YDL020C / RPN4

Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL020C / RPN4

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:8.04|P-value:9.47E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:7.58|P-value:2.16E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:7.25|P-value:3.77E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:11.30|P-value:8.29E-8 ID:SGTC_46|Compound:0329-0187a|FD-Score:10.00|P-value:1.72E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:7.31|P-value:3.45E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:8.08|P-value:8.77E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:53.80|P-value:1.09E-137 ID:SGTC_67|Compound:0335-0847|FD-Score:35.10|P-value:4.57E-60 ID:SGTC_69|Compound:0096-0274|FD-Score:8.55|P-value:3.58E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:17.70|P-value:1.12E-16 ID:SGTC_93|Compound:0109-0045|FD-Score:6.76|P-value:8.50E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.82|P-value:2.12E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:14.90|P-value:2.62E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:37.40|P-value:9.68E-68 ID:SGTC_141|Compound:0443-0274|FD-Score:15.40|P-value:5.12E-13 ID:SGTC_142|Compound:0335-0849|FD-Score:42.80|P-value:4.64E-88 ID:SGTC_148|Compound:3253-0744|FD-Score:9.61|P-value:4.06E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:8.04|P-value:9.47E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:12.00|P-value:1.18E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:10.60|P-value:3.82E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:16.90|P-value:1.91E-15 ID:SGTC_180|Compound:1486-1293|FD-Score:9.23|P-value:9.10E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:7.37|P-value:3.07E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:12.50|P-value:3.64E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:7.10|P-value:4.91E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:12.70|P-value:1.78E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:12.00|P-value:1.26E-8 ID:SGTC_274|Compound:sirtinol|FD-Score:8.21|P-value:6.85E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.30|P-value:8.70E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:9.42|P-value:6.06E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-11.00|P-value:1.60E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:18.60|P-value:3.04E-18 ID:SGTC_332|Compound:4112-0506|FD-Score:9.65|P-value:3.74E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:7.75|P-value:1.60E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:10.10|P-value:1.37E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:8.89|P-value:1.83E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:8.61|P-value:3.19E-5 ID:SGTC_398|Compound:bronopol|FD-Score:-7.91|P-value:1.22E-4 ID:SGTC_401|Compound:neomycin|FD-Score:7.15|P-value:4.49E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:7.87|P-value:1.29E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-7.52|P-value:2.43E-4 ID:SGTC_417|Compound:st075190|FD-Score:9.13|P-value:1.11E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:8.05|P-value:9.18E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:7.47|P-value:2.60E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.64|P-value:2.00E-4 ID:SGTC_470|Compound:aa-861|FD-Score:9.45|P-value:5.74E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:8.86|P-value:1.94E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:12.80|P-value:1.31E-9 ID:SGTC_511|Compound:blebbistatin|FD-Score:6.75|P-value:8.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:15.70|P-value:1.54E-13 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.98|P-value:1.08E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:8.79|P-value:2.22E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:12.80|P-value:1.56E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:14.90|P-value:2.60E-12 ID:SGTC_575|Compound:k072-0246|FD-Score:16.80|P-value:2.60E-15 ID:SGTC_577|Compound:r071-0003|FD-Score:10.20|P-value:1.21E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:9.79|P-value:2.71E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:20.00|P-value:9.33E-21 ID:SGTC_642|Compound:0335-0876|FD-Score:11.90|P-value:1.64E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:9.06|P-value:1.29E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:7.30|P-value:3.50E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.51|P-value:5.06E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:6.99|P-value:5.85E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:9.10|P-value:1.19E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:7.86|P-value:1.32E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:8.95|P-value:1.62E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:15.30|P-value:6.24E-13 ID:SGTC_758|Compound:0868-0029|FD-Score:11.40|P-value:6.80E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:8.84|P-value:2.02E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:10.20|P-value:1.04E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:8.67|P-value:2.82E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:9.83|P-value:2.51E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:8.11|P-value:8.28E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:7.02|P-value:5.58E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:8.89|P-value:1.83E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:-7.42|P-value:2.90E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:17.90|P-value:5.44E-17 ID:SGTC_957|Compound:1187-1561|FD-Score:8.21|P-value:6.88E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:24.80|P-value:4.73E-31 ID:SGTC_1042|Compound:0350-0096|FD-Score:8.20|P-value:6.98E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:7.40|P-value:2.92E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.92|P-value:6.56E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:18.20|P-value:1.33E-17 ID:SGTC_1162|Compound:k048-0130|FD-Score:7.62|P-value:2.00E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:20.20|P-value:4.17E-21 ID:SGTC_1173|Compound:0443-0020|FD-Score:12.30|P-value:5.00E-9 ID:SGTC_1233|Compound:0325-0408|FD-Score:7.85|P-value:1.34E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:9.50|P-value:5.09E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:20.40|P-value:1.30E-21 ID:SGTC_1304|Compound:1165-0502|FD-Score:7.82|P-value:1.42E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-7.65|P-value:1.94E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:8.54|P-value:3.67E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:10.70|P-value:3.24E-7 ID:SGTC_1403|Compound:3909-7815|FD-Score:8.33|P-value:5.50E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:9.06|P-value:1.30E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:11.60|P-value:3.42E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:9.18|P-value:1.00E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:8.19|P-value:7.18E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:9.48|P-value:5.36E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:13.10|P-value:5.32E-10 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-8.82|P-value:2.17E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-9.42|P-value:6.25E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:10.50|P-value:5.25E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:9.48|P-value:5.41E-6 ID:SGTC_1604|Compound:st002052|FD-Score:12.70|P-value:1.62E-9 ID:SGTC_1643|Compound:st009866|FD-Score:7.12|P-value:4.70E-4 ID:SGTC_1661|Compound:st013063|FD-Score:8.34|P-value:5.36E-5 ID:SGTC_1687|Compound:st020778|FD-Score:8.45|P-value:4.31E-5 ID:SGTC_1696|Compound:st025591|FD-Score:7.93|P-value:1.16E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.67|P-value:1.84E-4 ID:SGTC_1773|Compound:st048542|FD-Score:12.00|P-value:1.13E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.65|P-value:3.69E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:10.70|P-value:3.71E-7 ID:SGTC_1888|Compound:azatryptophan|FD-Score:10.80|P-value:2.68E-7 ID:SGTC_1941|Compound:st076221|FD-Score:13.70|P-value:8.71E-11 ID:SGTC_1953|Compound:st076800|FD-Score:8.44|P-value:4.40E-5 ID:SGTC_2013|Compound:4024628|FD-Score:7.46|P-value:2.65E-4 ID:SGTC_2151|Compound:5563267|FD-Score:8.48|P-value:4.08E-5 ID:SGTC_2157|Compound:5649910|FD-Score:7.83|P-value:1.37E-4 ID:SGTC_2181|Compound:6316240|FD-Score:6.80|P-value:7.92E-4 ID:SGTC_2183|Compound:6420625|FD-Score:9.42|P-value:6.13E-6 ID:SGTC_2194|Compound:5927483|FD-Score:9.44|P-value:5.81E-6 ID:SGTC_2197|Compound:6588183|FD-Score:13.10|P-value:5.57E-10 ID:SGTC_2225|Compound:6654152|FD-Score:7.06|P-value:5.19E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:8.73|P-value:2.53E-5 ID:SGTC_2246|Compound:7293507|FD-Score:8.85|P-value:1.99E-5 ID:SGTC_2248|Compound:tofa|FD-Score:26.10|P-value:3.75E-34 ID:SGTC_2254|Compound:7938975|FD-Score:-8.77|P-value:2.38E-5 ID:SGTC_2259|Compound:7964009|FD-Score:11.10|P-value:1.18E-7 ID:SGTC_2289|Compound:7946404|FD-Score:12.30|P-value:5.82E-9 ID:SGTC_2312|Compound:7706453|FD-Score:18.70|P-value:2.29E-18 ID:SGTC_2322|Compound:7413319|FD-Score:18.90|P-value:7.17E-19 ID:SGTC_2346|Compound:9031566|FD-Score:8.74|P-value:2.47E-5 ID:SGTC_2377|Compound:9073351|FD-Score:-7.26|P-value:3.83E-4 ID:SGTC_2385|Compound:9074692|FD-Score:25.40|P-value:2.06E-32 ID:SGTC_2397|Compound:5161689|FD-Score:11.20|P-value:9.42E-8 ID:SGTC_2401|Compound:5128683|FD-Score:14.60|P-value:5.78E-12 ID:SGTC_2443|Compound:5493264|FD-Score:7.41|P-value:2.89E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:6.97|P-value:6.01E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:24.40|P-value:4.18E-30 ID:SGTC_2508|Compound:celastrol|FD-Score:11.50|P-value:4.88E-8 ID:SGTC_2526|Compound:patulin|FD-Score:16.50|P-value:1.04E-14 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-7.04|P-value:5.50E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:7.20|P-value:4.11E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-9.68|P-value:3.57E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-6.82|P-value:7.82E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:9.49|P-value:5.30E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:9.32|P-value:7.57E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.57|P-value:2.24E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:10.40|P-value:6.35E-7 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:7.12|P-value:4.75E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:14.80|P-value:3.36E-12 ID:SGTC_2659|Compound:sanguinarine|FD-Score:9.97|P-value:1.85E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:21.80|P-value:2.71E-24 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:12.70|P-value:1.97E-9 ID:SGTC_2681|Compound:menadione|FD-Score:6.80|P-value:7.88E-4 ID:SGTC_2694|Compound:st077685|FD-Score:8.06|P-value:9.05E-5 ID:SGTC_2695|Compound:st077686|FD-Score:19.70|P-value:3.20E-20 ID:SGTC_2701|Compound:st077767|FD-Score:23.40|P-value:8.60E-28 ID:SGTC_2735|Compound:sertaconazole|FD-Score:7.26|P-value:3.72E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.15|P-value:4.57E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:10.60|P-value:3.93E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:19.90|P-value:1.38E-20 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.71|P-value:9.30E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:10.20|P-value:1.03E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:13.40|P-value:2.19E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:9.24|P-value:8.84E-6 ID:SGTC_2787|Compound:5284540|FD-Score:11.40|P-value:5.66E-8 ID:SGTC_2788|Compound:5282734|FD-Score:12.80|P-value:1.51E-9 ID:SGTC_2790|Compound:5423970|FD-Score:7.80|P-value:1.45E-4 ID:SGTC_2851|Compound:9015922|FD-Score:9.07|P-value:1.27E-5 ID:SGTC_2858|Compound:9025781|FD-Score:16.70|P-value:4.47E-15 ID:SGTC_2865|Compound:9030313|FD-Score:7.35|P-value:3.20E-4 ID:SGTC_2867|Compound:9039098|FD-Score:7.96|P-value:1.08E-4 ID:SGTC_2918|Compound:7977171|FD-Score:16.40|P-value:1.46E-14 ID:SGTC_3002|Compound:9075603|FD-Score:8.53|P-value:3.72E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-7.21|P-value:4.15E-4 ID:SGTC_3025|Compound:9087895|FD-Score:12.00|P-value:1.35E-8 ID:SGTC_3118|Compound:9124250|FD-Score:7.57|P-value:2.19E-4 ID:SGTC_3277|Compound:9138724|FD-Score:8.41|P-value:4.73E-5 ID:SGTC_3279|Compound:9140807|FD-Score:18.30|P-value:9.12E-18 ID:SGTC_3282|Compound:9108498|FD-Score:13.40|P-value:2.83E-10 ID:SGTC_3311|Compound:9131146|FD-Score:7.29|P-value:3.52E-4 ID:SGTC_3317|Compound:9138495|FD-Score:8.73|P-value:2.52E-5 ID:SGTC_3336|Compound:9143619|FD-Score:8.61|P-value:3.19E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:8.04|P-value:9.47E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:7.58|P-value:2.16E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:7.25|P-value:3.77E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:11.30|P-value:8.29E-8 ID:SGTC_46|Compound:0329-0187a|FD-Score:10.00|P-value:1.72E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:7.31|P-value:3.45E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:8.08|P-value:8.77E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:53.80|P-value:1.09E-137 ID:SGTC_67|Compound:0335-0847|FD-Score:35.10|P-value:4.57E-60 ID:SGTC_69|Compound:0096-0274|FD-Score:8.55|P-value:3.58E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:17.70|P-value:1.12E-16 ID:SGTC_93|Compound:0109-0045|FD-Score:6.76|P-value:8.50E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.82|P-value:2.12E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:14.90|P-value:2.62E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:37.40|P-value:9.68E-68 ID:SGTC_141|Compound:0443-0274|FD-Score:15.40|P-value:5.12E-13 ID:SGTC_142|Compound:0335-0849|FD-Score:42.80|P-value:4.64E-88 ID:SGTC_148|Compound:3253-0744|FD-Score:9.61|P-value:4.06E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:8.04|P-value:9.47E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:12.00|P-value:1.18E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:10.60|P-value:3.82E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:16.90|P-value:1.91E-15 ID:SGTC_180|Compound:1486-1293|FD-Score:9.23|P-value:9.10E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:7.37|P-value:3.07E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:12.50|P-value:3.64E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:7.10|P-value:4.91E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:12.70|P-value:1.78E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:12.00|P-value:1.26E-8 ID:SGTC_274|Compound:sirtinol|FD-Score:8.21|P-value:6.85E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.30|P-value:8.70E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:9.42|P-value:6.06E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-11.00|P-value:1.60E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:18.60|P-value:3.04E-18 ID:SGTC_332|Compound:4112-0506|FD-Score:9.65|P-value:3.74E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:7.75|P-value:1.60E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:10.10|P-value:1.37E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:8.89|P-value:1.83E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:8.61|P-value:3.19E-5 ID:SGTC_398|Compound:bronopol|FD-Score:-7.91|P-value:1.22E-4 ID:SGTC_401|Compound:neomycin|FD-Score:7.15|P-value:4.49E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:7.87|P-value:1.29E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-7.52|P-value:2.43E-4 ID:SGTC_417|Compound:st075190|FD-Score:9.13|P-value:1.11E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:8.05|P-value:9.18E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:7.47|P-value:2.60E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.64|P-value:2.00E-4 ID:SGTC_470|Compound:aa-861|FD-Score:9.45|P-value:5.74E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:8.86|P-value:1.94E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:12.80|P-value:1.31E-9 ID:SGTC_511|Compound:blebbistatin|FD-Score:6.75|P-value:8.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:15.70|P-value:1.54E-13 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.98|P-value:1.08E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:8.79|P-value:2.22E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:12.80|P-value:1.56E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:14.90|P-value:2.60E-12 ID:SGTC_575|Compound:k072-0246|FD-Score:16.80|P-value:2.60E-15 ID:SGTC_577|Compound:r071-0003|FD-Score:10.20|P-value:1.21E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:9.79|P-value:2.71E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:20.00|P-value:9.33E-21 ID:SGTC_642|Compound:0335-0876|FD-Score:11.90|P-value:1.64E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:9.06|P-value:1.29E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:7.30|P-value:3.50E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.51|P-value:5.06E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:6.99|P-value:5.85E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:9.10|P-value:1.19E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:7.86|P-value:1.32E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:8.95|P-value:1.62E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:15.30|P-value:6.24E-13 ID:SGTC_758|Compound:0868-0029|FD-Score:11.40|P-value:6.80E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:8.84|P-value:2.02E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:10.20|P-value:1.04E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:8.67|P-value:2.82E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:9.83|P-value:2.51E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:8.11|P-value:8.28E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:7.02|P-value:5.58E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:8.89|P-value:1.83E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:-7.42|P-value:2.90E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:17.90|P-value:5.44E-17 ID:SGTC_957|Compound:1187-1561|FD-Score:8.21|P-value:6.88E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:24.80|P-value:4.73E-31 ID:SGTC_1042|Compound:0350-0096|FD-Score:8.20|P-value:6.98E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:7.40|P-value:2.92E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.92|P-value:6.56E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:18.20|P-value:1.33E-17 ID:SGTC_1162|Compound:k048-0130|FD-Score:7.62|P-value:2.00E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:20.20|P-value:4.17E-21 ID:SGTC_1173|Compound:0443-0020|FD-Score:12.30|P-value:5.00E-9 ID:SGTC_1233|Compound:0325-0408|FD-Score:7.85|P-value:1.34E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:9.50|P-value:5.09E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:20.40|P-value:1.30E-21 ID:SGTC_1304|Compound:1165-0502|FD-Score:7.82|P-value:1.42E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-7.65|P-value:1.94E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:8.54|P-value:3.67E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:10.70|P-value:3.24E-7 ID:SGTC_1403|Compound:3909-7815|FD-Score:8.33|P-value:5.50E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:9.06|P-value:1.30E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:11.60|P-value:3.42E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:9.18|P-value:1.00E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:8.19|P-value:7.18E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:9.48|P-value:5.36E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:13.10|P-value:5.32E-10 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-8.82|P-value:2.17E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-9.42|P-value:6.25E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:10.50|P-value:5.25E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:9.48|P-value:5.41E-6 ID:SGTC_1604|Compound:st002052|FD-Score:12.70|P-value:1.62E-9 ID:SGTC_1643|Compound:st009866|FD-Score:7.12|P-value:4.70E-4 ID:SGTC_1661|Compound:st013063|FD-Score:8.34|P-value:5.36E-5 ID:SGTC_1687|Compound:st020778|FD-Score:8.45|P-value:4.31E-5 ID:SGTC_1696|Compound:st025591|FD-Score:7.93|P-value:1.16E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.67|P-value:1.84E-4 ID:SGTC_1773|Compound:st048542|FD-Score:12.00|P-value:1.13E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.65|P-value:3.69E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:10.70|P-value:3.71E-7 ID:SGTC_1888|Compound:azatryptophan|FD-Score:10.80|P-value:2.68E-7 ID:SGTC_1941|Compound:st076221|FD-Score:13.70|P-value:8.71E-11 ID:SGTC_1953|Compound:st076800|FD-Score:8.44|P-value:4.40E-5 ID:SGTC_2013|Compound:4024628|FD-Score:7.46|P-value:2.65E-4 ID:SGTC_2151|Compound:5563267|FD-Score:8.48|P-value:4.08E-5 ID:SGTC_2157|Compound:5649910|FD-Score:7.83|P-value:1.37E-4 ID:SGTC_2181|Compound:6316240|FD-Score:6.80|P-value:7.92E-4 ID:SGTC_2183|Compound:6420625|FD-Score:9.42|P-value:6.13E-6 ID:SGTC_2194|Compound:5927483|FD-Score:9.44|P-value:5.81E-6 ID:SGTC_2197|Compound:6588183|FD-Score:13.10|P-value:5.57E-10 ID:SGTC_2225|Compound:6654152|FD-Score:7.06|P-value:5.19E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:8.73|P-value:2.53E-5 ID:SGTC_2246|Compound:7293507|FD-Score:8.85|P-value:1.99E-5 ID:SGTC_2248|Compound:tofa|FD-Score:26.10|P-value:3.75E-34 ID:SGTC_2254|Compound:7938975|FD-Score:-8.77|P-value:2.38E-5 ID:SGTC_2259|Compound:7964009|FD-Score:11.10|P-value:1.18E-7 ID:SGTC_2289|Compound:7946404|FD-Score:12.30|P-value:5.82E-9 ID:SGTC_2312|Compound:7706453|FD-Score:18.70|P-value:2.29E-18 ID:SGTC_2322|Compound:7413319|FD-Score:18.90|P-value:7.17E-19 ID:SGTC_2346|Compound:9031566|FD-Score:8.74|P-value:2.47E-5 ID:SGTC_2377|Compound:9073351|FD-Score:-7.26|P-value:3.83E-4 ID:SGTC_2385|Compound:9074692|FD-Score:25.40|P-value:2.06E-32 ID:SGTC_2397|Compound:5161689|FD-Score:11.20|P-value:9.42E-8 ID:SGTC_2401|Compound:5128683|FD-Score:14.60|P-value:5.78E-12 ID:SGTC_2443|Compound:5493264|FD-Score:7.41|P-value:2.89E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:6.97|P-value:6.01E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:24.40|P-value:4.18E-30 ID:SGTC_2508|Compound:celastrol|FD-Score:11.50|P-value:4.88E-8 ID:SGTC_2526|Compound:patulin|FD-Score:16.50|P-value:1.04E-14 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-7.04|P-value:5.50E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:7.20|P-value:4.11E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-9.68|P-value:3.57E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-6.82|P-value:7.82E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:9.49|P-value:5.30E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:9.32|P-value:7.57E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.57|P-value:2.24E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:10.40|P-value:6.35E-7 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:7.12|P-value:4.75E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:14.80|P-value:3.36E-12 ID:SGTC_2659|Compound:sanguinarine|FD-Score:9.97|P-value:1.85E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:21.80|P-value:2.71E-24 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:12.70|P-value:1.97E-9 ID:SGTC_2681|Compound:menadione|FD-Score:6.80|P-value:7.88E-4 ID:SGTC_2694|Compound:st077685|FD-Score:8.06|P-value:9.05E-5 ID:SGTC_2695|Compound:st077686|FD-Score:19.70|P-value:3.20E-20 ID:SGTC_2701|Compound:st077767|FD-Score:23.40|P-value:8.60E-28 ID:SGTC_2735|Compound:sertaconazole|FD-Score:7.26|P-value:3.72E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.15|P-value:4.57E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:10.60|P-value:3.93E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:19.90|P-value:1.38E-20 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.71|P-value:9.30E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:10.20|P-value:1.03E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:13.40|P-value:2.19E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:9.24|P-value:8.84E-6 ID:SGTC_2787|Compound:5284540|FD-Score:11.40|P-value:5.66E-8 ID:SGTC_2788|Compound:5282734|FD-Score:12.80|P-value:1.51E-9 ID:SGTC_2790|Compound:5423970|FD-Score:7.80|P-value:1.45E-4 ID:SGTC_2851|Compound:9015922|FD-Score:9.07|P-value:1.27E-5 ID:SGTC_2858|Compound:9025781|FD-Score:16.70|P-value:4.47E-15 ID:SGTC_2865|Compound:9030313|FD-Score:7.35|P-value:3.20E-4 ID:SGTC_2867|Compound:9039098|FD-Score:7.96|P-value:1.08E-4 ID:SGTC_2918|Compound:7977171|FD-Score:16.40|P-value:1.46E-14 ID:SGTC_3002|Compound:9075603|FD-Score:8.53|P-value:3.72E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-7.21|P-value:4.15E-4 ID:SGTC_3025|Compound:9087895|FD-Score:12.00|P-value:1.35E-8 ID:SGTC_3118|Compound:9124250|FD-Score:7.57|P-value:2.19E-4 ID:SGTC_3277|Compound:9138724|FD-Score:8.41|P-value:4.73E-5 ID:SGTC_3279|Compound:9140807|FD-Score:18.30|P-value:9.12E-18 ID:SGTC_3282|Compound:9108498|FD-Score:13.40|P-value:2.83E-10 ID:SGTC_3311|Compound:9131146|FD-Score:7.29|P-value:3.52E-4 ID:SGTC_3317|Compound:9138495|FD-Score:8.73|P-value:2.52E-5 ID:SGTC_3336|Compound:9143619|FD-Score:8.61|P-value:3.19E-5

Top fitness defect scores for YDL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 53.80 272.1 µM 1.09E-137 ubiquinone biosynthesis & proteasome 1 0
2 SGTC_142 0335-0849 42.80 62.7 µM 4.64E-88 ubiquinone biosynthesis & proteasome 1 0
3 SGTC_137 0438-0332 37.40 85.4 µM 9.68E-68 ubiquinone biosynthesis & proteasome 1 3.42E-306
4 SGTC_67 0335-0847 35.10 266.0 µM 4.57E-60 ubiquinone biosynthesis & proteasome 1 1.17E-270
5 SGTC_2248 tofa 26.10 1.1 µM 3.75E-34 sphingolipid biosynthesis & PDR1 1 8.47E-151
6 SGTC_2385 9074692 25.40 200.0 µM 2.06E-32 1 9.06E-143
7 SGTC_1026 k007-1105 24.80 30.6 µM 4.73E-31 ERAD & cell cycle 1 1.76E-136
8 SGTC_2499 avocadenofuran 24.40 51.5 µM 4.18E-30 2 4.10E-132
9 SGTC_2701 st077767 23.40 14.7 µM 8.60E-28 2 1.93E-121
10 SGTC_2660 2',4'-dihydroxychalcone 21.80 17.1 µM 2.71E-24 1 2.58E-105
11 SGTC_1287 0971-0001 20.40 34.6 µM 1.30E-21 sphingolipid biosynthesis & PDR1 2 5.72E-93
12 SGTC_1165 k072-0275 20.20 30.3 µM 4.17E-21 1 1.24E-90
13 SGTC_637 1181-0519 20.00 7.3 µM 9.33E-21 fatty acid desaturase (OLE1) 5 5.05E-89
14 SGTC_2752 diclazuril 19.90 33.1 µM 1.38E-20 4 3.11E-88
15 SGTC_2695 st077686 19.70 52.0 µM 3.20E-20 1 1.47E-86
16 SGTC_2322 7413319 18.90 38.2 µM 7.17E-19 ERAD & cell cycle 2 2.38E-80
17 SGTC_2312 7706453 18.70 155.7 µM 2.29E-18 1 4.90E-78
18 SGTC_315 k915-0449 18.60 187.0 µM 3.04E-18 2 1.83E-77
19 SGTC_3279 9140807 18.30 49.5 µM 9.12E-18 1 2.84E-75
20 SGTC_1161 k007-0610 18.20 110.0 µM 1.33E-17 ERAD & cell cycle 3 1.59E-74

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.432 3.46E-152 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.378 7.07E-114 YBR106W PHO88 hom Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
0.353 1.10E-98 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.351 2.18E-97 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.348 7.47E-96 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.347 6.23E-95 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.343 5.82E-93 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.340 4.77E-91 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.337 1.07E-89 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.328 1.34E-84 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.326 8.33E-84 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.324 2.61E-82 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.323 6.22E-82 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.322 1.58E-81 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.321 7.53E-81 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder