YDL016C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL016C / YDL016C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.92|P-value:8.20E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:5.21|P-value:1.85E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:3.38|P-value:4.94E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.56|P-value:4.46E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.49|P-value:3.34E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.63|P-value:2.02E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.70|P-value:1.56E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.80|P-value:1.47E-6 ID:SGTC_276|Compound:colchicine|FD-Score:4.97|P-value:6.24E-7 ID:SGTC_316|Compound:k060-0003|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.35|P-value:5.37E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.64|P-value:3.03E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:4.72|P-value:2.05E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:-3.95|P-value:5.81E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.46|P-value:3.69E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.32|P-value:5.97E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.74|P-value:1.07E-8 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.83|P-value:9.35E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.25|P-value:7.54E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.83|P-value:9.35E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.58|P-value:2.40E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.19|P-value:9.29E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.07|P-value:3.57E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.86|P-value:8.30E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.93|P-value:6.49E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.17|P-value:9.96E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.13|P-value:2.79E-5 ID:SGTC_2087|Compound:5276107|FD-Score:4.03|P-value:4.18E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.77|P-value:1.18E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.60|P-value:3.59E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.93|P-value:6.39E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_2388|Compound:9080168|FD-Score:4.20|P-value:2.14E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.32|P-value:6.09E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:6.30|P-value:3.95E-10 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.88|P-value:7.66E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.47|P-value:3.60E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.93|P-value:6.34E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.92|P-value:8.20E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:5.21|P-value:1.85E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:3.38|P-value:4.94E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.56|P-value:4.46E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.49|P-value:3.34E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.63|P-value:2.02E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.70|P-value:1.56E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.80|P-value:1.47E-6 ID:SGTC_276|Compound:colchicine|FD-Score:4.97|P-value:6.24E-7 ID:SGTC_316|Compound:k060-0003|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.35|P-value:5.37E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.64|P-value:3.03E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:4.72|P-value:2.05E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:-3.95|P-value:5.81E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.46|P-value:3.69E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.32|P-value:5.97E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.74|P-value:1.07E-8 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.83|P-value:9.35E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.25|P-value:7.54E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.83|P-value:9.35E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.58|P-value:2.40E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.19|P-value:9.29E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.07|P-value:3.57E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.86|P-value:8.30E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.93|P-value:6.49E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.17|P-value:9.96E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.13|P-value:2.79E-5 ID:SGTC_2087|Compound:5276107|FD-Score:4.03|P-value:4.18E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.77|P-value:1.18E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.60|P-value:3.59E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.93|P-value:6.39E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_2388|Compound:9080168|FD-Score:4.20|P-value:2.14E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.32|P-value:6.09E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:6.30|P-value:3.95E-10 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.88|P-value:7.66E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.47|P-value:3.60E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.93|P-value:6.34E-5

Top fitness defect scores for YDL016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2635 hydroquinidine 6.30 100.0 µM 3.95E-10 2 1.44E-10 2.72
2 SGTC_1045 1348-1485 5.74 165.0 µM 1.07E-8 1 4.61E-9 1.05
3 SGTC_76 0433-0009 5.21 400.3 µM 1.85E-7 3 9.21E-8 0.53
4 SGTC_276 colchicine 4.97 750.0 µM 6.24E-7 1 3.30E-7 0.87
5 SGTC_272 doxorubicin 4.80 8.1 µM 1.47E-6 anthracycline transcription coupled DNA repair 7 8.11E-7 0.79
6 SGTC_566 0958-0068 4.72 16.5 µM 2.05E-6 RSC & ERG11 12 1.15E-6 0.35
7 SGTC_548 1436-0017 4.64 110.0 µM 3.03E-6 TSC3-RPN4 3 1.74E-6 0.31
8 SGTC_2237 6667747 4.60 47.2 µM 3.59E-6 3 2.08E-6 0.25
9 SGTC_171 k064-0041 4.56 9.7 µM 4.46E-6 heme requiring 12 2.61E-6 0.38
10 SGTC_2388 9080168 4.20 200.0 µM 2.14E-5 2 1.35E-5 0.76
11 SGTC_2042 p-Dimethylaminoacetophenone 4.13 200.0 µM 2.79E-5 5 1.79E-5 0.19
12 SGTC_1812 st052057 4.07 4.3 µM 3.57E-5 calcium & mitochondrial duress 7 2.32E-5 0.11
13 SGTC_2087 5276107 4.03 200.0 µM 4.18E-5 5 2.73E-5 0.06
14 SGTC_3285 9112818 3.93 20.9 µM 6.34E-5 cell wall 14 4.23E-5 0.05
15 SGTC_2311 7694451 3.93 200.0 µM 6.39E-5 9 4.26E-5 0.02
16 SGTC_1853 st056710 3.93 91.2 µM 6.49E-5 amide catabolism 6 4.33E-5 0.11
17 SGTC_1815 st051655 3.86 58.2 µM 8.30E-5 TSC3-RPN4 17 5.61E-5 0.11
18 SGTC_1131 3454-3128 3.83 32.3 µM 9.35E-5 16 6.36E-5 0.07
19 SGTC_1051 3253-3903 3.83 78.0 µM 9.35E-5 6 6.36E-5 0.02
20 SGTC_2775 cyproheptadine 3.79 69.6 µM 1.09E-4 4 7.46E-5 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.95E-9 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.100 6.13E-9 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.077 7.09E-6 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.077 7.31E-6 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.076 1.07E-5 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.075 1.22E-5 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.073 2.18E-5 YML020W_p YML020W_p hom Putative protein of unknown function
0.073 2.44E-5 YIL066C RNR3 hom Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
0.073 2.55E-5 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.072 2.81E-5 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.071 3.93E-5 YOR097C_p YOR097C_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
0.070 4.46E-5 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.070 5.04E-5 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.069 6.31E-5 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.068 9.05E-5 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically