YDL013W / SLX5

Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL013W / SLX5

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.23|P-value:1.96E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.01|P-value:1.33E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.49|P-value:7.76E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.21|P-value:6.20E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.72|P-value:3.67E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.53|P-value:6.82E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.08|P-value:1.01E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.11|P-value:3.91E-7 ID:SGTC_755|Compound:1995-0008|FD-Score:3.81|P-value:2.70E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.61|P-value:1.25E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:4.80|P-value:5.69E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.78|P-value:5.98E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.85|P-value:2.37E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.67|P-value:4.42E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.75|P-value:3.31E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:4.43|P-value:2.65E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.38|P-value:3.16E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.16|P-value:1.10E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.58|P-value:5.88E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.40|P-value:3.00E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.32|P-value:4.04E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.44|P-value:9.11E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.58|P-value:5.94E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.09|P-value:9.81E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.29|P-value:6.13E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.47|P-value:8.49E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.91|P-value:1.87E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.14|P-value:8.24E-5 ID:SGTC_1801|Compound:st050089|FD-Score:5.21|P-value:8.92E-7 ID:SGTC_2123|Compound:5259487|FD-Score:3.69|P-value:4.04E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.38|P-value:3.20E-5 ID:SGTC_2304|Compound:7443016|FD-Score:3.79|P-value:2.89E-4 ID:SGTC_2321|Compound:7390090|FD-Score:5.58|P-value:1.45E-7 ID:SGTC_2411|Compound:st077133|FD-Score:-3.93|P-value:6.43E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.57|P-value:2.45E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.83|P-value:9.64E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.47|P-value:8.51E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.45|P-value:2.43E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-5.56|P-value:4.12E-8 ID:SGTC_2872|Compound:9044037|FD-Score:3.57|P-value:5.98E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.57|P-value:1.47E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.57|P-value:6.07E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.56|P-value:2.52E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.34|P-value:5.44E-4 ID:SGTC_3013|Compound:9080133|FD-Score:7.42|P-value:3.34E-12 ID:SGTC_3015|Compound:9080845|FD-Score:-3.18|P-value:9.03E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.33|P-value:5.53E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.73|P-value:7.43E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.62|P-value:1.21E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.42|P-value:9.79E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.54|P-value:1.66E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.10|P-value:9.56E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.23|P-value:1.96E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.01|P-value:1.33E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.49|P-value:7.76E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.21|P-value:6.20E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.72|P-value:3.67E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.53|P-value:6.82E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.08|P-value:1.01E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.11|P-value:3.91E-7 ID:SGTC_755|Compound:1995-0008|FD-Score:3.81|P-value:2.70E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.61|P-value:1.25E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:4.80|P-value:5.69E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.78|P-value:5.98E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.85|P-value:2.37E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.67|P-value:4.42E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.75|P-value:3.31E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:4.43|P-value:2.65E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.38|P-value:3.16E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.16|P-value:1.10E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.58|P-value:5.88E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.40|P-value:3.00E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.32|P-value:4.04E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.44|P-value:9.11E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.58|P-value:5.94E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.09|P-value:9.81E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.29|P-value:6.13E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.47|P-value:8.49E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.91|P-value:1.87E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.14|P-value:8.24E-5 ID:SGTC_1801|Compound:st050089|FD-Score:5.21|P-value:8.92E-7 ID:SGTC_2123|Compound:5259487|FD-Score:3.69|P-value:4.04E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.38|P-value:3.20E-5 ID:SGTC_2304|Compound:7443016|FD-Score:3.79|P-value:2.89E-4 ID:SGTC_2321|Compound:7390090|FD-Score:5.58|P-value:1.45E-7 ID:SGTC_2411|Compound:st077133|FD-Score:-3.93|P-value:6.43E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.57|P-value:2.45E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.83|P-value:9.64E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.47|P-value:8.51E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.45|P-value:2.43E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-5.56|P-value:4.12E-8 ID:SGTC_2872|Compound:9044037|FD-Score:3.57|P-value:5.98E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.57|P-value:1.47E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.57|P-value:6.07E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.56|P-value:2.52E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.34|P-value:5.44E-4 ID:SGTC_3013|Compound:9080133|FD-Score:7.42|P-value:3.34E-12 ID:SGTC_3015|Compound:9080845|FD-Score:-3.18|P-value:9.03E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.33|P-value:5.53E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.73|P-value:7.43E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.62|P-value:1.21E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.42|P-value:9.79E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.54|P-value:1.66E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.10|P-value:9.56E-5

Top fitness defect scores for YDL013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3013 9080133 7.42 71.4 µM 3.34E-12 3 5.66E-14
2 SGTC_2321 7390090 5.58 138.8 µM 1.45E-7 10 1.19E-8
3 SGTC_1707 st032323 5.29 6.3 µM 6.13E-7 DNA damage response 31 6.23E-8
4 SGTC_1801 st050089 5.21 28.4 µM 8.92E-7 NEO1-PIK1 67 9.61E-8
5 SGTC_1513 0337-0559 5.16 19.0 µM 1.10E-6 5 1.22E-7
6 SGTC_1064 honokiol 4.80 6.8 µM 5.69E-6 11 8.11E-7
7 SGTC_1099 5-nonyloxytryptamine 4.78 2.9 µM 5.98E-6 7 8.59E-7
8 SGTC_3148 9097893 4.73 49.5 µM 7.43E-6 24 1.10E-6
9 SGTC_3152 9099253 4.62 49.5 µM 1.21E-5 NEO1-PIK1 99 1.93E-6
10 SGTC_940 3232-1287 4.61 54.8 µM 1.25E-5 NEO1 20 2.02E-6
11 SGTC_2873 9040596 4.57 71.4 µM 1.47E-5 30 2.43E-6
12 SGTC_3213 9129884 4.54 49.5 µM 1.66E-5 13 2.79E-6
13 SGTC_2762 leflunomide 4.45 42.1 µM 2.43E-5 15 4.32E-6
14 SGTC_1434 4073-0095 4.43 163.0 µM 2.65E-5 7 4.79E-6
15 SGTC_1539 benzyladenosine 4.40 56.0 µM 3.00E-5 9 5.52E-6
16 SGTC_1506 4226-2149 4.38 212.0 µM 3.16E-5 17 5.86E-6
17 SGTC_2161 5662504 4.38 8.5 µM 3.20E-5 tubulin folding & SWR complex 16 5.95E-6
18 SGTC_1547 harmine 4.32 94.2 µM 4.04E-5 ergosterol biosynthesis 31 7.79E-6
19 SGTC_221 trifluoperazine 4.21 10.3 µM 6.20E-5 NEO1-PIK1 193 1.28E-5
20 SGTC_1781 st038725 4.14 66.3 µM 8.24E-5 NEO1 93 1.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.08E-31 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.188 4.75E-28 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.185 2.68E-27 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.185 3.12E-27 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.185 4.12E-27 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.183 8.41E-27 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.183 8.96E-27 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.179 1.83E-25 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.168 9.50E-23 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.163 3.15E-21 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.156 1.19E-19 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.154 2.67E-19 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.152 8.40E-19 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.152 8.99E-19 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.151 1.22E-18 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard