YDL024C / DIA3

Protein of unknown function, involved in invasive and pseudohyphal growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL024C / DIA3

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.99|P-value:3.68E-8 ID:SGTC_47|Compound:0149-0135|FD-Score:4.87|P-value:5.94E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:4.81|P-value:7.65E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:4.06|P-value:1.34E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.49|P-value:8.53E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:5.42|P-value:5.46E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.75|P-value:3.75E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.02|P-value:1.51E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.31|P-value:5.43E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.67|P-value:4.46E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.67|P-value:4.91E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.02|P-value:1.51E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.51|P-value:2.27E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.53|P-value:7.61E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.03|P-value:1.50E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-8.54|P-value:6.00E-15 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.19|P-value:8.43E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.10|P-value:1.16E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-4.19|P-value:7.64E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.02|P-value:1.40E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.62|P-value:5.78E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.46|P-value:8.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.63|P-value:2.09E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.62|P-value:2.17E-7 ID:SGTC_2305|Compound:7443522|FD-Score:4.11|P-value:1.10E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.22|P-value:6.72E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.77|P-value:3.55E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.30|P-value:5.63E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.03|P-value:3.05E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.99|P-value:1.67E-4 ID:SGTC_2868|Compound:9035608|FD-Score:7.15|P-value:6.25E-11 ID:SGTC_2997|Compound:9067075|FD-Score:4.54|P-value:2.29E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.75|P-value:3.76E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.49|P-value:2.72E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:5.99|P-value:3.68E-8 ID:SGTC_47|Compound:0149-0135|FD-Score:4.87|P-value:5.94E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:4.81|P-value:7.65E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:4.06|P-value:1.34E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.49|P-value:8.53E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:5.42|P-value:5.46E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.75|P-value:3.75E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.02|P-value:1.51E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.31|P-value:5.43E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.67|P-value:4.46E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.67|P-value:4.91E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.02|P-value:1.51E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.51|P-value:2.27E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.53|P-value:7.61E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.03|P-value:1.50E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-8.54|P-value:6.00E-15 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.19|P-value:8.43E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.10|P-value:1.16E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-4.19|P-value:7.64E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.02|P-value:1.40E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.62|P-value:5.78E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.46|P-value:8.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.63|P-value:2.09E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.62|P-value:2.17E-7 ID:SGTC_2305|Compound:7443522|FD-Score:4.11|P-value:1.10E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.22|P-value:6.72E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.77|P-value:3.55E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.30|P-value:5.63E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.03|P-value:3.05E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.99|P-value:1.67E-4 ID:SGTC_2868|Compound:9035608|FD-Score:7.15|P-value:6.25E-11 ID:SGTC_2997|Compound:9067075|FD-Score:4.54|P-value:2.29E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.75|P-value:3.76E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.49|P-value:2.72E-5

Top fitness defect scores for YDL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2868 9035608 7.15 32.5 µM 6.25E-11 1 4.30E-13
2 SGTC_6 0844-0013 5.99 19.8 µM 3.68E-8 15 1.08E-9
3 SGTC_1787 fluconazole 5.63 80.0 µM 2.09E-7 iron homeostasis 3 9.07E-9
4 SGTC_1788 fluconazole 5.62 20.0 µM 2.17E-7 azole & statin 33 9.50E-9
5 SGTC_624 k048-0052 5.42 28.0 µM 5.46E-7 Golgi 6 2.95E-8
6 SGTC_2560 caryophyllene 5.03 100.0 µM 3.05E-6 6 2.42E-7
7 SGTC_47 0149-0135 4.87 24.2 µM 5.94E-6 TSC3-RPN4 9 5.49E-7
8 SGTC_60 0986-0278 4.81 202.0 µM 7.65E-6 3 7.47E-7
9 SGTC_2997 9067075 4.54 71.4 µM 2.29E-5 unfolded protein response 37 2.86E-6
10 SGTC_3197 9113331 4.49 49.5 µM 2.72E-5 24 3.53E-6
11 SGTC_644 1498-1197 4.31 63.3 µM 5.43E-5 11 8.21E-6
12 SGTC_2420 aureobasidin a 4.30 50.0 nM 5.63E-5 31 8.59E-6
13 SGTC_1052 3253-3998 4.19 198.0 µM 8.43E-5 13 1.41E-5
14 SGTC_2305 7443522 4.11 69.2 µM 1.10E-4 12 1.96E-5
15 SGTC_1200 1643-0193 4.10 18.4 µM 1.16E-4 13 2.08E-5
16 SGTC_95 0471-0001 4.06 561.1 µM 1.34E-4 23 2.48E-5
17 SGTC_2736 butenafine 4.04 14.7 µM 1.41E-4 28 2.65E-5
18 SGTC_825 1988-2224 4.03 89.6 µM 1.50E-4 cell wall signaling 32 2.84E-5
19 SGTC_816 0325-0417 4.02 81.3 µM 1.51E-4 11 2.86E-5
20 SGTC_640 3381-0960 4.02 37.1 µM 1.51E-4 9 2.87E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.51E-10 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.095 3.28E-8 YCL011C GBP2 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
0.095 3.68E-8 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.094 4.44E-8 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.083 2.07E-6 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.081 3.03E-6 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.077 7.37E-6 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.077 8.37E-6 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.075 1.39E-5 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.075 1.49E-5 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.075 1.55E-5 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.074 1.68E-5 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.073 2.09E-5 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.65E-5 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.072 3.20E-5 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases