YDL021W / GPM2

Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL021W / GPM2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.65|P-value:1.25E-8 ID:SGTC_54|Compound:0159-0055|FD-Score:3.34|P-value:4.98E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:13.00|P-value:8.24E-38 ID:SGTC_121|Compound:0557-0495|FD-Score:6.33|P-value:2.08E-10 ID:SGTC_122|Compound:0236-0016|FD-Score:3.91|P-value:5.91E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.46|P-value:9.27E-11 ID:SGTC_218|Compound:alverine citrate|FD-Score:-3.12|P-value:9.51E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:5.26|P-value:1.08E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:3.31|P-value:5.51E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.60|P-value:1.95E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.85|P-value:7.51E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.81|P-value:8.76E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:11.70|P-value:2.99E-31 ID:SGTC_483|Compound:fpl-64176|FD-Score:4.33|P-value:1.01E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.34|P-value:2.02E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:12.50|P-value:4.59E-35 ID:SGTC_597|Compound:k018-0003|FD-Score:4.58|P-value:3.11E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.71|P-value:1.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.38|P-value:4.45E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.73|P-value:1.21E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.76|P-value:1.05E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.25|P-value:1.43E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:5.81|P-value:5.07E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:8.23|P-value:2.24E-16 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.59|P-value:2.62E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.16|P-value:1.81E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.51|P-value:2.81E-8 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.49|P-value:2.96E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.35|P-value:4.42E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.61|P-value:1.66E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.12|P-value:2.50E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.23|P-value:6.62E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.48|P-value:3.01E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.86|P-value:3.63E-9 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.68|P-value:1.26E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.61|P-value:1.92E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.17|P-value:9.19E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.22|P-value:7.61E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-5.11|P-value:1.99E-7 ID:SGTC_2342|Compound:7990637|FD-Score:3.20|P-value:8.18E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.13|P-value:2.36E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.49|P-value:4.83E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.24|P-value:1.27E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.63|P-value:1.79E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.12|P-value:9.72E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:7.31|P-value:2.70E-13 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.15|P-value:6.58E-10 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.52|P-value:2.67E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:3.67|P-value:1.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.70|P-value:1.33E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.25|P-value:6.08E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.95|P-value:5.21E-7 ID:SGTC_3052|Compound:9092717|FD-Score:3.35|P-value:4.79E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.07|P-value:3.03E-5 ID:SGTC_3231|Compound:9132313|FD-Score:-3.48|P-value:2.69E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.87|P-value:6.86E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-6.05|P-value:9.91E-10 ID:SGTC_3266|Compound:9136860|FD-Score:4.71|P-value:1.68E-6 ID:SGTC_3311|Compound:9131146|FD-Score:7.40|P-value:1.44E-13 ID:SGTC_6|Compound:0844-0013|FD-Score:5.65|P-value:1.25E-8 ID:SGTC_54|Compound:0159-0055|FD-Score:3.34|P-value:4.98E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:13.00|P-value:8.24E-38 ID:SGTC_121|Compound:0557-0495|FD-Score:6.33|P-value:2.08E-10 ID:SGTC_122|Compound:0236-0016|FD-Score:3.91|P-value:5.91E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.46|P-value:9.27E-11 ID:SGTC_218|Compound:alverine citrate|FD-Score:-3.12|P-value:9.51E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:5.26|P-value:1.08E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:3.31|P-value:5.51E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.60|P-value:1.95E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.85|P-value:7.51E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.81|P-value:8.76E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:11.70|P-value:2.99E-31 ID:SGTC_483|Compound:fpl-64176|FD-Score:4.33|P-value:1.01E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.34|P-value:2.02E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:12.50|P-value:4.59E-35 ID:SGTC_597|Compound:k018-0003|FD-Score:4.58|P-value:3.11E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.71|P-value:1.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.38|P-value:4.45E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.73|P-value:1.21E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.76|P-value:1.05E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.25|P-value:1.43E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:5.81|P-value:5.07E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:8.23|P-value:2.24E-16 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.59|P-value:2.62E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.16|P-value:1.81E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.51|P-value:2.81E-8 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.49|P-value:2.96E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.35|P-value:4.42E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.61|P-value:1.66E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.12|P-value:2.50E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.23|P-value:6.62E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.48|P-value:3.01E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.86|P-value:3.63E-9 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.68|P-value:1.26E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.61|P-value:1.92E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.17|P-value:9.19E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.22|P-value:7.61E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-5.11|P-value:1.99E-7 ID:SGTC_2342|Compound:7990637|FD-Score:3.20|P-value:8.18E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.13|P-value:2.36E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.49|P-value:4.83E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.24|P-value:1.27E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.63|P-value:1.79E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.12|P-value:9.72E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:7.31|P-value:2.70E-13 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.15|P-value:6.58E-10 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.52|P-value:2.67E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:3.67|P-value:1.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.70|P-value:1.33E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.25|P-value:6.08E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.95|P-value:5.21E-7 ID:SGTC_3052|Compound:9092717|FD-Score:3.35|P-value:4.79E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.07|P-value:3.03E-5 ID:SGTC_3231|Compound:9132313|FD-Score:-3.48|P-value:2.69E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.87|P-value:6.86E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-6.05|P-value:9.91E-10 ID:SGTC_3266|Compound:9136860|FD-Score:4.71|P-value:1.68E-6 ID:SGTC_3311|Compound:9131146|FD-Score:7.40|P-value:1.44E-13

Top fitness defect scores for YDL021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 13.00 9.0 µM 8.24E-38 cell wall 40 1.07E-38
2 SGTC_528 3492-0019 12.50 172.0 µM 4.59E-35 calcium & mitochondrial duress 27 6.93E-36
3 SGTC_467 ro 31-8220 11.70 72.8 µM 2.99E-31 calcium & mitochondrial duress 6 5.54E-32
4 SGTC_951 1171-0579 8.23 82.7 µM 2.24E-16 cell wall 14 9.35E-17
5 SGTC_3311 9131146 7.40 2.9 µM 1.44E-13 cell wall 39 7.02E-14
6 SGTC_2584 androsterone 7.31 48.7 µM 2.70E-13 cell wall 32 1.33E-13
7 SGTC_138 0850-0259 6.46 40.9 µM 9.27E-11 cell wall 91 5.26E-11
8 SGTC_488 nitrendipine 6.34 139.0 µM 2.02E-10 13 1.17E-10
9 SGTC_121 0557-0495 6.33 61.3 µM 2.08E-10 calcium & mitochondrial duress 16 1.20E-10
10 SGTC_2651 1327-0036 6.15 5.0 µM 6.58E-10 69 3.92E-10
11 SGTC_1712 st032288 5.86 53.4 µM 3.63E-9 calcium & mitochondrial duress 80 2.25E-9
12 SGTC_928 2764-0428 5.81 58.7 µM 5.07E-9 cell wall 16 3.17E-9
13 SGTC_6 0844-0013 5.65 19.8 µM 1.25E-8 20 8.00E-9
14 SGTC_1282 0886-0010 5.51 32.4 µM 2.81E-8 endomembrane recycling 13 1.83E-8
15 SGTC_304 1310-0298 5.26 97.0 µM 1.08E-7 cell wall 29 7.24E-8
16 SGTC_2931 9014674 4.95 55.7 µM 5.21E-7 6 3.65E-7
17 SGTC_3266 9136860 4.71 49.5 µM 1.68E-6 cell wall 32 1.21E-6
18 SGTC_597 k018-0003 4.58 82.8 µM 3.11E-6 RNA pol III & RNase P/MRP 5 2.27E-6
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.49 3.7 µM 4.83E-6 51 3.57E-6
20 SGTC_483 fpl-64176 4.33 144.0 µM 1.01E-5 cell wall 8 7.59E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.462 2.47E-177 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.437 2.94E-156 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.429 3.58E-150 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.416 8.28E-141 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.415 1.06E-139 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.380 7.47E-116 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.375 2.34E-112 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.361 3.82E-104 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.359 1.88E-102 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.356 2.28E-100 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.344 1.07E-93 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.341 2.84E-92 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.340 1.77E-91 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.335 9.80E-89 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.333 1.71E-87 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly