.25E-7 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.17|P-value:6.51E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.62|P-value:1.42E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.09|P-value:8.71E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.48|P-value:2.14E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.46|P-value:3.08E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.80|P-value:2.13E-9 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.15|P-value:8.95E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.95|P-value:3.08E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.67|P-value:9.82E-5 ID:SGTC_1699|Compound:st031318|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.30|P-value:4.17E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.79|P-value:6.02E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.11|P-value:8.14E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.55|P-value:1.62E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.74|P-value:7.48E-5 ID:SGTC_2153|Compound:5569715|FD-Score:3.05|P-value:9.83E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.97|P-value:2.83E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.11|P-value:8.01E-4 ID:SGTC_2534|Compound:helenine|FD-Score:3.61|P-value:1.27E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.76|P-value:6.96E-5 ID:SGTC_2537|Compound:larixol|FD-Score:4.57|P-value:1.80E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.48|P-value:2.14E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.06|P-value:9.50E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.27|P-value:4.53E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.35|P-value:3.39E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.50|P-value:1.97E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.16|P-value:6.77E-4 ID:SGTC_3314|Compound:9135860|FD-Score:4.03|P-value:2.18E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.24|P-value:5.20E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.24|P-value:8.56E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.74|P-value:7.85E-7 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.72|P-value:8.05E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.17|P-value:6.65E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.14|P-value:1.38E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.74|P-value:7.49E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.55|P-value:1.59E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.49|P-value:1.99E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.73|P-value:8.38E-7 ID:SGTC_347|Compound:4534-1311|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.61|P-value:1.49E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.80|P-value:5.95E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:5.35|P-value:2.95E-8 ID:SGTC_462|Compound:ag-879|FD-Score:3.43|P-value:2.57E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:4.04|P-value:2.12E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.07|P-value:9.41E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.75|P-value:7.25E-7 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.17|P-value:6.51E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.62|P-value:1.42E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.09|P-value:8.71E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.48|P-value:2.14E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.46|P-value:3.08E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.80|P-value:2.13E-9 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.15|P-value:8.95E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.95|P-value:3.08E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.67|P-value:9.82E-5 ID:SGTC_1699|Compound:st031318|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.30|P-value:4.17E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.79|P-value:6.02E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.11|P-value:8.14E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.55|P-value:1.62E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.74|P-value:7.48E-5 ID:SGTC_2153|Compound:5569715|FD-Score:3.05|P-value:9.83E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.97|P-value:2.83E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.11|P-value:8.01E-4 ID:SGTC_2534|Compound:helenine|FD-Score:3.61|P-value:1.27E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.76|P-value:6.96E-5 ID:SGTC_2537|Compound:larixol|FD-Score:4.57|P-value:1.80E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.48|P-value:2.14E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.06|P-value:9.50E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.27|P-value:4.53E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.35|P-value:3.39E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.50|P-value:1.97E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.16|P-value:6.77E-4 ID:SGTC_3314|Compound:9135860|FD-Score:4.03|P-value:2.18E-5

Top fitness defect scores for YDL009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1447 4239-0816 5.80 81.9 µM 2.13E-9 4 3.39E-9
2 SGTC_413 propylparaben 5.35 100.0 µM 2.95E-8 amide catabolism 7 4.40E-8
3 SGTC_1455 4262-0120 5.15 131.0 µM 8.95E-8 plasma membrane duress 12 1.30E-7
4 SGTC_669 0108-0021 4.75 26.2 µM 7.25E-7 fatty acid desaturase (OLE1) 46 9.97E-7
5 SGTC_87 0100-0052 4.74 35.5 µM 7.85E-7 63 1.08E-6
6 SGTC_339 3091-4833 4.73 71.4 µM 8.38E-7 iron homeostasis 10 1.15E-6
7 SGTC_919 tnp00227 4.62 403.6 nM 1.42E-6 RNA pol III & RNase P/MRP 19 1.92E-6
8 SGTC_2537 larixol 4.57 68.9 µM 1.80E-6 13 2.41E-6
9 SGTC_1401 3807-4679 4.46 7.6 µM 3.08E-6 tubulin folding & SWR complex 12 4.09E-6
10 SGTC_71 0417-1750 4.24 47.8 µM 8.56E-6 Golgi 36 1.11E-5
11 SGTC_122 0236-0016 4.14 402.4 µM 1.38E-5 RNA processing & uracil transport 28 1.77E-5
12 SGTC_624 k048-0052 4.04 28.0 µM 2.12E-5 Golgi 12 2.68E-5
13 SGTC_3314 9135860 4.03 59.4 µM 2.18E-5 12 2.75E-5
14 SGTC_2349 9023730 3.97 187.1 µM 2.83E-5 23 3.55E-5
15 SGTC_1456 k015-0012 3.95 13.0 µM 3.08E-5 31 3.85E-5
16 SGTC_409 arachidonic acid 3.80 100.0 µM 5.95E-5 20 7.32E-5
17 SGTC_2535 4',4'-dimethoxydalbergione 3.76 51.2 µM 6.96E-5 DNA damage response 18 8.52E-5
18 SGTC_1952 st077036 3.74 64.1 µM 7.48E-5 41 9.15E-5
19 SGTC_213 1246-0773 3.74 967.0 nM 7.49E-5 27 9.16E-5
20 SGTC_347 4534-1311 3.63 26.2 µM 1.17E-4 RPP1 & pyrimidine depletion 20 1.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.84E-14 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.128 1.06E-13 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.128 1.06E-13 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.117 1.07E-11 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.113 4.85E-11 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.113 4.99E-11 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.100 6.41E-9 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.089 2.43E-7 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.087 4.19E-7 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.085 7.67E-7 YPR006C ICL2 hom 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
0.083 1.36E-6 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.081 2.31E-6 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.078 6.03E-6 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.076 1.13E-5 YJR096W YJR096W hom Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.075 1.25E-5 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress