YDL014W / NOP1

Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL014W / NOP1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.69|P-value:2.90E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.36|P-value:8.68E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.34|P-value:9.22E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.91|P-value:1.30E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.34|P-value:9.21E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.41|P-value:7.20E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.94|P-value:1.18E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:4.55|P-value:1.05E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:3.69|P-value:2.83E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.07|P-value:7.35E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.19|P-value:4.53E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.34|P-value:8.53E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.46|P-value:6.16E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:5.15|P-value:7.65E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.91|P-value:1.21E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.67|P-value:6.52E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:4.15|P-value:5.30E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.40|P-value:7.56E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:7.10|P-value:1.59E-11 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.96|P-value:1.01E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.51|P-value:5.22E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.52|P-value:5.05E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.98|P-value:9.96E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.63|P-value:6.86E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.57|P-value:4.27E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.75|P-value:2.34E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.54|P-value:4.82E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.14|P-value:5.44E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.69|P-value:2.63E-4 ID:SGTC_1761|Compound:st044296|FD-Score:5.04|P-value:1.24E-6 ID:SGTC_1763|Compound:st044482|FD-Score:3.72|P-value:2.54E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.52|P-value:5.04E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-4.31|P-value:2.63E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.86|P-value:1.54E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.38|P-value:2.17E-5 ID:SGTC_2052|Compound:5265182|FD-Score:-5.32|P-value:3.07E-7 ID:SGTC_2053|Compound:5265679|FD-Score:5.59|P-value:8.80E-8 ID:SGTC_2055|Compound:5235184|FD-Score:-5.57|P-value:8.89E-8 ID:SGTC_2171|Compound:5739187|FD-Score:4.62|P-value:7.88E-6 ID:SGTC_2246|Compound:7293507|FD-Score:-3.30|P-value:9.68E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.02|P-value:8.70E-5 ID:SGTC_2316|Compound:5844804|FD-Score:5.39|P-value:2.37E-7 ID:SGTC_2386|Compound:9075165|FD-Score:4.09|P-value:6.74E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:6.32|P-value:1.76E-9 ID:SGTC_2585|Compound:alliin|FD-Score:3.41|P-value:7.33E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.51|P-value:5.20E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.08|P-value:7.03E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.58|P-value:9.58E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.40|P-value:7.11E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.67|P-value:2.82E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.65|P-value:7.10E-6 ID:SGTC_2930|Compound:9013230|FD-Score:-6.30|P-value:1.73E-9 ID:SGTC_3066|Compound:9117245|FD-Score:3.65|P-value:3.33E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.09|P-value:6.18E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.94|P-value:1.08E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.63|P-value:3.49E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.69|P-value:2.90E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.36|P-value:8.68E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.34|P-value:9.22E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.91|P-value:1.30E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.34|P-value:9.21E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.41|P-value:7.20E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.94|P-value:1.18E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:4.55|P-value:1.05E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:3.69|P-value:2.83E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.07|P-value:7.35E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.19|P-value:4.53E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.34|P-value:8.53E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.46|P-value:6.16E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:5.15|P-value:7.65E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.91|P-value:1.21E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.67|P-value:6.52E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:4.15|P-value:5.30E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.40|P-value:7.56E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:7.10|P-value:1.59E-11 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.96|P-value:1.01E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.51|P-value:5.22E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.52|P-value:5.05E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.98|P-value:9.96E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.63|P-value:6.86E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.57|P-value:4.27E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.75|P-value:2.34E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.54|P-value:4.82E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.14|P-value:5.44E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.69|P-value:2.63E-4 ID:SGTC_1761|Compound:st044296|FD-Score:5.04|P-value:1.24E-6 ID:SGTC_1763|Compound:st044482|FD-Score:3.72|P-value:2.54E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.52|P-value:5.04E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-4.31|P-value:2.63E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.86|P-value:1.54E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.38|P-value:2.17E-5 ID:SGTC_2052|Compound:5265182|FD-Score:-5.32|P-value:3.07E-7 ID:SGTC_2053|Compound:5265679|FD-Score:5.59|P-value:8.80E-8 ID:SGTC_2055|Compound:5235184|FD-Score:-5.57|P-value:8.89E-8 ID:SGTC_2171|Compound:5739187|FD-Score:4.62|P-value:7.88E-6 ID:SGTC_2246|Compound:7293507|FD-Score:-3.30|P-value:9.68E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.02|P-value:8.70E-5 ID:SGTC_2316|Compound:5844804|FD-Score:5.39|P-value:2.37E-7 ID:SGTC_2386|Compound:9075165|FD-Score:4.09|P-value:6.74E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:6.32|P-value:1.76E-9 ID:SGTC_2585|Compound:alliin|FD-Score:3.41|P-value:7.33E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.51|P-value:5.20E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.08|P-value:7.03E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.58|P-value:9.58E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.40|P-value:7.11E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.67|P-value:2.82E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.65|P-value:7.10E-6 ID:SGTC_2930|Compound:9013230|FD-Score:-6.30|P-value:1.73E-9 ID:SGTC_3066|Compound:9117245|FD-Score:3.65|P-value:3.33E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.09|P-value:6.18E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.94|P-value:1.08E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.63|P-value:3.49E-4

Top fitness defect scores for YDL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1043 0916-0009 7.10 19.3 µM 1.59E-11 1 6.22E-13 2.41
2 SGTC_2565 isoliquiritigenin 6.32 100.0 µM 1.76E-9 1 1.32E-10 0.83
3 SGTC_2053 5265679 5.59 138.0 µM 8.80E-8 1 1.14E-8 0.79
4 SGTC_2316 5844804 5.39 197.4 µM 2.37E-7 5 3.52E-8 0.06
5 SGTC_882 0843-0131 5.15 351.0 µM 7.65E-7 4 1.34E-7 0.22
6 SGTC_1761 st044296 5.04 37.0 µM 1.24E-6 2 2.32E-7 0.18
7 SGTC_919 tnp00227 4.67 403.6 nM 6.52E-6 RNA pol III & RNase P/MRP 9 1.53E-6 0.30
8 SGTC_2870 9038528 4.65 13.0 µM 7.10E-6 2 1.68E-6 0.44
9 SGTC_2171 5739187 4.62 198.1 µM 7.88E-6 copper-dependent oxidative stress 2 1.90E-6 0.89
10 SGTC_2751 anetholtrithion 4.58 17.2 µM 9.58E-6 4 2.37E-6 0.18
11 SGTC_617 3770-0098 4.55 35.0 µM 1.05E-5 exosome 22 2.64E-6 0.37
12 SGTC_1870 st057514 4.38 26.5 µM 2.13E-5 RSC & ERG11 7 5.86E-6 0.31
13 SGTC_1967 st070177 4.38 51.4 µM 2.17E-5 1 6.01E-6 0.34
14 SGTC_840 0245-0196 4.19 390.0 µM 4.53E-5 2 1.39E-5 0.51
15 SGTC_931 2812-0076 4.15 566.0 µM 5.30E-5 4 1.66E-5 0.36
16 SGTC_1737 st035557 4.14 69.7 µM 5.44E-5 4 1.71E-5 0.04
17 SGTC_2386 9075165 4.09 157.4 µM 6.74E-5 1 2.17E-5 0.33
18 SGTC_2749 bexarotene 4.08 57.4 µM 7.03E-5 2 2.28E-5 0.23
19 SGTC_800 3448-7362 4.07 155.0 µM 7.35E-5 translation 45 2.40E-5 0.06
20 SGTC_2247 cerulenin 4.02 830.0 nM 8.70E-5 4 2.91E-5 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.22E-9 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.095 3.69E-8 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.092 9.12E-8 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.091 1.35E-7 YPL093W NOG1 het Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
0.090 1.96E-7 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.089 2.09E-7 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.088 3.08E-7 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.088 3.59E-7 YDR083W RRP8 hom Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1
0.086 6.39E-7 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.086 6.94E-7 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.083 1.31E-6 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.082 1.89E-6 YKR098C UBP11 hom Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
0.082 2.00E-6 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.082 2.11E-6 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.079 4.11E-6 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles