YDL018C / ERP3

Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL018C / ERP3

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:7.26|P-value:7.71E-12 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.70|P-value:2.94E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.73|P-value:5.52E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:3.89|P-value:1.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.54|P-value:4.93E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.26|P-value:4.97E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.37|P-value:8.75E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.44|P-value:1.83E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.89|P-value:1.53E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.51|P-value:5.52E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.54|P-value:5.01E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.48|P-value:6.05E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.48|P-value:6.13E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.19|P-value:4.99E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.93|P-value:1.30E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.00|P-value:1.02E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.61|P-value:4.02E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.38|P-value:8.45E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-4.44|P-value:1.83E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.67|P-value:3.23E-4 ID:SGTC_1726|Compound:st035556|FD-Score:6.84|P-value:1.05E-10 ID:SGTC_1730|Compound:st033808|FD-Score:-6.15|P-value:5.63E-9 ID:SGTC_1732|Compound:st034308|FD-Score:-5.23|P-value:5.78E-7 ID:SGTC_1805|Compound:st050013|FD-Score:-3.45|P-value:6.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.18|P-value:5.11E-5 ID:SGTC_1831|Compound:st055328|FD-Score:5.60|P-value:9.92E-8 ID:SGTC_1835|Compound:st008666|FD-Score:-4.93|P-value:2.29E-6 ID:SGTC_1837|Compound:st055472|FD-Score:-4.91|P-value:2.50E-6 ID:SGTC_1842|Compound:st055362|FD-Score:5.97|P-value:1.43E-8 ID:SGTC_1843|Compound:st055809|FD-Score:4.02|P-value:9.23E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.19|P-value:4.93E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.66|P-value:3.35E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.49|P-value:5.83E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-4.68|P-value:6.80E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.33|P-value:9.88E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.72|P-value:2.08E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.78|P-value:4.42E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.89|P-value:1.49E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.59|P-value:4.30E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.03|P-value:1.48E-6 ID:SGTC_2962|Compound:9082311|FD-Score:4.25|P-value:3.82E-5 ID:SGTC_2994|Compound:9053520|FD-Score:-3.37|P-value:8.67E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.40|P-value:7.80E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.77|P-value:2.30E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.39|P-value:2.24E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.47|P-value:6.19E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.34|P-value:9.59E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.80|P-value:2.07E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.28|P-value:3.43E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:7.26|P-value:7.71E-12 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.70|P-value:2.94E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.73|P-value:5.52E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:3.89|P-value:1.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.54|P-value:4.93E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.26|P-value:4.97E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.37|P-value:8.75E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.44|P-value:1.83E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.89|P-value:1.53E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.51|P-value:5.52E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.54|P-value:5.01E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.48|P-value:6.05E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.48|P-value:6.13E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.19|P-value:4.99E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.93|P-value:1.30E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.00|P-value:1.02E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.61|P-value:4.02E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.38|P-value:8.45E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-4.44|P-value:1.83E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.67|P-value:3.23E-4 ID:SGTC_1726|Compound:st035556|FD-Score:6.84|P-value:1.05E-10 ID:SGTC_1730|Compound:st033808|FD-Score:-6.15|P-value:5.63E-9 ID:SGTC_1732|Compound:st034308|FD-Score:-5.23|P-value:5.78E-7 ID:SGTC_1805|Compound:st050013|FD-Score:-3.45|P-value:6.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.18|P-value:5.11E-5 ID:SGTC_1831|Compound:st055328|FD-Score:5.60|P-value:9.92E-8 ID:SGTC_1835|Compound:st008666|FD-Score:-4.93|P-value:2.29E-6 ID:SGTC_1837|Compound:st055472|FD-Score:-4.91|P-value:2.50E-6 ID:SGTC_1842|Compound:st055362|FD-Score:5.97|P-value:1.43E-8 ID:SGTC_1843|Compound:st055809|FD-Score:4.02|P-value:9.23E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.19|P-value:4.93E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.66|P-value:3.35E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.49|P-value:5.83E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-4.68|P-value:6.80E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.33|P-value:9.88E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.72|P-value:2.08E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.78|P-value:4.42E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.89|P-value:1.49E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.59|P-value:4.30E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.03|P-value:1.48E-6 ID:SGTC_2962|Compound:9082311|FD-Score:4.25|P-value:3.82E-5 ID:SGTC_2994|Compound:9053520|FD-Score:-3.37|P-value:8.67E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.40|P-value:7.80E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.77|P-value:2.30E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.39|P-value:2.24E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.47|P-value:6.19E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.34|P-value:9.59E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.80|P-value:2.07E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.28|P-value:3.43E-5

Top fitness defect scores for YDL018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 7.26 19.8 µM 7.71E-12 3 2.00E-13
2 SGTC_1726 st035556 6.84 14.6 µM 1.05E-10 8 4.07E-12
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.72 3.7 µM 2.08E-10 7 8.96E-12
4 SGTC_1842 st055362 5.97 61.2 µM 1.43E-8 1 1.18E-9
5 SGTC_1831 st055328 5.60 12.0 µM 9.92E-8 heme biosynthesis & mitochondrial translocase 8 1.10E-8
6 SGTC_769 0302-0231 5.26 76.0 µM 4.97E-7 14 7.06E-8
7 SGTC_2858 9025781 5.03 9.0 µM 1.48E-6 sphingolipid biosynthesis & PDR1 66 2.49E-7
8 SGTC_2582 agaric acid 4.78 100.0 µM 4.42E-6 redox potentiating 237 8.74E-7
9 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.73 8.0 µM 5.52E-6 14 1.13E-6
10 SGTC_3025 9087895 4.39 49.5 µM 2.24E-5 PDR1 30 5.66E-6
11 SGTC_3323 9138564 4.28 53.9 µM 3.43E-5 14 9.23E-6
12 SGTC_2962 9082311 4.25 13.2 µM 3.82E-5 14 1.05E-5
13 SGTC_1911 st060208 4.19 74.3 µM 4.93E-5 29 1.40E-5
14 SGTC_1843 st055809 4.02 45.5 µM 9.23E-5 14 2.88E-5
15 SGTC_1412 3909-8563 3.93 178.0 µM 1.30E-4 8 4.25E-5
16 SGTC_627 1391-0720 3.89 175.0 µM 1.51E-4 15 5.06E-5
17 SGTC_3023 9089636 3.77 49.5 µM 2.30E-4 5 8.22E-5
18 SGTC_628 1636-0253 3.54 16.0 µM 4.93E-4 sphingolipid biosynthesis & PDR1 47 1.97E-4
19 SGTC_952 1185-0122 3.51 232.0 µM 5.52E-4 33 2.25E-4
20 SGTC_1988 st071872 3.49 53.4 µM 5.83E-4 15 2.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 1.72E-40 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.191 7.65E-29 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.178 3.54E-25 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.163 1.66E-21 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.158 2.85E-20 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.157 5.35E-20 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.157 7.50E-20 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.155 1.64E-19 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.154 3.31E-19 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.153 3.82E-19 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.152 8.04E-19 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.150 2.30E-18 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.149 4.06E-18 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.148 7.38E-18 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.147 1.14E-17 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p